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| 1 | Risk factors and clinical responses of pneumonia patients with colistin-resistant Acinetobacter baumannii-calcoaceticus显示文摘BACKGROUND Nosocomial infections with carbapenem-resistant Acinetobacter baumanniicalcoaceticus complex(ABC)strains are great problem for intensive care units.ABC strains can develop resistance to all the antibiotics available.Carbapenem resistance is common and colistin resistance is rare in our country.Knowing the risk factors for colistin resistance is important since colistin seems to be the only remaining therapeutic option for the patients with pneumonia due to extensively drug resistant ABC for our country.AIM To investigate the comparison of clinical responses and outcomes between pneumonia patients with colistin-susceptible and-resistant Acinetobacter sp.Strains.METHODS During the study period,108 patients with pneumonia due to colistin-susceptible strains and 16 patients with colistin-resistant strains were included retrospectively.Continuous variables were compared with the Mann-Whitney U test,and categorical variables were compared using Pearson’s chi-square test or Fisher’s Exact chi-square test for two groups.A binary logistic regression model was developed to identify the potential independent factors associated with colistin resistance in patients with colistin-resistant strains.RESULTS High Acute Physiology and Chronic Health Evaluation II scores(OR=1.9,95%CI:1.4-2.7;P<0.001)and prior receipt of teicoplanin(OR=8.1,95%CI:1.0-63.3;P=0.045)were found to be independent risk factors for infection with colistin-resistant Acinetobacter sp.Different combinations of antibiotics including colistin,meropenem,ampicillin/sulbactam,amikacin and trimethoprim/sulfamethoxazole were used for the treatment of patients with colistin-resistant strains.Although the median duration of microbiological cure(P<0.001)was longer in the colistin-resistant group,clinical(P=0.703),laboratory(P=0.277),radiological(P=0.551),microbiological response(P=1.000)and infection related mortality rates(P=0.603)did not differ between the two groups.Among the patients with infections due to colistin-resistant strains,seven were treated with antibiotic combinations that included sulbactam.Clinical(6/7)and microbiological(5/7)response rates were quite high in these patients.CONCLUSION The optimal therapy regimen is unclear for colistin-resistant Acinetobacter sp.infections.Although combinations with sulbactam seems to be more effective in our study patients,data supporting the usefulness of combinations with sulbactam is very limited. | Hande Aydemir Hande Idil Tuz Nihal Piskin Guven Celebi Canan Kulah Furuzan Kokturk | 2019 | World Journal of Clinical Cases2019，7，10： | 7 |
| 2 | Comparison of intravitreal bevacizumab and triamcinolone acetonide theraphies for diffuse diabetic macular edema显示文摘AIM: To compare therapeutic effects of intravitreal triamcinolone acetonide(IVTA) versus intravitreal bevacizumab(IVB) injections for bilateral diffuse diabetic macular edema(DDME). METHODS: Forty eyes of 20 patients with bilateral DDME participated in this study. For each patient, 4 mg/0.1 m L IVTA was injected to one eye and 2.5 mg/0.1 m L IVB was injected to the other eye. The effects of injection for diabetic macular edema(DME) were evaluated using best-corrected visual acuity(BCVA), central macular thickness(CMT) by optical coherence tomography(OCT)and intraocular pressure(IOP) by applanation tonometer.Patients underwent eye examinations, including BCVA,CMT, and IOP at pre-injection, 1, 4, 8, 12 and 24 wk after injection. During the follow-up, second injections were performed to eyes which have CMT greater than 400 μm at 12 wk for salvage therapy.RESULTS: BCVA(logarithm of the minimum angle of resolution) at pre-injection, 1, 4, 8, 12 and 24 wk after injection was 0.71 ±0.19, 0.62 ±0.23, 0.63 ±0.12, 0.63 ±0.13,0.63±0.14 and 0.61±0.24 in the IVTA group and 0.68±0.25,0.61 ±0.22, 0.60 ±0.24, 0.62 ±0.25, 0.65 ±0.26 and 0.59 ±0.25 in the IVB group, respectively. CMT(μm) at pre-injection,1, 4, 8, 12 and 24 wk after injection was 544 ±125, 383±96,335 ±87, 323 ±87, 333 ±92, 335 ±61 in the IVTA group and514 ±100, 431 ±86, 428 ±107, 442 ±106, 478 ±112, 430 ±88 in the IVB group respectively. Reduction ratios of mean CMT were 29% at 1wk, 38% at 4wk, 40% at 8wk, 38% at12 wk, and 38% at 24 wk in the IVTA group. Second IVTA injections were performed to the 6 eyes(30%) at 12 wk.Reduction ratios of mean CMT were 16% at 1wk, 17% at4wk, 14% at 8wk, 7% at 12 wk, and 16% at 24 wk in the IVB group. Second IVB injections were performed to the15 eyes(75%) at 12 wk.CONCLUSION: This study showed earlier and more frequent macular edema recurrences in the eyes treated with bevacizumab compared with the ones treated with triamcinolone acetonide. Triamcinolone acetonide was found to provide more efficient and long-standing effect in terms of reducing CMT compared with the bevacizumab. | Sibel Aksoy Gursel Yilmaz Imren Akkoyun Ayse Canan Yazici | 2015 | International Journal of Ophthalmology(English edition)2015，8，3： | 6 |
| 3 | Choroidal thickness measurements with optical coherence tomography in branch retinal vein occlusion显示文摘AIM: To evaluate central macular thickness(CMT) and mean choroidal thickness(MCT) in eyes with branch retinal vein occlusion(BRVO), before and after ranibizumab treatment using spectral domain-optical coherence tomography(SD-OCT).·METHODS: Forty-two patients with unilateral BRVO and macular edema were included in this study. There were 25 men and 17 women. Using SD-OCT, choroidal thickness was measured at 500 μm intervals up to 1500μm temporal and nasal to the fovea. MCT was calculated based on the average of the 7 locations. All the eyes with BRVO were treated with intravitreal ranibizumab(0.5 mg/0.05 m L). Comparisons between the BRVO and fellow eyes were analyzed using Mann-Whitney U test. Preinjection and post-injection measurements were analyzed using Wilcoxon test and repeated measure analysis.· RESULTS: At baseline, there was a significant difference between the BRVO and fellow eyes in MCT[BRVO eyes 245(165-330) μm, fellow eyes 229(157-327) μm]and CMT [BRVO eyes 463(266-899) μm, fellow eyes 235(148-378) μm(P =0.041, 0.0001, respectively)]. Following treatment, CMT [295(141-558) μm] and MCT [229(157-329) μm] decreased significantly compared to the baseline measurements(P =0.001, 0.006, respectively).Also BCVA(log MAR) improved significantly(P=0.0001) in the BRVO eyes following treatment. After treatment CMT[BRVO eyes 295(141-558) μm, fellow eyes 234(157-351) μm]and MCT [BRVO eyes 229(157-329) μm, fellow eyes 233(162-286) μm] values did not reveal any significant difference in BRVO eyes and fellow eyes(P=0.051, 0.824,respectively).· CONCLUSION: In eyes with BRVO, CMT and MCT values are greater than the fellow eyes, and decrease significantly following ranibizumab injection. | Muge Coban-Karatas Rana Altan-Yaycioglu Burak Ulas Selcuk Sizmaz Handan Canan Cagla Sariturk | 2016 | International Journal of Ophthalmology(English edition)2016，9，5： | 6 |
| 4 | A tailored,electronic textile conformable suit for large-scale spatiotemporal physiological sensing in vivo显示文摘The rapid advancement of electronic devices and fabrication technologies has further promoted the field of wearables and smart textiles.However,most of the current efforts in textile electronics focus on a single modality and cover a small area.Here,we have developed a tailored,electronic textile conformable suit(E-TeCS)to perform large-scale,multimodal physiological(temperature,heart rate,and respiration)sensing in vivo.This platform can be customized for various forms,sizes and functions using standard,accessible and high-throughput textile manufacturing and garment patterning techniques.Similar to a compression shirt,the soft and stretchable nature of the tailored E-TeCS allows intimate contact between electronics and the skin with a pressure value of around~25 mmHg,allowing for physical comfort and improved precision of sensor readings on skin.The E-TeCS can detect skin temperature with an accuracy of 0.1℃ and a precision of 0.01℃,as well as heart rate and respiration with a precision of 0.0012 m/s^(2) through mechano-acoustic inertial sensing.The knit textile electronics can be stretched up to 30%under 1000 cycles of stretching without significant degradation in mechanical and electrical performance.Experimental and theoretical investigations are conducted for each sensor modality along with performing the robustness of sensor-interconnects,washability,and breathability of the suit.Collective results suggest that our E-TeCS can simultaneously and wirelessly monitor 30 skin temperature nodes across the human body over an area of 1500 cm2,during seismocardiac events and respiration,as well as physical activity through inertial dynamics. | Irmandy Wicaksono Carson ITucker Tao Sun Cesar A.Guerrero Clare Liu Wesley M.Woo Eric J.Pence Canan Dagdeviren | 2020 | npj Flexible Electronics2020，4，1： | 4 |
| 5 | Anti-pancreatic antibody in Turkish patients with inflammatory bowel disease and first-degree relatives显示文摘AIM: To identify the role of anti-pancreatic antibody (PAB) in the diagnosis of inflammatory bowel diseases (IBD) among Turkish patients, and its frequency in firstdegree relatives.METHODS: PAB and anti-Saccharomyces cerevisiae (ASCA) were examined in serum samples of 214 subjects including patients with Crohn's disease (CD, n = 64), ulcerative colitis (UC, n = 63), first-degree relatives of patients with CD (n = 25), first-degree relatives of patients with UC (n = 28),and a control group with gastrointestinal symptoms other than (IBD) (n = 34) by indirect immunofluorescence Positivity of PAB and ASCA was compared in terms of Vienna classification, disease activity and medications used.RESULTS: In terms of PAB positivity, no difference was found between patients with CD (14.1%) and UC (7.9%) however, significant difference was observed between patients with CD and subjects in the control group (P < 0.05). No difference was found between patients with CD and their relatives in terms of ASCA positivity, whereas a significant difference was found between other groups (P < 0.001). Compared to ASCA, the sensitivity of the PAB was 19% (7/37), its specificity was 93% (25/27), positive predictive value was 77% (7/9) and negative predictive value was 45% (25/55). ASCA was found with significantly higher prevalence in patients with CD activity index > 150 (P < 0.05).CONCLUSION: PAB is valuable in the diagnosis of IBD rather than CD, but cannot be used alone for diagnostic purposes. PAB is not superior to ASCA in CD diagnosis and in detecting CD among relatives of patients with CD. | Huseyin Demirsoy Kamil Ozdil Ozdal Ersoy Besir Kesici Cetin Karaca Canan Alkim Nihat Akbayir Levent Kamil Erdem Mehmet Derya Onuk Hulya Tugrul Beyzadeoglu | 2010 | World Journal of Gastroenterology2010，16，45： | 3 |
| 6 | 优势眼测量法的研究(英文)显示文摘目的:为了检查一项新的性能测试,对同以受试者用两种不同的方法进行检测和再测试,并比较和讨论这些检测方法的可靠性。方法:共179个大学生(平均年龄±标准差为19.37±1.62)a自愿参加这项由110名女性(61.5%)和69名男性(38.5%)组成的调查。优势眼由两种不同的方法检测,一个为McManus方法,一个为Gndo■an方法。利用SPSS的重测信度的可靠性分析保证该项调查的可靠性。结果:McManus方法检测128名(71.5%)参加者右眼为优势眼,无性别差异。同样利用Gndogˇan方法再检测发现110名(61.5%)参加者右眼为优势眼。两种方法的检测结果由Fisher确切概率法分析发现呈显著性相关(P<0.01),一致性数值为为κ=0.256,P<0.001。利用Mc-Manus法发现女性参加者中74名(67.3%)右眼为优势眼,36名(32.7%)左眼为优势眼。利用Gndog■an法再检测发现62名女(56.4%)右眼为优势眼,48名女(43.6%)左眼为优势眼。通过Fisher确切概率法分析发现McMa-nus和Gndo■an两种方法在女性优势眼检测方面呈显著性相关(P<0.05),一致性数值为κ=0.239,P<0.01。在男性参与者中,通过McManus法检测右眼优势眼为54眼(78.3%),左眼优势眼为15眼(21.7%),利用Gndo■an法再检测右眼优势眼为48眼(69.6%),左眼优势眼为21眼(30.4%)。利用χ2检验和Fisher确切概率法分析数据。利用Kappa一致性检验分析不同方法的一致性。比例的比较由z检验完成,P值小于0.05为差异显著。结论:通过检测观察到女性和男性均以右眼优势眼为主,没有性别差异。右眼优势这种功能性偏侧化现象可能是由于大脑左半球的主导作用造成的。这对于将来在一侧面偏重方面的研究很重要,也许会成为一个重要的模式系统。 | Nimet Unay Gundogan Ayse Canan Yazici Ayten Simsek | 2008 | 国际眼科杂志2008，8，10： | 3 |
| 7 | Effect of diluted povidone iodine in adenoviral keratoconjunctivitis on the rate of subepithelial corneal infiltrates显示文摘AIM: To evaluate the clinical characteristics of adenoviral keratoconjunctivitis, the management modalities, as well as the incidence of subepithelial corneal infiltrates(SEI).METHODS: Patients with characteristic clinical symptoms and signs, who presented to our clinic within the first week of symptoms and received the diagnosis of adenoviral keratoconjunctivitis between January 2013 and April 2016, were included in the study. A total of 211 patients were included in the study. Patients were evaluated for the incidence of clinical signs, late complications, management preferences, and the effect of diluted povidone-iodine(d-PVP-I) 2%. RESULTS: Patients’ mean age was 33.03±14.76 y. We observed an increase in the number of cases according to the years. At presentation and/or early follow-up, the clinical signs were conjunctival hyperemia(100%), conjunctival follicules(79.1%), edema of the eyelids(39.3%), chemosis(16.1%), pseudomembrane formation(16.6%), and corneal epitheliopathy(29.9%). During late follow-up 13.3% patients developed conjunctival subepithelial fibrosis, and 39.8% developed SEI. A significant decrease in the incidence of SEI development was observed in patients who used d-PVP-I 2%(P=0.032;33.3% vs 45.9%, respectively in patients who received d-PVP-I 2% and who did not).CONCLUSION: Adenoviral keratoconjunctivitis has a tremendous effect on patient’s comfort and abilities in short-term. Additionally, almost half of the patients develop visual problems related to SEI. According to our clinical experience, using d-PVP-I 2% in the first days of adenoviral keratoconjunctivitis might be helpful in reducing the risk of SEI as a complication. | Rana Altan-Yaycioglu Nedime Sahinoglu-Keskek Handan Canan Muge Coban-Karatas Burak Ulas | 2019 | International Journal of Ophthalmology(English edition)2019，12，9： | 2 |
| 8 | Optimal Restocking Fees and Information Provision in an Integrated Demand-Supply Model of Product Returns显示文摘 | Jeffrey D. Shulman Anne T. Coughlan R. Canan Savaskan | 2009 | Manufacturing & Service Operations Management2009，，4： | 2 |
| 9 | Effect of intracorneal ring segment implantation on corneal asphericity显示文摘AIM: To evaluate the visual, refractive and corneal asphericity changes after intrastromal corneal ring segment(ICRS) implantation for visual rehabilitation of keratoconus.METHODS: A total of 42 eyes of 32 patients were included. After creation of intrastromal tunnels of 5.01±0.03 mm inner diameter, 5.71±0.03 mm outer diameter and at 384.21±34.12 μm depth, 1 or 2 ICRS of 150-300 μm thickness and 90°-210° arc length were implanted. Changes in uncorrected distance visual acuity(UDVA), corrected distance visual acuity(CDVA), refractive errors, mean simulated keratometry readings SimK_(avg), anterior and posterior corneal asphericity values(Q_(ant) and Q_(post), respectively) measured with Scheimpflug topography were evaluated retrospectively. RESULTS: There was a significant improvement in UDVA and CDVA, along with a significant decrease in refractive spherical equivalent(SE), cylinder and SimK_(avg) postoperatively(P<0.001 for all). Mean Qant increased from-1.06±0.48 to-0.57±0.58 postoperatively(P<0.001). Change in mean Qpost was insignificant(P=0.92). Postoperative changes in UDVA and CDVA were not correlated with the postoperative changes in SE and cylinder(P>0.05 for all); but were correlated with the preoperative SimK_(avg) and Q_(ant) values(P<0.001 for all). CONCLUSION: ICRS implantation seems to approximate the anterior corneal asphericity of 'advanced prolate' shape to 'optimal prolate' shape and an 'ideal Q value' of-0.46; which may have a role in improved UDVA and CDVA postoperatively, besides decreased refractive cylinder values. | Canan A.Utine Ziya Ayhan Ceren Durmaz Engin | 2018 | International Journal of Ophthalmology(English edition)2018，11，8： | 2 |
| 10 | Relation of eye dominancy with color vision discrimination performance ability in normal subjects显示文摘AIM:To evaluate the performance of dominant eye(DE) for color vision discrimination ability among the medical students with normal color vision.METHODS:Total of 50 students studying at Baskent University Faculty of Medicine,including 31 males(62%) and 19 females(38%),with visual acuity of 20/20 and without congenital color vision deficiency(CCVD) evaluated by Ishihara pseudoisochromatic plate test(IPPT) were recruited for this prospective comparative study upon their voluntary participation.DE was determined by the Gündogan Method.The color discrimination ability was examined with the FarnsworthMunsell 100 hue(FM100) test.Test was applied by two days interval to all subjects for the three times while two eyes(TE),right eye(RE) and left eye(LE) were seeing for detecting red-green(r/g),blue-yellow(b/y) local color spectral regions error scores.The error scores were evaluated for both in DE and non-dominant(NDE).P values below 0.05 were considered to be statistically significant.RESULTS:The students aged 21.18±2.52 years(mean±SD).Without sex difference the RE and the LE dominancy were found 22(44%) and 28(56%) respectively and FM 100 test total error scores of DE in both r/g-b/y regions were found without gender difference 24.12±14.70,34.68±18.95,respectively.For the NDE in both,r/gb/y regions error scores without gender difference were 32.20±19.21,36.24±17.56,respectively.The difference of total error scores between the DE and NDE was found as 58.80±29.92,68.44±31.46.The statistical differences among the DE and the NDE in r/g local region and total error scores were found significant in both genders(P<0.05,P<0.001). CONCLUSION:The color vision discrimination performance ability was found prominent for DE.This superiority was attributed to higher sensitivity of the r/g local color spectral region.We conclude that DE has priority in r/g color spectral region,probably including inhibition of NDE. | Belkis Koctekin Nimet ünay Gündogan Ays Gül Kocak Altintas Ayse Canan Yazici | 2013 | International Journal of Ophthalmology(English edition)2013，6，5： | 2 |
| 11 | Clinical Review: Topical Ophthalmic Use of Cyclosporin A显示文摘 | Canan Asli Utine Michael Stern Esen K. Akpek | 2010 | Ocular Immunology and Inflammation2010，，5： | 2 |
| 12 | Reverse Channel Design: The Case of Competing Retailers显示文摘 | R. Canan Savaskan Luk N. Van Wassenhove | 2006 | Management Science2006，，： | 2 |
| 13 | Closed-Loop Supply Chain Models with Product Remanufacturing显示文摘 | R. Canan Savaskan Shantanu Bhattacharya Luk N. Van Wassenhove | 2004 | Management Science2004，，： | 2 |
| 14 | In vitro effects of phenytoin and DAPT on MDA-MB-231 breast cancer cells显示文摘电压门钠隧道(VGSC ) 活动提高与转移有关的房间行为,例如活动性,侵略,和 oncogene 表示。新生的选择拼接 Nav1.5 isoform 的形式在变形乳癌被表示。而且,异常槽口发信号小径能导致 oncogenesis 并且可以支持乳癌的前进。在这研究,我们试图分析 nNav1.5 禁止者 phenytoin 和槽口信号禁止者 N- 的效果[经由分别地发信号的 nNav1.5 VGSC 活动和槽口的抑制的三倍的否定乳癌房间线(MDA-MB-231 ) 上的 N-(3,5-difluorophenacetyl )-L-alanyl]-S-phenylglycine-t-butyl 酉旨(DAPT ) 。以便决定这些禁止者的单个、联合的效果, 4-[3-(4-iyodophenyl )-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate (WST-1 ) 测试,创伤愈合试金,和 zymography 被执行检测增长,侧面的活动性,和矩阵 metalloproteinase-9 (MMP9 ) 活动分别地。metalloproteinases-1 (TIMP1 ) 的 nNav1.5, Notch4, MMP9,和织物禁止者的表情被量的即时反向的 transcriptasepolymerase 链反应也检测。当剂量比 10 眠獡 ? ┵高时, DAPT 引起了 antiproliferative 效果吗?? | Canan Cakir Aktas N. Dilara Zeybek A. Kevser Piskin | 2015 | Acta Biochimica et Biophysica Sinica2015，47，9： | 2 |
| 15 | Fabrication and tribological properties of titanium nitride coatings incorporating solid lubricant micro reservoirs显示文摘 | John H Z Canan G G James E K | 2008 | Surface&Coatings Technology2008，202，： | 1 |
| 16 | Empirical Research Opportunities in Reverse Supply Chains 显示文摘 | Carol Prahinski Canan Kocabasoglu | 2006 | Omega2006，34，： | 1 |
| 17 | A new citrus linkage map based on SRAP, SSR, ISSR, POGP, RGA and RAPD markers 显示文摘 | Gulsen O Uzun A Canan I | 2010 | Euphytica2010，173，2： | 1 |
| 18 | Studies on the extraction and purification of phytic acid from rice bran显示文摘 | Canan C Cruz F T L Delaroza F | | 0，，07： | 1 |
| 19 | Combined Spinal-Epidural Anesthesia with Epidural Volume Extension causes a Higher Level of Block than Single-Shot Spinal Anesthesia显示文摘 | Canan Salman Nurten Kayacan Fatma Ertu?rul Zekiye B?gat Bilge Karsl? | 2013 | Brazilian Journal of Anesthesiology2013，，3： | 1 |
| 20 | The New Pest Cydalima perspectalis (Walker, 1859)(Lepidoptera: Crambidae) in Turkey 显示文摘 | Erdem H Muhsin K Canan Y | 2012 | Journal of Animal and Veterinary Advances2012，11，3： | 1 |
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