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| 1 | Organic photovoltaic cell with 17% efficiency and superior processability显示文摘The development of organic photoactive materials,especially the newly emerging non-fullerene electron acceptors(NFAs),has enabled rapid progress in organic photovoltaic(OPV)cells in recent years.Although the power conversion efficiencies(PCEs)of the top-performance OPV cells have surpassed 16%,the devices are usually fabricated via a spin-coating method and are not suitable for large-area production.Here,we demonstrate that the fine-modification of the flexible side chains of NFAs can yield 17%PCE for OPV cells.More crucially,as the optimal NFA has a suitable solubility and thus a desirable morphology,the high efficiencies of spin-coated devices can be maintained when using scalable blade-coating processing technology.Our results suggest that optimization of the chemical structures of the OPV materials can improve device performance.This has great significance in larger-area production technologies that provide important scientific insights for the commercialization of OPV cells. | Yong Cui Huifeng Yao Ling Hong Tao Zhang Yabing Tang Baojun Lin Kaihu Xian Bowei Gao Cunbin An Pengqing Bi Wei Ma Jianhui Hou | 2020 | National Science Review2020,7,7: | 7 |
| 2 | Ability to detect weak effective seismic signals by utilizing chaotic vibrator system显示文摘Taking the advantage of CVS (Chaotic Vibrator System) sensitivity of large-scale periodic phase-state response to quasi-periodic or periodic signals,a series of numerical experiments were made to understand the ability of CVS to detect weak effective seismic signals in the common-shot seismic record distorted by strong stochastic noise. The re-sults demonstrate that the large-scale periodic phase-states of CVS are correlated with the signal composition of the quasi-periodic wavelet sequence constructing from horizontal moveout of seismic events,noise strength and the noise distortion de-gree to signal. For the same kind of events,the higher the noise distortion degree is,the lower the detectable SNR can be reached by CVS. For seismic data with the same noise distortion degree,the closer the scanning seismic velocity (the trial moveout ve-locity) approaches to the accurate velocity,the higher the detectable SNR can be reached by CVS. More-over,the truncating scanning velocities form an asymmetric belt,which indirectly makes CVS achieve a large-scale periodic phase-state and then the ratio of wavelet distortion coefficients in events can be a biggish variable scope. | LI Yue YANG Baojun YUAN Ye ZHAO Xueping LIN Hongbo | 2006 | Chinese Science Bulletin2006,51,24: | 6 |
| 3 | Smoother and Bayesian filter based semi-codeless tracking of dual-frequency GPS signals显示文摘To precisely determine the integrated orbit of the Chinese manned spacecraft mission,a smoother and Bayesian filter based technique for optimum semi-codeless tracking of the P(Y) code on dual-frequency GPS signals has been advanced. This signal processing technique has been proven effective and robust for affording access to dual-frequency GPS signals. This paper introduces the signal dynamics and measurement models, describes the W·D bit estimation method, and corrects the mistakes of direct estimation of W bit in current semi-codeless tracking. Median filter is chosen as a smoother to find the best measurements at the current time among the history and current information. The Bayesian filter is used to track the L2 P(Y) code phase and L2 carrier phase recursively. | LIAO Bingyu YUAN Hong LIN Baojun | 2006 | Science in China(Series F)2006,49,4: | 5 |
| 4 | Suppression of strong random noise in seismic data by using time-frequency peak filtering显示文摘Time-frequency peak filtering (TFPF) is highly efficient in suppressing random noise in seismic data. Although the hypothesis of stationary Gaussian white noise cannot be fulfilled in practical seismic data, TFPF can effectively suppress white and colored random noise with different intensities, as can be theoretically demonstrated by detecting such noise in synthetic seismic data. However, a 'zero-drift' effect is observed in the filtered signal and is independent of the average power and variance of the random noise, but related to its mean value. Furthermore, we consider the situation where the local linearization of the seismic data cannot be satisfied absolutely and study the 'distortion' characteristics of the filtered signal using TFPF on a triangular wave. We found that over-compensation is possible in the frequency band for the triangular wave. In addition, it is nonsymmetrical and has a relationship to the time-varying curvature of the seismic wavelet. The results also present an improved approach for TFPF. | LI Yue YANG BaoJun LIN HongBo MA HaiTao NIE PengFei | 2013 | Science China Earth Sciences2013,56,7: | 5 |
| 5 | Post-surgical resection prognostic value of combined OPN, MMP7, and PSG9 plasma biomarkers in hepatocellular carcinoma显示文摘Biomarkers for hepatocellular carcinoma (HCC) following curative resection are not currently sufficient for prognostic indication of overall survival (OS) and disease-free survival (DFS). The aim of this study was to investigate the prognostic performance of osteopontin (OPN), matrix metalloproteinase 7 (MMP7), and pregnancy specific glycoprotein 9 (PSG9) in patients with HCC. A total of 179 prospective patients with HCC provided plasma before hepatectomy. Plasma OPN, MMP7, and PSG9 levels were determined by enzyme-linked immunosorbent assay. Correlations between plasma levels, clinical parameters, and outcomes (OS and DFS) were overall analyzed. High OPN (≥149.97 ng/mL), MMP7 (≥2.28 ng/mL), and PSG9 (≥45.59 ng/mL) were prognostic indicators of reduced OS (P<0.001, P<0.001, and P=0.007, respectively). Plasma PSG9 protein level was an independent factor in predicting OS (P=0.008) and DFS (P=0.038). Plasma OPN+MMP7+PSG9 elevation in combination was a prognostic factor for OS (P<0.001). OPN was demonstrated to be a risk factor-associated OS in stage I patients with HCC and patients with low α-fetoprotein levels (<20 ng/mL). These findings suggested that OPN, MMP7, PSG9 and their combined panels may be useful for aiding in tumor recurrence and mortality risk prediction of patients with HCC, particularly in the early stage of HCC carcinogenesis. | Weiqi Rong Yang Zhang Lei Yang Lin Feng Baojun Wei Fan Wu Liming Wang Yanning Gao Shujun Cheng Jianxiong Wu Ting Xiao | 2019 | Frontiers of Medicine2019,13,2: | 5 |
| 6 | Minimally inva- sive plate osteosynthesis with a locking compression plate is superior to open reduction and internal fixation in the management of the proximal humerus fractures 显示文摘 | Tao Lin Baojun Xiao Xiucai Ma | 2014 | BMC Musculoskelet Disord2014,15,206: | 1 |
| 7 | Spatiotemporal analysis of drought variability based on the standardized precipitation evapotranspiration index in the Koshi River Basin, Nepal显示文摘Drought is an inevitable condition with negative impacts in the agricultural and climatic sectors,especially in developing countries.This study attempts to examine the spatial and temporal characteristics of drought and its trends in the Koshi River Basin(KRB)in Nepal,using the standardized precipitation evapotranspiration index(SPEI)over the period from 1987 to 2017.The Mann-Kendall test was used to explore the trends of the SPEI values.The study illustrated the increasing annual and seasonal drought trends in the KRB over the study period.Spatially,the hill region of the KRB showed substantial increasing drought trends at the annual and seasonal scales,especially in summer and winter.The mountain region also showed a significant increasing drought trend in winter.The drought characteristic analysis indicated that the maximum duration,intensity,and severity of drought events were observed in the KRB after 2000.The Terai region presented the highest drought frequency and intensity,while the hill region presented the longest maximum drought duration.Moreover,the spatial extent of drought showed a significant increasing trend in the hill region at the monthly(drought station proportion of 7.6%/10 a in August),seasonal(drought station proportion of 7.2%/10 a in summer),and annual(drought station proportion of 6.7%/10 a)scales.The findings of this study can assist local governments,planners,and project implementers in understanding drought and developing appropriate mitigation strategies to cope with its impacts. | Nirmal M DAHAL XIONG Donghong Nilhari NEUPANE Belayneh YIGEZ ZHANG Baojun YUAN Yong Saroj KOIRALA LIU Lin FANG Yiping | 2021 | Journal of Arid Land2021,13,5: | 1 |
| 8 | The role of macromolecular Entanglements inthe Gel Spinning Process and Properties of High Performance Polyacrylonitrile Fibers显示文摘 | Qian Baojun Lin Weiping | 1995 | Journal of Polymer Engineering1995,15,34: | 1 |
| 9 | The Role of Macromolecular Entanglements in the Gel Spin- ning Process and Properties of High Performance Poly- acrylonitrile Fibers 显示文摘 | Qian Baojun Lin Weiping He Jianming | 1995 | Journal of Polymer Engineer- ing1995,15,34: | 1 |
| 10 | Construction of Armored RNA Containing Long-Size Chimeric RNA by Increasing the Number and Affinity of the Pac Site in Exogenous RNA and Sequence Coding Coat Protein of the MS2 Bacteriophage显示文摘 | Wei Baojun Wei Yuxiang Zhang Kuo Yang Changmei Wang Jing Xu Ruihuan Zhan Sien Lin Guigao Wang Wei Liu Min Wang Lunan Zhang Rui Li Jinming | 2008 | Intervirology2008,,2: | 1 |
| 11 | Land surface roughness impacted by typical vegetation restoration projects on aeolian sandy lands in the Yarlung Zangbo River valley,southern Tibetan plateau显示文摘Aeolian sandy lands are widespread and desertification is recognized as one of the main environmental issues in the Yarlung Zangbo River valley,southern Tibetan plateau.The surface microtopographic var-iations induced by the near soil surface characteristics of plant communities are important compositions of land surface roughness,which likely influence wind erosion.This study was conducted to quantify the effects of typical vegetation restoration on land surface roughness on the aeolian sandy lands,and to identify the main influencing factors of land surface roughness in the Yarlung Zangbo River valley.Two bare sandy lands(as controls)and eight vegetated sandy lands with different restoration communities and ages were selected,and land surface roughness(LSR),as represented by surface microtopographic variations in this study,was measured by photogrammetric surveys.The results showed that LSR significantly increased by 7.9-16.8 times after vegetation restoration on the aeolian sandy lands,and varied among different restoration communities and ages.The mostly restored communities of Sophora moorcroftiana and Populus L.had greater LSR as compared to Artemisia wellbyi and Hedysarum scoparium.With succession from 6 to over 30 years,LSR gradually increased in the Sophora moorcroftiana restored sandy lands,but decreased in the Populus L restored sandy lands.The variations of LSR were mainly attributed to the differences in near soil surface characteristics of vegetation(plant stem diameter and coverage,and plant residue density)and biological soil crusts(coverage and thickness).Mixed plantation of Populus L and Sophora moorcroftiana was considered as the best restoration communities because of their effectiveness in increasing land surface roughness on the aeolian sandy lands in the Yarlung Zangbo River valley.The results would facilitate the understanding of the benefits of vegetation restoration in controlling wind erosion on the aeolian sandy lands. | Baojun Zhang Donghong Xiong Yongfa Tang Lin Liu | 2022 | International Soil and Water Conservation Research2022,10,1: | 1 |
| 12 | Feasibility and physics potential of detecting ^(8)B solar neutrinos at JUNO显示文摘The Jiangmen Underground Neutrino Observatory(JUNO)features a 20 kt multi-purpose underground liquid scintillator sphere as its main detector.Some of JUNO's features make it an excellent location for^8B solar neutrino measurements,such as its low-energy threshold,high energy resolution compared with water Cherenkov detectors,and much larger target mass compared with previous liquid scintillator detectors.In this paper,we present a comprehensive assessment of JUNO's potential for detecting^8B solar neutrinos via the neutrino-electron elastic scattering process.A reduced 2 MeV threshold for the recoil electron energy is found to be achievable,assuming that the intrinsic radioactive background^(238)U and^(232)Th in the liquid scintillator can be controlled to 10^(-17)g/g.With ten years of data acquisition,approximately 60,000 signal and 30,000 background events are expected.This large sample will enable an examination of the distortion of the recoil electron spectrum that is dominated by the neutrino flavor transformation in the dense solar matter,which will shed new light on the inconsistency between the measured electron spectra and the predictions of the standard three-flavor neutrino oscillation framework.IfDelta m^(2)_(21)=4.8times10^(-5);(7.5times10^(-5))eV^(2),JUNO can provide evidence of neutrino oscillation in the Earth at approximately the 3sigma(2sigma)level by measuring the non-zero signal rate variation with respect to the solar zenith angle.Moreover,JUNO can simultaneously measureDelta m^2_(21)using^8B solar neutrinos to a precision of 20% or better,depending on the central value,and to sub-percent precision using reactor antineutrinos.A comparison of these two measurements from the same detector will help understand the current mild inconsistency between the value of Delta m^2_(21)reported by solar neutrino experiments and the KamLAND experiment. | Angel Abusleme Thomas Adam Shakeel Ahmad Sebastiano Aiello Muhammad Akram Nawab Ali Fengpeng An Guangpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Andrej Babic Wander Baldini Andrea Barresi Eric Baussan Marco Bellato Antonio Bergnoli Enrico Bernieri David Biare Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Max Buesken Mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Jinfan Chang Yun Chang Pingping Chen Po-An Chen Shaomin Chen Shenjian Chen Xurong Chen Yi-Wen Chen Yixue Chen Yu Chen Zhang Chen Jie Cheng Yaping Cheng Alexander Chepurnov Davide Chiesa Pietro Chimenti Artem Chukanov Anna Chuvashova Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Salvatore Costa Flavio Dal Corso Christophe De La Taille Jiawei Deng Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Georgy Donchenko Jianmeng Dong Damien Dornic Evgeny Doroshkevich Marcos Dracos Frédéric Druillole Shuxian Du Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Lukas Fajt Donghua Fan Lei Fan Can Fang Jian Fang Marco Fargetta Anna Fatkina Dmitry Fedoseev Vladko Fekete Li-Cheng Feng Qichun Feng Richard Ford Andrey Formozov Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Alexandre Göttel Christoph Genster Marco Giammarchi Agnese Giaz Nunzio Giudice Franco Giuliani Maxim Gonchar Guanghua Gong Hui Gong Oleg Gorchakov Yuri Gornushkin Marco Grassi Christian Grewing Maxim Gromov Vasily Gromov Minghao Gu Xiaofei Gu Yu Gu Mengyun Guan Nunzio Guardone Maria Gul Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yang Han Miao He Wei He Tobias Heinz Patrick Hellmuth Yuekun Heng Rafael Herrera Daojin Hong YuenKeung Hor Shaojing Hou Yee Hsiung Bei-Zhen Hu Hang Hu Jianrun Hu Jun Hu Shouyang Hu Tao Hu Zhuojun Hu Chunhao Huang Guihong Huang Hanxiong Huang Qinhua Huang Wenhao Huang Xingtao Huang Yongbo Huang Jiaqi Hui Wenju Huo Cédric Huss Safeer Hussain Antonio Insolia Ara Ioannisian Daniel Ioannisyan Roberto Isocrate Kuo-Lun Jen Xiaolu Ji Xingzhao Ji Huihui Jia Junji Jia Siyu Jian Di Jiang Xiaoshan Jiang Ruyi Jin Xiaoping Jing Cécile Jollet Jari Joutsenvaara Sirichok Jungthawan Leonidas Kalousis Philipp Kampmann Li Kang Michael Karagounis Narine Kazarian Amir Khan Waseem Khan Khanchai Khosonthongkee Patrick Kinz Denis Korablev Konstantin Kouzakov Alexey Krasnoperov Svetlana Krokhaleva Zinovy Krumshteyn Andre Kruth Nikolay Kutovskiy Pasi Kuusiniemi Tobias Lachenmaier Cecilia Landini Sébastien Leblanc Frederic Lefevre Liping Lei Ruiting Lei Rupert Leitner Jason Leung Demin Li Fei Li Fule Li Haitao Li Huiling Li Jiaqi Li Jin Li Kaijie Li Mengzhao Li Nan Li Nan Li Qingjiang Li Ruhui Li Shanfeng Li Shuaijie Li Tao Li Weidong Li Weiguo Li Xiaomei Li Xiaonan Li Xinglong Li Yi Li Yufeng Li Zhibing Li Ziyuan Li Hao Liang Hao Liang Jingjing Liang Jiajun Liao Daniel Liebau Ayut Limphirat Sukit Limpijumnong Guey-Lin Lin Shengxin Lin Tao Lin Jiajie Ling Ivano Lippi Fang Liu Haidong Liu Hongbang Liu Hongjuan Liu Hongtao Liu Hu Liu Hui Liu Jianglai Liu Jinchang Liu Min Liu Qian Liu Qin Liu Runxuan Liu Shuangyu Liu Shubin Liu Shulin Liu Xiaowei Liu Yan Liu Alexey Lokhov Paolo Lombardi Claudio Lombardo Kai Loo Chuan Lu Haoqi Lu Jingbin Lu Junguang Lu Shuxiang Lu Xiaoxu Lu Bayarto Lubsandorzhiev Sultim Lubsandorzhiev Livia Ludhova Fengjiao Luo Guang Luo Pengwei Luo Shu Luo Wuming Luo Vladimir Lyashuk Qiumei Ma Si Ma Xiaoyan Ma Xubo Ma Jihane Maalmi Yury Malyshkin Fabio Mantovani Francesco Manzali Xin Mao Yajun Mao Stefano MMari Filippo Marini Sadia Marium Cristina Martellini Gisele Martin-Chassard Agnese Martini Davit Mayilyan Axel Müller Ints Mednieks Yue Meng Anselmo Meregaglia Emanuela Meroni David Meyhöfer Mauro Mezzetto Jonathan Miller Lino Miramonti Salvatore Monforte Paolo Montini Michele Montuschi Nikolay Morozov Pavithra Muralidharan Massimiliano Nastasi Dmitry VNaumov Elena Naumova Igor Nemchenok Alexey Nikolaev Feipeng Ning Zhe Ning Hiroshi Nunokawa Lothar Oberauer Juan Pedro Ochoa-Ricoux Alexander Olshevskiy Domizia Orestano Fausto Ortica Hsiao-Ru Pan Alessandro Paoloni Nina Parkalian Sergio Parmeggiano Teerapat Payupol Yatian Pei Nicomede Pelliccia Anguo Peng Haiping Peng Frédéric Perrot Pierre-Alexandre Petitjean Fabrizio Petrucci Luis Felipe Piñeres Rico Oliver Pilarczyk Artyom Popov Pascal Poussot Wathan Pratumwan Ezio Previtali Fazhi Qi Ming Qi Sen Qian Xiaohui Qian Hao Qiao Zhonghua Qin Shoukang Qiu Muhammad Rajput Gioacchino Ranucci Neill Raper Alessandra Re Henning Rebber Abdel Rebii Bin Ren Jie Ren Taras Rezinko Barbara Ricci Markus Robens Mathieu Roche Narongkiat Rodphai Aldo Romani Bedřich Roskovec Christian Roth Xiangdong Ruan Xichao Ruan Saroj Rujirawat Arseniy Rybnikov Andrey Sadovsky Paolo Saggese Giuseppe Salamanna Simone Sanfilippo Anut Sangka Nuanwan Sanguansak Utane Sawangwit Julia Sawatzki Fatma Sawy Michaela Schever Jacky Schuler Cédric Schwab Konstantin Schweizer Dmitry Selivanov Alexandr Selyunin Andrea Serafini Giulio Settanta Mariangela Settimo Muhammad Shahzad Vladislav Sharov Gang Shi Jingyan Shi Yongjiu Shi Vitaly Shutov Andrey Sidorenkov FedorŠimkovic Chiara Sirignano Jaruchit Siripak Monica Sisti Maciej Slupecki Mikhail Smirnov Oleg Smirnov Thiago Sogo-Bezerra Julanan Songwadhana Boonrucksar Soonthornthum Albert Sotnikov Ondrej Sramek Warintorn Sreethawong Achim Stahl Luca Stanco Konstantin Stankevich DušanŠtefánik Hans Steiger Jochen Steinmann Tobias Sterr Matthias Raphael Stock Virginia Strati Alexander Studenikin Gongxing Sun Shifeng Sun Xilei Sun Yongjie Sun Yongzhao Sun Narumon Suwonjandee Michal Szelezniak Jian Tang Qiang Tang Quan Tang Xiao Tang Alexander Tietzsch Igor Tkachev Tomas Tmej Konstantin Treskov Andrea Triossi Giancarlo Troni Wladyslaw Trzaska Cristina Tuve Stefan van Waasen Johannes van den Boom Guillaume Vanroyen Nikolaos Vassilopoulos Vadim Vedin Giuseppe Verde Maxim Vialkov Benoit Viaud Cristina Volpe Vit Vorobel Lucia Votano Pablo Walker Caishen Wang Chung-Hsiang Wang En Wang Guoli Wang Jian Wang Jun Wang Kunyu Wang Lu Wang Meifen Wang Meng Wang Ruiguang Wang Siguang Wang Wei Wang Wenshuai Wang Xi Wang Xiangyue Wang Yangfu Wang Yaoguang Wang Yi Wang Yifang Wang Yuanqing Wang Yuman Wang Zhe Wang Zheng Wang Zhimin Wang Zongyi Wang Apimook Watcharangkool Lianghong Wei Wei Wei Yadong Wei Liangjian Wen Christopher Wiebusch Steven Chan-Fai Wong Bjoern Wonsak Diru Wu Fangliang Wu Qun Wu Wenjie Wu Zhi Wu Michael Wurm Jacques Wurtz Christian Wysotzki Yufei Xi Dongmei Xia Yuguang Xie Zhangquan Xie Zhizhong Xing Benda Xu Donglian Xu Fanrong Xu Jilei Xu Jing Xu Meihang Xu Yin Xu Yu Xu Baojun Yan Xiongbo Yan Yupeng Yan Anbo Yang Changgen Yang Huan Yang Jie Yang Lei Yang Xiaoyu Yang Yifan Yang Haifeng Yao Zafar Yasin Jiaxuan Ye Mei Ye Ugur Yegin Frédéric Yermia Peihuai Yi Xiangwei Yin Zhengyun You Boxiang Yu Chiye Yu Chunxu Yu Hongzhao Yu Miao Yu Xianghui Yu Zeyuan Yu Chengzhuo Yuan Ying Yuan Zhenxiong Yuan Ziyi Yuan Baobiao Yue Noman Zafar Andre Zambanini Pan Zeng Shan Zeng Tingxuan Zeng Yuda Zeng Liang Zhan Feiyang Zhang Guoqing Zhang Haiqiong Zhang Honghao Zhang Jiawen Zhang Jie Zhang Jingbo Zhang Peng Zhang Qingmin Zhang Shiqi Zhang Tao Zhang Xiaomei Zhang Xuantong Zhang Yan Zhang Yinhong Zhang Yiyu Zhang Yongpeng Zhang Yuanyuan Zhang Yumei Zhang Zhenyu Zhang Zhijian Zhang Fengyi Zhao Jie Zhao Rong Zhao Shujun Zhao Tianchi Zhao Dongqin Zheng Hua Zheng Minshan Zheng Yangheng Zheng Weirong Zhong Jing Zhou Li Zhou Nan Zhou Shun Zhou Xiang Zhou Jiang Zhu Kejun Zhu Honglin Zhuang Liang Zong Jiaheng Zou | 2021 | Chinese Physics C2021,45,2: | 0 |
| 13 | ROCK inhibitor:Focus on recent updates显示文摘Rho-associated coiled-coil-containing protein kinase(RoCK)belongs to the serine-threonine family,and RoCK is involved in a variety of biological processes including cell migration,adhesion,proliferation and differentiation through phosphorylation of different downstream substrates.The aberrant activation of ROCK is associated with the pathological conditions in different systems including various diseases,including cancer,neurological diseases,inflammation,cardiovascular diseases and glaucoma.Therefore,the ROCK inhibitors have potential applicability for treating the aforementioned diseases.Four small molecule ROCK inhibitors have been approved for clinical use:fasudil,ripasudil,netarsudil and belumosudil.In recent years,more small molecule ROCK inhibitors have been identified.This paper reviews the ROCK inhibitors reported in past seven years.We mainly focused on the summarization of the structure-activity relationships,inhibitory efficacy,pharmacological mechanisms and the relevant clinical studies of the reported ROCK inhibitors.Besides the small molecular inhibitors,the peptides and biological extracts which exhibit ROCK inhibitory effects are also included.We also provide suggestions for the future development of the potent ROCK inhibitors. | Yaodong You Kun Zhu Jie Wang Qi Liang Wen Li Lin Wang Baojun Guo Jing Zhou Xuanlin Feng Jianyou Shi | 2023 | Chinese Chemical Letters2023,34,12: | 0 |
| 14 | Estimation and Long-term Trend Analysis of Surface Solar Radiation in Antarctica: A Case Study of Zhongshan Station显示文摘Long-term,ground-based daily global solar radiation (DGSR) at Zhongshan Station in Antarctica can quantitatively reveal the basic characteristics of Earth’s surface radiation balance and validate satellite data for the Antarctic region.The fixed station was established in 1989,and conventional radiation observations started much later in 2008.In this study,a random forest (RF) model for estimating DGSR is developed using ground meteorological observation data,and a highprecision,long-term DGSR dataset is constructed.Then,the trend of DGSR from 1990 to 2019 at Zhongshan Station,Antarctica is analyzed.The RF model,which performs better than other models,shows a desirable performance of DGSR hindcast estimation with an R^2 of 0.984,root-mean-square error of 1.377 MJ m^(-2),and mean absolute error of 0.828 MJ m^(-2).The trend of DGSR annual anomalies increases during 1990–2004 and then begins to decrease after 2004.Note that the maximum value of annual anomalies occurs during approximately 2004/05 and is mainly related to the days with precipitation (especially those related to good weather during the polar day period) at this station.In addition to clouds and water vapor,bad weather conditions (such as snowfall,which can result in low visibility and then decreased sunshine duration and solar radiation) are the other major factors affecting solar radiation at this station.The high-precision,longterm estimated DGSR dataset enables further study and understanding of the role of Antarctica in global climate change and the interactions between snow,ice,and atmosphere. | Zhaoliang ZENG Zemin WANG Minghu DING Xiangdong ZHENG Xiaoyu SUN Wei ZHU Kongju ZHU Jiachun AN Lin ZANG Jianping GUO Baojun ZHANG | 2021 | Advances in Atmospheric Sciences2021,38,9: | 0 |
| 15 | Selectivity switching between CO and formate for CO_(2) reduction on Sb modified amorphous ZnO by electronic effect显示文摘The adjustable intermediate binding capacity in electrocatalytic carbon dioxide(CO_(2))reduction is critical for varying the reaction pathways to desired products.Herein,we first report the synthesis of boron-doped amorphous zinc oxide with(B-a-ZnO-Sb)or without antimony nanoparticles embedding(B-a-ZnO)via one-step wet chemical method,which is easy to scale up by enlarging the vessel and increasing feeding.Sb successfully realizes the product switching from CO on B-a-ZnO to formate on B-a-ZnOSb.Both experimental and theoretical results reveal that Sb weakens the charge interaction on Zn atoms.Based on the moderate adsorption of*COOH and strong adsorption of*OCHO and*HCOOH for B-a-ZnO,the foreign Sb weakens the adsorption of these intermediates and brings about a favor formate production instead of CO.This work points out a new direction for the synthesis of amorphous ZnO-based catalysts and provides advanced insights into the aimed selectivity switch for CO_(2)reduction by electronic effect. | Hongyu Chen Shoufu Cao Lu Wang Xiaojing Lin Qiuying Zhu Yizhu Shang Shuxian Wei Siyuan Liu Zhaojie Wang Baojun Wei Xiaoqing Lu | 2023 | Nano Research2023,16,10: | 0 |
| 16 | Flexible organic integrated electronics for self-powered multiplexed ocular monitoring显示文摘Smart contact lens has drawn extensive research interests due to the noninvasive real-time detection of the human body to provide biomedical information for health management.However,it has been difficult to accurately measure the physiological signals in tears,and the use of external power source has also hindered the future applications.Here,we demonstrated an organic electrochemical transistor based multiplexed sensors self-powered by the organic solar cells(OSCs).The integrated device was fabricated via simple process including solution blade-coating and thermal evaporation.OSCs were optimized to provide optimal operation voltage for the sensors that exhibit semilog-linear response to the glucose and calcium ions in tear fluids without any peripheral circuits.The sensing signals can be transmitted to the laptop wirelessly through a near filed communication unit.This integrated self-powered multiplexed sensing device will provide real-time monitoring of the biomarkers in tears,prospected to be installed on the smart contact lens for the early detection and diagnosis of diabetes. | Baojun Lin Meng Wang Chao Zhao Shijie Wang Kai Chen Xiao Li Zaishang Long Chenxu Zhao Xinyue Song Sen Yan Laili Wang Wei Ma | 2022 | npj Flexible Electronics2022,6,1: | 0 |