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| 1 | Soluble forms of extracellular cytokeratin 18 may differentiate simple steatosis from nonalcoholic steatohepatitis显示文摘AIM: To investigate whether serum levels of two soluble forms of extracellular cytokeratin 18 (M30-antigen and M65-antigen) may differentiate nonalcoholic steatohepatitis (NASH) from simple steatosis in patients with nonalcoholic fatty liver disease (NAFLD). METHODS: A total of 83 patients with suspected NAFLD and 49 healthy volunteers were investigated. Patients with suspected NAFLD were classified according to their liver histology into four groups: definitive NASH (n = 45), borderline NASH (n = 24), simple fatty liver (n = 9), and normal tissue (n = 5). Serum levels of caspase-3 generated cytokeratin-18 fragments (M30-antigen) and total cytokeratin-18 (M65-antigen) were determined by ELISA. RESULTS: Levels of M30-antigen and M65-antigen were significantly higher in patients with definitive NASH compared to the other groups. An abnormal value (> 121.60 IU/L) of M30-antigen yielded a 60.0% sensitivity and a 97.4% specificity for the diagnosis of NASH. Sensitivity and specificity of an abnormal M65-antigen level (> 243.82 IU/L) for the diagnosis of NASH were 68.9% and 81.6%, respectively. Among patients with NAFLD, M30-antigen and M65-antigen levels distinguished between advanced fibrosis and early-stage fibrosis with a sensitivity of 64.7% and 70.6%, and a specificity of 77.3% and 71.2%, respectively. CONCLUSION: Serum levels of M30-antigen and M65-antigen may be of clinical usefulness to identify patients with NASH. Further studies are mandatory to better assess the role of these apoptonecrotic biomarkers in NAFLD pathophysiology. | Yusuf Yilmaz Enver Dolar Engin Ulukaya Semra Akgoz Murat Keskin Murat Kiyici Sibel Aker Arzu Yilmaztepe Selim Gurel Macit Gulten Selim Giray Nak | 2007 | World Journal of Gastroenterology2007，13，6： | 19 |
| 2 | 对比偏头痛和发作性紧张型头痛的头痛前期症状和触发因素:二者是否具有相似的临床病理生理学机制 | Karli N. Zarifoglu M. Calisir N. Akgoz S. 周永 | 2005 | 世界核心医学期刊文摘(神经病学分册)2005，0，9： | 2 |
| 3 | Medical experience of a university hospital in Turkey after the 1999 Marmara earthquake显示文摘 | Bulut M Fedakar R Akkose S Akgoz S Ozguc H Tokyay R | 2005 | Emerg Med J2005，22，： | 1 |
| 4 | Rehabilitation outcome after traumatic brtain injury显示文摘 | Irdesel J Aydiner SB Akgoz S | 2007 | Neurocirugia(Astur)2007，18，1： | 1 |
| 5 | The levels of caspase-cleaved cytokeratin 18 are elevated in serum from patients with lung cancer and helpful to predict the survival显示文摘 | Ulukaya E Yilmaztepe A Akgoz S | 2007 | Lung Cancer2007，56，3： | 1 |
| 6 | Rehabilitation outcomeafter traumatic brain injury 显示文摘 | Irdesel J Aydiner S B Akgoz S | 2007 | Neurocirugia2007，18，1： | 1 |
| 7 | The safety and efficacy of the Angio-Seal closure device in diagnostic and interventional neuroangiography setting: a single-center experience with 1,443 closures显示文摘 | Serdar Geyik Kivilcim Yavuz Ayca Akgoz Osman Koc Bora Peynircioglu Barbaros Cil Saruhan Cekirge Isil Saatci | 2007 | Neuroradiology2007，，9： | 1 |
| 8 | The levels of caspase cleaved cytokeratin 18 are elevated in serum from patients with lung cancer and helpful to predict the survival显示文摘 | Ulukaya E Yilmaztepe A Akgoz S | 2007 | Lung Cancer2007，56，3： | 1 |
| 9 | Multidetectorrow computed tomography findings of sclerosing mesenteritis with associated diseases and its prevalence显示文摘 | CANYIGIT M KOKSAL A AKGOZ A | 2011 | Jpn J Radiol2011，29，7： | 1 |
| 10 | The effect of blood albumin and total lymphocyte count on short-term results in elderly patients with hip fractures显示文摘 | OZTURK A OZKAN Y AKGOZ S | 2009 | Ulus Travma Acil Cerrahi Derg2009，15，6： | 1 |
| 11 | Diagnostic efficacy of low dose paranasal sinus CT examination显示文摘 | Metin K Arslan A Akgoz Y | 2003 | Tani Girisim Radyol2003，9，3： | 1 |
| 12 | Comparison of reboxetine and sertraline in terms of efficacy and safety in major depressive disorder显示文摘 | Eker SS Akkaya C Akgoz S | 2005 | TurkPsikiyatriDerg2005，16，3： | 1 |
| 13 | Comparison of efficacy and tolerability of reboxetine and venlafaxine XR in major depression andmajordepression with anxiety features:an open label study 显示文摘 | Akkaya C Sivrioglu EV Akgoz S | 2006 | Hum Psychopharmacol2006，21，5： | 1 |
| 14 | Diagnostic efficacy of low dose paranasal sinus CT examination显示文摘 | Metin K Arslan A Akgoz Y | 2003 | Tani-Girisim-Radyol2003，9，3： | 1 |
| 15 | Comparison of efficacy and tolerability of reboxetine and venlafaxine XR in major depression and major depression with anxiety features: an open label study显示文摘 | AKKAYA C SIVRIOGLU E V AKGOZ S | 2006 | Hum Psychopharmacol2006，21，5： | 1 |
| 16 | Comparison of reboxetine and sertraline in terms of efficacy and safety in major depressive disorder显示文摘 | EKER S S AKKAYA C AKGOZ S | 2005 | Turk Psikiyatri Derg2005，16，3： | 1 |
| 17 | The effects of acute acetaminophen toxicity on hepatic mRNA expression of SOD, CAT, GSH-Px, and levels of peroxynitrite, nitric oxide, reduced glutathione, and malondialdehyde in rabbit显示文摘 | Yilmaz Cigremis Huseyin Turel Kevser Adiguzel Muslum Akgoz Asim Kart Musa Karaman Hasan Ozen | 2009 | Molecular and Cellular Biochemistry (-)2009，，1： | 1 |
| 18 | Multidetector-row computed tomography findings of sclerosing mesenteritis with associated diseases and its prevalence 显示文摘 | Canyigit M Koksal A Akgoz A | 2011 | Jpn J Radial2011，29，7： | 1 |
| 19 | Comparison of the effectiveness and side-effects of tolterodine and oxybutynin in children with detrusor instability显示文摘 | i Kilic N Balkan E Akgoz S Sen N Dognayol H | 2006 | Int J Urol2006，13，2： | 1 |
| 20 | Diagnostic efficacy oflow dose paranasal sinus CT examination 显示文摘 | Metin K Arslan A Akgoz Y | 2003 | Tani - Girisim - Radyol2003，9，3： | 1 |
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