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| 1 | Role of farnesoid X receptor and bile acids in alcoholic liver disease显示文摘Alcoholic liver disease(ALD) is one of the major causes of liver morbidity and mortality worldwide. Chronic alcohol consumption leads to development of liver pathogenesis encompassing steatosis, inflammation, fibrosis, cirrhosis, and in extreme cases, hepatocellular carcinoma. Moreover,ALD may also associate with cholestasis. Emerging evidence now suggests that farnesoid X receptor(FXR) and bile acids also play important roles in ALD. In this review, we discuss the effects of alcohol consumption on FXR, bile acids and gut microbiome as well as their impacts on ALD. Moreover, we summarize the findings on FXR, Fox O3a(forkhead box-containing protein class O3a) and PPARα(peroxisome proliferator-activated receptor alpha) in regulation of autophagy-related gene transcription program and liver injury in response to alcohol exposure. | Sharon Manley Wenxing Ding | 2015 | Acta Pharmaceutica Sinica B2015，5，2： | 12 |
| 2 | 非胰岛素依赖型糖尿病冠状动脉疾病的危险因素:英国糖尿病前瞻性研究(UKPDS:23)显示文摘目的:评价2型糖尿病患者冠状动脉疾病的基线危险因素。设计:对2 693例资料完整的患者进行年龄和性别调整的逐步选择过程分析,以确定哪些冠状动脉疾病的危险因素应纳入 Cox 比例风险模型。对象:3 055例白人患者,平均年龄52岁,均新近诊断为2型糖尿病,且无动脉粥样硬化相关疾病的证据。平均随访期7.9年。335例患者于10年内出现冠状动脉疾病。结局评定:具有明确异常心电图的心绞痛、致死或非致死性心肌梗塞。结果:冠状动脉疾病与低密度脂蛋白胆固醇浓度升高、高密度脂蛋白胆固醇浓度降低、甘油三酯浓度升高、高血红蛋白 A_(1c)、高收缩压、高空腹血糖以及吸烟史密切相关。低密度脂蛋白胆固醇较高1/3对较低1/3区间的估计风险比为2.26(95%可信区间为1.70~3.00),高密度脂蛋白胆固醇为0.55(0.41~0.73),血红蛋白 A_(1c)为1.52(1.15~2.01),收缩压为1.82(1.34~2.47)。吸烟者的估计风险比为1.41(1.06~1.88)。结论:2型糖尿病患者中,存在冠状动脉疾病潜在的、可变的5种危险因素的交叉重叠影响。它们是低密度脂蛋白胆固醇浓度升高、高密度脂蛋白胆固醇浓度降低、高血压、高血糖和吸烟。 | R C Turner H Millns H A W Neil I M Stratton S E Manley D R Matthews R R Holman 赵维纲 | 1998 | 英国医学杂志中文版1998，0，3： | 11 |
| 3 | New advances in molecular mechanisms and emerging therapeutic targets in alcoholic liver diseases显示文摘Alcoholic liver disease is a major health problem in the United States and worldwide. Chronic alcohol consumption can cause steatosis, inflammation, fibrosis, cirrhosis and even liver cancer. Significant progress has been made to understand key events and molecular players for the onset and progression of alcoholic liver disease from both experimental and clinical alcohol studies. No successful treatments are currently available for treating alcoholic liver disease; therefore, development of novel pathophysiological-targeted therapies is urgently needed. This review summarizes the recent progress on animal models used to study alcoholic liver disease and the detrimental factors that contribute to alcoholic liver disease pathogenesis including miRNAs, S-adenosylmethionine, Zinc deficiency, cytosolic lipin-1β, IRF3-mediated apoptosis, RIP3-mediated necrosis and hepcidin. In addition, we summarize emerging adaptive protective effects induced by alcohol to attenuate alcohol-induced liver pathogenesis including FoxO3, IL-22, autophagy and nuclear lipin-1α. | Jessica A Williams Sharon Manley Wen-Xing Ding | 2014 | World Journal of Gastroenterology2014，20，36： | 10 |
| 4 | Prediction of hepatocellular carcinoma biological behaviorin patient selection for liver transplantation显示文摘Morphological criteria have always been considered the benchmark for selecting hepatocellular carcinoma(HCC)patients for liver transplantation(LT).These criteria,which are often inappropriate to express the tumor’s biological behavior and aggressiveness,offer only a static view of the disease burden and are frequently unable to correctly stratify the tumor recurrence risk after LT.Alpha-fetoprotein(AFP)and its progression as well as AFP-m RNA,AFP-L3%,des-γ-carboxyprothrombin,inflammatory markers and other serological tests appear to be correlated with post-transplant outcomes.Several other markers for patient selection including functional imaging studies such as18F-FDG-PET imaging,histological evaluation of tumor grade,tissue-specific biomarkers,and molecular signatures have been outlined in the literature.HCC growth rate and response to pre-transplant therapies can further contribute to the transplant evaluation process of HCC patients.While AFP,its progression,and HCC response to pretransplant therapy have already been used as a part of an integrated prognostic model for selecting patients,the utility of other markers in the transplant setting is still under investigation.This article intends to review the data in the literature concerning predictors that could be included in an integrated LT selection model and to evaluate the importance of biological aggressiveness in the evaluation process of these patients. | Umberto Cillo Tommaso Giuliani Marina Polacco Luz Maria Herrero Manley Gino Crivellari Alessandro Vitale | 2016 | World Journal of Gastroenterology2016，22，1： | 7 |
| 5 | Differential reactivity of mouse monoclonal anti-HBs antibodies with recombinant mutant HBs antigens显示文摘AIM: To investigate the reactivity of a panel of 8 mouse anti-hepatitis B surface antigen (HBsAg) monoclonal antibodies (mAbs) using a collection of 9 recombinant HBsAg mutants with a variety of amino acid substitutions mostly located within the “a” region.METHODS: The entire HBs genes previously cloned into a mammalian expression vector were transiently transfected into COS7 cells. Two standard unmutated sequences of the ayw and adw subtypes served as controls. Secreted mutant proteins were collected and measured by three commercial diagnostic immunoassays to assess transfection efficiency. Reactivity of anti-HBs mAbs with mutated HBsAgs was determined by sandwich enzyme-linked immunosorbent assay (ELISA).RESULTS: Reactivity of anti-HBs mAbs with mutated HBsAgs revealed different patterns. While three mutants reacted strongly with all mAbs, two mutants reacted weakly with only two mAbs and the remaining proteins displayed variable degrees of reactivity towards different mAbs. Accordingly, four groups of mAbs with different but overlapping reactivity patterns could be envisaged. One group consisting of two mAbs (37C5-S7 and 35C6-S11) was found to recognize stable linear epitopes conserved in all mutants. Mutations outside the “a” determinant at positions 120 (P→S), 123(T→N) and 161(M→T) were found to affect reactivity of these mAbs.CONCLUSION: Our findings could have important implications for biophysical studies, vaccination strategies and immunotherapy of hepatitis B virus (HBV) mutants. | Azam Roohi Yaghoub Yazdani Jalal Khoshnoodi Seyed Mohammad Jazayeri William F Carman Mahmood Chamankhah Manley Rashedan Fazel Shokri | 2006 | World Journal of Gastroenterology2006，12，33： | 4 |
| 6 | Expansion of Bcr-Abl-Positive Leukemic Stem Cells Is Dependent on Hedgehog Pathway Activation显示文摘 | Christine Dierks Ronak Beigi Gui-Rong Guo Katja Zirlik Mario R. Stegert Paul Manley Christopher Trussell Annette Schmitt-Graeff Klemens Landwerlin Hendrik Veelken Markus Warmuth | 2008 | Cancer Cell2008，，3： | 2 |
| 7 | Aquaporin-4 detection in mice reduces brain edema after acute water intoxication and ischemic stroke显示文摘 | Manley GT Fujimura M Ma T | 2000 | Nat Med2000，6，： | 2 |
| 8 | 重型颅脑损伤的早期治疗(英文)显示文摘Severe traumatic brain injury remains a major health-care problem worldwide. Although major progress has been made in understanding of the pathophysiology of this injury,this has not yet led to substantial improvements in outcome. In this report,we address present knowledge and its limitations,research innovations,and clinical implications. Improved outcomes for patients with severe traumat- ic brain injury could result from progress in pharmacological and other treatments,neural repair and regeneration,optimisation of surgical indications and techniques,and combination and individually targeted treatments. Expanded classification of traumatic brain injury and in- novations in research design will underpin these advances. We are optimistic that further gains in outcome for patients with severe traumat- ic brain injury will be achieved in the next decade. | Rosenfeld JV Maas AI Bragge P Morganti-Kossmann MC Manley GT Gruen RL | 2012 | 中华神经外科疾病研究杂志2012，11，6： | 2 |
| 9 | Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and iachemic stroke显示文摘 | Manley GT Fujimura M Ma T | 2000 | Nat Med2000，6，2： | 1 |
| 10 | Aquaporin-4 deletion in mice reduces brain edema after acute water toxication and ischemic stroke显示文摘 | Manley GT Fujimura M Ma T | 2000 | Nat Med2000，6，2： | 1 |
| 11 | Volumetric Visualization: An Effective use of GIS Technology in the Field of Oceanography 显示文摘 | Manley T O Tallet J A | 1990 | Oceanography1990，3，： | 1 |
| 12 | Stage-specific changes in fetal thymocyte proliferation during the CD4-8- to CD4+8+ transition in wild type,Rag1-/-, and Hoxa3, Pax1 mutant mice 显示文摘 | Su DM and Manley N R | 2002 | BMC Immunol2002，3，： | 1 |
| 13 | Comparison of 11 human insulin assays: implications for clinical investiga?tion and research显示文摘 | Manley S E Stratton 1M Clark PM | 2007 | Clin Chern2007，53，5： | 1 |
| 14 | High-flow nasal cannulae for respiratory support of preterm infants: a review of the evi- dence 显示文摘 | Manley B J Dold SK Davis PG | 2012 | Neonatology2012，102，4： | 1 |
| 15 | Acute-phase serum amyloid A:perspectives on its physiological and pathological roles显示文摘 | Kisilevsky R Manley PN | 2012 | Amyloid2012，19，1： | 1 |
| 16 | Volumetric visualization:an effective use of GIS technology in the field of oceanography显示文摘 | Manley T O Tallet J A | | 0，，01： | 1 |
| 17 | Mechanisms of primary blast-induced traumatic brain injury: insights from shock-wave research 显示文摘 | Nakagawa A Manley GT Gean AD | 2011 | J Neurotrauma2011，28，6： | 1 |
| 18 | Aquaporin-4 gene deletion in mice increases focal edema associated with staphylococcal brain abscess显示文摘 | Bloch O Papadopoulos MC Manley GT | | J Neurochem0，95，1： | 1 |
| 19 | Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke 显示文摘 | Fujimura M Ma T | 2000 | Nat Med2000，6，1： | 1 |
| 20 | Estimated average glucose derived from HbA1 C(eAG) : report from European Association for the Study of Diabetes ( EASD ), Amsterdam 2007 显示文摘 | Manley S | 2008 | Diabetic Medicine2008，25，： | 1 |
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