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| 1 | Targeting NF-κB pathway for the therapy of diseases:mechanism and clinical study显示文摘NF-κB pathway consists of canonical and non-canonical pathways.The canonical NF-κB is activated by various stimuli,transducing a quick but transient transcriptional activity,to regulate the expression of various proinflammatory genes and also serve as the critical mediator for inflammatory response.Meanwhile,the activation of the non-canonical NF-κB pathway occurs through a handful of TNF receptor superfamily members.Since the activation of this pathway involves protein synthesis,the kinetics of non-canonical NF-κB activation is slow but persistent,in concordance with its biological functions in the development of immune cell and lymphoid organ,immune homeostasis and immune response.The activation of the canonical and non-canonical NF-κB pathway is tightly controlled,highlighting the vital roles of ubiquitination in these pathways.Emerging studies indicate that dysregulated NF-κB activity causes inflammation-related diseases as well as cancers,and NF-κB has been long proposed as the potential target for therapy of diseases.This review attempts to summarize our current knowledge and updates on the mechanisms of NF-κB pathway regulation and the potential therapeutic application of inhibition of NF-κB signaling in cancer and inflammatory diseases. | Hui Yu Liangbin Lin Zhiqiang Zhang Huiyuan Zhang Hongbo Hu | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 35 |
| 2 | Multispherical interactions and their effects on the Tibetan Plateau's earth system: a review of the recent researches显示文摘The Tibetan Plateau(TP) is a regional Earth system showing very strong interactions among its lithosphere, hydrosphere, cryosphere, biosphere, atmosphere, and anthrosphere. hese interactions manifest TP's impact on surrounding regions and relect TP's response to the global change. Quantifying the multispherical interactions is critically important to understand the TP environment. Our recent years researches including the ongoing program entitled ‘Tibetan Multi-Spheres Interactions and heir Resource-Environment Signiicance(TIMI)', the completed program entitled. ‘Paleo-Altitudes of Tibetan Plateau and Environment(PATE)', as well as the other relating projects have focused on multidisciplinary research approaches and emphasized on three major pathways: Eurasia-Indian plates collision on deep-Earth dynamics, uplit impact on Earth's mantle–crust dynamics, and contemporary interface on land surface and atmospheric dynamics. Our researches have taken in situ measurement as priority and developed several platforms of data acquisition and analysis, including the platforms of water-phase transformations, and ecosystem observations. Our ield investigations have been conducted to obtain data about stratum, paleontology, paleoenvironment, genetic diferentiation of animals and plants. We have developed conceptual and mathematical models for crust uplit formation, paleoclimate, glacial melt,water–air interface lux, vegetation climate, and soil erosion. We have also assessed the anthropogenic impacts on environment. Our researches have achieved new and reliable redating of the mantle–crust interaction and initial formation of the TP, found the interaction between tectonics and uplit of the TP and resultant paleoaltitude acting as a spreading source; discovered the interaction between the westerlies and Indian monsoon acting as a control chain that dominates the TP's contemporary environment. he scientiic results can play fundamental roles in supporting the TP's resource exploration and societal sustainable development. | Tandong Yao Fuyuan Wu Lin Ding Jimin Sun Liping Zhu Shilong Piao Tao Deng Xijun Ni Hongbo Zheng Hua Ouyang | 2015 | National Science Review2015，2，4： | 35 |
| 3 | Temperature variations in the past 6000 years inferred from δ^(18)O of peat cellulose from Hongyuan,China显示文摘Trends of the temperature variations recorded in δ18O in Hongyuan peat cellulose are similar to those recorded in δ18O of Jinchuan peat cellulose and in δ18O of Dunde ice core. Climate events have been identified to be globally homogeneous. Two notable climate transition periods have been detected in the past 6000 years, namely 4000 aBP with climate shifting from cold to warm and 1500 aBP with climate shifting from warm to relatively cold. Power spectrum analysis was performed to investigate the periodical signals in the δ18O time series. Typical periodicities of 1200-1087 a, 752 a, 444 a, 325 a, 213 a, 127-123 a, 88 a, 79 a were discovered, indicating an integrated influence on Hongyuan climate from solar, monsoon and ocean activities. Solar forcing has been addressed to be the main driving forcing of Hongyuan climate. | XU Hai, HONG Yetang, LIN Qinghua, HONG Bing, JIANG Hongbo & ZHU YongxuanInstitute of Geochemistry, Chinese Academy of Sciences, Guiyang 550002, China Graduate School of Chinese Academy of Sciences, Beijing 100039, China | 2002 | Chinese Science Bulletin2002，47，18： | 31 |
| 4 | Basement of the South China Sea Area:Tracing the Tethyan Realm显示文摘华南海( SCS )和邻近的区域的地下室能被划分成六个部门(区域)在 Beibu 海湾的古生代的 Erathem 指责graben 的地下室分割,在 Yinggehai 的古生代的 Erathem 罢工滑倒拉开流水,在东方海南的古生代的 Erathem 差错消沉,在北 Xisha ( Paracel )的古生代的 Erathem rifted ,古生代的 Erathem 罢工滑倒在在 Nansha 岛延长的南部的 Xisha ,和古生代中生代的 Erathem 延长( Spratly )水。在 SCS 和 Yunkai 大陆人区域的新生代前地下室在在新生代前时期的 Tethyan 构造领域以内是同时代的。他们在 Paleo-Tethyan 构造领域的背景上被形成,并且是东方 Tethyan multi-island-ocean 系统的重要部件。东方 Paleo-Tethys 构造领域,北方 Yunkai,诺思海南,和南方海南海盆的三个分支,演变为北方 Yunkai,诺思海南,和南方海南缝术地区分别地。这为新生代前地下室显示出本地化的一个特殊特征。 Qiongnan (即南方海南)华南海的北边缘上的缝术地区能被认为 Paleo-Tethys 的主要海洋盆的痕迹,并且与 Longmucuo-Shuanghu beltBitu 带 Changning-Menglian-Bentong-Raub 带的缝术地区连接了,华南海的西方上的 Bitu-Changning-MenglianChing Mai beltChanthaburi-Raub-Bentong 带的南方延期,并且与 Lianhua-Taidong 缝术地区(沿着在台湾的纵的山谷的东方方面的一个差错) Hida Qiongbei (诺思海南) 缝术地区可以向东沿着 Wangwu-Wenjiao 差错地区延长了,并且深与 Lufeng-Dapu-Zhenghe-Shangyu (Lianhuashan ) 连接通过珍珠河嘴盆的差错地区。Meso-Tethys 在华南海的南方上发展了。Nansha 马槽可以被认为 Meso-Tethys 的北架的痕迹。 Meso-Tethys 的海洋的外壳向南沿着 subduction-collision-thrust 有 subducted 有华南海的西方上的 Yarlung Zangbo-Mytkyina-Bago 地区的到那些的subduction杆反面的 Nansha 马槽的南部的边缘,并且 Meso-Tethyan (例如 Meso-Tethys 的北 Chichibu 海洋)在在西南日本的侏罗记早的白垩纪地球组的外部带的缝术地区 Butsozo 构造的线,在华南海的东方上。 | LIU Hailing ZHENG Hongbo WANG Yanlin LIN Qiujin WU Chaohua ZHAO Meisong DU Yunkong | 2011 | Acta Geologica Sinica(English Edition)2011，85，3： | 13 |
| 5 | Biomimetic Corrugated Silicon Nanocone Arrays for Self-Cleaning Antireflection Coatings显示文摘Corrugated silicon nanocone(SiNC)arrays have been fabricated on a silicon wafer by two polystyrene-sphere-monolayer-masked etching steps in order to create high-performance antireflective coatings.The reflectance was reduced from above 35%to less than 0.7%in the range 400-1050 nm,and it remained below 0.5%at incidence angles up to 70°at 632.8 nm for both s-and p-polarized light.The fluorinated corrugated SiNC array surface exhibits superhydrophobic properties with a water contact angle of 164°. | Yandong Wang Nan Lu Hongbo Xu Gang Shi Miaojun Xu Xiaowen Lin Haibo Li Wentao Wang Dianpeng Qi Yanqing Lu Lifeng Chi | 2010 | Nano Research2010，3，7： | 8 |
| 6 | Ability to detect weak effective seismic signals by utilizing chaotic vibrator system显示文摘Taking the advantage of CVS (Chaotic Vibrator System) sensitivity of large-scale periodic phase-state response to quasi-periodic or periodic signals,a series of numerical experiments were made to understand the ability of CVS to detect weak effective seismic signals in the common-shot seismic record distorted by strong stochastic noise. The re-sults demonstrate that the large-scale periodic phase-states of CVS are correlated with the signal composition of the quasi-periodic wavelet sequence constructing from horizontal moveout of seismic events,noise strength and the noise distortion de-gree to signal. For the same kind of events,the higher the noise distortion degree is,the lower the detectable SNR can be reached by CVS. For seismic data with the same noise distortion degree,the closer the scanning seismic velocity (the trial moveout ve-locity) approaches to the accurate velocity,the higher the detectable SNR can be reached by CVS. More-over,the truncating scanning velocities form an asymmetric belt,which indirectly makes CVS achieve a large-scale periodic phase-state and then the ratio of wavelet distortion coefficients in events can be a biggish variable scope. | LI Yue YANG Baojun YUAN Ye ZHAO Xueping LIN Hongbo | 2006 | Chinese Science Bulletin2006，51，24： | 6 |
| 7 | Influence of polymers on the stability of Gudao crude oil emulsions显示文摘The influence of different types and concentrations of polymers on the stability of Gudao crude oil emulsion was investigated by measuring the volume of water separated from the emulsions and the interfacial shear viscosity of the oil/water interfacial film.Experimental results indicate that the simulated water-in-oil emulsion with 40 mg/L of partially hydrolyzed polyacrylamide(HPAM)3530S could be easily broken by adding demulsifier C and was readily separated into two layers.However, HPAM AX-74H and hydrophobically associating water-soluble polymer(HAP)could stabilize the crude oil emulsion.With increasing concentration of AX-74H and HAP,crude oil emulsions became more stable.Water droplets were loosely packed in the water-in model oil emulsion containing HPAM 3530S, but water droplets were smaller and more closely packed in the emulsion containing AX-74H or HAP.The polymers could be adsorbed on the oil/water interface,thereby increasing the strength of the interfacial film and enhancing the emulsion stability. | Lin Meiqin Zhang Chunling Zong Hua Li Mingyuan Fang Hongbo Guo Jixiang | 2008 | Petroleum Science2008，5，2： | 6 |
| 8 | High-performance aqueous symmetric sodium-ion battery using NASICON-structured Na2VTi(PO4)3显示文摘 | Hongbo wang Tianran Zhang Chao Chen Min Ling Zhan Lin Shanqing Zhang Feng Pan Chengdu Liang | 2018 | Nano Research2018，11，1： | 6 |
| 9 | FABP4 secreted by M1-polarized macrophages promotes synovitis and angiogenesis to exacerbate rheumatoid arthritis显示文摘Increasing evidence shows that adipokines play a vital role in the development of rheumatoid arthritis(RA).Fatty acid-binding protein 4(FABP4),a novel adipokine that regulates inflammation and angiogenesis,has been extensively studied in a variety of organs and diseases.However,the effect of FABP4 on RA remains unclear.Here,we found that FABP4 expression was upregulated in synovial M1-polarized macrophages in RA.The increase in FABP4 promoted synovitis,angiogenesis,and cartilage degradation to exacerbate RA progression in vivo and in vitro,whereas BMS309403(a FABP4 inhibitor)and anagliptin(dipeptidyl peptidase 4 inhibitor)inhibited FABP4 expression in serum and synovial M1-polarized macrophages in mice to alleviate RA progression.Further studies showed that constitutive activation of mammalian target of rapamycin complex 1(mTORC1)by TSC1 deletion specifically in the myeloid lineage regulated FABP4 expression in macrophages to exacerbate RA progression in mice.In contrast,inhibition of mTORC1 by ras homolog enriched in brain(Rheb1)disruption specifically in the myeloid lineage reduced FABP4 expression in macrophages to attenuate RA development in mice.Our findings established an essential role of FABP4 that is secreted by M1-polarized macrophages in synovitis,angiogenesis,and cartilage degradation in RA.BMS309403 and anagliptin inhibited FABP4 expression in synovial M1-polarized macrophages to alleviate RA development.Hence,FABP4 may represent a potential target for RA therapy. | Dong Guo Chuangxin Lin Yuheng Lu Hong Guan Weizhong Qi Hongbo Zhang Yan Shao Chun Zeng Rongkai Zhang Haiyan Zhang Xiaochun Bai Daozhang Cai | 2022 | Bone Research2022，10，4： | 5 |
| 10 | Suppression of strong random noise in seismic data by using time-frequency peak filtering显示文摘Time-frequency peak filtering (TFPF) is highly efficient in suppressing random noise in seismic data. Although the hypothesis of stationary Gaussian white noise cannot be fulfilled in practical seismic data, TFPF can effectively suppress white and colored random noise with different intensities, as can be theoretically demonstrated by detecting such noise in synthetic seismic data. However, a 'zero-drift' effect is observed in the filtered signal and is independent of the average power and variance of the random noise, but related to its mean value. Furthermore, we consider the situation where the local linearization of the seismic data cannot be satisfied absolutely and study the 'distortion' characteristics of the filtered signal using TFPF on a triangular wave. We found that over-compensation is possible in the frequency band for the triangular wave. In addition, it is nonsymmetrical and has a relationship to the time-varying curvature of the seismic wavelet. The results also present an improved approach for TFPF. | LI Yue YANG BaoJun LIN HongBo MA HaiTao NIE PengFei | 2013 | Science China Earth Sciences2013，56，7： | 5 |
| 11 | Protective effect of oxysophoridine on cerebral ischemia/reperfusion injury in mice显示文摘Oxysophoridine, a new alkaloid extracted from Sophora alopecuroides L., has been shown to have a protective effect against ischemic brain damage. In this study, a focal cerebral ischemia/reperfusion injury model was established using middle cerebral artery occlusion in mice. Both 62.5, 125, and 250 mg/kg oxysophoridine, via intraperitoneal injection, and 6 mg/kg nimodipine, via intragastric administration, were administered daily for 7 days before modeling. After 24 hours of reperfusion, mice were tested for neurological deficit, cerebral infarct size was assessed and brain tissue was collected. Results showed that oxysophoridine at 125, 250 mg/kg and 6 mg/kg nimodipine could reduce neurological deficit scores, cerebral infarct size and brain water content in mice. These results provided evidence that oxysophoridine plays a protective role in cerebral ischemia/reperfusion injury. In addition, oxysophoridine at 62.5, 125, and 250 mg/kg and 6 mg/kg nimodipine increased adenosine-triphosphate content, and decreased malondialdehyde and nitric oxide content. These compounds enhanced the activities of glutathione-peroxidase, superoxide dismutase, catalase, and lactate dehydrogenase, and decreased the activity of nitric oxide synthase. Protein and mRNA expression levels of N-methyl-D-aspartate receptor subunit NR1 were markedly inhibited in the presence of 250 mg/kg oxysophoridine and 6 mg/kg nimodipine. Our experimental findings indicated that oxysophoridine has a neuroprotective effect against cerebral ischemia/reperfusion injury in mice, and that the effect may be due to its ability to inhibit oxidative stress and expression of the N-methyl-D-aspartate receptor subunit NR1. | Hongbo Wang Yuxiang Li Ning Jiang Xiaoping Chen Yi Zhang Kuai Zhang Tengfei Wang Yinju Hao Lin Ma Chengjun Zhao Yanrong Wang Tao Sun Jianqiang Yu | 2013 | Neural Regeneration Research2013，8，15： | 5 |
| 12 | Challenges and strategies for in situ endothelialization and long-term lumen patency of vascular grafts显示文摘Vascular diseases are the most prevalent cause of ischemic necrosis of tissue and organ,which even result in dysfunction and death.Vascular regeneration or artificial vascular graft,as the conventional treatment modality,has received keen attentions.However,small-diameter(diameter<4 mm)vascular grafts have a high risk of thrombosis and intimal hyperplasia(IH),which makes long-term lumen patency challengeable.Endothelial cells(ECs)form the inner endothelium layer,and are crucial for anti-coagulation and thrombogenesis.Thus,promoting in situ endothelialization in vascular graft remodeling takes top priority,which requires recruitment of endothelia progenitor cells(EPCs),migration,adhesion,proliferation and activation of EPCs and ECs.Chemotaxis aimed at ligands on EPC surface can be utilized for EPC homing,while nanofibrous structure,biocompatible surface and cell-capturing molecules on graft surface can be applied for cell adhesion.Moreover,cell orientation can be regulated by topography of scaffold,and cell bioactivity can be modulated by growth factors and therapeutic genes.Additionally,surface modification can also reduce thrombogenesis,and some drug release can inhibit IH.Considering the influence of macrophages on ECs and smooth muscle cells(SMCs),scaffolds loaded with drugs that can promote M2 polarization are alternative strategies.In conclusion,the advanced strategies for enhanced long-term lumen patency of vascular grafts are summarized in this review.Strategies for recruitment of EPCs,adhesion,proliferation and activation of EPCs and ECs,anti-thrombogenesis,anti-IH,and immunomodulation are discussed.Ideal vascular grafts with appropriate surface modification,loading and fabrication strategies are required in further studies. | Yu Zhuang Chenglong Zhang Mengjia Cheng Jinyang Huang Qingcheng Liu Guangyin Yuan Kaili Lin Hongbo Yu | 2021 | Bioactive Materials2021，6，6： | 5 |
| 13 | Characterization and acid-mobilization study for typical iron- bearing clay mineral显示文摘In this study, iron speciation in five standard clay samples was characterized. Iron mobilization from these clays was then measured in acidic media. For comparison, a commercially available Arizona test dust(ATD) was also observed. The results showed that the free-Fe contents of clays were commonly lower than that of dust aerosols. The components of clays were dominant by the structural Fe held in the aluminosilicate lattice.The iron solubility of the clays were in the order of KGa-2 > SWy-2 > CCa-2 > IMt-2 > NAu-2. Based upon the M?ssbauer spectrum and transmission electron microscopy(TEM)analysis, the Fe(II) fraction and the Fe/Si ratio of clay particles changed after dissolution,suggesting the total Fe solubility depended on the Fe atom states existing within the aluminosilicate lattice. The Fe in KGa-2 and SWy-2 was most likely substituted for alkaline elements as the interlayer ions held by ionic bonds in the aluminosilicate, which are more liable to dissolution. However, the Fe in NAu-2 was more likely to be bound by strong covalent bonds in aluminosilicate mineral, which is less soluble. The much highly soluble Fe in ATD was not only linked to the dissolution of an appreciable fraction of Fe(II), but also could be attributed to the fact that the Fe bonds in the clay fraction of ATD were mainly present as ionic bonds. The TEM images showed that reacted clay particles displayed less aggregate particles, with nanoparticle aggregates and the Fe/S-rich tiny particles attached to the remains. | Zhenzhen Wang Rui Li Lulu Cui Hongbo Fu Jun Lin Jianmin Chen | 2018 | Journal of Environmental Sciences2018，30，9： | 4 |
| 14 | Genome architecture and tetrasomic inheritance of autotetraploid potato显示文摘Potato(Solanum tuberosum)is the most consumed non-cereal food crop.Most commercial potato cultivars are autotetraploids with highly heterozygous genomes,severely hampering genetic analyses and improvement.By leveraging the state-of-the-art sequencing technologies and polyploid graph binning,we achieved a chromosome-scale,haplotype-resolved genome assembly of a cultivated potato,Cooperation-88(C88).lntra-haplotype comparative analyses revealed extensive sequence and expression differences in this tetraploid genome.We identified haplotype-specific pericentromeres on chromosomes,suggesting a distinct evolutionary trajectory of potato homologous centromeres.Furthermore,we detected double reduction events that are unevenly distributed on haplotypes in 1021 of 1034 selfing progeny,a feature of autopolyploid inheritance.By distinguishing maternal and paternal haplotype sets in C88,we simulated the origin of heterosis in cultivated tetraploid with a survey of 3110 tetra-allelic loci with deleterious mutations,which were masked in the heterozygous condition bytwo parents.This study provides insights into the genomic architecture of autopolyploids and will guide their breeding. | Zhigui Bao Canhui Li Guangcun Li Pei Wang Zhen Peng Lin Cheng Hongbo Li Zhiyang Zhang Yuying Li Wu Huang Mingwang Ye Daofeng Dong Zhukuan Cheng Peter VanderZaag Evert Jacobsen Christian W.B.Bachem Suomeng Dong Chunzhi Zhang Sanwen Huang Qian Zhou | 2022 | Molecular Plant2022，15，7： | 4 |
| 15 | Individual particle analysis of aerosols collected at Lhasa City in the Tibetan Plateau显示文摘To understand the composition and major sources of aerosol particles in Lhasa City on the Tibetan Plateau(TP), individual particles were collected from 2 February to 8 March, 2013 in Tibet University. The mean concentrations of both PM2.5and PM10 during the sampling were25.7 ± 21.7 and 57.2 ± 46.7 μg/m3, respectively, much lower than those of other cities in East and South Asia, but higher than those in the remote region in TP like Nam Co, indicating minor urban pollution. Combining the observations with the meteorological parameters and back trajectory analysis, it was concluded that local sources controlled the pollution during the sampling. Transmission electron microscopy(TEM) combined with energydispersive X-ray spectra(EDS) was used to study 408 particles sampled on four days. Based on the EDS analysis, a total of 8 different particle categories were classified for all 408 particles, including Si-rich, Ca-rich, soot, K-rich, Fe-rich, Pb-rich, Al-rich and other particles.The dominant elements were Si, Al and Ca, which were mainly attributed to mineral dust in the earth's crust such as feldspar and clay. Fe-, Pb-, K-, Al-rich particles and soot mainly originated from anthropogenic sources like firework combustion and biomass burning during the sampling. During the sampling, the pollution mainly came from mineral dust,while the celebration ceremony and religious ritual produced a large quantity of anthropogenic metal-bearing particles on 9 and 25 February 2013. Cement particles also had a minor influence. The data obtained in this study can be useful for developing pollution control strategies. | Bu Duo Yunchen Zhang Lingdong Kong Hongbo Fu Yunjie Hu Jianmin Chen Lin Li A.Qiong | 2015 | Journal of Environmental Sciences2015，27，3： | 4 |
| 16 | 晚期转移性膀胱癌患者血清CA125检测的临床意义(英文)显示文摘Objective: To explore the clinical significance of the examination of serum CA125 level of patients with metastatic bladder carcinoma. Methods: Electrochemiluminescence technique was used to examine the serum CA125 concentration of 58 cases with metastatic bladder cancer. 30 cases of superficial bladder cancer and 8 cases of other urological diseases were collected as the control group. Results: Serum CA125 level in 39 (67.2%) out of 58 cases ranged from 36.7 U/mL to 1485.6 U/mL (mean 498.3 U/mL), being higher than normal (< 35 U/mL). Serum CA125 level of metastatic bladder cancer patients was 324.5 U/mL, significantly higher than that in control group (P < 0.001). Serum CA125 level of 10 patients after transure- thral resection operation was significantly lower than that before operation (P < 0.05). Serum CA125 level of 16 patients who refused further treatment significantly increased from 450.4 U/mL, to 505.8 U/mL (P = 0.041) 3 months after discharge from the hospital. Serum CA125 level of 17 patients significantly decreased from 475.8 U/L to 237.9 U/mL (P < 0.001) after bilateral iliac-arterial embolism treatment. Conclusion: CA125 may be a valuable marker for the judgment of advanced metastatic bladder cancer. | Jinyi Yang Wei Wei Jianguang Liu Xiaoqi Hu Lin Ye Jie Zhou Hongbo Jiang Xingjin Jiang | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，8： | 3 |
| 17 | Layer-block tectonics of Cenozoic basements and formation of intra-plate basins in Nansha micro-plate, southern South China Sea显示文摘Layer-block tectonics (LBT) concept, with the core of pluralistic geodynamic outlook and multi- layer-sliding tectonic outlook, is one of new keys to study 3-dimensional solid and its 4-dimensional evolution history of global tectonic system controlled by global geodynamics system. The LBT concept is applied to study the lithospheric tectonics of the southern South China Sea (SCS). Based on the analysis of about 30 000 km of geophysical and geological data, some layer-blocks in the Nansha micro-plate can be divided as Nansha ultra-crustal layer-block, Zengmu crustal layer-block, Nanwei (Rifleman bank)-Andu (Ardasier bank) and Liyue (Reed bank)-North Palawan crustal layer-blocks, Andu-Bisheng and Liyue-Banyue basemental layer-blocks. The basic characteristics of the basemental layer-blocks have been dicussed, and three intra-plate basin groups are identified. The intra-plate basins within Nansha micro-plate can be divided into three basin groups of NanweiAndu, Feixin-Nanhua, and Liyue-North Palawan based on the different geodynamics. In the light of pluralistic geodynamic concept, the upheaving force induced by the mid-crust plastic layer is proposed as the main dynamical force which causes the formation of the intra-plate basins within the Nansha micro-plate. Finally, models of a face-to-face dip-slip-detachment of basemental layer- block and a unilateral dip-slip-detachment of basemental layer-block are put forward for the forming mechanisms of the Nanwei-Andu and Liyue-North Palawan intra-plate basin groups, respectively. | LIU Hailing XIE Guofa LIN Qiujin ZHENG Hongbo LIU Yingchun | 2009 | Acta Oceanologica Sinica2009，28，3： | 3 |
| 18 | Comprehensive profiling of EBV gene expression in nasopharyn- geal carcinoma through paired-end transcriptome sequencing显示文摘在鼻咽的癌(NPC ) 的 Epstein-Barr 病毒(EBV ) 基因的潜伏的表示模式广泛地被调查了,并且在 NPC 的几 lysin 的基因的表示被报导了。然而,通过在 NPC 的 EBV transcriptome 分析的全面信息是有限的。我们执行了对结束 RNA-seq 到系统地并且包括地在 NPC 织物和 C666-1 NPC 房间线描绘 EBV 基因的表示,它一致地带 EBV。除了限制打 II 潜伏感染,类型 III 潜伏 EBNA3s 基因和lysin 的基因的一个实质的数字的抄本,例如 BZLF1 , BRLF1 ,和 BMRF1 ,通过 RNA-seq 被检测并且进一步通过也执行的实时 PCR.We 在 C666-1 房间和 NPC 织物被验证聚类分析以 EBV 基因表示分类 NPC 耐心的组,它介绍了 NPC 样品的二种子类型。结果在 NPC 病人揭示了 EBV 基因表示的有趣的模式。这个聚类与 heterotrimeric G 蛋白质发信号有关与许多发信号的小径被相关,例如那些,发炎由 chemokine 并且 cytokine 发信号调停了,核糖体,蛋白质新陈代谢,流行性感冒感染,和 ECM 受体相互作用。我们的联合调查结果建议在 NPC 的 EBV 基因的表示被限制不仅打 II 潜伏基因而且打 III 潜伏和 lysin 的基因。这研究在 NPC 的发展提供了进一步的卓见进 EBV 的潜在的角色。 | Lijuan Hu Zhirui Lin YanhengWu Juqin Dong Bo Zhao Yanbing Cheng Peiyu Huang Lihua Xu Tianliang Xia Dan Xiong Hongbo Wang Manzhi Li Ling Guo Elliott Kieff YixinZeng | 2016 | Frontiers of Medicine2016，10，1： | 3 |
| 19 | Changes in dendritic cells and dendritic cell subpopulations in peripheral blood of recipients during acute rejection after kidney transplantation显示文摘 | Ma Linlin Liu Yong Wu Junjie Xu Xiuhong Liu Fen Feng Lang Xie Zelin Tang Yawang Sun Wen Guo Hongbo Zhang Lei Lin Jun Tian Ye | 2014 | Chinese Medical Journal2014，，8： | 3 |
| 20 | Variation in contact load at the most loaded position of the outer raceway of a bearing in high-speed train gearbox显示文摘For the fatigue failure and tribological property of a rolling element bearing,the contact load variation plays a significant role while the most loaded position of the bearing outer raceway takes the greatest risk of failure.This paper focuses on the variation in contact load on the most loaded position of the outer raceway of a gearbox bearing in high-speed train.Under operation conditions of different input speeds and torques,the dynamic contact load distribution in a gearbox bearing of high-speed train was measured by instrumenting the bearing with strain gauges.The most loaded position was identified accordingly and the features and reasons of the variation in contact load on this position were suggested.Three factors were found to have varying degrees of impact on the contact load variation under different gear meshing conditions:modal vibration of the cage or shaft,radial geometrical differences among the rollers and vibration of the gearbox housing. | Yu Hou Xi Wang Hongbo Que Rubing Guo Xinhai Lin Siqin Jin Chengpan Wu Yue Zhou Xiaolong Liu | 2021 | Acta Mechanica Sinica2021，37，11： | 2 |
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