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| 1 | Evidence chain-based causality identification in herb-induced liver injury: exemplification of a well-known liver-restorative herb Polygonum multiflorum显示文摘草药的药最近在美国作为导致药的肝损害(DILI ) 的第二个很普通的原因被认出了。然而,识别一些植物的 DILI 诱发性的可靠方法例如 Heshouwu (蓼 multiflorum 的弄干的根) ,留下缺乏。在这研究,有肝机能障碍和 Heshouwu DILI 的 147 个报导文学的案例的 12 307 个住院病人的一个总数被屏蔽。一个一般算法仅仅显示了那 22.5%(9/40 ) 并且(45/147 ) 分别地, 30.6% 所有住院和文学案例报告表明 Heshouwu 的 DILI 诱发性的高概率。由对比,(19/20 )95% 生药学,植物化学,和 metabolomic 有希望地调查的所有情况测试展出高度可能的诱发性,包括不正确地以前被归因的一个病人和从由 pharmacognostic 证据的 Heshouwu 诱发性被排除的一个案例。污染也是的毒素(重金属,杀虫剂,和 mycotoxins ) 从 Heshouwu DILI 诱发性排除了。为 Heshouwu DILI 诊断地址安全的这些屏蔽方法的客观性担心考虑包含芪的草药的药和饮食的补充。 | Jiabo Wang Zhijie Ma Ming Niu Yun Zhu Qingsheng Liang Yanling Zhao Jingyuan Song Zhaofang Bai Yaming Zhang Ping Zhang Na Li Yakun Meng Qi Li Lushan Qin Guangju Teng Junling Cao Baosen Li Shilin Chen Yonggang Li Zhengsheng Zou Honghao Zhou Xiaohe Xiao | 2015 | Frontiers of Medicine2015，9，4： | 47 |
| 2 | Shock tube study of kerosene ignition delay at high pressures显示文摘Ignition delay times of China No.3 aviation kerosene were measured behind reflected shock waves using a heated high-pressure shock tube.Experimental conditions covered a wider temperature range of 820-1500 K,at pressures of 5.5,11 and 22 atm,equivalence ratios of 0.5,1.0 and 1.5,and oxygen concentration of 20%.Adsorption of kerosene on the shock tube wall was taken into account.Ignition delay times were determined from the onset of the excited radical OH emission in conjunction with the pressure profiles.The experimental results of ignition delay time were correlated with the equations:11 0.22 1.09 2 3.2 10 [Keros ene ] [O2] exp(69941 RT) and 7 0.88 0.23 4.72 10 P exp(62092 RT).The current measurements provide the ignition delay behavior of China No.3 aviation kerosene at high pressures and air-like O2 concentration. | LIANG JinHu WANG Su HU HongHao ZHANG ShengTao FAN BingCheng CUI JiPing | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，6： | 13 |
| 3 | Heterotic Group Classification of 63 Inbred Lines and Hybrid Purity Identification by Using SSR Markers in Winter Cabbage(Brassica Oleracea L. var. capitata)显示文摘Winter cabbage is an important crop cultivated through winter in the region near the Yangtze River, enabling the supply of fresh cabbage there at that time of year. However, a problem has emerged regarding the newly developed parents of winter cabbage, which is completely different from spring and autumn cabbage, namely, how to combine these parents to breed an elite hybrid. To classify the heterotic groups and improve the efficiency of parent selection in winter cabbage breeding, 20 polymorphic SSR markers were selected to screen 63 winter cabbage inbred lines. Seventeen pairs among the 20 SSR markers amplified polymorphic bands. These primers amplified two to six bands,with an average of 2.8 bands per primer, and a total of 47 polymorphic bands were generated in the 63 inbred lines. These lines included flatheaded morphotype and round-headed morphotype, thus they were separately classified into heterotic groups based on the SSR markers. The flat-headed morphotype contained 21 inbred lines and was classified into three heterotic groups, named Hanchun 4, Jiali, and Dongsheng, in accordance with the representative germplasm contained in each group. The round-headed morphotype contained 42 inbred lines and was classified into five heterotic groups, named Parte, Bejo1039, YK-143, SCA002, and Golden B90. Meanwhile, parent analysis of 20 developed elite combinations showed that their parents were all distributed in different heterotic groups, indicating that the group classification was reasonable,which can provide a basis for further parent selection in winter cabbage breeding. Furthermore, polymorphic SSR primers were successfully used to identify the hybrid purity of three elite varieties. | LI Xing YU Hailong LI Zhiyuan LIU Xiaoping FANG Zhiyuan LIU Yumei YANG Limei ZHUANG Mu LV Honghao ZHANG Yangyong | 2018 | Horticultural Plant Journal2018，4，4： | 11 |
| 4 | Spinel + quartz-bearing ultrahigh-temperature granulites from Xumayao,Inner Mongolia Suture Zone,North China Craton:Petrology,phase equilibria and counterclockwise p-T path显示文摘在在北方中国 Craton 的内部蒙古缝术地区(IMSZ ) 以内的 Khondalite 带是为 Paleoproterozoic 的一个经典例子超离频温度(UHT ) 变态。这里,我们在 IMSZ 的南部的领域以内在 Xumayao 从一个新地区报导新忍受尖晶石的 metapelitic granulites。Petrological 研究并且尖晶石 + 的热力学的建模忍受石英的集合证明这些岩石以 UHT 条件经历了极端变态。尖晶石组织上发生在二背景:1 ) 高 XZn (Zn/(Mg +FeII + Zn )= 0.0710.232 ) 有在岩石矩阵的 perthitic K 长石,矽线石和石英的尖晶石;并且 2 ) 低 XZn (0.0450.070 ) 尖晶石作为在与石英和矽线石联合的石榴石 porphyroblasts 以内的包括。我们当模特儿的阶段 equilibria 在这些岩石的变形进化期间显示二个主要阶段: 1 )从 975 的在等压附近的冷却????畘慭慹?????????????朠慲畮楬整????????????????慲潴????????煥極楬牢慩?????????????胴?? | Huatian Zhang Jianghai Li Shoujie Liu Wenshan Li M. Santosh Honghao Wang | 2012 | Geoscience Frontiers2012，3，5： | 8 |
| 5 | Utilization of Ogura CMS germplasm with the clubroot resistance gene by fertility restoration and cytoplasm replacement in Brassica oleracea L显示文摘Clubroot disease,a major plant root disease caused by Plasmodiophora brassicae,has become one of the most destructive diseases among cultivated cruciferous vegetables.However,clubroot-resistant Brassica oleracea materials are rare.A few clubroot-resistant cabbage varieties are available on the market,but all are Ogura cytoplasmic male sterile(CMS)types.Therefore,in this study,to reutilize the clubroot-resistant Ogura CMS germplasm of cabbage,a new fertility-restored Ogura CMS material,16Q2-11,was used as a bridge to transfer the clubroot resistance(CR)gene from the Ogura CMS cytoplasm to the normal cytoplasm by a two-step method(a fertility restoration and cytoplasm replacement method).In the first cross for fertility restoration of Ogura CMS clubroot-resistant cabbage(FRCRC),16Q2-11 was used as a restorer to cross with Ogura CMS materials containing the CR gene CRb2.Eleven Rfo-positive progenies were generated,of which four contained CRb2:F8-514,F8-620,F8-732 and F8-839.After inoculation with race 4 of P.brassicae,these four CRb2-positive individuals showed resistance.Furthermore,F8-514 and F8-839 were then used as male parents in the second cross of FRCRC to cross with cabbage inbred lines,resulting in the successful introgression of the CRb2 gene into the inbred lines.All offspring produced from this step of cross,which had a normal cytoplasm,showed a high resistance to race 4 of P.brassicae and could be utilized for the breeding of clubrootresistant cabbage varieties in the future.This is the first time that the Ogura CMS restorer has been used to restore the fertility of Ogura CMS clubroot-resistant cabbages,which could improve germplasm diversity in cabbage and provide a reference method for using CMS germplasm in Brassica crops. | Wenjing Ren Zhiyuan Li Fengqing Han Bin Zhang Xing Li Zhiyuan Fang Limei Yang Mu Zhuang Honghao Lv Yumei Liu Yong Wang Hailong Yu Yangyong Zhang | 2020 | Horticulture Research2020，7，1： | 7 |
| 6 | Cells derived from iPSC can be immunogenic -- Yes or No?显示文摘导致的 pluripotent 干细胞(iPSCs ) ,在体的房间由 reprogramming 因素的宫外的表示发源,能潜在地为再生药提供无限的自体同源的房间。在理论,没有任何有免疫力的拒绝,从耐心的 iPSCs 导出的自体同源的房间应该是由主人容忍的免疫者。然而,我们的最近的研究发现了那平 syngeneic 导出 iPSC 的细胞能在由使用一个 teratoma 移植模型的 syngeneic 宿主产生免疫性(自然 474:212215, 2011 ) 。最近,二个研究组区分了 iPSCs 进不同细菌层或房间,移植了那些房间到 syngeneic 主人,并且评估了那些房间的 immunogenicity。尽管他们在 iPSC 衍生物宣称可以忽略的任何一个或 immunogenicity 的缺乏,两个都,二,研究支持我们肯定的一些然而并非从 iPSCs 导出的所有纸巾能是产生免疫性的结论(自然 494:100104, 2013;房间干细胞 12:407412, 2013 ) 。到测试,区分开来与人的 iPSCs 的临床上珍贵的房间的 immunogenicity 突现地为 iPSC 技术的翻译被要求到诊所。 | Jiani Cao Xiaoyan Li Xiao Lu Chao Zhang Honghao Yu Tongbiao Zhao | 2014 | Protein & Cell2014，5，1： | 6 |
| 7 | Cloning and characterization of the gene encoding β-amyrin synthase in the glycyrrhizic acid biosynthetic pathway in Glycyrrhiza uralensis显示文摘Glycyrrhiza uralensis is considered to be one of the most important herbs in traditional Chinese medicine due to its numerous pharmacological effects particularly its ability to relieve cough and act as a mucolytic.Based on previous research,these effects are mediated by a number of active ingredients,especially glycyrrhizic acid(GA).In the present study,a gene encodingβ-amyrin synthase(β-AS)involved in GA biosynthesis in G.uralensis has been cloned and expressed in Saccharomyces cerevisiae.The cloned enzyme showed similar activity to native enzymes isolated from other Glycyrrhiza species to catalyze the conversion of 2,3-oxidosqualene intoβ-amyrin.In fact theβ-AS gene is particularly important in the GA biosynthetic pathway in G.uralensis.The complete sequence of the enzyme was determined and a phylogenetic tree based on theβ-AS gene of G.uralensis and 20 other species was created.This showed that Glycyrrhiza glabra had the closest kinship with G.uralensis.The results of this work will be useful in determining how to improve the efficacy of G.uralensis by improving its GA content and in exploring the biosynthesis of GA in vitro. | Honghao Chen Ying Liu Xiaoqin Zhang Xinjie Zhan Chunsheng Liu | 2013 | Acta Pharmaceutica Sinica B2013，3，6： | 5 |
| 8 | Proteome analysis of hepatic non-parenchymal cells of immune liver fibrosis rats显示文摘Elucidation of the mechanisms of liver fibrogenesis is important to treat liver fibrosis.In this study,we established rat models of liver fibrosis with stages from 0–1,2,and 3–4 to 4 at 2,4,6,and 8 weeks,respectively,by injection of pig serum.Liver fibrogenesis was detected by Masson’s trichrome staining.Rat non-parenchymal cells(NPCs)were enriched 4-fold by Percoll density gradient centrifugation.Protein extracts from NPCs were prepared at 4 and 8 weeks,separated by two-dimensional electrophoresis,and then stained with Coomassie Blue G-250.At 4 weeks,we identified 18 non-redundant differentially expressed proteins of which protein disulfide-isomerase associated protein 3(PDIA3)and NDUV showed consistent expression at protein and mRNA levels from 4 to 8 weeks.PDIA3 was found to be down-regulated by Western blotting in the rat model and immunohistochemically in human liver.Our results revealed important aspects of the pathogenesis/progression of liver fibrosis and demonstrated important changes in protein expression levels of NPCs at various stages of liver fibrosis. | ZHAO QianQian FENG YanLing JIA XiaoFang YIN Lin ZHENG Ye OUYANG DongSheng ZHOU HongHao ZHANG LiJun | 2014 | Science China(Life Sciences)2014，57，3： | 5 |
| 9 | Keep Healthcare Workers Safe:Application of Teleoperated Robot in Isolation Ward for COVID‑19 Prevention and Control显示文摘At the time of writing,the coronavirus disease(COVID-19)has affected 212 countries and territories across the globe.According to the world health organization(WHO),a total number of 4,735,622 confirmed cases,including 316,289 deaths was reported[1].In the fight against COVID-19,nurses,doctors,and other healthcare workers are in the front line of the battle bearing the higher risk of infection[2].The International Council of Nurses(ICN)gathered further information to suggest that more than 90,000 healthcare workers have been infected worldwide[3].Personal protective equipment(PPE)shortage is one of the key factors increasing the infection risk for the medical staffs.Therefore,finding alternative ways to lower the infection risk has become an urgent problem to be solved. | Geng Yang Honghao Lv Zhiyu Zhang Liu Yang Jia Deng Siqi You Juan Du Huayong Yang | 2020 | Chinese Journal of Mechanical Engineering2020，33，3： | 4 |
| 10 | Light-Written Reversible 3D Fluorescence and Topography Dual-Pattern with Memory and Self-Healing Abilities显示文摘To achieve the dynamical dual-pattern with multiplex information of complex topography and 3D fluorescence is challenging yet promising for wide applications ranging from visual bioassays,memory,smart devices to smart display.Here,we develop a convenient,reliable,and versatile method to realize the well-ordered dual-pattern with reversible topography and 3D fluorescence via a light direct-writing approach based on the wrinkle mechanism.By introducing the charge transfer(CT)interaction betweenπ-electron-rich anthracene(AN)andπ-electron-poor naphthalene diimide(NDI)into the polymer system,both modulus and fluorescence of the polymer films can be spatially regulated through the photodimerization of AN,which is controlled in-plane by photomasks,and becomes gradient in the vertical direction due to the filter effect of light.Therefore,the exposed sample displays a well-ordered complex pattern with the same topography as the applied photomask and 3D gradient change of fluorescence from red to green laterally across the layers simultaneously.The spatial cross-linking and CT interaction of the gradient layer can be controlled independently,which not only provides the reliability and reversibility of the topographical and fluorescence dual-pattern but also endows the possibility for tailoring the pattern with memory and selfhealing.These characters of the dual-pattern with reversible topography and 3D fluorescence declare the clear applications in smart multiplex displays,memory,anticounterfeiting,visual detections,and so on. | Jing Bai Luzhi Zhang Honghao Hou Zixing Shi Jie Yin Xuesong Jiang | 2019 | Research2019，，1： | 4 |
| 11 | Balancing the anionic framework polarity for enhanced thermoelectric performance in YbMg_(2)Sb_(2) Zintl compounds显示文摘1-2-2-type Zintl phase compound has aroused great interest for potential thermoelectric applications.However,YbMg_(2)Sb_(2) is seldom studied due to the very low electrical conductivity resulting from the large difference in the electronegativity between Mg and Sb.In this paper,we adjust the covalently bonded network of MgeSb by replacing part of the Mg with Zn which has the electronegativity closer to that of Sb.The decreased polarity in the anionic framework offers more free distance for electrons for the enhanced Hall mobility and electrical conductivity.Together with the increased point defect and the decreased lattice thermal conductivity by introduction of Zn,the maximum ZT value of ~0.8 at 773 K is achieved in YbMg_(0.9)Zn_(1.1)Sb_(2) which is~100% enhancement compared with that of YbMg_(2)Sb_(2). | Zongwei Zhang Xinyu Wang Yijie Liu Chen Chen Honghao Yao Li Yin Xiaofang Li Shan Li Fan Zhang Fengxian Bai Jiehe Sui Bo Yu Feng Cao Xingjun Liu Jun Mao Guoqiang Xie Qian Zhang | 2019 | Journal of Materiomics2019，5，4： | 3 |
| 12 | Host Proteome Research in HIV Infection显示文摘Proteomics has been widely used in the last few years to look for new biomarkers and decipher the mechanism of HIV-host interaction.Herein,we review the recent developments of HIV/AIDS proteomic research,including the samples used in HIV/AIDS related research,the technologies used for proteomic study,the diagnosis biomarkers of HIV-associated disease especially HIV-associated neurocognitive impairment,the mechanisms of HIV-host interaction,HIV-associated dementia,substance abuse,and so on.In the end of this review,we also give some prospects about the limitation and future improvement of HIV/AIDS proteomic research. | Lijun Zhang Xiaojun Zhang Qing Ma Honghao Zhou | 2010 | Genomics, Proteomics & Bioinformatics2010，8，1： | 2 |
| 13 | An update on the arsenal:mining resistance genes for disease management of Brassica crops in the genomic era显示文摘Brassica species include many economically important crops that provide nutrition and health-promoting substances to humans worldwide.However,as with all crops,their production is constantly threatened by emerging viral,bacterial,and fungal diseases,whose incidence has increased in recent years.Traditional methods of control are often costly,present limited effectiveness,and cause environmental damage;instead,the ideal approach is to mine and utilize the resistance genes of the Brassica crop hosts themselves.Fortunately,the development of genomics,molecular genetics,and biological techniques enables us to rapidly discover and apply resistance(R)genes.Herein,the R genes identified in Brassica crops are summarized,including their mapping and cloning,possible molecular mechanisms,and application in resistance breeding.Future perspectives concerning how to accurately discover additional R gene resources and efficiently utilize these genes in the genomic era are also discussed. | Honghao Lv Zhiyuan Fang Limei Yang Yangyong Zhang Yong Wang | 2020 | Horticulture Research2020，7，1： | 2 |
| 14 | A reusable SMA actuated non-explosive lockrelease mechanism for space application显示文摘After the satellite is launched with the carrier rocket,it is necessary to separate the satellite from the rocket at an appropriate time to ensure that the satellite enters the intended orbit.In this process,it is vital to ensure a reliable connection and accurate separation.With the increasing use of microsatellite in orbit,the contradiction between the shock of separation and the requirement of the platform’s dynamic environment is becoming increasingly prominent.Therefore,the traditional pyrotechnic separation device can no longer meet the requirements.This paper presents a reusable non-explosive release actuator using shape memory alloy(SMA)wire for high load and low shock.The system is based on the Fast Acting Shock-less Separation Nut(FASSN)technology.Using the shape memory effect of SMA,a biased SMA wire trigger has been developed,which is used as the driver source of the actuator.At the moment of receiving the electrical signal,the SMA wire generates stress and deformation.The trigger set free the constraints on the mechanical components,and the target is released.Experimental results indicate that the trigger device can unlock successfully and well meet the technical objectives. | Xueting Pan Yuliang Zhang Yifan Lu Fei Yang Honghao Yue | 2020 | International Journal of Smart and Nano Materials2020，11，1： | 1 |
| 15 | Statins exert differential effects on angiotensin II-induced atherosclerosis, but no benefit for abdominal aortic aneurysms显示文摘 | Jian-an Wang Wen-ai Chen Yifan Wang Songzhao Zhang Honghao Bi Bo Hong Yueqiu Luo Alan Daugherty Xiaojie Xie | 2011 | Atherosclerosis2011，，： | 1 |
| 16 | Unsupervised machine learning for discovery of promising half-Heusler thermoelectric materials显示文摘hermoelectric materials can be potentially applied to waste heat recovery and solid-state cooling because they allow a direct energy conversion between heat and electricity and vice versa.The accelerated materials design based on machine learning has enabled the systematic discovery of promising materials.Herein we proposed a successful strategy to discover and design a series of promising half-Heusler thermoelectric materials through the iterative combination of unsupervised machine learning with the labeled known half-Heusler thermoelectric materials.Subsequently,optimized zT values of~0.5 at 925 K for p-type Sc_(0.7)Y_(0.3)NiSb_(0.97)Sn_(0.03)and~0.3 at 778 K for n-type Sc_(0.65)Y_(0.3)Ti_(0.05)NiSb were experimentally achieved on the same parent ScNiSb. | Xue Jia Yanshuai Deng Xin Bao Honghao Yao Shan Li Zhou Li Chen Chen Xinyu Wang Jun Mao Feng Cao Jiehe Sui Junwei Wu Cuiping Wang Qian Zhang Xingjun Liu | 2022 | npj Computational Materials2022，，1： | 1 |
| 17 | Pharmacokinetics of the new proton pump inhibitor ilaprazole in Chinese healthy subjects in relation to CYP3A5 and CYP2C19 genotypes显示文摘 | Yalin Li Wei Zhang Dong Guo Gan Zhou Honghao Zhou Zhousheng Xiao | 2008 | Clinica Chimica Acta2008，，1： | 1 |
| 18 | Curcumin induces apaf-1-dependent,p21-mediated caspase activation and apoptosis显示文摘 | Raghu Gogada Michael Amadori Honghao Zhang | 2011 | Cell Cycle2011，10，： | 1 |
| 19 | SUN: A bayesian framework for saliency usingnatural statistics显示文摘 | Lingyun Zhang Tim K Marks Honghao Shan | 2008 | Journal of Vision(S1534-7362)2008，8，7： | 1 |
| 20 | A porous hydrogel scaffold mimicking the extracellular matrix with swim bladder derived collagen for renal tissue regeneration显示文摘As a worldwide public health issue, chronic kidney disease still lacks of effective therapeutic approaches due to the challenges in conventional organ transplantation and dialysis. Renal tissue engineering offers an advantageous therapeutic or regenerative option over typical donor organ. However, despite the great progress of decellularized extracellular matrix based scaffold for the renal regeneration, several safety concerns and complex composition still remain to be addressed. Herein, the extracellular matrix-mimicking hydrogel scaffolds were developed through covalent and physical cross-linking between swim bladder-derived natural collagen(COL) and anti-fibrosis chondroitin sulfate(CS) derivatives.The biomimetic hydrogels showed proper mechanical property, excellent thermal stability and high biocompatibility both in vitro and in vivo, by altering the mass ratio of COL and CS. When implanted in partially nephrectomized rat model, the 1 COL/2CS scaffold enable it recruit more native kidney cells, reduce the tubular damage, and even induce the regeneration of renal tubular-like tissue and restore renal metabolic function more effectively comparing with the pure 2COL and 2CS scaffold. These results suggest that the biomimetic scaffold is a promising functional platform for treating renal diseases. | Heng Wu Rui Zhang Bianxiang Hu Yutong He Yuehang Zhang Liu Cai Leyu Wang Guobao Wang Honghao Hou Xiaozhong Qiu | 2021 | Chinese Chemical Letters2021，32，12： | 1 |
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