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| 1 | 丙肝病毒相关的 hepatocellular 癌: 卓见进分子的机制和治疗学的策略显示文摘 Hepatitis C virus(HCV) infects more than 170 million people worldwide,and thereby becomes a series global health challenge.Chronic infection with HCV is considered one of the major causes of end-stage liver disease including cirrhosis and hepatocellular carcinoma.Although the multiple functions of the HCV proteins and their impacts on the modulation of the intracellular signaling transduction processes,the drive of carcinogenesis during the infection with HCV,is thought to result from the interactions of viral proteins with host cell proteins.Thus,the induction of mutator phenotype,in liver,by the expression of HCV proteins provides a key mechanism for the development of HCV-associated hepatocellular carcinoma(HCC).HCC is considered one of the most common malignancies worldwide with increasing incidence during the past decades.In many countries,the trend of HCC is attributed to several liver diseases including HCV infection.However,the development of HCC is very complicated and results mainly from the imbalance between tumor suppressor genes and oncogenes,as well as from the alteration of cellular factors leading to a genomic instability.Besides the poor prognosis of HCC patients,this type of tumor is quite resistance to the available therapies.Thus,understanding the molecular mechanisms,which are implicated in the development of HCC during the course of HCV infection,may help to design a general therapeutic protocol for the treatment and/or the prevention of this malignancy.This review summarizes the current knowledge of the molecular mechanisms,which are involved in the development of HCV-associated HCC and the possible therapeutic strategies. | Denis Selimovic Abdelouahid El-Khattouti Hanan Ghozlan Youssef Haikel Ola Abdelkader Mohamed Hassan | 2012 | World Journal of Hepatology2012，4，12： | 7 |
| 2 | Zinc oxide nano-enabled microfluidic reactor for water purification and its applicability to volatile organic compounds显示文摘This paper reports fast and efficient chemical decontamination of water within a tree-branched centimeter-scale microfluidic reactor.The microreactor integrates Zinc oxide nanowires(ZnO NWs)in situ grown acting as an efficient photocatalytic nanomaterial layer.Direct growth of ZnO NWs within the microfluidic chamber brings this photocatalytic medium at the very close vicinity of the water flow path,hence minimizing the required interaction time to produce efficient purification performance.We demonstrate a degradation efficiency of 95%in o5 s of residence time in one-pass only.According to our estimates,it becomes attainable using microfluidic reactors to produce decontamination of merely 1 l of water per day,typical of the human daily drinking water needs.To conduct our experiments,we have chosen a laboratory-scale case study as a seed for addressing the health concern of water contamination by volatile organic compounds(VOCs),which remain difficult to remove using alternative decontamination techniques,especially those involving water evaporation.The contaminated water sample contains mixture of five pollutants:Benzene;Toluene;Ethylbenzene;m–p Xylenes;and o-Xylene(BTEX)diluted in water at 10 p.p.m.concentration of each.Degradation was analytically monitored in a selective manner until it falls below 1 p.p.m.for each of the five pollutants,corresponding to the maximum contaminant level(MCL)established by the US Environmental Protection Agency(EPA).We also report on a preliminary study,investigating the nature of the chemical by-products after the photocatalytic VOCs degradation process. | Imadeddine Azzouz Yamina Ghozlane Habba Martine Capochichi-Gnambodoe Frédéric Marty Jérôme Vial Yamin Leprince-Wang Tarik Bourouina | 2018 | Microsystems & Nanoengineering2018，4，1： | 4 |
| 3 | Phenotypic characterization of microbes in the rhizosphere of Alyssum murale 显示文摘 | ABOU-SHANAB R A I DELORME T A ANGLE J S CHANEY R L GHANEM K MOAWAD H GHOZLAN H A | 2003 | International Journal of Phytoremediation2003，5，： | 1 |
| 4 | Hepatitis C virus-mediated angiogenesis:Molecular mechanisms and therapeutic strategies显示文摘Angiogenesis is an essential process for organ growth and repair. Thus, an imbalance in this process can lead to several diseases including malignancy. Angiogenesis is a critical step in vascular remodeling, tissue damage and wound healing besides being required for invasive tumor growth and metastasis. Because angiogenesis sets an important point in the control of tumor progression, its inhibition is considered a valuable therapeutic approach for tumor treatment. Chronic liver disease including hepatitis C virus(HCV) infection is one of the main cause for the development of hepatic angiogenesis and thereby plays a critical role in the modulation of hepatic angiogenesis that finally leads to hepatocellular carcinoma progression and invasion. Thus, understanding of the molecular mechanisms of HCV-mediated hepatic angiogenesis will help design a therapeutic protocol for the intervention of HCV-mediated angiogenesis and subsequently its outcome. In this review, we will focus on the molecular mechanisms of HCV-mediated hepatic angiogenesis and the related signaling pathways that can be target for current and under development therapeutic approaches. | Mohamed Hassan Denis Selimovic Abdelouahid El-Khattouti Martine Soell Hanan Ghozlan Youssef Haikel Ola Abdelkader Mosaad Megahed | 2014 | World Journal of Gastroenterology2014，20，42： | 1 |
| 5 | Progressive rise in red cell distribution width is associated with poor outcome after transcatheter aortic valve implantation显示文摘 | Nay Aung Rafal Dworakowski Jonathan Byrne Emma Alcock Ranjit Deshpande Kailasam Rajagopal Beth Brickham Mark J Monaghan Darlington O Okonko Olaf Wendler Philip A MacCarthy Guleed Adan Samer H Ghozlan | 2013 | Heart2013，，： | 1 |
| 6 | A long-term study to evaluate the safety and efficacy of meloxicam therapy in patients with rheumatoid arthritis显示文摘 | Huskisson EC Ghozlan R Kurthen R | 1996 | Br J Rheumatol1996，35，1： | 1 |
| 7 | A long -term study to evaluate the safety and efficacy of meloxicam therapy in patients with rheumatoid arthritis显示文摘 | Huskisson EC Ghozlan R Kurthen R | 2006 | Br J Rheumatol2006，35，1： | 1 |
| 8 | The leukemia inhibitory factor (LIF) and p21 mediate the TGF显示文摘 | Humbert L Ghozlan M Canaff L | 2015 | BMC Cancer2015，15，： | 1 |
| 9 | Biodiversity of moderately halophilic bacteria in hypersaline habitats in Egypt显示文摘 | GHOZLAN H DEIF H KANDIL R A | 2006 | J Gen Appl Microbiol2006，52，2： | 1 |
| 10 | 13-Amino-13( pyrid4-yl ) acrylonitrile in heterocyelic synthesis: synthesis of some new pyridine, pyridone, pyrazole, thiophene, fused pyrimidine and triazine derivatives显示文摘 | GHOZLAN S A S HASSANIEN A Z A | 2002 | Tetrahedron2002，58，46： | 1 |
| 11 | Behaviour of Bacterial Populations Isolated from Rhizosphere of Diplachne fusca Dominant in Industrial Sites显示文摘 | R. A. Abou-Shanab H. Ghozlan K. Ghanem H. Moawad | 2005 | World Journal of Microbiology and Biotechnology (-)2005，，6： | 1 |
| 12 | Myostatin inhibits proliferation and insulin-stimulated glucose uptake in mouse liver cells显示文摘 | Watts R Ghozlan M Hughey CC | 2014 | Biochem Cell Biol2014，92，3： | 1 |
| 13 | Association of Takayasu disease and ankylosing spondylarthritis:a further case显示文摘 | Ghozlan R Amor B Delbarre F | 1977 | Ann Med Interne(Paris)1977，128，： | 1 |
| 14 | Higher circulating bile acid concentrations in obese patients with type 2 diabetes 显示文摘 | Vincent RP Omar S Ghozlan S | 2013 | Ann Clin Biochem2013，50，4： | 1 |
| 15 | Higher circulating bile acid concentrations in obese patients with type 2 diabetes显示文摘 | Vincent RP Omar S Ghozlan S | 2013 | Ann Clin Biochem2013，50，4： | 1 |
| 16 | Induction of high-molec ular-weight (HMW) tumor necrosis factor (TNF) alpha by hepatitis C virus (HCV) non-structural protein 3 (NS3) in liver cells is AP-1 and NF-kappa B dependent activation显示文摘 | Hassan M Selimovic D Ghozlan H | 2007 | Cell Signal2007，19，2： | 1 |
| 17 | Higher circulating bile acid concentrations in obese patients with type 2 diabetes显示文摘 | Vincent RP Omar S Ghozlan S | 2013 | Ann Clin Biochem2013，50，4： | 1 |
| 18 | Biodiversity of moderately halophilic bacteria in hypersaline habitats in Egypt显示文摘 | Ghozlan Hanan Deif Hisham | 2006 | The Journa of General and Applied Microbiology2006，52，2： | 1 |
| 19 | Biodiversity of moderately halophilic bacteria in hypersaline habitats in Egypt显示文摘 | Ghozlan Hanan Deif Hishim | 2006 | J Gen Appl Microbiol2006，52，2： | 1 |
| 20 | Biodiversity of moderately halophilic bacteria in hypersaline habitats in Egypt显示文摘 | Ghozlan H Deif H Kandil RA | 2006 | J Gen Appl Microbiol2006，52，2： | 1 |
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