Scoring the collective effects of SNPs: association of minor alleles with complex traits in model organisms

查看全文 作　　者：YUAN [1]DeJian;ZHU [1]ZuoBin;TAN [1]XiaoHua;LIANG [1]Jie;ZENG [1]Chen;ZHANG [2]JieGen;CHEN [2]Jun;MA [1]Long;DOGAN [3]Ayca;BROCKMANN [3]Gudrun;GOLDMANN [4]Oliver;MEDINA [4]Eva;RICE Amanda [5]D.;MOYER Richard [5]W.;MAN [1]Xian;YI [1]Ke;LI [1]YanKe;LU [1]Qing;HUANG [1]YiMin;HUANG [1]Shi

机构地区：[1]State Key Laboratory of Medical Genetics, Central South University;[2]High Performance Computing Center, Modern Educational Technology Center, New Campus, Central South University;[3]Department of Crop and Animal Sciences, Faculty of Agriculture and Horticulture, Humboldt-Universitt zu Berlin,Invalidenstraβe 42,Berlin 10115, Germany;[4]Infection Immunology Group, Helmholtz Centre for Infection Research, Inhoffenstrae 7,Braunschweig 38124, Germany;[5]Department of Molecular Genetics and Microbiology, University of Florida

出　　处：《Science China(Life Sciences)》索引2014年第57卷第9期,共13页

基　　金：supported by the National Natural Science Foundation of China(81171880);the National Basic Research Program of China(2011CB51001 to S.Huang);the GeNeSys Consortium(to O.Goldmann and E.Medina 摘　　要：It has long been assumed that most parts of a genome and most genetic variations or SNPs are non-functional with regard to reproductive fitness.However,the collective effects of SNPs have yet to be examined by experimental science.We here developed a novel approach to examine the relationship between traits and the total amount of SNPs in panels of genetic reference populations.We identified the minor alleles(MAs)in each panel and the MA content(MAC)that each inbred strain carried for a set of SNPs with genotypes determined in these panels.MAC was nearly linearly linked to quantitative variations in numerous traits in model organisms,including life span,tumor susceptibility,learning and memory,sensitivity to alcohol and anti-psychotic drugs,and two correlated traits poor reproductive fitness and strong immunity.These results suggest that the collective effects of SNPs are functional and do affect reproductive fitness. 关键词：集体效应模式生物等位基因未成年人 SNP 多性状单核苷酸多态性 MAC地址

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Scoring the collective effects of SNPs: association of minor alleles with complex traits in model organisms

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