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| 1 | Cell–cell contact with proinflammatory macrophages enhances the immunotherapeutic effect of mesenchymal stem cells in two abortion models显示文摘Mesenchymal stem cells(MSCs),which are pluripotent cells with immunomodulatory properties,have been considered good candidates for the therapy of several immune disorders,such as inflammatory bowel diseases,concanavalin A-induced liver injury,and graft-versus-host disease.The embryo is a natural allograft to the maternal immune system.A successful pregnancy depends on the timely extinction of the inflammatory response induced by embryo implantation,followed by the switch to a tolerant immune microenvironment in both the uterus and the system.Excessive infiltration of immune cells and serious inflammatory responses are triggers for embryo rejection,which results in miscarriage.Here,we demonstrated that adoptive transfer of MSCs could prevent fetal loss in a lipopolysaccharide(LPS)-induced abortion model and immune response-mediated spontaneous abortion model.The immunosuppressive MSCs alleviated excessive inflammation by inhibiting CD4+T cell proliferation and promoting the decidual macrophage switch to M2 in a tumor necrosis factor-stimulated gene-6(TSG-6)-dependent manner.Cell-tocell contact with proinflammatory macrophages increased the TSG-6 production by the MSCs,thereby enhancing the suppressive regulation of T cells and macrophages.Moreover,proinflammatory macrophages in contact with the MSCs upregulated the expression of CD200 on the stem cells and facilitated the reprogramming of macrophages towards an anti-inflammatory skew through the interaction of CD200 with CD200R on proinflammatory macrophages.Therefore,the results demonstrate that a TSG-6-mediated paracrine effect,reinforced by cell-to-cell contact between MSCs and proinflammatory macrophages,is involved in the mechanism of MSC-mediated abortion relief through the induction of immune tolerance.Our study also indicates the potential application of MSCs in clinical recurrent miscarriages. | Yanhong Li Di Zhang Ling Xu Lin Dong Ji Zheng Yikong Lin Jiefang Huang Yanyun Zhang Yu Tao Xingxing Zang Dajin Li Meirong Du | 2019 | Cellular & Molecular Immunology2019，16，12： | 23 |
| 2 | Safety and efficacy of ciprofol vs.propofol for sedation in intensive care unit patients with mechanical ventilation:a multi-center,open label,randomized,phase 2 trial显示文摘Background:Ciprofol(HSK3486;Haisco Pharmaceutical Group Co.,Ltd.,Chengdu,China),developed as a novel 2,6-disubstituted phenol derivative showed similar tolerability and efficacy characteristics as propofol when applicated as continuous intravenous infusion for 12 h maintenance sedation in a previous phase 1 trial.The phase 2 trial was designed to investigate the safety,efficacy,and pharmacokinetic characteristics of ciprofol for sedation of patients undergoing mechanical ventilation.Methods:In this multicenter,open label,randomized,propofol positive-controlled,phase 2 trial,39 Chinese intensive care unit patients receiving mechanical ventilation were enrolled and randomly assigned to a ciprofol or propofol group in a 2:1 ratio.The ciprofol infusion was started with a loading infusion of 0.1-0.2 mg/kg for 0.5-5.0 min,followed by an initial maintenance infusion rate of 0.30 mg·kg^(-1)·h^(-1),which could be adjusted to an infusion rate of 0.06 to 0.80 mg·kg^(-1)·h^(-1),whereas for propofol the loading infusion dose was 0.5-1.0 mg/kg for 0.5-5.0 min,followed by an initial maintenance infusion rate of 1.50 mg·kg^(-1)·h^(-1),which could be adjusted to 0.30-4.00 mg·kg^(-1)·h^(-1)to achieve-2 to+1 Richmond Agitation-Sedation Scale sedation within 6-24 h of drug administration.Results:Of the 39 enrolled patients,36 completed the trial.The median(min,max)of the average time to sedation compliance values for ciprofol and propofol were 60.0(52.6,60.0)min and 60.0(55.2,60.0)min,with median difference of 0.00(95%confidence interval:0.00,0.00).In total,29(74.4%)patients comprising 18(69.2%)in the ciprofol and 11(84.6%)in the propofol group experienced 86 treatment emergent adverse events(TEAEs),the majority being of severity grade 1 or 2.Drug-and sedation-related TEAEs were hypotension(7.7%vs.23.1%,P=0.310)and sinus bradycardia(3.8%vs.7.7%,P=1.000)in the ciprofol and propofol groups,respectively.The plasma concentration-time curves for ciprofol and propofol were similar.Conclusions:ciprofol is comparable to propofol with good tolerance and efficacy for sedation of Chinese intensive care unit patients undergoing mechanical ventilation in the present study setting.Trial registration:ClinicalTrials.gov,NCT04147416. | Yongjun Liu Xiangyou Yu Duming Zhu Jun Zeng Qinhan Lin Bin Zang Chuanxi Chen Ning Liu Xiao Liu Wei Gao Xiangdong Guan | 2022 | Chinese Medical Journal2022，，9： | 19 |
| 3 | 基于DOPO的阻燃剂合成及其对不同高分子材料的阻燃效率(英文)显示文摘由于环境可持续性的需要,在过去的几十年,无卤含磷阻燃剂的重要性越来越受到社会的关注。9,10-二氢-9-氧杂-10-磷杂菲-10-氧化物(DOPO)及其衍生物作为一种无卤含磷阻燃剂,在聚合物中主要以气相阻燃的机理而表现出优异的阻燃性能。相比于卤系阻燃剂,DOPO及其衍生物在燃烧过程中所释放出的腐蚀性和毒性气体很少,因此许多反应型和添加型的DOPO衍生物得到学术界和工业界的青睐,品种越来越多。DOPO中的P-H键具有较强的反应活性,可以与含活泼双键的化合物(如苯醌、丙烯酸酯、醛类和环氧衍生物等)反应制备出反应型或添加型阻燃剂。反应型DOPO衍生物阻燃剂主要应用于热固性环氧树脂化合物(EP)的阻燃,包括基于DOPO的环氧单体和基于DOPO的胺基和酸酐固化剂,通常这类阻燃剂在环氧树脂中的磷含量达到1.5%以上就可以达到UL 94 V-0级。添加型DOPO衍生物阻燃剂主要是将DOPO中的P-H键转化为P-C,P-O或P-N键的DOPO衍生物,包括基于DOPO的三聚氰胺盐和锌盐以及将P-H键烷基化的DOPO衍生物等,通常这类阻燃剂在聚合物(如EP,PU,PA,PBT和PET等)中的磷含量达到1.0%以上就可以达到UL 94 V-0级。 | ChristophKlinkowski Lin Zang Manfred Doering | 2013 | 中国材料进展2013，32，3： | 14 |
| 4 | Protective Effect of Hydroxysafflor Yellow A on Bleomycin-Induced Pulmonary Inflammation and Fibrosis in Rats显示文摘Objective: To observe the effect of hydroxysafflor yellow A(HSYA), an active ingredient of a traditional Chinese herbal medicine Carthamus tinctorius L., on lung inflammation and pulmonary fibrosis induced by bleomycin(BLM) in rats. Methods: Animals were divided into 6 groups including normal group, model group, three HSYA groups and dexamethasone(DXM) group. Three doses of HSYA(35.6, 53.3, and 80.0 mg·kg^(–1)·day^(–1)) were intraperitoneally(i.p.) injected in rats for 3 weeks after BLM administration and DXM was used as the positive control(n=8 or 12). Arterial blood gas was assayed and morphological changes were observed. Lung mRNA expressions of tumor necrosis factor(TNF)-α, interleukin(IL)-1β, IL-6 and some cytokines in lung tissue were detected by real-time polymerase chain reaction. Nuclear factor-κB p65 or α-smooth muscle actin(α-SMA) protein distribution in rat lung tissue was observed by immunohistochemistry. Results: On the 7 th day after BLM administration, lung tissue showed serious inflammation. Treatment with HSYA or DXM ameliorated lung inflammation. After treatment with HSYA or DXM, oxygen partial pressure(PaO_2) increased(HSYA 80.0 mg·kg^(–1), P<0.01) and CO_2 partial pressure(PaCO_2) decreased(HSYA 53.3, 80.0 mg·kg^(–1), P<0.05). Moreover, the mRNA expression of TNF-α, IL-1β, and IL-6; and the number of NF-κB p65 positive cells was lower in HSYA 53.3 and 80.0 mg·kg^(–1) groups than those in the model group(all P<0.05). Twenty-one days after BLM administration, HSYA or DXM treatment ameliorated fibrosis, increased PaO_2(HSYA 53.3, 80.0 mg·kg^(–1), P<0.01), and decreased PaCO_2(53.3 and 80.0 mg·kg^(–1), P<0.05). Further, the mRNA expression of TGF-β1, α-SMA, and collagen Ⅰ as well as the number of α-SMA positive cells increased in the model group and HSYA can attenuate these changes(53.3, 80.0 mg·kg^(–1), P<0.05). Hematoxylin and eosin and Masson's trichrome staining indicated that the fibrosis and collagen deposition were ameliorated in HSYA groups(53.3, 80.0 mg·kg^(–1), P<0.05). Conclusion: HSYA could alleviate acute lung inflammation and chronic pulmonary fibrosis induced by BLM in rats. | JIN Ming WANG Lin WU Yan ZANG Bao-xia TAN Li | 2018 | Chinese Journal of Integrative Medicine2018，24，1： | 12 |
| 5 | High density collinear holographic data storage system显示文摘Holographic 数据存储系统(HDSS ) 是一种容量的记录技术的一个好候选人,由于他们的大存储能力和高转移率,并且在雷射摄影术的原则首先被建议以后,被研究十年了。然而,这些系统,叫的常规 2 轴雷射摄影术,仍然为产品的商品化有必要问题。在同一直线上的 HDSS,信息和参考横梁在是由一样的空间轻调节的人(直线波松) 调制了合作向轴的方向,因为为 HDSS 的一个新读 / 写的方法是很有希望的。与这种唯一的配置,光拾起能被设计象 DVD,和罐头一样小被放在记录媒介(圆盘) 的一个方面上。在圆盘结构,预先格式化的反射的层被用于焦点 / 轨道伺服和读的地址信息,并且二色性的镜子层被用于检测没有防碍预先格式化的信息,记录信息的 holographic。A 2-dimensional 数字页数据格式被使用,移动复合的方法被采用到增加记录密度。当伺服技术正在被介绍控制客观透镜在记录并且重建的进程精确被坚持说到磁盘,颤动隔离乾不再是必要的。在同一直线上的雷射摄影术能比常规 2 轴雷射摄影术更容易生产小、实际 HDSS。在这份报纸,我们介绍了在同一直线上的雷射摄影术的原则和它圆盘的媒介结构。试验性、理论的研究的一些结果建议它是一个很有效的方法。我们也讨论了一些方法增加在同一直线上的雷射摄影术的记录密度和数据转移率。 | Xiaodi TAN Xiao LIN An'an WU Jingliang ZANG | 2014 | Frontiers of Optoelectronics2014，7，4： | 9 |
| 6 | BubR1 phosphorylates CENP-E as a switch enabling the transition from lateral association to end-on capture of spindle microtubules显示文摘Error-free mitosis depends on accurate chromosome attachment to spindle microtubules, powered congression of those chromosomes, their segregation in anaphase, and assembly of a spindle midzone at mitotic exit. The centromere-associated kinesin motor CENP-E, whose binding partner is BubR1, has been implicated in congression of misaligned chromosomes and the transition from lateral kinetochore-microtubule association to end-on capture. Although previously proposed to be a pseudokinase, here we report the structure of the kinase domain of Drosophila melanogaster BubR1, revealing its folding into a conformation predicted to be catalytically active. BubR1 is shown to be a bona fide kinase whose phosphorylation of CENP-E switches it from a laterally attached microtubule motor to a plus-end microtubule tip tracker. Computational modeling is used to identify bubristatin as a selective BubR1 kinase antagonist that targets the αN1 helix of N-terminal extension and αC helix of the BubR1 kinase domain. Inhibition of CENP-E phosphorylation is shown to prevent proper microtubule capture at kinetochores and, surprisingly, proper assembly of the central spindle at mitotic exit. Thus, BubR1-mediated CENP-E phosphorylation produces a temporal switch that enables transition from lateral to end-on microtubule capture and organization of microtubules into stable midzone arrays. | Yuejia Huang Lin Lin Xing Liu Sheng Ye Phil Y. Yao Wenwen Wang Fengrui Yang Xinjiao Gao Junying Li Yin Zhang Jiancun Zhang Zhihong Yang Xu Liu Zhenye Yang Jianye Zang Maikun Teng Zhiyong Wang Ke Ruan Xia Ding Lin Li Don W. Cleveland Rongguang Zhang Xuebiao Yao | 2019 | Cell Research2019，29，7： | 8 |
| 7 | Associated risk factors of knee osteoarthritis: a population survey in Taiyuan, China显示文摘背景自从膝骨关节炎(洋槐的一种) 是普通疾病之一,它的联系风险因素的鉴定具有预防意义。这调查被设计在太原调查洋槐的一种的流行,并且识别洋槐的一种的联系风险因素。一件人口样品 2188 个成年人被调查的方法从 35 ~ 64 年变老,生活没有电梯的 in6 故事大楼。为风湿病的疾病(COPCORD ) 核心问询表的控制的风湿病学(APLAR ) 社区面向的节目的协会的亚太联盟的协议被实现。膝疼痛和洋槐的一种上的数据镇定、分析。是的 Variablessuch 性别,年龄,身体团索引(BMI ) ,腰圆周(WC ) ,教育水平,和吸烟历史,为进一步的分析在二进制逻辑回归模型被包括。分别地,膝疼痛和洋槐的一种的结果 Theprevalence 率是 13.6% 和 10.9% 比那些显著地高在华南的 Shantou 并且类似于那些在北方中国的北京。洋槐的一种的流行比在男人(18.3% 对 8.7% 和 15.1% 对 6.3%) 在女人是显著地更高的,与有年龄的增加的一个趋势。流行在 45 岁以后在 40 岁以后并且在男人在女人更显然被增加。在洋槐的一种组的 BMI 在 non-KOAgroup 比那显著地高。而没有重要关联在象爬楼梯, WC,职业服务的时间长度,教育水平,吸烟历史和宗教信仰那样的洋槐的一种和另外的因素之间被看见,二进制逻辑回归表明年龄,性别,和 BMI 显著地与洋槐的一种被联系。结论地理,年龄,性别,和 BMI 可能是洋槐的一种的风险因素,但是爬楼梯, WC,职业服务的时间长度,教育水平,吸烟历史和宗教信仰没与洋槐的一种被相关。洋槐的一种的预防以前应该被开始中年特别在女成年人,并且重量控制是必要的。另外的因素可能也贡献洋槐的一种的发展,但是进一步的学习被需要阐明这些因素的角色。 | ZENG Qing-yu ZANG Chang-hai LI Xiao-feng DONG Hai-yuan ZHANG Ai-lian LIN Ling | 2006 | Chinese Medical Journal2006，，18： | 7 |
| 8 | Robust superhydrophobic polyurethane sponge functionalized with perfluorinated graphene oxide for efficient immiscible oil/water mixture, stable emulsion separation and crude oil dehydration显示文摘In recent years, graphene oxide(GO), prepared by the modified Hummers’ method, and its derivatives have become a focus of research owing to their outstanding physical and chemical properties and low cost. Drawing inspiration from the mussel protein,a facile and environmentally-friendly method was employed to fabricate superhydrophobic/superoleophilic reduced graphene oxide(rGO) derivative. The preparation comprises two steps: coating GO nanosheets with polydopamine(PDA) and subsequent reaction with 1H,1H,2H,2H-perfluorodecanethiol. Due to the excellent adhesive ability of PDA, the resulting f PDA modified rGO nanosheets(rGO-f PDA) were firmly immobilized onto polyurethane(PU) sponge skeleton by a simple drop-coating method. The as-prepared rGO-f PDA functionalized sponge exhibited superhydrophobic behavior with a water contact angle of 162°±2°, high organic adsorption capacity, recyclability and stable oil/water separation behavior under different acidic/alkaline conditions. Due to its facile fabrication technique and outstanding properties, the superhydrophobic-superoleophilic PU-rGOf PDA sponge holds great promise as an oil adsorbent for cleaning up large-scale pollution of oil and organic solvents, and dehydrating crude oil. | CAO Ning GUO JingYu BOUKHERROUB Rabah SHAO QingGuo ZANG XiaoBei LI Jin LIN XueQiang JU Hong LIU EnYang ZHOU ChaoFan LI HuiPing | 2019 | Science China(Technological Sciences)2019，62，9： | 6 |
| 9 | Mode splitting transmission effect of surface wave excitation through a metal hole array显示文摘The resonant frequencies of the excited surface waves on a metal hole array with respect to the incident angle were studied in the terahertz region.The experimental and theoretical results demonstrate that the resonant peak of surface wave excitation splits into two when transmitted through a metal hole array off-normally.The high-order mode with resonant frequency above the cutoff frequency fc(plasma frequency effect)has a shorter attenuation length than that of the low-order mode whose resonant frequency is below fc.The reason is that the high-order mode is a coupled mode consisting of surface wave and hole modes,while the low-order mode is just an excited surface wave(which can be considered as the spoof surface plasmons).Our investigation may open a door to distinguish the spoof surface plasmons and the coupled modes of surface waves and hole modes. | Lin Chen Yiming Zhu Xiaofei Zang Bin Cai Zhou Li Le Xie Songlin Zhuang | 2013 | Light(Science & Applications)2013，2，1： | 6 |
| 10 | DNA cleavage mediated by water-soluble manganese corrole显示文摘水的 DNA 像核酸酶的活动可溶的锰 corrole 5, 10, 15-tris (N-methyl-4-pyridyl )- corrolatomanganese (III )(MnIIITMPyC ) 被调查了。MnIIITMPyC 可以经由由吸收系列,粘性大小和 CD 系列显示了的外面的沟绑定模式强烈绑在 DNA。MnIIITMPyC 面对 hydroperoxide 在 DNA 氧化劈开展出了优秀催化活动。 | Jun Lu Hai Yang Liu Lei Shi Xiang Li Wang Xiao Ying Lei Zhang Liang Nian Ji Lin Quan Zang Chi K. Chang | 2011 | Chinese Chemical Letters2011，22，1： | 6 |
| 11 | Kirigami-inspired,highly stretchable microsupercapacitor patches fabricated by laser conversion and cutting显示文摘The recent developments in material sciences and rational structural designs have advanced the field of compliant and deformable electronics systems.However,many of these systems are limited in either overall stretchability or areal coverage of functional components.Here,we design a construct inspired by Kirigami for highly deformable microsupercapacitor patches with high areal coverages of electrode and electrolyte materials.These patches can be fabricated in simple and efficient steps by laser-assisted graphitic conversion and cutting.Because the Kirigami cuts significantly increase structural compliance,segments in the patches can buckle,rotate,bend and twist to accommodate large overall deformations with only a small strain(<3%)in active electrode areas.Electrochemical testing results have proved that electrical and electrochemical performances are preserved under large deformation,with less than 2%change in capacitance when the patch is elongated to 382.5%of its initial length.The high design flexibility can enable various types of electrical connections among an array of supercapacitors residing in one patch,by using different Kirigami designs. | Renxiao Xu Anton Zverev Aaron Hung Caiwei Shen Lauren Irie Geoffrey Ding Michael Whitmeyer Liangjie Ren Brandon Griffin Jack Melcher Lily Zheng Xining Zang Mohan Sanghadasa Liwei Lin | 2018 | Microsystems & Nanoengineering2018，4，1： | 6 |
| 12 | Anatomical variation of infra-pyloric artery origination: A prospective multicenter observational study (IPA-Origin)显示文摘Objective: Infra-pyloric artery(IPA) is an important anatomical landmark in treatment of gastric cancer and is the key vessel for pylorus-preserving gastrectomy and subgroup of infra-pyloric lymph nodes. However, its anatomical variation is not thoroughly understood. Our study aimed to clarify the origination of the IPA.Methods: We did this prospective, multicenter, open-label, observational study at gastric surgery departments of34 hospitals in China. Gastric cancer patients aged 18 years or older and scheduled to undergo elective total or distal gastrectomy were assigned. During the surgery, IPA dissecting and exposing the origination point with photographs or video clips were required. The primary outcome was the origination of the IPA. Analysis of variance, χ~2 tests and Fisher's tests were used to analyze the differences between groups. The study is registered at Clinicaltrials.gov(No. NCT03071237).Results: Between May 8 and July 31, 2017, 429 patients were assigned for the study, and 419(97.7%) patients had the IPA dissected and recorded through photograph or video and were included in the primary outcome analysis. The median age was 62 years old, and 73.7% were male. Among the patients, 78.5% received laparoscopic surgery. Single IPA origination was identified in 398(95.0%) patients, including gastroduodenal artery(GDA) in154(36.8%) patients, anterior superior pancreaticoduodenal artery(ASPDA) in 130(31.0%) patients, and right gastroepiploic artery(RGEA) in 114(27.2%) patients. Fifteen(3.6%) patients were identified with multiple IPA and 6(1.4%) patients were identified as IPA absence. The differences in the distribution of surgical approach(P=0.003) and geographic area(P=0.030) were statistically significant. No difference was shown in sex, age,gastrectomy type, tumor location, and clinical T, N and M stage.Conclusions: Our study found that the IPA originates from GDA, ASPDA and RGEA in similar proportions.Laparoscopic surgery may be more helpful in dissection of the IPA than open surgery. | Rulin Miao Jianjun Qu Zhengrong Li Daguang Wang Jiang Yu Weidong Zang Yong Li Fenglin Liu Jian Zhang Wu Song Kai Ye Su Yan Wei Wang Shuangyi Ren Lu Zang Changqing Jing Li Zhang Kuan Wang Weihua Fu Lin Fan Bin Liang Gang Zhao Jun Cai Li Yang Jiaming Zhu Jun You Kun Yang Qingxing Huang Zhaojian Niu Ning Ning Xingfeng Qiu Gang Ji Feng Liang Hua Huang Chao Gao Fei Shan Shuangxi Li Yongning Jia Lianhai Zhang Xiangji Ying Yan Zhang Zhaode Bu Xiangqian Su Gang Zhao Ziyu Li Jiafu Ji | 2018 | Chinese Journal of Cancer Research2018，30，5： | 5 |
| 13 | Rapid and sensitive liquid chromatography–tandem mass spectrometric method for the quantitative determination of potentially harmful substance 5,5′-oxydimethylenebis (2-furfural) in traditional Chinese medicine injections显示文摘With the rapid development and wide application of traditional Chinese medicine injection(TCMI), a number of adverse events of some TCMIs have incessantly been reported and have drawn broad attention in recent years. Establishing effective and practical analytical methods for safety evaluation and quality control of TCMI can help to improve the safety of TCMIs in clinical applications. In this study, a sensitive and rapid high-performance liquid chromatography–tandem mass spectrometry(HPLC–MS/MS)method has been developed and validated for the quantitative determination of potentially harmful substance5,5′-oxydimethylenebis(2-furfural, OMBF) in TCMI samples. Chromatographic separation was performed on a C18 reversed-phase column(150 mm × 2.1 mm, 5 μm) by gradient elution, using methanol–water containing 0.1% formic acid as mobile phase at the flow rate of 0.3 m L/min. MS/MS detection was performed on a triple quadrupole mass spectrometer with positive electrospray ionization in the multiple reaction-monitoring mode. The method was sensitive with a limit of quantification of 0.3 ng/m L and linear over the range of 0.3–30 ng/m L(r = 0.9998). Intra-and inter-day precision for analyte was o9.52% RSD withrecoveries in the range 88.0–109.67% at three concentration levels. The validated method was successfully applied to quantitatively determine the compound OMBF in TCMIs and glucose injections. Our study indicates that this method is simple, sensitive, practicable and reliable, and could be applied for safety evaluation and quality control of TCMIs and glucose injections. | Qingce Zang Yang Gao Luojiao Huang Jiuming He Sheng Lin Hongtao Jin Ruiping Zhang Zeper Abliz | 2018 | Acta Pharmaceutica Sinica B2018，8，2： | 4 |
| 14 | CZ-7, a new derivative of Claulansine F, ameliorates 2V0-induced vascular dementia in rats through a Nrf2-mediated antioxidant responses显示文摘Vascular dementia (VD) results from accumulated damage in the vascular system, which is characterized by progressive impairments in memory and cognition and is second only to Alzheimer’s disease (AD) in prevalence among all types of dementia. In contrast to AD, there is no FDA-approved treatment for VD owing to its multiple etiologies. In this study, we investigated whether CZ-7, a new derivative of Claulansine F (Clau F) with verified neuroprotective activity in vitro, could ameliorate the cognitive impairment of rats with permanent occlusion of bilateral common carotid arteries (2VO) and its potential mechanisms of action. The 2VO rats were orally administered CZ-7 (10, 20, 40?mg/kg) from day 27 to day 53 post-surgery. Morris water maze tests conducted at day 48–51 revealed that CZ-7 administration significantly reduced the escape latency in 2VO rats. After the rats were sacrificed on day 53, morphological studies using Nissl and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining showed that administration of CZ-7 markedly attenuated the pathological changes in CA1–CA3 area of the hippocampus, including neuronal cell loss, nuclear shrinkage, and dark staining of neurons, and significantly decreased the chronic cerebral hypoperfusion-induced cell loss. Klüver–Barrera staining study revealed that CZ-7 administration significantly improved the white matter lesions. 8-OHdG and reactive oxygen species (ROS) immunofluorescent analyses showed that CZ-7 administration significantly decreased oxidative stress in CA1–CA3 area of the hippocampus. Finally, we found that the CZ-7-improved oxidative stress might be mediated via the Nrf2 pathway, evidenced by the double immunofluorescent staining of Nrf2 and the elevation of expression levels of oxidative stress proteins HO-1 and NQO1. In conclusion, CZ-7 has therapeutic potential for VD by alleviating oxidative stress injury through Nrf2-mediated antioxidant responses. | Dan-dan Liu Xia Yuan Shi-feng Chu Chen Chen Qian Ren Piao Luo Mei-yu Lin Sha-sha Wang Tian-bi Zhu Qi-di Ai Ying-da Zang Dong-ming Zhang Xin He Zhi-hua Huang Hong-shuo Sun Zhong-ping Feng Nai-hong Chen | 2019 | Acta Pharmacologica Sinica2019，40，4： | 4 |
| 15 | AMPK regulates anaphase central spindle Length by phosphorylation of KIF4A显示文摘激活安培的蛋白质 kinase (AMPK ) 是与基本生物过程联合细胞的精力状态的一个精力传感器。尽管内在的机制仍然保持大部分未知, AMPK 被认为与房间分割被连接。这里,我们证明 AMPK 机能上地在整个房间分割和那 AMPK 参与催化子单元,特别 2,顺序与分开的有丝分裂的仪器被联系。用量的 phosphoproteomics 分析,我们发现强壮的直接底层 KIF4A 是由在 Ser801 的 AMPK 的 phosphorylated。进一步的分析竞争地揭示了那 AMPK 和曙光 B phosphoregulates KIF4A 在有丝分裂的阶段期间由于重叠识别主题,为 KIF4A 依赖的中央锭子长度控制导致精致的 phosphoregulation。给 AMPK 的内在的察觉到精力的函数,我们的学习与细胞的葡萄糖应力连接中央锭子长度的 KIF4A 依赖的控制。 | Qian-Ru Li Xiu-Min Yan Lin Guo Jia Li Yi Zang | 2018 | Journal of Molecular Cell Biology2018，10，1： | 4 |
| 16 | Metasurfaces for manipulating terahertz waves显示文摘Terahertz(THz)science and technology have attracted significant attention based on their unique applications in non-destructive imaging,communications,spectroscopic detection,and sensing.However,traditional THz devices must be sufficiently thick to realise the desired wave-manipulating functions,which has hindered the development of THz integrated systems and applications.Metasurfaces,which are two-dimensional metamaterials consisting of predesigned meta-atoms,can accurately tailor the amplitudes,phases,and polarisations of electromagnetic waves at subwavelength resolutions,meaning they can provide a flexible platform for designing ultra-compact and high-performance THz components.This review focuses on recent advancements in metasurfaces for the wavefront manipulation of THz waves,including the planar metalens,holograms,arbitrary polarisation control,special beam generation,and active metasurface devices.Such ultra-compact devices with unique functionality make metasurface devices very attractive for applications such as imaging,encryption,information modulation,and THz communications.This progress report aims to highlight some novel approaches for designing ultra-compact THz devices and broaden the applications of metasurfaces in THz science. | Xiaofei Zang Bingshuang Yao Lin Chen Jingya Xie Xuguang Guo Alexei VBalakin Alexander P.Shkurinov Songlin Zhuang | 2021 | Light(Advanced Manufacturing)2021，2，2： | 4 |
| 17 | Predictors of short-term outcomes related to central subfield foveal thickness after intravitreal bevacizumab for macular edema due to central retinal vein occlusion显示文摘AIM:To investigate the predictive factors for shortterm effects of intravitreal bevacizumab injections on central subfield foveal thickness(CSFT)in patients with macular edema(ME)secondary to central retinal vein occlusion(CRVO).·METHODS:This was a retrospective study in 60 eyes treated with intravitreal bevacizumab injections for ME due to CRVO.Follow-up was three months.The Early Treatment Diabetic Retinopathy Study(ETDRS)score and CSFT measured by spectral-domain optical coherence tomography(SD-OCT)were used to observe the changes in best-corrected visual acuity(BCVA).Baseline BCVA,CSFT,age,CRVO duration and the presence of cystoid macular edema(CME)or subretinal fluid(SRF)were analyzed as potential predictive factors of the effects of intravitreal bevacizumab injections.·RESULTS:BCVA improved from 0.9 log MAR at baseline to 0.6 log MAR at 3mo,which was associated with a significant reduction in CSFT from 721μm to 392μm 3mo after injection.About 50%of CME cases and more than90%of SRF cases responded to treatment with a complete resolution at 3mo.Age(P=0.036)and low baseline CSFT(P=0.037)were associated with a good 3-month prognosis.Patients>60 years old achieved better CME resolution(P=0.031)and lower CSFT at 3mo(305μm vs 474μm,P=0.003).·CONCLUSION:Intravitreal bevacizumab significantly improved visual acuity and CSFT in patients with CRVO after 3mo.Older age and lower baseline CSFT were good predictors of short-term CSFT outcomes.The retinalthickness response to bevacizumab might depend on the resolution of CME rather than SRF. | Mei-Zi Wang Kang Feng Yao Lu Fang Qian Xin-Rong Lu Si-Wen Zang Lin Zhao | 2016 | International Journal of Ophthalmology(English edition)2016，9，1： | 3 |
| 18 | Linear polarization holography显示文摘Polarization holography is a newly researched field,that has gained traction with the development of tensor theory.It primarily focuses on the interaction between polarization waves and photosensitive materials.The extraordinary capabil-ities in modulating the amplitude,phase,and polarization of light have resulted in several new applications,such as holo-graphic storage technology,multichannel polarization multiplexing,vector beams,and optical functional devices.In this paper,fundamental research on polarization holography with linear polarized wave,a component of the theory of polariz-ation holography,has been reviewed.Primarily,the effect of various polarization changes on the linear and nonlinear po-larization characteristics of reconstructed wave under continuous exposure and during holographic recording and recon-struction have been focused upon.The polarization modulation realized using these polarization characteristics exhibits unusual functionalities,rendering polarization holography as an attractive research topic in many fields of applications.This paper aims to provide readers with new insights and broaden the application of polarization holography in more sci-entific and technological research fields. | Jinyu Wang Xiaodi Tan Peiliang Qi Chenhao Wu Lu Huang Xianmiao Xu Zhiyun Huang Lili Zhu Yuanying Zhang Xiao Lin Jinliang Zang Kazuo Kuroda | 2022 | Opto-Electronic Science2022，1，2： | 3 |
| 19 | Dynamics of algae growth and nutrients in experimental enclosures culturing bighead carp and common carp: Phosphorus dynamics显示文摘This is the third paper of the series about 'Dynamics of algae growth and nutrients in experimental enclosures culturing bighead carp and common carp'.In this paper,phosphorus dynamics were investigated under the condition of culturing bighead carp and common carp with added fish food(nitrogen dynamics is discussed in the second paper because their behaviors are so different from each other).Nearly fifty days' observation results indicated that the reservoir water was typical of 'phosphorus limited' water,and soluble reactive phosphorus(SRP) was the main constituent of measured total phosphorus(TP).The presence of fish food resulted in significantly higher SRP,dissolved total phosphorus(DTP) and TP concentrations in contrast with the reservoir water.Moreover,continuous supply of fish food led to the decline of total nitrogen to total phosphorus(TN:TP) from more than 100 to less than5.Variations in the ratio of TN to TP favored the growth of blue-green algae.Fish species affected phosphorus concentrations,and culturing bait-eating common carp contributed more to reducing the SRP,DTP and TP concentrations than culturing planktivorous bighead carp.0.5%,4.1%and 3.1%TP can be removed in enclosures with culturing bighead carp,common carp and mixed bighead carp and common carp,respectively.Abundant phosphorus in the fish culturing activities may be present as the uneaten food,algae cells,and within the water column and sediment,which should be taken into serious consideration for the target of future water eutrophication prevention and safety of the drinking water supply. | Suiliang Huang Min Wu Changjuan Zang Shenglan Du Joseph Domagalski Magdalena Gajewska Feng Gao Chao Lin Yong Guo Baoyan Liu Shaoming Wang Yang Luo Adam Szymkiewicz Romuald Szymkiewicz | 2016 | International Journal of Sediment Research2016，31，2： | 3 |
| 20 | Laser test of the prototype of CEE time projection chamber显示文摘A prototype thick-GEM-based cooling storage ring external-target experiment(CEE) time projection chamber(TPC) is constructed and tested with the pulsed ultraviolet laser beams. The results indicate that the prototype TPC has a good performance in three-dimensional track resolution. In X direction the position resolution is about 0.2 mm, and in Y direction the position resolution is about 0.5 mm. The results also determine that the energy resolution is about 5.4%, which achieve the requirements of the CEE experiment and can be used to study the nuclear state equation and the quantum chromo dynamics. | Wen Huang Fei Lu He Li He Dong Yong-jin Ye Chen-Sheng Zhou Long-Xiang Liu Long Du Xiao-Hai Jin Peng-Liu Jin-Hui Chen Song Zhang Chen Zhong Chen Wu Qi-Te Li Hong-Liang Zang Yu-Cheng Ge Cheng-Jian Lin Hui-Ming Jia Nan-Ru Ma Dong-Xi Wang Peng Ma Jun Xu De-Qing Fang Yu-Gang Ma | 2018 | Nuclear Science and Techniques2018，29，3： | 3 |
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