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| 1 | 中国人多吃水果可降低心血管疾病风险显示文摘在2004年至2008年,来自牛津大学和中国医学科学院的研究人员招募了512891名30-79岁成人,他们来自中国10个不同的地区。研究长达7年,经过320万人年的随访,在基线没有心血管病史或降压治疗的451665名参与者中,共发生5173例心血管疾病死亡事件,2551例主要冠脉事件(致命性或非致命性),14579例缺血性卒中事件,3523例脑内出血事件。研究人员利用Cox回归计算出新鲜水果消耗与发病率之间的调整后危险比。 | Du H Li L Bennett D | 2016 | 甘肃医药2016，35，4： | 27 |
| 2 | Systematic review of TCF2 anomalies in renal cysts and diabetes syndrome/maturity onset diabetes of the young type 5显示文摘在那里的目的是出版工作的少量系统地与肾的包囊和年轻类型的糖尿病症候群(RCAD )/maturity 发作糖尿病评估基因异例或病人的临床的特征 5 (MODY5 ) 。这评论的目的是系统地估计察觉率,基因并且异质接合的正染色体的主导的 TCF2 anomalies.Data 来源 MEDLINE 数据库的 phenotypic 含意被寻找选择从 1997 ~ 2008 用英语记录的文章。焦点是 monoallelic germline TCF2 基因变化 / 删除。 Biallelic inactivation ,多型性, DNA 修正( hypomethylation 和 hypermethylation ),与癌症风险联系的 loci ,和体的 TCF2 异例都是在寻找文学以后的 excluded.Study 选择, 50 篇文章是 TCF2 异例的察觉率是的 selected.Results 9.7%并且在 MODY (1.4%)之中更加变化了,肾的结构异例( RSA )(21.4%)和有 MODY (41.2%)亚群的 RSA 。变化惊人地位于 DNA 有约束力的域以内并且在 DNA 有约束力的域的 exons 之中变化了:exons 2 和 4 是最热的点,当变化在 exon 是偶发地分布式的时 3。一致显型是 RSA (89.6%) 和糖尿病 mellitus (DM )(45.0%) 。然而, RSA 和 DM 的同时发生是相对低的(27.5%) ,它妨碍基因测试和及时诊断的获得的最佳的表演。另外的机关参与为有 TCF2 异例的病人的早鉴定补足、必要。TCF2 点变化的显型的分析根据变化类型然而并非 utation location.Conclusion 处于 RSA,损害肾的功能(IRF ) 和 DM 的察觉率显示出重要差别以前没收到足够的注意的 TCF2 异例的这些珍贵特征不应该被忽视。 | CHEN Yi-zhi GAO Qing ZHAO Xue-zhi CHEN Ying-zhang Craig L Bennett XIONG Xi-shan MEI Chang-lin SHI Yong-quan CHEN Xiang-mei | 2010 | Chinese Medical Journal2010，，22： | 21 |
| 3 | Autoantibody to MOG suggests two distinct clinical subtypes of NMOSD显示文摘We characterized a unique group of patients with neuromyelitis optica spectrum disorder(NMOSD) who carried autoantibodies of aquaporin-4(AQP4) and myelin-oligodendrocyte glycoprotein(MOG). Among the 125 NMOSD patients, 10(8.0%) were AQP4- and MOG-ab double positive, and 14(11.2%) were MOG-ab single positive. The double-positive patients had a multiphase disease course with a high annual relapse rate(P=0.0431), and severe residual disability(P<0.0001). Of the double-positive patients, 70% had MS-like brain lesions, more severe edematous, multifocal regions on spinal magnetic resonance imaging(MRI), pronounced decreases of retinal nerve fiber layer thickness and atrophy of optic nerves. In contrast, patients with only MOG-ab had a higher ratio of monophasic disease course and mild residual disability. Spinal cord MRI illustrated multifocal cord lesions with mild edema, and brain MRIs showed more lesions around lateral ventricles. NMOSD patients carrying both autoantibodies to AQP4 and MOG existed and exhibited combined features of prototypic NMO and relapsing-remitting form of MS, whereas NMOSD with antibodies to MOG only exhibited an 'intermediate' phenotype between NMOSD and MS. Our study suggests that antibodies against MOG might be pathogenic in NMOSD patients and that determination of anti-MOG antibodies maybe instructive for management of NMOSD patients. | Yaping Yan Yujing Li Ying Fu Li Yang Lei Su Kaibin Shi Minshu Li Qiang Liu Aimee Borazanci Yaou Liu Yong He Jeffrey L Bennett Timothy L Vollmer Fu-Dong Shi | 2016 | Science China(Life Sciences)2016，59，12： | 20 |
| 4 | Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density显示文摘 | W.S Simonet D.L Lacey C.R Dunstan M Kelley M.-S Chang R Lüthy H.Q Nguyen S Wooden L Bennett T Boone G Shimamoto M DeRose R Elliott A Colombero H.-L Tan G Trail J Sullivan E Davy N Bucay L Renshaw-Gegg T.M Hughes D Hill W Pattison P Campbell S Sander G Van | 1997 | Cell1997，，2： | 6 |
| 5 | TLR8: the forgotten relative revindicated显示文摘endosomal 像使用费的受体(TLR ) TLR3, TLR7, TLR8 和 TLR9 在察觉到吞噬细胞遇到的外国 nucleic 酸是重要的。因为 TLR8 开始被认为在老鼠非功能,更少比遗传上并且机能上地相关的 TLR7 对 TLR8 被知道。原来与病毒的起源的搁浅单人赛的 RNA 的识别联系了,现在有证据,人的 TLR8 也能察觉到在 phagosomal 液泡以内释放的细菌的 RNA,导致两原子因素(NF )-κB-dependent cytokines 和类型的生产我干扰素(IFN ) ,例如 IFN-β。TLR8 的功能在外国病原体的识别以外延长并且与另外的 endosomal TLR 包括串音,可以也在 autoimmunity 的产生有一个角色的一个过程。 | Jorge L Cervantes Bennett Weinerman Chaitali Basole Juan C Salazar | 2012 | Cellular & Molecular Immunology2012，9，6： | 4 |
| 6 | Outcomes and patients' perspectives of transition from paediatric to adult care in inflammatory bowel disease显示文摘AIM: To describe the disease and psychosocialoutcomes of an inflammatory bowel disease(IBD) transition cohort and their perspectives.METHODS: Patients with IBD, aged > 18 years, who had moved from paediatric to adult care within 10 years were identified through IBD databases at three tertiary hospitals. Participants were surveyed regarding demographic and disease specific data and their perspectives on the transition process. Survey response data were compared to contemporaneously recorded information in paediatric service case notes. Data were compared to a similar age cohort who had never received paediatric IBD care and therefore who had not undergone a transition process. RESULTS: There were 81 returned surveys from 46 transition and 35 non-transition patients. No statistically significant differences were found in disease burden, disease outcomes or adult roles and responsibilities between cohorts. Despite a high prevalence of mood disturbance(35%), there was a very low usage(5%) of psychological services in both cohorts. In the transition cohort, knowledge of their transition plan was reported by only 25/46 patients and the majority(54%) felt they were not strongly prepared. A high rate(78%) of discussion about work/study plans was recorded prior to transition, but a near complete absence of discussion regarding sex(8%), and other adult issues was recorded. Both cohorts agreed that their preferred method of future transition practices(of the options offered) was a shared clinic appointment with all key stakeholders. CONCLUSION: Transition did not appear to adversely affect disease or psychosocial outcomes. Current transition care processes could be optimised, with better psychosocial preparation and agreed transition plans. | Alice L Bennett David Moore Peter A Bampton Robert V Bryant Jane M Andrews | 2016 | World Journal of Gastroenterology2016，22，8： | 3 |
| 7 | 青少年甘油磷酸胆碱代谢和心血管病的危险因素:一项队列研究显示文摘甘油磷酸胆碱(glycerophosphocholine,GPC)代谢物可调节动脉粥样硬化,从而导致心血管病风险。临床前期心血管病可能从青春期就开始。研究人员应用靶向血清脂质组学鉴定一组新的GPC,并测试在青春期时这些GPC中的任何一种是否与心血管病传统危险因子,如过量内脏脂肪、升高的血压、胰岛素抵抗和致动脉粥样硬化血脂异常相关。 | Syme C Czajkowski S Shin J Abrahamowicz M Leonard G Perron M Richer L Veillette S Gaudet D Strug L Wang Y Xu H Taylor G Paus T Bennett S Pausova Z 刘莉 叶鹏 | 2016 | 中华高血压杂志2016，24，10： | 3 |
| 8 | The endoscopic assessment of esophagitis: A progress report on observer agreement显示文摘 | D Armstrong JR Bennett AL Blum J Dent FT De Dombal JP Galmiche L Lundell M Margulies JE Richter SJ Spechler GN Tytgat L Wallin | 1996 | Gastroenterology1996，，1： | 2 |
| 9 | 显示文摘 | Cooke D W Bennett B L Farnum E H | 1997 | Appl Phys Lett1997，70，： | 2 |
| 10 | Serelaxin increases the antifibrotic action of rosiglitazone in a model of hepatic fibrosis显示文摘AIM To determine the effect of combined serelaxin and rosiglitazone treatment on established hepatic fibrosis.METHODS Hepatic fibrosis was induced in mice by carbon tetrachloride administration for 6 wk, or vehicle alone(nonfibrotic mice). For the final 2 wk, mice were treated with rosiglitazone, serelaxin, or both rosiglitazone and serelaxin. Serum liver enzymes and relaxin levels were determined by standard methods. The degree of liver collagen content was determined by histology and immunohistochemistry. Expression of type?Ⅰ?collagen was determined by quantitative PCR. Activation of hepatic stellate cells was assessed by alpha-smoothmuscle actin(SMA) levels. Liver peroxisome proliferator activated receptor-gamma coactivator 1 alpha(PGC1α) was determined by Western blotting.RESULTS Treatment of mice with CCl4 resulted in hepatic fibrosis as evidenced by increased liver enzyme levels(ALT and AST), and increased liver collagen and SMA. Monotherapy with either serelaxin or rosiglitazone for 2 wk was generally without effect. In contrast, the combination of serelaxin and rosiglitazone resulted in significantly improved ALT levels(P < 0.05). Total liver collagen content as determined by Sirius red staining revealed that only combination treatment was effective in reducing total liver collagen(P < 0.05). These results were supported by immunohistochemistry for type?Ⅰ?collagen, in which only combination treatment reduced fibrillar collagen levels(P < 0.05). The level of hepatic stellate cell activation was modestly, but significantly, reduced by serelaxin treatment alone, but combination treatment resulted in significantly lower SMA levels. Finally, while hepatic fibrosis reduced liver PGC1α levels, the combination of serelaxin and rosiglitazone resulted in restoration of PGC1α protein levels.CONCLUSION The combination of serelaxin and rosiglitazone treatment for 2 wk was effective in significantly reducing established hepatic fibrosis, providing a potential new treatment strategy. | Robert G Bennett Ronda L Simpson Frederick G Hamel | 2017 | World Journal of Gastroenterology2017，23，22： | 2 |
| 11 | Precision atomic gravimeter based on Bragg diffraction显示文摘 | P A Altin M T Johnsson V Negnevitsky G R Dennis R P Anderson J E Debs S S Szigeti K S Hardman S Bennetts G D McDonald L D Turner J D Close N P Robins | 2013 | New Journal of Physics2013，，2： | 2 |
| 12 | The learning curve for laparoscopic cholecystectomy显示文摘 | The Southern Surgeons Club Michael J Moore Charles L Bennett | 1995 | The American Journal of Surgery1995，，1： | 2 |
| 13 | Circumventricular organs:a Novel site of neural stem cells in the adult brain显示文摘 | Bennett L Yang M Enikolopov G | | 0，，03： | 2 |
| 14 | Imaging Fourier Transform Spectrometer显示文摘 | Bennett C L Carter M Fields D | 1993 | SPIE1993，1937，： | 1 |
| 15 | Live cell analysis of aquaporin 4 ml/m23 interactions and regulated orthogonal array assembly in gilal cells显示文摘 | Crane J M Bennett J L Verkman A S | 2009 | J Biol Chem2009，284，35： | 1 |
| 16 | Natural killer(NK) cell-mediated cytotoxicity:differential use of TRAIL and Fas ligand by immature and mature primary human NK cells显示文摘 | Zamai L Ahmad M Bennett IL | 1998 | J Exp Med1998，188，： | 1 |
| 17 | Experimental Test of the Presach-Arrhenius Model with Temperature 显示文摘 | TORRE E D SWARTZENDTUBER L J BENNETT L H | 2000 | Phys B2000，275，： | 1 |
| 18 | Linear unsaturated polyamides: Nylons 6 18 and 18 18显示文摘 | Bennett C Mathias L J | 2004 | Macromol Chem phys2004，205，18： | 1 |
| 19 | Understanding relationships among multiple ecosystem services显示文摘 | Bennett E M Peterson G D Gordon L J | 2009 | Ecol Let2009，，12： | 1 |
| 20 | Circumventricular or- gans: a novel site of neural stem cells in the adult brain 显示文摘 | Bennett L Yang M Enikolopov G | 2009 | Mol Cell Neurosci2009，41，3： | 1 |
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