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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density显示文摘 | W.S Simonet D.L Lacey C.R Dunstan M Kelley M.-S Chang R Lüthy H.Q Nguyen S Wooden L Bennett T Boone G Shimamoto M DeRose R Elliott A Colombero H.-L Tan G Trail J Sullivan E Davy N Bucay L Renshaw-Gegg T.M Hughes D Hill W Pattison P Campbell S Sander G Van | 1997 | Cell1997，，2： | 6 |
| 3 | Precision atomic gravimeter based on Bragg diffraction显示文摘 | P A Altin M T Johnsson V Negnevitsky G R Dennis R P Anderson J E Debs S S Szigeti K S Hardman S Bennetts G D McDonald L D Turner J D Close N P Robins | 2013 | New Journal of Physics2013，，2： | 2 |
| 4 | Apramycin-resistant Escheriehia coli isolated from pigs and a stockman显示文摘 | Hunter J E B Bennett M Hart C A | 1994 | Epidemiol infect1994，112，： | 1 |
| 5 | Calculation of the avrami parameters for heterogeneous solid-state reactions using a modification of the Kissinger method显示文摘 | Augius J A Bennett J E | 1978 | J Therm Anal1978，13，2： | 1 |
| 6 | Experimental Test of the Presach-Arrhenius Model with Temperature 显示文摘 | TORRE E D SWARTZENDTUBER L J BENNETT L H | 2000 | Phys B2000，275，： | 1 |
| 7 | Tolerance,hospital stay,and recovery after uterine artery embolization for fibroids the ontario uterine fibroid embolization trial显示文摘 | Pron G Mocarski E Bennett J | 2003 | J Vasc Interv Radiol2003，，14： | 1 |
| 8 | Understanding relationships among multiple ecosystem services显示文摘 | Bennett E M Peterson G D Gordon L J | 2009 | Ecol Let2009，，12： | 1 |
| 9 | Embedded librarians and reference traffic: A quantitative analysis显示文摘 | Bennett E Simning J | 2010 | Journal of Library Administration2010，50，56： | 1 |
| 10 | Promoting learn-ing, memory, and transfer in a time - constrained, highhazard environment显示文摘 | MolesworthB R Bennett L Kehoe E J | 2011 | Accid Anal Prev2011，43，3： | 1 |
| 11 | The role of sodium chan- nels in chronic inflammatory and neuropathic pain 显示文摘 | Amir R Argoff C E Bennett G J | 2006 | J Pain2006，7，5： | 1 |
| 12 | Heavy metals in wild rice from northern Wisconsin显示文摘 | BENNETT J P CHIRIBOGA E WALLER D M | 2000 | The Science of the Total Environment2000，246，23： | 1 |
| 13 | Pleiotropic cell division defects and apoptosisi induced by interference with Survivin function显示文摘 | Li F Ackermann E J Bennett C F | 1999 | Nat cell Biol1999，1，8： | 1 |
| 14 | Risk Analysis Techniques and Their Application to Software Development 显示文摘 | BENNETT J C BOHORIS G A ASHNWALL E M HALL R C | 1996 | European Journal of Operational Research1996，95，： | 1 |
| 15 | Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease显示文摘 | WANG Z KLIPFELL E BENNETT B J | 2011 | Nature2011，472，7341： | 1 |
| 16 | Seed hydration using the drum priming system显示文摘 | Warren J E Bennett M A | 1997 | Horticulture Science1997，32，7： | 1 |
| 17 | Heavy metals in wild rice from northern wisconsin 显示文摘 | Bennett J P Chiribog A E Coleman J | 2000 | Sci Total Environ2000，246，23： | 1 |
| 18 | Measuring the impact and distress of health problems from the individualrs perspective:development of the Perceived Impact of Problem Profile(PIPP) 显示文摘 | PaUant J F Misajon R Bennett E | 2006 | Health Qual Life Outcomes2006，，4： | 1 |
| 19 | Tradeoffs between arbuscular mycorrhizal fungal competitive ability and host growth promotion in Plantago lanceolata显示文摘 | BENNETT A E BEVER J D | 2009 | Oecologia2009，160，： | 1 |
| 20 | A comparative study of oxidative DNA damage in mammalian spermatozoa 显示文摘 | Bennetts L E Aitken R J | 2005 | Mol Reprod Dev2005，71，： | 1 |
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