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| 1 | Nat Genet:单细胞分析解开结直肠癌细胞的神秘面纱显示文摘结合单细胞基因组学和计算机技术,一个研究团队(包括来自杰克逊实验室(JAx)单细胞生物学主任Paul Robson博士在内)鉴定出了11种结直肠癌肿瘤的癌细胞组成及邻近的非癌细胞。这对于更好的肿瘤靶向诊断和治疗很重要。”使用单细胞测序。”JAX科学家、这篇发表在Nature Genetics上的文章共同第一作者Elise Courtois说道。”我们可以根据肿瘤中的细胞组成将结直肠癌进一步分类。因为每种亚型的肿瘤病人生存率存在差别,我们的方法将为肿瘤医生提供更多的关于肿瘤预后和治疗的信息。” | Huipeng Li, Elise T Courtois, Debarka Sengupta, Yuliana Tan Shyam Prabhakar Elise T Courtois, Yuliana Tan Paul Robson Debarka Sengupta Kok Hao Chen, Jolene Jie Lin Goh Paul Jongjoon Choi Say Li Kong, Axel M Hillmer Iain Beehuat Tan Clarinda Chua Iain Beehuat Tan Lim Kiat Hon Wah Siew Tan Mark Wong Lawrence J K Wee Iain Beehuat Tan Paul Robson Paul Robson Paul Robson | 2017 | 现代生物医学进展2017，17，15： | 37 |
| 2 | Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial显示文摘 | Axel Grothey Eric Van Cutsem Alberto Sobrero Salvatore Siena Alfredo Falcone Marc Ychou Yves Humblet Olivier Bouché Laurent Mineur Carlo Barone Antoine Adenis Josep Tabernero Takayuki Yoshino Heinz-Josef Lenz Richard M Goldberg Daniel J Sargent Frank Ciho | 2012 | The Lancet2012，，： | 10 |
| 3 | Chronic intestinal failure and short bowel syndrome in Crohn’s disease显示文摘Chronic intestinal failure(CIF)is a rare but feared complication of Crohn’s disease.Depending on the remaining length of the small intestine,the affected intestinal segment,and the residual bowel function,CIF can result in a wide spectrum of symptoms,from single micronutrient malabsorption to complete intestinal failure.Management of CIF has improved significantly in recent years.Advances in home-based parenteral nutrition,in particular,have translated into increased survival and improved quality of life.Nevertheless,60%of patients are permanently reliant on parenteral nutrition.Encouraging results with new drugs such as teduglutide have added a new dimension to CIF therapy.The outcomes of patients with CIF could be greatly improved by more effective prevention,understanding,and treatment.In complex cases,the care of patients with CIF requires a multidisciplinary approach involving not only physicians but also dietitians and nurses to provide optimal intestinal rehabilitation,nutritional support,and an improved quality of life.Here,we summarize current literature on CIF and short bowel syndrome,encompassing epidemiology,pathophysiology,and advances in surgical and medical management,and elucidate advances in the understanding and therapy of CIF-related complications such as catheter-related bloodstream infections and intestinal failure-associated liver disease. | Aysegül Aksan Karima Farrag Irina Blumenstein Oliver Schröder Axel U Dignass Jürgen Stein | 2021 | World Journal of Gastroenterology2021，27，24： | 4 |
| 4 | Second European evidence-based consensus on the diagnosis and management of ulcerative colitis: Special situations显示文摘 | Gert Van Assche Axel Dignass Bernd Bokemeyer Silvio Danese Paolo Gionchetti Gabriele Moser Laurent Beaugerie Fernando Gomollón Winfried H?user Klaus Herrlinger Bas Oldenburg Julian Panes Francisco Portela Gerhard Rogler Jürgen Stein Herbert Tilg Simon Tra | 2012 | Journal of Crohn’s and Colitis2012，，： | 4 |
| 5 | MicroRNAs in the Human Heart: A Clue to Fetal Gene Reprogramming in Heart Failure显示文摘 | Thomas Thum Paolo Galuppo Christian Wolf Jan Fiedler Susanne Kneitz Linda W. van Laake Pieter A. Doevendans Christine L. Mummery Jürgen Borlak Axel Haverich Carina Gross Stefan Engelhardt Georg Ertl Johann Bauersachs | 2007 | Circulation2007，，3： | 3 |
| 6 | Quantum model simulations of attosecond electron diffraction显示文摘Ultrafast diffraction with free attosecond electron pulses promises insight into the four-dimensional motion of charge density inatoms,molecules and condensed matter. Here we consider the quantum dynamics of the electron-electron scattering process on anattosecond time scale. By numerically solving the time-dependent two-electron Schrdinger equation,we investigate the interactionof an incoming keV-range electron wavepacket by the bound electron of an aligned H+2 molecule,using a one-dimensional model.Our findings reveal the ratio of elastic to inelastic contributions,the role of exchange interaction,and the influence of the molecularelectron density to diffraction. Momentum transfer during the scattering process,from the incoming to the bound electron mediatedby the nuclei,leaves the bound electron in a state of coherent oscillation with attosecond recurrences. Entanglement causes relatedstate-selective oscillations in the phase shift of the scattered electron. Two scenarios of distinguishable and indistinguishable freeand bound electrons yield equivalent results,irrespective of the electronic spins. This suggests to employ the scenario of distinguishable electrons,which is computationally less demanding. Our findings support the possibility of using electron diffraction forimaging the motion of charge density,but also suggest the application of free electron pulses for inducing attosecond dynamics. | Peter BAUM Jrn MANZ Axel SCHILD | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，6： | 3 |
| 7 | Global review and synthesis of trends in observed terrestrial near-surface wind speeds: Implications for evaporation显示文摘 | Tim R. McVicar Michael L. Roderick Randall J. Donohue Ling Tao Li Thomas G. Van Niel Axel Thomas Jürgen Grieser Deepak Jhajharia Youcef Himri Natalie M. Mahowald Anna V. Mescherskaya Andries C. Kruger Shafiqur Rehman Yagob Dinpashoh | 2011 | Journal of Hydrology2011，，： | 2 |
| 8 | Long-term Results of Partial Pancreaticoduodenectomy for Ductal Adenocarcinoma of the Pancreatic Head: 25-Year Experience显示文摘 | Axel Richter M.D. Marco Niedergethmann M.D. J?rg W. Sturm M.D. Dietmar Lorenz M.D. Stefan Post M.D. Michael Trede M.D | 2003 | World Journal of Surgery2003，，3： | 2 |
| 9 | Transvaginal/Transumbilical Hybrid—NOTES—Versus 3-Trocar Needlescopic Cholecystectomy: Short-term Results of a Randomized Clinical Trial显示文摘 | Dirk Rolf Bulian Jürgen Knuth Nicola Cerasani Axel Sauerwald Rolf Lefering Markus Maria Heiss | 2015 | Annals of Surgery2015，，3： | 2 |
| 10 | Identification of Gene Expression–Based Prognostic Markers in the Hematopoietic Stem Cells of Patients With Myelodysplastic Syndromes显示文摘 | Andrea Pellagatti Axel Benner Ken I. Mills Mario Cazzola Aristoteles Giagounidis Janet Perry Luca Malcovati Matteo G. Della Porta Martin J?dersten Amit Verma Emma-Jane McDonald Sally Killick Eva Hellstr?m-Lindberg Lars Bullinger James S. Wainscoat Jacquel | 2013 | Journal of Clinical Oncology2013，，28： | 2 |
| 11 | Long-term Results of Partial Pancreaticoduodenectomy for Ductal Adenocarcinoma of the Pancreatic Head: 25-Year Experience显示文摘 | Axel Richter Marco Niedergethmann J?rg W. Sturm Dietmar Lorenz Stefan Post Michael Trede | 2003 | World Journal of Surgery2003，，3： | 2 |
| 12 | Pro-fibrogenic potential of PDGF-D in liver fibrosis显示文摘 | Erawan Borkham-Kamphorst Claudia R.C. van Roeyen Tammo Ostendorf Jürgen Floege Axel M. Gressner Ralf Weiskirchen | 2007 | Journal of Hepatology2007，，6： | 2 |
| 13 | Interleukin-33 – cytokine of dual function or novel alarmin?显示文摘 | Guttorm Haraldsen Johanna Balogh Jürgen Pollheimer Jon Sponheim Axel M. Küchler | 2009 | Trends in Immunology2009，，5： | 1 |
| 14 | Nuclear Interleukin-33 Is Generally Expressed in Resting Endothelium but Rapidly Lost upon Angiogenic or Proinflammatory Activation显示文摘 | Axel M. Küchler Jürgen Pollheimer Johanna Balogh Jon Sponheim Linda Manley Dag R. Sorensen Paula M. De Angelis Helge Scott Guttorm Haraldsen | 2008 | The American Journal of Pathology2008，，4： | 1 |
| 15 | Effect of Gamma Irradiation on Human Cortical Bone Transplants Contaminated with Enveloped and Non-enveloped Viruses显示文摘 | Axel Pruss Moujahed Kao Uwe Gohs Jürgen Koscielny Rüdiger von Versen Georg Pauli | 2002 | Biologicals2002，，： | 1 |
| 16 | Transaction costs,institutional rigidities and the size of the clean development mechanism 显示文摘 | FRANK J | 2005 | Energy Policy2005，，33： | 1 |
| 17 | Metalloproteinase Disintegrins ADAM8 and ADAM19 Are Highly Regulated in Human Primary Brain Tumors and their Expression Levels and Activities Are Associated with Invasiveness显示文摘 | Dirk Wildeboer Silvia Naus Qing-Xiang Amy Sang J?rg W. Bartsch Axel Pagenstecher | 2006 | Journal of Neuropathology and Experimental Neurology2006，，5： | 1 |
| 18 | Chemoradiotherapy with capecitabine versus fluorouracil for locally advanced rectal cancer: a randomised, multicentre, non-inferiority, phase 3 trial显示文摘 | Ralf-Dieter Hofheinz Frederik Wenz Stefan Post Axel Matzdorff Stephan Laechelt J?rg T Hartmann Lothar Müller Hartmut Link Markus Moehler Erika Kettner Elisabeth Fritz Udo Hieber Hans Walter Lindemann Martina Grunewald Stephan Kremers Christian Constantin | 2012 | Lancet Oncology2012，，6： | 1 |
| 19 | Visualizing neuromodulation in vivo:TANGO-mapping of dopamine signaling reveals appetite control of sugar sensing显示文摘 | Inagaki Hidehiko K Ben-Tabou de-Leon S Wong AM Jagadish S Ishimoto H Barnea G Kitamoto T Axel R Anderson David J | | 0，，03： | 1 |
| 20 | All-tram retinoic acid regulates proliferation, migration, differentiation, and extracellular matrix turnover of human arterial smooth mus- cle cells显示文摘 | Axel DI Frigge A Dittmann J | 2001 | Cardiovasc Res2001，49，4： | 1 |
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