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| 1 | Periodontopathogen profile of healthy and oral lichen planus patients with gingivitis or periodontitis显示文摘Oral lichen planus (OLP) is a chronic inflammatory disease that is frequently detected in oral tissues. The aim of our study was to identify the prevalence of the detection of periodontopathogenic microorganisms (Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythia and Treponema denticola in OLP patients and to compare with this prevalence of periodontopathogenic microorganisms in healthy non-OLP patients. Our study included 27 (18 chronic periodontitis (OLPP) and 9 gingivitis (OLPG)) patients diagnosed with OLP along with 26 (13 chronic periodontitis (HP) and 13 gingivitis (HG)) healthy non-OLP patients. The multiplex polymerase chain reaction (PCR) with subsequent reverse hybridization method (micro-IDent) was used for identifying periodontopathogenic microorganisms present in subgingival plaque samples. The percentages of detection for A. actinomycetemcomitans, P. gingivalis, P. intermedia, T. forsythia and T. denticola in subgingival plaque samples taken from OLP patients (OLPG and OLPP) were 18.5%, 85.1%, 81.4%, 88.8% and 74%, respectively. Meanwhile, in the non-OLP patients (HG and HP), these values were 7.6%, 50%, 46.1%, 73% and 57.7%, respectively. Thus, comparing the non-OLP groups with the OLP groups, the periodontopathogens' percentages of detection in the OLP groups were higher than those in the non-OLP groups. According to our study results, OLP patients have higher levels of infection with A. actinomycetemcomitans, P. gingivalis, P. intermedia, T. forsythia and T. denticola than non-OLP patients. We argue that the high percentages in patients with OLP may help identify the importance of periodontopathogenic microorganisms in the progress of periodontal diseases of OLP. | Abdullah Seckin Ertugrul Ugur Arslan Recep Dursun Sema Sezgin Hakki | 2013 | International Journal of Oral Science2013，5，2： | 15 |
| 2 | Effects of estrogen replacement therapy on apoptosis and vascular endothelial growth factor expression in ocular surface epithelial cells:An experimental study显示文摘AIM:To investigate the effects of estrogen replacement therapy (ERT) on apoptosis and vascular endothelial growth factor (VEGF) expression in ocular surface in an experimental rat model.· METHODS:Forty female,Wistar rats were randomized in 4 groups in the study.Subcutaneous ERT (17β-estradiol,10g/kg/day) was administered to the first group without ovariectomy and to the second group with ovariectomy for three months.Third group had only ovariectomy and fourth group had sham operation.All rats were sacrificed in estrous cycles determined by vaginal smear test and their right eyes were enucleated at the end of the third month.Enucleated eyes were analyzed by immunohistochemical method for expressions of caspase-3,bcl-2,VEGF and TUNEL assay.· RESULTS:Caspase-3 expression of conjunctival epithelium was significantly higher in group 3 than group 1 (P =0.005),and group 2 (P =0.007).TUNEL score of conjunctival epithelium was significantly higher in group 3 than group 1 (P =0.006).TUNEL score of corneal epithelium was significantly higher in group 3 than group 2 (P =0.012),and group 4 (P =0.002).There was no significant difference between groups in that bcl-2 and VEGF expressions.· CONCLUSION:We determined increased apoptosis in ocular surface epithelial cells in ovariectomized rats.ERT and endogen estrogen decreased the apoptosis,and did not result in difference in VEGF expression between the groups.Estrogen may be beneficial for the treatment of apoptosis-mediated ocular surface disorders such as dry eye.Further studies are needed on this subject for a better understanding of the role of estrogen and to provide a new insight for treatment and prevention of apoptosis-mediated ocular surface disorders. | Fatih zcura Sema Oru Dndar Emel Dikicioglu etin Nahit Beder Mehmet Dndar | 2012 | International Journal of Ophthalmology(English edition)2012，5，1： | 7 |
| 3 | Recombinant amelogenin regulates the bioactivity of mouse cementoblasts in vitro显示文摘Amelogenin(AMG) is a cell adhesion molecule that has an important role in the mineralization of enamel and regulates events during dental development and root formation. The purpose of the present study was to investigate the effects of recombinant human AMG(rhAMG) on mineralized tissue-associated genes in cementoblasts. Immortalized mouse cementoblasts(OCCM-30)were treated with different concentrations(0.1, 1, 10, 100, 1 000, 10 000, 100 000 ng · mL^(-1)) of recombinant human AMG(rhAMG)and analyzed for proliferation, mineralization and mRNA expression of bone sialoprotein(BSP), osteocalcin(OCN), collagen type I(COL I), osteopontin(OPN), runt-related transcription factor 2(Runx2), cementum attachment protein(CAP), and alkaline phosphatase(ALP) genes using quantitative RT-PCR. The dose response of rhAMG was evaluated using a real-time cell analyzer.Total RNA was isolated on day 3, and cell mineralization was assessed using von Kossa staining on day 8. COL I, OPN and lysosomalassociated membrane protein-1(LAMP-1), which is a cell surface binding site for amelogenin, were evaluated using immunocytochemistry. F-actin bundles were imaged using confocal microscopy. rhAMG at a concentration of 100 000 ng · mL^(-1) increased cell proliferation after 72 h compared to the other concentrations and the untreated control group. rhAMG(100 000 ng · mL^(-1)) upregulated BSP and OCN mRNA expression levels eightfold and fivefold, respectively. rhAMG at a concentration of 100 000 ng · mL^(-1) remarkably enhanced LAMP-1 staining in cementoblasts. Increased numbers of mineralized nodules were observed at concentrations of 10 000 and 100 000 ng · mL^(-1) rhAMG. The present data suggest that rhAMG is a potent regulator of gene expression in cementoblasts and support the potential application of rhAMG in therapies aimed at fast regeneration of damaged periodontal tissue. | Sema S.Hakki S.Buket Bozkurt Emre Türkay Michel Dard Nuhan Purali Werner Gotz | 2018 | International Journal of Oral Science2018，10，2： | 3 |
| 4 | Hepatitis B reactivation related to everolimus显示文摘Reactivation of hepatitis B virus (HBV) during chemotherapy is a well known complication in patients with chronic hepatitis B and cancer.The clinical manifestations range from subclinical elevation of liver enzymes to severe,potentially fatal fulminant hepatitis.Reactivation can occur in a patient with previous inactive HBV infection;either an inactive carrier or a patient with resolved hepatitis.Everolimus is a mammalian target of rapamycin (mTOR) inhibitor approved in renal cell carcinoma,neuroendocrine tumours and breast cancer.mTOR inhibitors are a new generation of drugs for targeted treatment;therefore,little about their side effects is known.Here,we report a patient with renal cell carcinoma who experienced a flare of hepatitis B infection during treatment with everolimus.Clinicians should be aware of HBV reactivation in patients who are undergoing treatment with everolimus,and screening for hepatitis B infection and prophylactic antiviral treatment should be considered. | Sema Sezgin Gksu Serife Bilal Hasan Senol Coskun | 2013 | World Journal of Hepatology2013，5，1： | 3 |
| 5 | LONG-TIME DYNAMICS OF THE STRONGLY DAMPED SEMILINEAR PLATE EQUATION IN R^N显示文摘We investigate the initial-value problem for the semilinear plate equation containing localized strong damping, localized weak damping and nonlocal nonlinearity. We prove that if nonnegative damping coefficients are strictly positive almost everywhere in the exterior of some ball and the sum of these coefficients is positive a.e. in R^n, then the semigroup generated by the considered problem possesses a global attractor in H^2(R^n) × L^2(R^n).We also establish the boundedness of this attractor in H^3(R^n) × H^2(R^n). | Azer KHANMAMEDOV Sema YAYLA | 2018 | Acta Mathematica Scientia2018，38，3： | 3 |
| 6 | Blastocystis in ulcerative colitis patients:Genetic diversity and analysis of laboratory findings显示文摘Objective:To determine Blastocystis frequency and subtypes(ST) in ulcerative colitis(UC) patients and analyse some laboratory findings between Blastocystis positive and negative cases.Methods:Faecal samples from 150 UC patients in Adnan Menderes University,Training and Research Hospital were examined by direct microscopy and cultivated in Jones medium.Blastocystis positive cultures were subjected to DNA isolation and subtypes were identified by sequencing of barcode region.A retrospective analysis was conducted on C reactive protein(CRP),leukocyte counts(WBC),neutrophil counts,and sedimentation rates.Results:The overall positive rate of Blastocystis was 8%(12 patients) and the most abundant subtype was ST3(eight isolates,66.7%),followed by ST1,ST2 and ST7.Laboratory findings between Blastocystis infected and non-infected UC patients were not significantly different.Blastocystisfrequency was 3.8% among the patients in active stage,while it was 11.8% among the patients in remission stage.Conclusions:The present study confirms previous findings that have indicated the predominance of Blastocystis ST3 in humans and contributes additional evidence that suggests the low colonization of Blastocystis infection in ulcerative colitis patients during active stage. | Adil Coskun Erdogan Malatyali Hatice Ertabaklar Mustafa B Yasar Ali O Karaoglu Sema Ertug | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，9： | 3 |
| 7 | An unusual case of incidental rupture of liver hemangioma during labor显示文摘Cavernous hemangiomas are the most common benign tumors of the liver and are found in about 2% of autopsy patients. 1,2 The vast majority of these tumors are small and asymptomatic; however, there have been a few reported cases in which these lesions led to spontaneous fatal hemorrhage. 1,2 Although liver hemangiomas occur in both sexes, most studies point to a female predominance; one study reported a ratio of female predominance of 4. 5: 1.3 It has been suggested that estrogen may be associated with the growth of liver hemangiomas, but the incidence of these lesions in pregnancy and the effect on them of the increased estrogen levels during pregnancy are unknown. 2 Symptomatic liver hemangiomas have been treated by steroids, radiation therapy, surgical resection and recently embolization, but surgeons may sometimes be confronted with intraabdominal hemorrhage originating from rupture of asymptomatic liver hemangiomas. This case describes an incidental intraabdominal hemorrhage originating from a liver hemangioma in a 36 weeks twin pregnancy being delivered emergently by Cesarean section due to fetal distress. | TayfunGüng(o|¨)r Hakan Aytan (O|¨)merLütfiTapisiz Sema Zergeroglu | 2004 | Chinese Medical Journal2004，17，2： | 2 |
| 8 | The diagnostic value of non-invasive tests for the evaluation of liver fibrosis in chronic hepatitis B patients显示文摘 | Serpil Erdogan Halef Okan Dogan Sevilay Sezer Sema Uysal Esra Ozhamam Serra Kayacetin Yuksel Koca | 2013 | Scandinavian Journal of Clinical & Laboratory Investigation2013，，4： | 2 |
| 9 | Gut homeostasis, injury, and healing: New therapeutic targets显示文摘The integrity of the gastrointestinal mucosa plays a crucial role in gut homeostasis,which depends upon the balance between mucosal injury by destructive factors and healing via protective factors.The persistence of noxious agents such as acid,pepsin,nonsteroidal anti-inflammatory drugs,or Helicobacter pylori breaks down the mucosal barrier and injury occurs.Depending upon the size and site of the wound,it is healed by complex and overlapping processes involving membrane resealing,cell spreading,purse-string contraction,restitution,differentiation,angiogenesis,and vasculogenesis,each modulated by extracellular regulators.Unfortunately,the gut does not always heal,leading to such pathology as peptic ulcers or inflammatory bowel disease.Currently available therapeutics such as proton pump inhibitors,histamine-2 receptor antagonists,sucralfate,5-aminosalicylate,antibiotics,corticosteroids,and immunosuppressants all attempt to minimize or reduce injury to the gastrointestinal tract.More recent studies have focused on improving mucosal defense or directly promoting mucosal repair.Many investigations have sought to enhance mucosal defense by stimulating mucus secretion,mucosal blood flow,or tight junction function.Conversely,new attempts to directly promote mucosal repair target proteins that modulate cytoskeleton dynamics such as tubulin,talin,Ehm^(2),filamin-a,gelsolin,and flightless I or that proteins regulate focal adhesions dynamics such as focal adhesion kinase.This article summarizes the pathobiology of gastrointestinal mucosal healing and reviews potential new therapeutic targets. | Sema Oncel Marc D Basson | 2022 | World Journal of Gastroenterology2022，28，17： | 2 |
| 10 | Liquid-Liquid Equilibria of Water + Butyric Acid + Nonanol Ternary System显示文摘Liquid-liquid equilibrium (LLE) data for the water + butyric acid + nonanol system have been determined experimentally at the temperatures of 298.15 K, 308.15 K and 318.15 K. Tie-line compositions were correlated by Othmer-Tobias method. The universal quasichemical functional group activity coefficient (UNIFAC) and modified UNIFAC methods were used to predict the phase equilibrium in the system using the interaction parameters between CH3, CH2, COOH, OH and H2O functional groups. Distribution coefficients and separation factors were evaluated for the immiscibility region. | S.Ismail Kirbaslar Sema Yüksel Erol Ince Ismail Boz | 2004 | Chinese Journal of Chemical Engineering2004，12，5： | 2 |
| 11 | Diffusing capacity limitations of the extent of lung volume reduction surgery in an animal model of emphysema显示文摘 | Chen J C Sema D L Brenner M | 1999 | J Thorac Cardiovasc Surg1999，117，4： | 2 |
| 12 | Effect of implanted Cl^- and deposited oxides on pitting behavior of aluminum显示文摘 | Sema L M Johnson C M Wall F D | 2005 | Journal of the Electrochemical Society2005，152，7： | 1 |
| 13 | A case of rhinocerebral mucormycosis presenting with garcin syndrome显示文摘 | Ozkul Ayca Basak Sema Ertugrul Mustafa Biilent | 2011 | Klimik Dergisi2011，24，3： | 1 |
| 14 | Comparison of the clinical efficacy of two different types of post systems which were restored with composite restorations显示文摘AIM To compare the efficacy of resin composite restorations, retained with either polyethylene or zirconia-rich glass fiber posts. METHODS Sixty-two single rooted maxillary and mandibularcentral incisor teeth in forty-four patients (15 males and 29 females; age range 15-32 years) were restored either with an ultrahigh molecular weight polyethylene(UHMWP) fiber post (Bondable Reinforcement Ribbon, DENSE, Ribbond, Seattle, WA, United States) or a zircon-rich glass fiber post (Snowpost, Lot H 040; Carbotech, Ganges, France). Then, direct resin composite restoration (Clearfil AP-X, Kuraray) was performed for both post systems in tooth color suitable. Patients were recalled for routine inspections at 6 mo, 1, 2 and 3 years.RESULTS The restorations were assessed during each recall evaluation according to predetermined clinical and radiographic criteria (periapical lesion; marginal leakage and integrity; color stability; surface stain and loss of retention of the post or the composite buildup material). The follow-up data showed no significant difference in these criteria between polyethylene fibre posts and zirconia-rich glass fibre posts.CONCLUSION The efficacy of resin composite restorations, retained with either polyethylene or zirconia-rich glass fiber posts were similar, suggesting that both types of fiber post can be used successfully to help retain resin composite restorations. | Buket Ayna Emrah Ayna Sema Celenk Emine Goncü Bacaran Berivan Dündar Yιlmaz Ìbrahim Halil Tacir Mehmet Cudi Tuncer | 2018 | World Journal of Clinical Cases2018，6，3： | 1 |
| 15 | LOCKHEED Martin Missiles & Space:Managing Change for a New Era显示文摘 | | 1997 | Electronic News1997，43，2171： | 1 |
| 16 | An early comparison between endoscopic ul trasound-guided fine-needlea spiration and mediastinoscopy for diagnosis of mediastinal malignancy显示文摘 | Sema DL Aryan HE Chang KJ | 1998 | Am Surg1998，64，10： | 1 |
| 17 | Separation of IPA/water mixtures by pervaporation: sorption and pervaporation results显示文摘 | Nilufer D H Sema T | 2004 | Vacuum2004，72，： | 1 |
| 18 | Live Donor Liver Transplantation for Acute Liver Failure显示文摘 | Murat Kilic Unal Aydin Aysin Noyan Cigdem Arikan Sema Aydogdu Murat Akyildiz Zeki Karasu Murat Zeytunlu Mehmet Alper Yucel Batur | 2007 | Transplantation2007，，4： | 1 |
| 19 | Substrate specificities in hydrolysis of polyhydroxyalkanoates by microbial esterases显示文摘 | Mukai K Doi Y Sema Y | 1993 | Biotechnol Lett1993，15，： | 1 |
| 20 | Effects of zinc and boron on fruit and quality traits in pineapple(Ananas comosus L)显示文摘 | Kar P L Sema A Maiti C S Singh A K Bendangsengla A | 2002 | South Indian Horticulture2002，50，16： | 1 |
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