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| 1 | Leptin treatment ameliorates acute lung injury in rats with cerulein-induced acute pancreatitis显示文摘AIM:To determine the effect of exogenous leptin on acute lung injury (ALI) in cerulein-induced acute pancreatitis (AP). METHODS:Forty-eight rats were randomly divided into 3 groups. AP was induced by intraperitoneal (i.p.) injection of cerulein (50 μg/kg) four times,at 1 h intervals. The rats received a single i.p. injection of 10 μg/kg leptin (leptin group) or 2 mL saline (AP group) after cerulein injections. In the sham group,animals were given a single i.p. injection of 2 mL saline. Experimental samples were collected for biochemical and histological evaluations at 24 h and 48 h after the induction of AP or saline administration. Blood samples were obtained for the determination of amylase,lipase,tumor necrosis factor (TNF)-a,interleukin (IL)-1β,macrophage inflammatory peptide (MIP)-2 and soluble intercellular adhesion molecule (sICAM)-1 levels,while pancreatic and lung tissues were removed for myeloperoxidase (MPO) activity,nitric oxide (NOx) level,CD40 expression and histological evaluation. RESULTS:Cerulein injection caused severe AP,confirmed by an increase in serum amylase and lipase levels,histopathological findings of severe AP,and pancreatic MPO activity,compared to the values obtained in the sham group. In the leptin group,serum levels of MIP-2,sICMA-1,TNF-a,and IL-1b,pancreatic MPO activity,CD40 expression in pancreas and lung tissues,and NOx level in the lung tissue were lower compared to those in the AP group. Histologically,pancreatic and lungdamage was less severe following leptin administration. CONCLUSION:Exogenous leptin attenuates inflammatory changes,and reduces pro-inflammatory cytokines,nitric oxide levels,and CD40 expression in ceruleininduced AP and may be protective in AP associated ALI. | Fatma Ayca Gultekin Mustafa Kerem Ertan Tatlicioglu Aysel Aricioglu Cigdem Unsal Neslihan Bukan | 2007 | World Journal of Gastroenterology2007，13，21： | 23 |
| 2 | KAP Survey of Turkish University Students on Sexuality,reproductive Health,Drug Addiction and Violence显示文摘Objective To investigate the attitudes, behaviours and reflections of the university students, on sexuality, reproductive health, violence, smoking, alcohol and drug use, and to find out their expectations from a youth health service. Methods A total of 5 300 students (1 880 girls, 3 420 boys) from various faculties of Kyrykkale University were enrolled into this cross-sectional study. Students com- pleted the self-administered questionnaire as one of the researchers was present at the classroom. Research monitors five categories of priority health-risk behaviours among youth and young adults. Results Mean age of 3 420 male (64.5%) and 1 880 female (35.5%) students were 20.3 years. Among all 4 380 (82.9%) students [1 350 girls (71.8%), 3 030 boys (88.5%)] had some kinds of information about sexuality, however this dropped to 2 730 students (51.5%) within the context of adequacy. Friends were the major source (34%) for the first information on sexuality. Using a condom was the mostly heard method of contraception (46.9%) and interestingly 1.1% of the students had no knowledge on any of the protection methods. Among all 25.3% of the students (33.0% boys, 11.4% girls) had some kind of sexual intercourse, and within this group 58.8% experienced his/her first sexual relationship at 18 years of age and over; 53.9% were protected in all intercourses. Using a condom was the main way of protection for boys (63.7%) and pills were for the girls (73.9%). None of the female students mentioned having an abortion but 8% had friends who had undergone abortion. Tobacco use was 35.1% among the group, and 8.7% of the male and 3.6% of the female students were using drugs. Although 67.4% students claimed they never witnessed violence between their parents, 43.2% witnessed violence among their siblings, 67.0% beween friends, 72.6% in the streets and 64.2% in the school. About 30.0% of the students reported having weight problems, and 14.7% admitted visiting a doctor for that problem. If there would be a service provided for the adolescents in the university, 67% of thestudents would attend in case of a problem. Past experiences were important for us and we saw that among all 8% of the participants had some kind of sexual problem, within this group 50.7% felt uncomfortable during the visit and only 60.4% were satisfied with the care of the physician. Conclusion Our study results show the current situation of adolescents in Kyrykkale University and will be used to improve policies and programs to reduce priority health- risk behaviours among youth of our and surrounding provinces and establish a youth friendly service in Kyrykkale University within this purposes. | H■zel Selda Sanli Cihat Albayrak Meryem Fidan Serdar Agar Ayca | 2006 | Journal of Reproduction and Contraception2006，17，4： | 4 |
| 3 | Scoring the collective effects of SNPs: association of minor alleles with complex traits in model organisms显示文摘It has long been assumed that most parts of a genome and most genetic variations or SNPs are non-functional with regard to reproductive fitness.However,the collective effects of SNPs have yet to be examined by experimental science.We here developed a novel approach to examine the relationship between traits and the total amount of SNPs in panels of genetic reference populations.We identified the minor alleles(MAs)in each panel and the MA content(MAC)that each inbred strain carried for a set of SNPs with genotypes determined in these panels.MAC was nearly linearly linked to quantitative variations in numerous traits in model organisms,including life span,tumor susceptibility,learning and memory,sensitivity to alcohol and anti-psychotic drugs,and two correlated traits poor reproductive fitness and strong immunity.These results suggest that the collective effects of SNPs are functional and do affect reproductive fitness. | YUAN DeJian ZHU ZuoBin TAN XiaoHua LIANG Jie ZENG Chen ZHANG JieGen CHEN Jun MA Long DOGAN Ayca BROCKMANN Gudrun GOLDMANN Oliver MEDINA Eva RICE Amanda D. MOYER Richard W. MAN Xian YI Ke LI YanKe LU Qing HUANG YiMin HUANG Shi | 2014 | Science China(Life Sciences)2014，57，9： | 2 |
| 4 | Nasal administration of heparin-loaded microspheres based on poly (lactic acid) 显示文摘 | Ayca Y Alper O Gill B | 2005 | Farrnaco2005，60，1112： | 1 |
| 5 | A case of rhinocerebral mucormycosis presenting with garcin syndrome显示文摘 | Ozkul Ayca Basak Sema Ertugrul Mustafa Biilent | 2011 | Klimik Dergisi2011，24，3： | 1 |
| 6 | Association of GJB2 gene mutation with cochlear implant performance in genetic non-syndromic hearing loss显示文摘 | Recep Karamert Yildirim A. Bayazit Senay Altinyay Ak?n Y?lmaz Adnan Menevse Ozan Gokdogan Cagil Gokdogan Ayca Ant | 2011 | International Journal of Pediatric Otorhinolaryngology2011，，12： | 1 |
| 7 | Prostaglandin E2 Prevents Helicobacter -Induced Gastric Preneoplasia and Facilitates Persistent Infection in a Mouse Model显示文摘 | Isabella M. Toller Iris Hitzler Ayca Sayi Anne Mueller | 2010 | Gastroenterology2010，，4： | 1 |
| 8 | Serum vitamin D levels are independently associated with severity of coronary artery disease 显示文摘 | Akin F Ayca B Kose N | 2012 | J Investig Med2012，60，6： | 1 |
| 9 | The safety and efficacy of the Angio-Seal closure device in diagnostic and interventional neuroangiography setting: a single-center experience with 1,443 closures显示文摘 | Serdar Geyik Kivilcim Yavuz Ayca Akgoz Osman Koc Bora Peynircioglu Barbaros Cil Saruhan Cekirge Isil Saatci | 2007 | Neuroradiology2007，，9： | 1 |
| 10 | Triple-Negative Breast Cancer Adjuvant Therapatic Optious 显示文摘 | Ayca Gucalp Tiffany A Traina | 2011 | Chemotherapy Research and practice2011，696，： | 1 |
| 11 | Pervaporation separation of ethyl acetate- water mixtures through a erosslinked poly (vinylalcohol) membrane 显示文摘 | Yavuz Salt Ayca Hasanoglu lnci Salt | 2005 | Vacuum2005，79，： | 1 |
| 12 | Triple-Negative Breast Cancer: Adjuvant Therapeutic Options显示文摘 | Ayca Gucalp Tiffany A. Traina J. B. Vermorken | 2011 | Chemotherapy Research and Practice2011，，： | 1 |
| 13 | Phase II Trial of Saracatinib (AZD0530), an Oral SRC-inhibitor for the Treatment of Patients with Hormone Receptor-negative Metastatic Breast Cancer显示文摘 | Ayca Gucalp Joseph A. Sparano James Caravelli Jean Santamauro Sujata Patil Alyson Abbruzzi Christine Pellegrino Jackie Bromberg Chau Dang Maria Theodoulou Joan Massague Larry Norton Clifford Hudis Tiffany A. Traina | 2011 | Clinical Breast Cancer2011，，： | 1 |
| 14 | Adsorptive remo- val of methylene blue from simulated dyeing wastewater with melamine-formaldehyde-urea resin显示文摘 | Ayca Ozdemir F Birsen Demirata | 2009 | J Appl Polym Sci2009，112，6： | 1 |
| 15 | Relationship between glycemic control, microalbuminuria and cognitive functions in elderly type 2 diabetic patients显示文摘 | Cuma Bulent Gul Ozen Oz Gul Soner Cander Ayca Eroglu Mustafa Hartavi Nermin Keni Aysenur Bayindir Canan Ersoy Erdin? Ertü rk Ercan Tuncel &Scedil azi &Idot mamo&gbreve lu | 2014 | Renal Failure2014，，： | 1 |
| 16 | Development of polyampholyte hydrogels based on laponite for electrically stimulated drug release显示文摘 | Sema Ekici Ayca Tetik | 2015 | Polym. Int2015，，3： | 1 |
| 17 | Effects of Nanopar- ticles on Film Properties of Waterborne Acrylic Emulsions 显示文摘 | AYCA B GAMZE G C TU L B I | 2011 | Polymer- plastics Technology and Engineering2011，，50： | 1 |
| 18 | Intelligent short-term load forecasting in Turkey 显示文摘 | Ayca Kumluca Topalli Ismet Erkmen Ihsan Topalli | 2006 | Electrical Power and Energy Systems2006，28，7： | 1 |
| 19 | The effect of terpenes on percutaneous absorption of tiaprofenic acid gel显示文摘 | Alper Okyar Maksat Nuriyev Ayca Yildiz | 2010 | Archives of Pharmacal Research2010，33，11： | 1 |
| 20 | The effect of exercise on urinary gamma-glutamyltransferase and protein levels of volleyball players 显示文摘 | Ayca B Sener A Apikoglu Rabus S | 2006 | J Sports Med Phys Fitness2006，46，4： | 1 |
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