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| 1 | 氮流失对淡水和海洋受体富营养化的重要意义显示文摘本文探讨了挪威南部两个大的流域内氮负荷对淡水和海水的影响。较大地区的氮固留的变化将强烈影响淡水中的氮的浓度和海水中氮的负荷并导致水体富营养化。大气沉降的增加、水文条件的改变、由于氮'饱和'或酸化对植物根系的损害造成植物对氮吸收量的减少都会促进富营养化作用。气候的波动强烈影响季节经流模式。较长期的气候变化将会造成大量有机氮矿质化的增加。生物可利用性和季节模式以及营养物质的比率将是决定受者反应的主要决定因素。对于人烟稀少的石南荒地占优势的Bjerkreim流域,营养元素的比例强烈趋向于高氮/磷比。磷元素浓度远远低于淡水富营养化所需浓度,氮的增加只会进一步加强流行的磷的制约性。类似的情况还会出现在海域。流入海洋的河流中氮相对于磷或硅过量而导致近岸海区磷或硅成为暂时性的制约因素。Auli河流集约农业活动产生了高氮、磷输出的但很分散、很难预测的具有可变氮/磷比的径流峰。相对于海水中的氮或磷浓度而言,Bjerkreim河低浓度的矿物质养分意味着稀释在起着作用。而Auli河流域可能在河水和峡湾内部形成富营养化。由于营养物质浓度显著的季节性变化和岸流的作用,河源对营养物质的影响将在夏季达到最大。来自两个流域及其子流域的数据表明农业活动对氮流失的整体重要性。 | Dag O.Hessen Gjertrud Holtan Alte Hindar 李杭 | 1997 | 人类环境杂志1997，26，5： | 11 |
| 2 | 从挪威观点看贵州省生态博物馆项目显示文摘 | 达格·梅克勒伯斯特( Dag Myklebust ) 张晋平(译) | 2005 | 中国博物馆2005，，3： | 10 |
| 3 | A Criteria-based Assessment of the Coverage of Scopus and Web of Science显示文摘Purpose: The purpose of this study is to assess the coverage of the scientific literature in Scopus and Web of Science from the perspective of research evaluation.Design/methodology/approach: The academic communities of Norway have agreed on certain criteria for what should be included as original research publications in research evaluation and funding contexts. These criteria have been applied since 2004 in a comprehensive bibliographic database called the Norwegian Science Index(NSI). The relative coverages of Scopus and Web of Science are compared with regard to publication type, field of research and language.Findings: Our results show that Scopus covers 72 percent of the total Norwegian scientific and scholarly publication output in 2015 and 2016, while the corresponding figure for Web of Science Core Collection is 69 percent. The coverages are most comprehensive in medicine and health(89 and 87 percent) and in the natural sciences and technology(85 and 84 percent). The social sciences(48 percent in Scopus and 40 percent in Web of Science Core Collection) and particularly the humanities(27 and 23 percent) are much less covered in the two international data sources. Research limitation: Comparing with data from only one country is a limitation of the study, but the criteria used to define a country's scientific output as well as the identification of patterns of field-dependent partial representations in Scopus and Web of Science should be recognizable and useful also for other countries. Originality/value: The novelty of this study is the criteria-based approach to studying coverage problems in the two data sources. | Dag W.Aksnes Gunnar Sivertsen | 2019 | Journal of Data and Information Science2019，4，1： | 7 |
| 4 | Survival and an overview of decision-making in patients with cholangiocarcinoma显示文摘BACKGROUND:Cholangiocarcinoma is rare,accounting for approximately 3%of all gastrointestinal cancers.This study aimed to identify the survival rate among surgically treated and palliated patients,and secondly to identify parameters that could predict a curative resection. METHODS:A total of 121 patients,55 men and 66 women, median age 70 years(range 31-91),who had been treated for cholangiocarcinoma in the period of 1990-2005 were evaluated retrospectively. RESULTS:Curative resection was performed in 40 patients (33%),whereas 81 received palliative treatment(67%).16% (19 of 121)of the patients had an explorative laparotomy without tumour resection.Age above 65 years(OR 3.4;95% CI 1.4-8.4;P=0.008),weight loss(OR 8.5;95%CI 1.5-46; P=0.01)or tumour location(The resection rate of hilar cholangiocarcinoma was lower than that of intrapancreatic cancer.)(OR 2.7;95%CI 1.7-4.5;P=0.001)predicted palliative treatment.The adjusted 5-year survival rate of patients who received tumour resection and palliative treatment was 30%and 1.2%,respectively(P<0.001).The survival rate of patients who were subjected to hepatectomy (70%)was better than that of patients who had a local or distal resection(20%)(P=0.02). CONCLUSIONS:In few patients with a resectable cholangiocarcinoma,an explorative laparotomy is often necessary to evaluate resectability.However,long-term survival is significantly better in patients who received radical surgical resection. | Hvard Mjφrud Forsmo Arild Horn Asgaut Viste Dag Hoem Kjell φvrebφ | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，4： | 6 |
| 5 | 终末期肾衰竭男性患者血清中抗苗勒管激素水平降低显示文摘终末期肾病男性患者的生殖功能是受损的。紊乱的下丘脑一垂体.性腺轴及随后的性激素水平的调控是主要因素之一。我们的研究重点包括抗苗勒管激素(AMH)和抑制素B的水平。我们分析了20名平均年龄为40岁(26.48岁)。正在接受透析的男性患者的卵泡刺激素(FSH)、黄体生成素(LH)、催乳素、性激素结合球蛋白、睾酮、雌二醇、抗苗勒管激素及抑制素B的水平。对照组为144名平均年龄为32岁(19__44岁)的已婚育正常男性,并使用多元线性回归分析其差异性。终末期肾病男性患者的催乳素平均值742w210mIEl。(95%CI:60.3~729),黄体生成素平均值8.87IEl—VS4.5IE1。f95%CI:2.75-6.14),雌二醇平均值89.7VS79.0pmol1-1(95%Ch-1.31,-0.15)均显著高于对照组。抗苗勒管激素平均值19.5VS47-3pmol1-1(95%CI:-37.6.-11.6)较对照组显著降低。卵泡刺激素、性激素结合球蛋白、抑制素B以及睾酮水平未见明显差异。在所有分析中,睾丸支持细胞功能标志物抗苗勒管激素水平的下调最为显著,其浓度较对照组下降近60%。结合黄体生成素升高的发现,支持细胞功能的紊乱以及睾丸间质细胞的作用可能是导致终末期肾病男性患者生殖功能障碍的潜在机制。 | Dag Eckersten Aleksander Giwercman Anders Christensson | 2015 | Asian Journal of Andrology2015，17，1： | 4 |
| 6 | 陆源物质对海洋的污染:东海显示文摘东海的环境面临着长江流域及沿海地区人类活动和污染增长的巨大威胁。对自然资源的不合理利用及短期经济目标导致了环境在相当短的时间内出现了严重退化,现在已达到威胁沿海人民生命和健康的程度。主要污染物是无机氮、磷酸盐、石油类、有机物及重金属。营养物导致了沿海水域和河口的富营养化,常常引发赤潮。长江流域的环境污染直接影响了东海的海洋环境状况。稳定的河流来水在河口与海洋咸水混合,河流带来的泥沙平衡了三角洲及相邻地区的海洋侵蚀,这样,生态系统稳定性才能得到维持。长江流域的大规模调水及大坝的修建将改变这种基础。东海面临的挑战是扭转正在发生的负面过程,保持生态系统平衡。主要任务是把社会经济与环境决策结合起来,以促进可持续发展。需要更好地了解造成这些环境压力的社会驱动力,以克服这些障碍。国际合作也许能为促进进步作出重要贡献,尤其是,国际合作是取得良好进展和获得资金、技术、科学及人力资源的途径。 | 李道季 Dag Daler | 2004 | AMBIO-人类环境杂志2004，33，1： | 4 |
| 7 | 远洋系统中的持久性有机污染物(POPs)显示文摘有几项研究表明水生生物群中富营养化与持久性有机污染物(POPs)的吸收之间存在着相互作用。其主要概念是:由于营养物的过度排放,水生生态系统中生物量与生产增加,引起了一系列的变化,从而造成初级生产者(浮游植物)对POPs的吸收减少。其影响还会波及不同营养级的消费者。这一系列的变化可以间接地通过有机物沉淀的增加起作用,使污染物向底层的沉降流量增加,从而使污染物在底层被有机沉淀物所结合。这一系列的变化还会直接地起作用,作为'生长稀释'作用的后果,生长快速的浮游植物对POPs的吸收减少,使污染物在食物网中的转移减少。这种作用也可能是食物网结构改变的结果,而食物网结构的变化在寡营养型和富营养型的生态系统中极为不同。本文运用现有的有关不同营养状况的水生系统中POPs行为的知识,对波罗的海的富营养化与污染物之间的相互作用进行了讨论。波罗的海受到POPs的重度污染并正在富营养化是众所周知的。对湖泊进行调查的结果用于对实验室研究结果和在波罗的海的现场研究结果进行比较。 | Per Larsson Agneta Andersson Dag Broman Johan Nordbck Erik Lundberg 李应仁 | 2000 | AMBIO-人类环境杂志2000，29，4： | 3 |
| 8 | Morphology and motor function of the gastrointestinal tract examined with endosonography显示文摘Endosonography 是为学习胃肠道的形态学和运动机能的一个有用工具。管腔内 ultrasonography 是用被插入到官方补给的道的体内变换器的超声考试的普通命名。因此,内脏的墙和邻近的结构能详细被想象。这评论在肠胃病学描述 endosonography 的实用性,特别地关于机械的简历和胃肠道的运动机能的研究。象 3-D EUS, elastography 和种类率成像那样的新技术被讨论。 | Svein Odegaard Lars Birger Nesje Dag Arne Lihaug Hoff Odd Helge Gilja Hans Gregersen | 2006 | World Journal of Gastroenterology2006，12，18： | 3 |
| 9 | Integrated lipidomics and proteomics network analysis highlights lipid and immunity pathways associated with Alzheimer's disease显示文摘Background:There is an urgent need to understand the pathways and processes underlying Alzheimer's disease(AD)for early diagnosis and development of effective treatments.This study was aimed to investigate Alzheimer's dementia using an unsupervised lipid,protein and gene multi-omics integrative approach.Methods:A lipidomics dataset comprising 185 AD patients,40 mild cognitive impairment(MCI)individuals and 185 controls,and two proteomics datasets(295 AD,159 MCI and 197 controls)were used for weighted gene CO-expression network analyses(WGCNA).Correlations of modules created within each modality with clinical AD diagnosis,brain atrophy measures and disease progression,as well as their correlations with each other,were analyzed.Gene ontology enrichment analysis was employed to examine the biological processes and molecular and cellular functions of protein modules associated with AD phenotypes.Lipid species were annotated in the lipid modules associated with AD phenotypes.The associations between established AD risk loci and the lipid/protein modules that showed high correlation with AD phenotypes were also explored.Results:Five of the 20 identified lipid modules and five of the 17 identified protein modules were correlated with clinical AD diagnosis,brain atrophy measures and disease progression.The lipid modules comprising phospholipids,triglycerides,sphingolipids and cholesterol esters were correlated with AD risk loci involved in immune response and lipid metabolism.The five protein modules involved in positive regulation of cytokine production,neutrophil-mediated immunity,and humoral immune responses were correlated with AD risk loci involved in immune and complement systems and in lipid metabolism(the APOE ε4 genotype).Conclusions:Modules of tightly regulated lipids and proteins,drivers in lipid homeostasis and innate immunity,are strongly associated with AD phenotypes. | Jin Xu Giulia Bankov Min Kim Asger Wretlind Jodie Lord Rebecca Green Angela Hodges Abdul Hye Dag Aarsland Latha Velayudhan Richard J.B.Dobson Petroula Proitsi Cristina Legido-Quigley on behalf of the AddNeuroMed Consortium | 2020 | Translational Neurodegeneration2020，9，3： | 3 |
| 10 | 水生生态系统的富营养化和污染物显示文摘富营养化和长效污染物是欧洲海洋和淡水生态系统存在的主要环境问题。由于它们趋于共同产生,所以富营养化和污染物之间就有了相互作用,因而无法根据它们各自独立的作用过程来预测它们共同导致的环境影响。为了预测防治措施(改变有机质、营养物和污染物的输入)的效果,认识改变生物可利用性和污染物的迁移转化的机制是非常重要的。环境风险取决于污染物的种类形成和它们与媒介及其物质间的联系,并以此影响暴露程度。而且,风险也将取决于物质的流动性和它们在食物链中的路径。1995年,瑞典环境保护局发起了一项为期5年的研究项目'富营养化和污染物之间的相互作用(EUCON)'。前期准备的有关背景资料罗列了大量相关的问题和假设。在这些资料的基础上,项目开始启动,主要致力于海洋环境研究,重点集中在波罗的海及湖泊的富营养化和污染物(持续性有机化合物和微量金属)的相互作用上。本文总结了该项目研究的现状、前提和重点部分,强调了研究结果的应用及其意义。 | Jens Skei Per Larsson Rutger Rosenberg Per Jonsson Mats Olsson Dag Broman 鲁春霞 | 2000 | AMBIO-人类环境杂志2000，29，4： | 2 |
| 11 | Wettability alteration in chalk显示文摘 | Dag C Standnes Tor Austad | 2000 | Journal of Petroleum Science and Engineering2000，，3： | 2 |
| 12 | Mucosal blood flow measurements using laser Doppler perfusion monitoring显示文摘Perfusion of individual tissues is a basic physiological process that is necessary to sustain oxygenation and nutrition at a cellular level. Ischemia, or the insuff iciency of perfusion, is a common mechanism for tissue death or degeneration, and at a lower threshold, a mechanism for the generation of sensory signalling including pain. It is of considerable interest to study perfusion of pe- ripheral abdominal tissues in a variety of circumstances. Microvascular disease of the abdominal organs has been implicated in the pathogenesis of a variety of disorders, including peptic ulcer disease, inflammatory bowel disease and chest pain. The basic principle of laser Doppler perfusion monitoring (LDPM) is to analyze changes in the spectrum of light reflected from tissues as a response to a beam of monochromatic laser light emitted. It reflects the total local microcirculatory blood perfusion, including perfusion in capillaries, arterioles, venules and shunts. During the last 20-25 years, numerous studies have been performed in different parts of the gastroin-testinal (GI) tract using LDPM. In recent years we have developed a multi-modal catheter device which includes a laser Doppler probe, with the intent primarily to investigate patients suffering from functional chest pain of presumed oesophageal origin. Preliminary studies show the feasibility of incorporating LDPM into such catheters for performing physiological studies in the GI tract. LDPM has emerged as a research and clinical tool in preference to other methods; but, it is important to be aware of its limitations and account for them when reporting results. | Dag Arne Lihaug Hoff Hans Gregersen Jan Gunnar Hatlebakk | 2009 | World Journal of Gastroenterology2009，15，2： | 2 |
| 13 | Wettability alteration in chalk显示文摘 | Dag C Standnes Tor Austad | 2000 | Journal of Petroleum Science and Engineering2000，，3： | 2 |
| 14 | Motor fluctuations and Helicobacter pylori in Parkinson’s disease显示文摘 | Karl-Erik Rahne Carl Tagesson Dag Nyholm | 2013 | Journal of Neurology2013，，12： | 2 |
| 15 | Pilot Study of Sentinel-Node-Based Adoptive Immunotherapy in Advanced Colorectal Cancer显示文摘 | Mona Karlsson PhD Per Marits PhD Kjell Dahl PhD Tobias Dag?? MD Sven Enerb?ck Magnus Th?rn Ola Winqvist | 2010 | Annals of Surgical Oncology2010，，7： | 2 |
| 16 | Folate and vitamin B12 in idiopathic male infertility显示文摘尽管 methylenetetrahydrofolate reductase,叶酸的酶基因,与自发的男不孕被联系了,很少研究检验了另外的叶酸相关的代谢物和基因。我们调查了自发的男不孕是否与变体被联系在叶酸,维生素 B 12(B12 ) 和全部的 homocysteine (tHcy ) 联系了基因并且在血测量了这些代谢物。我们进行了与自发的不孕和在生育力中心和胎儿的照顾中心招募的 184 肥沃的男控制包括了 153 个人的盒子控制研究,大学医院, Malmö并且 Lund,瑞典。浆液叶酸的、红房间叶酸(RCF ) ,浆液 B12,血浆 tHcy 和精液质量被测量。题目是为在与 folate/B12/homocysteine 新陈代谢有关的 12 基因的 20 普通变体的 genotyped。代谢物集中和遗传型分布为 covariates 与调整用线性、逻辑的回归在案例和控制之间被作比较。phosphatidylethanolamine N-methyltransferase (PEMT ) M175V 和 TCblR rs173665 多型性显著地与不孕被联系(P=0.01 和 P=0.009,分别地) ,然而并非与精液质量。在补充的非用户之中,有的不肥沃的人降低浆液叶酸的集中比肥沃的人(12.89 对 14.73 nmol l −1 ;P=0.02 ) ,但是在 RCF, B12 或 tHcy 没有重要差别。叶酸, B12 和 tHcy 集中没与任何精液参数被相关。这研究几乎不提供小支持为低叶酸或在自发的男不孕的致病的 B12 地位。尽管另外的数据被需要证实这些起始的调查结果,我们的结果建议那 PEMT 和 TCblR,基因在胆碱和 B12 新陈代谢包含了,在自发的男不孕应得进一步的调查。 | Laurel E Murphy James L Mills Anne M Molloy Cong Qian Tonia C Carter Helena Strevens Dag Wide-Swensson Aleksander Giwercman Richard J Levine | 2011 | Asian Journal of Andrology2011，13，6： | 2 |
| 17 | Major-effect candidate genes identified in cultivated strawberry(Fragaria×ananassa Duch.)for ellagic acid deoxyhexoside and pelargonidin-3-O-malonylglucoside biosynthesis,key polyphenolic compounds显示文摘Strawberries are rich in polyphenols which impart health benefits when metabolized by the gut microbiome,including anti-inflammatory,neuroprotective,and antiproliferative effects.In addition,polyphenolic anthocyanins contribute to the attractive color of strawberry fruits.However,the genetic basis of polyphenol biosynthesis has not been extensively studied in strawberry.In this investigation,ripe fruits from three cultivated strawberry populations were characterized for polyphenol content using HPLC-DAD-MSn and genotyped using the iStraw35k array.GWAS and QTL analyses identified genetic loci controlling polyphenol biosynthesis.QTL were identified on four chromosomes for pelargonidin-3-O-malonylglucoside,pelargonidin-3-O-acetylglucoside,cinnamoyl glucose,and ellagic acid deoxyhexoside biosynthesis.Presence/absence of ellagic acid deoxyhexoside and pelargonidin-3-O-malonylglucoside was found to be under the control of major gene loci on LG1X2 and LG6b,respectively,on the F.×ananassa linkage maps.Interrogation of gene predictions in the F.vesca reference genome sequence identified a single candidate gene for ellagic acid deoxyhexoside biosynthesis,while seven malonyltransferase genes were identified as candidates for pelargonidin-3-O-malonylglucoside biosynthesis.Homologous malonyltransferase genes were identified in the F.×ananassa‘Camarosa’genome sequence but the candidate for ellagic acid deoxyhexoside biosynthesis was absent from the‘Camarosa’sequence.This study demonstrated that polyphenol biosynthesis in strawberry is,in some cases,under simple genetic control,supporting previous observations of the presence or absence of these compounds in strawberry fruits.It has also shed light on the mechanisms controlling polyphenol biosynthesis and enhanced the knowledge of these biosynthesis pathways in strawberry.The above findings will facilitate breeding for strawberries enriched in compounds with beneficial health effects. | Jahn Davik Kjersti Aaby Matteo Buti Muath Alsheikh NadaŠurbanovski Stefan Martens Dag Røen Daniel James Sargent | 2020 | Horticulture Research2020，7，1： | 2 |
| 18 | 人类对氮循环的影响:从地区远景看全球问题显示文摘本章探讨有关全球氮循环中人为扰动的主要问题,并将项目研究中的一些地区性发现与大尺度影响联系起来。人类将大气中的N_2转化为生物化学活性更强的形式,这产生一系列的环境效应。本项目旨在评估挪威南部两大流域及其子流域的氮状况,并随着研究的进展阐述氮保持与流失的一些模式。对人口稀少的荒地而言,大气输入是氮的主要来源,约为2.5mg/m^2·a。低固定和明显的氮饱和源于大气氮的高输入,以及水文条件、土壤贫瘠和陆地磷的缺乏。在这个酸化的流域,NO_x和NH_x的扩散急剧下降,地表水的酸化中将近一半是由于氮的影响。磷的浓度较低,通常低干1μg/L,这使得流失物中氮/磷的比值高,从而导致淡水和近海中磷的缺乏。对农业化和森林覆盖的流域而言,大气中的氮沉降低于1.5mg/m^2·a,因此农业活动是氮的主要来源,同时淋溶水中氮和磷的浓度一般较高但波动较大。农业和林业是氮流失的主要因素。本流域入海口水流中高浓度的氮和磷是峡湾地区富营养化的主要原因。对两个流域而言,气候波动都强烈的影响氮的流失方式。氨盐的转化以及气候变化可能导致的土壤有机氮的矿质化都不可预测地作用于未来氮循环。 | Dag O.Hessen Arne Henriksen Atle Hindar Jan Mulder KjetilTφrseth Nils Vagstad 李本纲 | 1997 | 人类环境杂志1997，26，5： | 2 |
| 19 | Comparison of Nephelometric Turbidity Measurements Using Wavelengths 400 - 600 and 860 nm 显示文摘 | DAG H GUNVOR A | 1998 | Water Research ( S0043-1354 )1998，32，10： | 1 |
| 20 | Bacte-riocins of propionic acid bacteria 显示文摘 | Helge H Therese F Dag A B | 2002 | EPD Science2002，10，： | 1 |
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