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| 1 | Outcomes of partial splenic embolization in patients with massive splenomegaly due to idiopathic portal hypertension显示文摘AIM To determine the outcomes of partial splenic em-bolization(PSE) for massive splenomegaly due to idiopathic portal hypertension(IPH).METHODS In this prospective study, we evaluated the charac-teristics and prognosis of consecutive patients with IPH who underwent PSE for all indications at a single medical center between June 2009 and January 2015. The inclusion criteria were: presence of hypersplenism, massive splenomegaly, and resultant pancytopenia. The exclusion criteria were: presence of other diseases causing portal hypertension. During the post-PSE period, the patients were hospitalized. All patients underwent abdominal computed tomography imaging 4 wk post-PSE to determine total splenic and non-infarcted splenic volumes.RESULTS A total of 11 patients, with median age of 33.27 ± 4.8 years, were included in the study. Mean spleen size was 22.9 cm(21-28 cm), and severe hypersplenismwas diagnosed in all patients before PSE. Post-PSE, leukocyte and platelet counts increased significantly, reaching peak levels in the second week with gradual decreases thereafter. Liver function tests did not exhibit significant changes during post-intervention follow-up. All patients developed post-embolization syndrome, and one patient experienced serious complications; all complications were successfully treated with conservative therapy and no death occurred. CONCLUSION Our findings showed that PSE has a lower complication rate than previously-reported surgical complication rates, which supports this intervention as a viable alternative for high-risk operable patients with severe hypersplenism. | Omer Ozturk Gonca Eldem Bora Peynircioglu Taylan Kav Aysegul Gormez Barbaros Erhan Cil Ferhun Balkanci Cenk Sokmensuer Yusuf Bayraktar | 2016 | World Journal of Gastroenterology2016，22，43： | 18 |
| 2 | Expression of Notch pathway components (Numb, Itch, and Siah-1) in colorectal tumors: A clinicopathological study显示文摘BACKGROUND The role of the Notch pathway in carcinogenesis and tumor progression has been demonstrated in many organs,including the colon.Accordingly,studies aimed at developing therapies targeting this pathway in various cancers require the identification of several factors that may play a role in regulating Notch-1 expression.Although Numb,Itch,and seven in absentia homolog-1(Siah-1)have been shown to contribute to the regulation of Notch signaling,their role in colorectal carcinogenesis and tumor progression has not been fully elucidated to date.AIM To evaluate Numb,Itch,and Siah-1 expression in colorectal tumors to clarify their relationship with Notch-1 expression and their role in carcinogenesis and tumor behavior.METHODS Expression of Notch-1,Numb,Itch,and Siah-1 was investigated in 50 colorectal carcinomas,30 adenomas,and 20 healthy colonic tissues by immunohistochemistry and quantitative real-time polymerase chain reaction(PCR)analyses.RESULTS In contrast to Notch-1,which is expressed at higher levels in tumor tissues and adenomas,expression of Numb,Itch,and Siah-1 was stronger and more frequent in normal mucosa(P<0.01).There was a positive correlation between Notch-1 expression and high histological grade,the presence of lymph node metastasis,and advanced-stage tumors,whereas expression of Numb,Itch,and Siah-1 was absent or reduced in tumors with these clinicopathological parameters(P<0.05).In survival analysis,expression of Notch was related to poor prognosis but that of Numb,Itch,and Siah-1 correlated with improved survival(P<0.05).Multivariate analysis revealed Notch-1 expression and loss of Numb expression to be independent prognostic parameters together with lymph node metastasis(P<0.05).CONCLUSION Our findings support the role of Notch-1 in colorectal carcinoma and indicate that loss of Numb,Itch,and Siah-1 expression is associated with carcinogenesis.Our data also suggest that these three proteins might be involved in the Notch-1 pathway during colorectal carcinoma(CRC)progression and might play an essential role in approaches targeting Notch as novel molecular therapies for CRC. | Sinem Cil Gonulcu Betul Unal Ibrahim Cumhur Bassorgun Mualla Ozcan Hasan Senol Coskun Gulsum Ozlem Elpek | 2020 | World Journal of Gastroenterology2020，26，26： | 5 |
| 3 | First dorsal metacarpal arte-ry adipofascial flap for thenar burn contracture releasing显示文摘 | CIL Y ESKI M ISIK S | 2008 | BURNS2008，34，1： | 1 |
| 4 | Lanfivudine for the prevention of hepatitis B virus reactivation in hepatitis-B surface antigen(HBSAG) seropositive cancer patients undergoing cytotoxic chemotherapy显示文摘 | Cil T Altintas A Pasa S | 2008 | Leuk Lymphoma2008，49，5： | 1 |
| 5 | Distally hased venous flap:a new technique for the correction of syndaetyly without skin graft in adult patients 显示文摘 | End-of-skin grafts in flap for web Space defeets Cil Y Kocman AE Yapici AK | 2009 | Chir Orqani Mov2009，93，3： | 1 |
| 6 | Cardiac thrombus in Omenn syndrome显示文摘 | Kilic SS Cil E Meral A et ol | 2005 | Pediatr Cardiol2005，26，5： | 1 |
| 7 | Endothelial Dysfunction and Increased Responses to Renal Nerve Stimulation in Rat Kidneys during Rhabdomyolysis-Induced Acute Renal Failure: Role of Hydroxyl Radical显示文摘 | Onur Cil Mert Ertunc Kadri Safak Gucer Fatih Ozaltin Alper Bektas Iskit Rustu Onur | 2012 | Renal Failure2012，，2： | 1 |
| 8 | Consumption universes based supermarket layout through association rule mining and multidimensional scaling显示文摘 | Ibrahim Cil | 2012 | Expert Systems With Applications2012，，： | 1 |
| 9 | Convex growth arrest in the treatment of congenital spinal deformities,revisited显示文摘 | Uzumcugil A Cil A Yazici M | 2004 | J Pediatr Orthop2004，24，6： | 1 |
| 10 | The efficacy of rituximab in patients with splenectomized refractory chronic idiopathic thrombocythopenic purpura显示文摘 | Pasa S Altintas A Cil T | 2009 | J Thromb Thrombolysis2009，27，3： | 1 |
| 11 | Ongoing pregnancies from early retrieval of prematurely developing antral follicles after DHEA supplementation显示文摘 | SONMEZER M CIL AP OKTAY K | 2009 | Reprod Biomed Online2009，19，6： | 1 |
| 12 | Henoch-Schonlein purpurawith high factor Ⅷ levels and deep venous thrombosis: an association or coincidence 显示文摘 | TOPALOGLU R BAYRAKCI US CIL B | 2008 | Rheumatol Int Germany2008，28，9： | 1 |
| 13 | Reliability and validity of adapted Turkish Version of Scoliosis Research Society-22 (SRS-22) questionnaire显示文摘 | Alanay A Cil A Berk H | 2005 | Spine2005，30，21： | 1 |
| 14 | Isolated cortical vein thrombosisafter epidural anesthesia:report of three cases显示文摘 | Yildiz OK Balaban H Cil G | 2010 | Int J Neurosci2010，120，： | 1 |
| 15 | Reliability and validity of adapted Turkish Version of Scoliosis Research Society-22 (SRS-22) questionnaire显示文摘 | Alanay A Cil A Berk H | 2005 | Spine (Phila Pa 1976)2005，30，21： | 1 |
| 16 | Anatomical basis of the change in leaf mass per area and nitrogen investment with relative irradianee within the canopy of eight temperate tree species 显示文摘 | ARANDA I PARDO F CIL L | 2004 | Acta Oecologia2004，25，3： | 1 |
| 17 | Lamivudine for the prevention of hepatitis B virus reactivation in hepatitis-B surface antigen (HB- SAG) seropositive cancer patients undergoing cytotoxic chemo- therapy显示文摘 | Cil T Altintas A Pasa S | 2008 | Leuk Lymphoma2008，49，5： | 1 |
| 18 | Analytical performance of a direct assay for LDL-cholesterol: a comparative as- sessment versus Friedewald's formula 显示文摘 | Turkalp I Cil Z Ozkazanc D | 2006 | Anadolu Kardiyol Derg2006，5，1： | 1 |
| 19 | Antioxidant phenolic metabolites from fruit and vegetables and changes during postharvest storage and processing显示文摘 | Tomas-Barberan F A Ferreres F Cil M I | | 0，，： | 1 |
| 20 | Linked elbow replacement:a salvage procedure for distal humeral nonun-ion显示文摘 | Cil A Veillette CJH Sanchez-Sotelo J | 2008 | J Bone Joint Surg Am2008，90，9： | 1 |
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