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| 1 | Metabolic reprogramming in macrophages and dendritic cells in innate immunity显示文摘 | Beth Kelly Luke AJ O'Neill | 2015 | Cell Research2015，25，7： | 70 |
| 2 | 农田开垦对三江平原湿地土壤种子库影响及湿地恢复潜力显示文摘种子库是湿地植被恢复的重要途径之一,不同时期的耕作土壤中残留的种子对开垦湿地恢复具有重要的作用。本文采用温室萌发法在两种水分条件下对三江平原天然湿地、不同开垦年限湿地种子库结构和规模进行了研究,以了解不同开垦年限湿地种子库特征及其在湿地植被恢复中的潜力。本次实验共萌发物种50种,随着开垦年限增加,萌发物种逐渐减少,天然湿地、开垦1年、3年、10年、20年的湿地分别为34种、31种、21种、21种和8种,萌发物种数与种子库规模均表现出极显著差异(F1=8.32,F2=5.946,P<0.001)。种子库密度以天然湿地和开垦1年湿地最大,分别为7624粒/m2,9836粒/m2。随着开垦年限增加,种子库规模逐渐减小,开垦3年、10年种子库密度为4336粒/m2,4872粒/m2。开垦20 a后,显著减少为432粒/m2。湿润条件下萌发物种数及种子密度显著高于淹水处理,种子库具有明显的分层现象,0—5 cm土层种子库规模显著高于5—10 cm。小叶章(Calamagrostis angustifolia)作为该地区优势物种,由最初的1192粒/m2,经过20 a开垦后在种子库中消失。研究表明,在一定的开垦年限范围内,开垦湿地土壤中仍然保留大量的湿地物种种子,在湿地恢复中具有重要的作用。 | 王国栋 Beth A Middleton 吕宪国 姜明 王铭 赵魁义 娄彦景 | 2013 | 生态学报2013，33，1： | 18 |
| 3 | Lapatinib plus capecitabine in treating HER2-positive advanced breast cancer:efficacy,safety,and biomarker results from Chinese patients显示文摘Overexpression of human epidermal growth factor receptor-2(HER2) in metastatic breast cancer(MBC) is associated with poor prognosis.This single-arm open-label trial(EGF109491;NCT00508274) was designed to confirm the efficacy and safety of lapatinib in combination with capecitabine in 52 heavily pretreated Chinese patients with HER2-positive MBC.The primary endpoint was clinical benefit rate(CBR).Secondary endpoints included progression-free survival(PFS),time to response(TTR),duration of response(DoR),central nervous system(CNS) as first site of relapse,and safety.The results showed that there were 23 patients with partial responses and 7 patients with stable disease,resulting in a CBR of 57.7%.The median PFS was 6.34 months(95% confidence interval,4.93-9.82 months).The median TTR and DoR were 4.07 months(range,0.03-14.78 months) and 6.93 months(range,1.45-9.72 months),respectively.Thirteen(25.0%) patients had new lesions as disease progression.Among them,2(3.8%) patients had CNS disease reported as the first relapse.The most common toxicities were palmar-plantar erythrodysesthesia(59.6%),diarrhea(48.1%),rash(48.1%),hyperbilirubinemia(34.6%),and fatigue(30.8%).Exploratory analyses of oncogenic mutations of PIK3CA suggested that of 38 patients providing a tumor sample,baseline PIK3CA mutation status was not associated with CBR(P = 0.639) or PFS(P = 0.989).These data confirm that the lapatinib plus capecitabine combination is an effective and well-tolerated treatment option for Chinese women with heavily pretreated MBC,irrespective of PIK3CA status. | Bing-He Xu Ze-Fei Jiang Daniel Chua Zhi-Min Shao Rong-Cheng Luo Xiao-Jia Wang Dong-Geng Liu Winnie Yeo Shi-Ying Yu Beth Newstat Alka Preston Anne-Marie Martin Hai-Dong Chi Li wang | 2011 | Chinese Journal of Cancer2011，30，5： | 17 |
| 4 | Biochar and its importance on nutrient dynamics in soil and plant显示文摘Biochar,an environmentally friendly soil conditioner,is produced using several thermochemical processes.It has unique characteristics like high surface area,porosity,and surface charges.This paper reviews the fertilizer value of biochar,and its effects on soil properties,and nutrient use efficiency of crops.Biochar serves as an important source of plant nutrients,especially nitrogen in biochar produced from manures and wastes at low temperature(≤400℃).The phosphorus,potassium,and other nutrient contents are higher in manure/waste biochars than those in crop residues and woody biochars.The nutrient contents and pH of biochar are positively correlated with pyrolysis temperature,except for nitrogen content.Biochar improves the nutrient retention capacity of soil,which depends on porosity and surface charge of biochar.Biochar increases nitrogen retention in soil by reducing leaching and gaseous loss,and also increases phosphorus availability by decreasing the leaching process in soil.However,for potassium and other nutrients,biochar shows inconsistent(positive and negative)impacts on soil.After addition of biochar,porosity,aggregate stability,and amount of water held in soil increase and bulk density decreases.Mostly,biochar increases soil pH and,thus,influences nutrient availability for plants.Biochar also alters soil biological properties by increasing microbial populations,enzyme activity,soil respiration,and microbial biomass.Finally,nutrient use efficiency and nutrient uptake improve with the application of biochar to soil.Thus,biochar can be a potential nutrient reservoir for plants and a good amendment to improve soil properties. | Md Zahangir Hossain Md Mezbaul Bahar Binoy Sarkar Scott Wilfred Donne Young Sik Ok Kumuduni Niroshika Palansooriya Mary Beth Kirkham Saikat Chowdhury Nanthi Bolan | 2020 | Biochar2020，2，4： | 15 |
| 5 | Adalimumab Induces and Maintains Clinical Remission in Patients With Moderate-to-Severe Ulcerative Colitis显示文摘 | William J. Sandborn Gert van Assche Walter Reinisch Jean–Frederic Colombel Geert D’Haens Douglas C. Wolf Martina Kron Mary Beth Tighe Andreas Lazar Roopal B. Thakkar | 2012 | Gastroenterology2012，，2： | 9 |
| 6 | Autophagy in the Pathogenesis of Disease显示文摘 | Beth Levine Guido Kroemer | 2008 | Cell2008，，1： | 8 |
| 7 | Screening and Surveillance for the Early Detection of Colorectal Cancer and Adenomatous Polyps, 2008: A Joint Guideline From the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology显示文摘 | Bernard Levin David A. Lieberman Beth McFarland Kimberly S. Andrews Durado Brooks John Bond Chiranjeev Dash Francis M. Giardiello Seth Glick David Johnson C. Daniel Johnson Theodore R. Levin Perry J. Pickhardt Douglas K. Rex Robert A. Smith Alan Thorson S | 2008 | Gastroenterology2008，，5： | 8 |
| 8 | The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide显示文摘 | Joseph F. Perz Gregory L. Armstrong Leigh A. Farrington Yvan J.F. Hutin Beth P. Bell | 2006 | Journal of Hepatology2006，，4： | 7 |
| 9 | Adaptive and maladaptive expression of the mRNA regulatory protein HuR显示文摘The RNA-binding proteins involved in regulation of mRNA post-transcriptional processing and translation control the fates of thousands of mRNA transcripts and basic cellular processes. The best studied of these, HuR, is well characterized as a mediator of mRNA stability and translation, and more recently, as a factor in nuclear functions such as pre-mRNA splicing. Due to HuR's role in regulating thousands of mRNA transcripts, including those for other RNA-binding proteins, HuR can act as a master regulator of cell survival and proliferation. HuR itself is subject to multiple post-translationa modifications including regulation of its nucleocytoplasmic distribution. However, the mechanisms that govern HuR levels in the cell have only recently begun to be defined. These mechanisms are critical to cell health, as it has become clear in recent years that aberrant expression of HuR can lead alternately to decreased cell viability or to promotion of pathological proliferation and invasiveness. HuR is expressed as alternate mRNAs that vary in their untranslated regions, leading to differences in transcript stability and translatability. Multiple transcription factors and modulators of mRNA stability that regulate HuR mRNA expression have been identified. In addition, translation of HuR is regulated by numerous microRNAs, several of which have been demonstrated to have anti-tumor properties due to their suppression of HuR expression. This review summarizes the current state of knowledge of the factors that regulate HuR expression, along with the circumstances under which these factors contribute to cancer and inflammation. | Suman Govindaraju Beth S Lee | 2013 | World Journal of Biological Chemistry2013，4，4： | 7 |
| 10 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 11 | Characteristics of postintensive care syndrome in survivors of pediatric critical illness: A systematic review显示文摘AIM To synthesize the available evidence focusing on morbidities in pediatric survivors of critical illness that fall within the defined construct of postintensive care syndrome(PICS) in adults, including physical, neurocognitive and psychological morbidities.METHODS A comprehensive search was conducted in MEDLINE, EMBASE, the Cochrane Library, Psyc INFO, and CINAHL using controlled vocabulary and key word terms to identify studies reporting characteristics of PICS in pediatric intensive care unit(PICU) patients. Two reviewers independently screened all titles and abstracts and performed data extraction. From the 3176 articles identified in the search, 252 abstracts were identified for full text review and nineteen were identified for inclusion in the review. All studies reporting characteristics of PICS in PICU patients were included in the final synthesis. RESULTS Nineteen studies meeting inclusion criteria published between 1995 and 2016 were identified and categorized into studies reporting morbidities in each of three categories-physical, neurocognitive and psychological. The majority of included articles reported prospective cohort studies, and there was significant variability in the outcome measures utilized. A synthesis of the studies indicate that morbidities encompassing PICS are well-described in children who have survived critical illness, often resolving over time. Risk factors for development of these morbidities include younger age, lower socioeconomic status, increased number of invasive procedures or interventions, type of illness, and increased benzodiazepine andnarcotic administration.CONCLUSION PICS-related morbidities impact a significant proportion of children discharged from PICUs. In order to further define PICS in children, more research is needed using standardized tools to better understand the scope and natural history of morbidities after hospital discharge. Improving our understanding of physical, neurocognitive, and psychological morbidities after critical illness in the pediatric population is imperative for designing interventions to improve long-term outcomes in PICU patients. | Elizabeth A Herrup Beth Wieczorek Sapna R Kudchadkar | 2017 | World Journal of Critical Care Medicine2017，6，2： | 7 |
| 12 | 863 genomes reveal the origin and domestication of chicken显示文摘Despite the substantial role that chickens have played in human societies across the world,both the geographic and temporal origins of their domestication remain controversial.To address this issue,we analyzed 863 genomes from a worldwide sampling of chickens and representatives of all four species of wild jungle fowl and each of the five subspecies of red jungle fowl(RJF).Our study suggests that domestic chickens were initially derived from the RJF subspecies Gallus gallus spadiceus whose present-day distribution is predominantly in southwestern China,northern Thailand and Myanmar.Following their domestication,chickens were translocated across Southeast and South Asia where they interbred locally with both RJF subspecies and other jungle fowl species.In addition,our results show that the White Leghorn chicken breed possesses a mosaic of divergent ancestries inherited from other subspecies of RJF.Despite the strong episodic gene flow from geographically divergent lineages of jungle fowls,our analyses show that domestic chickens undergo genetic adaptations that underlie their unique behavioral,morphological and reproductive traits.Our study provides novel insights into the evolutionary history of domestic chickens and a valuable resource to facilitate ongoing genetic and functional investigations of the world's most numerous domestic animal. | Ming-Shan Wang Mukesh Thakur Min-Sheng Peng Yu Jiang Laurent Alain Francois Frantz Ming Li Jin-Jin Zhang Sheng Wang Joris Peters Newton Otieno Otecko Chatmongkon Suwannapoom Xing Guo Zhu-Qing Zheng Ali Esmailizadeh Nalini Yasoda Hirimuthugoda Hidayat Ashari Sri Suladari Moch Syamsul Arifin Zein Szilvia Kusza Saeed Sohrabi Hamed Kharrati-Koopaee Quan-Kuan Shen Lin Zeng Min-Min Yang Ya-Jiang Wu Xing-Yan Yang Xue-Mei Lu Xin-Zheng Jia Qing-Hua Nie Susan Joy Lamont Emiliano Lasagna Simone Ceccobelli Humpita Gamaralalage Thilini Nisanka Gunwardana Thilina Madusanka Senasige Shao-Hong Feng Jing-Fang Si Hao Zhang Jie-Qiong Jin Ming-Li Li Yan-Hu Liu Hong-Man Chen Cheng Ma Shan-Shan Dai Abul Kashem Fazlul Haque Bhuiyan Muhammad Sajjad Khan Gamamada Liyanage Lalanie Pradeepa Silva Thi-Thuy Le Okeyo Ally Mwai Mohamed Nawaz Mohamed Ibrahim Megan Supple Beth Shapiro Olivier Hanotte Guojie Zhang Greger Larson Jian-Lin Han Dong-Dong Wu Ya-Ping Zhang | 2020 | Cell Research2020，30，8： | 7 |
| 13 | Hepatitis B Virus Infection: Epidemiology and Vaccination显示文摘 | Colin W. Shepard Edgar P. Simard Lyn Finelli Anthony E. Fiore Beth P. Bell | 2006 | Epidemiologic Reviews2006，，： | 6 |
| 14 | Discovering the roles of subsurface microorganisms: Progress and future of deep biosphere investigation显示文摘The discovery of the marine 'deep biosphere'-microorganisms living deep below the seafloor-is one of the most significant and exciting discoveries since the ocean drilling program began more than 40 years ago. Study of the deep biosphere has become a research frontier and a hot spot both for geological and biological sciences. Here, we introduce the history of the discovery of the deep biosphere, and then we describe the types of environments for life below the seafloor, the energy sources for the living creatures, the diversity of organisms within the deep biosphere, and the new tools and technologies used in this research field. We will highlight several recently completed Integrated Ocean Drilling Program Expeditions, which targeted the subseafloor deep biosphere within the crust and sediments. Finally, future research directions and challenges of deep biosphere investigation towards uncovering the roles of subsurface microorganisms will be briefly addressed. | WANG FengPing LU ShuLin ORCUTT Beth N XIE Wei CHEN Ying XIAO Xiang EDWARDS Katrina J | 2013 | Chinese Science Bulletin2013，58，4： | 6 |
| 15 | Symptom management during and after treatment with concurrent chemoradiotherapy for oropharyngeal cancer:A review of the literature and areas for future research显示文摘Patients with locally advanced oropharyngeal cancer are at risk for poor outcomes due to the multi-modal nature of treatment and the potential for treatmentrelated toxicity.Although treatment with concurrent chemotherapy and radiotherapy has drastically reduced the need for a debilitating and disfiguring surgery,treatment related toxicities are often difficult to control.Acute toxicities include mucositis,skin desquamation,depression,cachexia,fatigue and nausea and vomiting.Failure to control these symptoms can adversely affect the patient's ability to complete their treatment regimen.Although there are many promising new treatments in the area of symptom management for this patient population,a review of the literature reflects the need for more research. | Heidi Mason Mary Beth De Rubeis Nancy Burke Melissa Shannon Danielle Karsies Gregory Wolf Avi Eisbruch Francis Worden | 2016 | World Journal of Clinical Oncology2016，7，2： | 5 |
| 16 | Microbial communities biostimulated by ethanol during uranium (VI) bioremediation in contaminated sediment as shown by stable isotope probing显示文摘(啜) 稳定的同位素探查被用来识别乙醇增加在包含在 US 能源部橡树理兹地点从 bioremediation 测试地区收集的二沉积的缩影刺激的微生物, TN,美国。一件样品是高度有乙醇的 bioreduced 当另外一个少些被减少时。有各自的沉积的缩影与标记乙醇并且为啜为 7 孵化了天的 13C 被修改。乙醇很快在伴有硝酸盐和硫酸盐的减小的 24 h 以内被变换成醋酸盐。醋酸盐的累积在远处坚持了 7 d 时期。水的 U 没由于 U 的解吸附作用与减少的沉积在缩影衰退,但是连续地在少些减少的样品衰退。微生物引起的生长和伴随物 < 啜 class= “ a-plus-plus ” > 13 C-DNA 生产被检测乙醇是否是精疲力尽的,丰富的醋酸盐在两个缩影积累了。这在少些减少的样品与 U (VI ) 减小与一致。< 啜 class= “ a-plus-plus ” > 13 从乙醇发源的 C 最终为生长被利用,直接或间接地,由在 7 天孵化以内的主导的微生物引起的社区成员。微生物引起的社区由包括 Desulfovibrio, Sphingomonas, Ferribacterium, Rhodanobacter, Geothrix, Thiobacillus 和其它减少细菌的已知的 denitrifiers,减少硫酸盐的细菌和铁(III ) 主要组成,包括减少细菌 Acidovorax, Anaeromyxobacter, Desulfovibrio, Geobacter 和 Desulfosporosinus 的已知的 U (VI ) 。调查结果建议那乙醇 biostimulates 由首先为硝酸盐,硫酸盐,铁( III )和 U ( VI )用作一个电子施主减少微生物引起的社区的 U ( VI )减小,并且然后为微生物引起的生长为 U ( VI )减小和碳来源作为电子施主工作的醋酸盐。 | Mary Beth LEIGH Wei-Min WU Erick CARDENAS Ondrej UHLIK Sue CARROLL Terry GENTRY Terence L. MARSH Jizhong ZHOU Philip JARDINE Craig S. CRIDDLE James M. TIEDJE | 2015 | Frontiers of Environmental Science & Engineering2015，9，3： | 5 |
| 17 | 书面修正性反馈有效性的元分析研究显示文摘书面修正性反馈是二语习得研究领域颇具争议的话题。学者们围绕要不要进行书面修正性反馈、反馈是否有效、哪些错误需要修正、应该何时进行修正、如何修正以及由谁来修正等问题进行了大量的理论探讨和实证研究。本研究对国外21项书面修正性反馈有效性实证研究进行了元分析。研究发现:1)书面修正性反馈具有大效应值,并具有持续效应; 2)外语环境下书面修正性反馈的效应值显著高于二语环境下书面修正性反馈的效应值; 3)大学组被试效应值高于中学组被试和语言培训项目组被试的效应值; 4)以指出错误(±标出错误类型)为代表的间接反馈的效应值高于明确纠错等直接反馈的效应值; 5)聚焦反馈的效应值高于非聚焦反馈的效应值; 6)以计算机为媒介提供的反馈的效应值高于教师(或研究者)提供的反馈的效应值; 7)即时反馈的效应值高于延时反馈的效应值。本研究既对认识和理解修正性反馈在二语习得中的作用具有理论意义,又对指导外语课堂修正性反馈具有实践意义。 | 王利娜 牟蕾 吴勇毅 Beth Cappelletti | 2018 | 西安外国语大学学报2018，26，4： | 4 |
| 18 | Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient: Society of Critical Care Medicine and American Society for Parenteral and Enteral Nutrition: Executive Summary*显示文摘 | Robert G. Martindale Stephen A. McClave Vincent W. Vanek Mary McCarthy Pamela Roberts Beth Taylor Juan B. Ochoa Lena Napolitano Gail Cresci | 2009 | Critical Care Medicine2009，，5： | 3 |
| 19 | Autophagy and the Integrated Stress Response显示文摘 | Guido Kroemer Guillermo Mari?o Beth Levine | 2010 | Molecular Cell2010，，2： | 3 |
| 20 | Green tea extract:A potential cause of acute liver failure显示文摘The use of herbal products has increased significantly in recent years.Because these products are not subject to regulation by the Food and Drug Administration and are often used without supervision by a healthcare provider,the indication for and consumption of these supplements is quite variable.Moreover,their use is generally regarded as safe and natural by the lay-public.Unfortunately,there has been an increase in the number of reported adverse events occurring with the use of herbal products.We present a case of acute impending liver failure in an adolescent male using a weightloss product containing green tea extract.Our case adds to the growing concern surrounding the ingestion of green tea extract and serves to heighten healthcare provider awareness of a potential green tea extract hepatotoxicity.Despite the generally touted benefits of green tea as a whole,clinical concern regarding its use is emerging and has been linked to its concentration in multiple herbal supplements.Interestingly,the suspected harmful compounds are those previously proposed to be advantageous for weight-loss,cancer remedy,and anti-inflammatory purposes.Yet,we emphasize the need to be aware of not just green tea extract,but the importance of monitoring patient use of all dietary supplements and herbal products. | Shreena S Patel Stacey Beer Debra L Kearney Garrett Phillips Beth A Carter | 2013 | World Journal of Gastroenterology2013，19，31： | 3 |
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