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| 1 | 膨胀石墨对各种油类的吸附动力学(英文)显示文摘通过对吸附率(有效吸附系数)Ks和饱和吸附量msat的测量,描述了粘度为0.001Pa.s^0.850Pa.s的各种油类在膨胀石墨柱中的吸附动力学,发现吸附率Ks对油类粘度有很强的相关性。吸入膨胀石墨柱中的饱和吸附量msat几乎恒定在50kg/kg,该值略低于由膨胀石墨块直接浸渍在油中测得的吸附容量,这是由于所吸附的油沿膨胀石墨柱高度存在重力梯度。 | Michio INAGAKI Tomoya NAGATA Taisuke SUWA Masahiro TOYODA | 2006 | 新型炭材料2006，21，2： | 18 |
| 2 | Long-term maintenance of brain tumor stem cell properties under at non-adherent and adherent culture conditions显示文摘 | Inagaki A Soeda A Oka N Kitajima H Nakagawa J Motohashi T Kunisada T lwama T | 2007 | 中国神经肿瘤杂志2007，5，3： | 16 |
| 3 | Controversies regarding and perspectives on clinical utility of biomarkers in hepatocellular carcinoma显示文摘The prevalence of hepatocellular carcinoma(HCC)worldwide parallels that of persistent infection with the hepatitis B virus(HBV)and/or hepatitis C virus(HCV).According to recommendations by the World Health Organization guidelines for HBV/HCV,alpha-fetoprotein(AFP)testing and abdominal ultrasound should be performed in routine surveillance of HCC every 6 mo for high-risk patients.These examinations have also been recommended worldwide by many other HCC guidelines over the past few decades.In recent years,however,the role of AFP in HCC surveillance and diagnosis has diminished due to advances in imaging modalities.AFP was excluded from the surveillance and/or diagnostic criteria in the HCC guidelines published by the American Association for the Study of Liver Diseases in 2010,the European Association for the Study of the Liver in 2012,and the National Comprehensive Cancer Network in 2014.Other biomarkers,including the Lens culinaris agglutinin-reactive fraction of AFP(AFP-L3),des-γ-carboxyprothrombin,Dickkopf-1,midkine,and micro RNA,are being studied in this regard.Furthermore,increasing attention has focused on the clinical utility of biomarkers as pre-treatment predictors for tumor recurrence and as post-treatment monitors.Serum and tissue-based biomarkers and genomics may aid in the diagnosis of HCC,determination of patient prognosis,and selection of appropriate treatment.However,further studies are needed to better characterize the accuracy and potential role of these approaches in clinical practice. | Pei-Pei Song Ju-Feng Xia Yoshinori Inagaki Kiyoshi Hasegawa Yoshihiro Sakamoto Norihiro Kokudo Wei Tang | 2016 | World Journal of Gastroenterology2016，22，1： | 15 |
| 4 | Chinese Medicine as Complementary Therapy for Female Infertility显示文摘Chinese medicine(CM) has been used in clinical treatment for thousands of years in China, Japan, Korea, and other countries. CM is at present attracting many attentions around the world for reproductive health care and disease prevention, including treatment of female infertility. This review focuses on the CM treatment for female infertility patients, and supplies a summary on the efficacy, safety, and mechanism of some Chinese herbal medicines, herbal medicine-derived active compounds, and acupuncture. A large number of researches have reported that CM could alleviate or even cure female infertility by regulating hormone, improving reproductive outcome of in vivo fertilization, affecting embryonic implantation, curing polycystic ovarian syndrome, endometriosis, pelvic inflammatory disease, relieving mental stress, and regulating immune system. Meanwhile, a few studies claimed that there was little adverse reaction of CM in randomized controlled trials. However, up to present there is a lack of adequate evidences with molecular mechanistic researches and randomized controlled trials to prove the CM as an effective and safe treatment for infertility. Thus, utility of CM as a complementary medicine will be a feasible method to improve the outcome of female infertility treatment. | XIA du-feng Yoshinori Inagaki ZHANG Jian-feng WANG Ling SONG Pei-pei | 2017 | Chinese Journal of Integrative Medicine2017，23，4： | 14 |
| 5 | 天然石墨——形成的实验证据和特殊应用(英文)显示文摘简要讨论了碳前驱物的石墨化现象,总结了当有或无其他矿物共存环境下碳材料在承压条件下发生石墨化的实验结果。以这些实验研究成果为基础,讨论了自然界石墨生成的机理。此外,对天然石墨的某些特殊应用作了综述,如用作可再充电锂离子电池的阳极材料,特别是片状石墨用作泄漏重油的吸附材料等。 | Michio INAGAKI | 2005 | 地学前缘2005，12，1： | 13 |
| 6 | Sorafenib-based combined molecule targeting in treatment of hepatocellular carcinoma显示文摘Sorafenib is the only and standard systematic chemotherapy drug for treatment of advanced hepatocellular carcinoma(HCC) at the current stage. Although sorafenib showed survival benefits in large randomized phase Ⅲ studies, its clinical benefits remain modest and most often consist of temporary tumor stabilization, indicating that more effective first-line treatment regimens or second-line salvage therapies are required. The molecular pathogenesis of HCC is very complex, involving hyperactivated signal transduction pathways such as RAS/RAF/MEK/ERK and PI3K/AKT/m TOR and aberrant expression of molecules such as receptor tyrosine kinases and histone deacetylases. Simultaneous or sequential abrogation of these critical pathways or the functions of these key molecules involved in angiogenesis, proliferation, and apoptosis may yield major improvements in the management of HCC. In this review, we summarize the emerging sorafenib-based combined molecule targeting for HCC treatment and analyze the rationales of these combinations. | Jian-Jun Gao Zhen-Yan Shi Ju-Feng Xia Yoshinori Inagaki Wei Tang | 2015 | World Journal of Gastroenterology2015，21，42： | 12 |
| 7 | Role of mi RNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancer显示文摘Alterations in epigenetic control of gene expression play an important role in many diseases, including gastric cancer. Many studies have identified a large number of upregulated oncogenic mi RNAs and downregulated tumour-suppressor mi RNAs in this type of cancer. In this review, we provide an overview of the role of mi RNAs, pointing to their potential to be useful as diagnostic and/or prognostic biomarkers in gastric cancer. Moreover, we discuss the influence of polymorphisms and epigenetic modifications on mi RNA activity. | Kelly Cristina da Silva Oliveira Taíssa Maíra Thomaz Araújo Camila Inagaki Albuquerque Gabriela Alcantara Barata Carolina Oliveira Gigek Mariana Ferreira Leal Fernanda Wisnieski Fernando Augusto Rodrigues Mello Junior André Salim Khayat Paulo Pimentel de Assumpcao Rommel Mário Rodriguez Burbano Marília Cardoso Smith Danielle Queiroz Calcagno | 2016 | World Journal of Gastroenterology2016，22，35： | 11 |
| 8 | KL-6 mucin expression in carcinoma of the ampulla of Vater: Association with cancer progression显示文摘AIM: To assess histochemical expression of KL-6 and its clinicopathological significance in carcinoma of the ampulla of Vater.METHODS: Ampullary carcinoma tissues were collected from 38 patients who underwent pancreatoduodenectomy or local resection. Tissues were subjected to immunohistochemical analysis using KL-6 antibody.RESULTS: Positive staining of ampullary carcinoma cells was observed in 26 (68.4%) cases. Staining was not found in the surrounding non-cancer regions of the ampullary tissues. Remarkable KL-6 expression was observed in invasive carcinoma cells in pancreatic and duodenal tissues and in metastatic carcinoma cells in lymph nodes. Positive KL-6 expression was related to lymph node metastasis (P = 0.020), pancreatic invasion (P = 0.016), duodenal invasion (P = 0.034), and advanced stage of TNM clinical classification (P = 0.010). Survival analysis showed that positive expression of KL-6 was related to a poorer prognosis (P = 0.029).CONCLUSION: The aberrant expression of KL-6 mucin is significantly related to unfavorable behaviors of carcinoma of the ampulla of Vater. | Wei Tang Yoshinori Inagaki Norihiro Kokudo Qian Guo Yasuji Seyama Munehiro Nakata Hiroshi Imamura Keiji Sano Yasuhiko Sugawara Masatoshi Makuuchi | 2005 | World Journal of Gastroenterology2005，11，35： | 10 |
| 9 | TiO_2/浮石复合材料降解有机污染物亚甲基蓝的实验研究显示文摘利用天然浮石的孔隙结构和小比重等特点,以浮石为原料、TiOSO4为TiO2前驱体,采用水热合成法,在200 C、15 h条件下,制备出可漂浮的TiO2/浮石复合材料。采用10×10 mol/L严甲基蓝水溶液,在紫外光下进行光催化实验。并用紫外可见分光光度计检测亚甲基蓝浓度变化。实验结果表明,TiO2/浮石复合材料能够降解亚甲基蓝。该材料的孔隙结构对亚甲基蓝有聚集怍用,促进了负载的TiO2的光催化性能的发挥。因为成本低廉, 性能优越,TiO2/浮石复合材料在有机污染物治理方面具有很大的应用潜力。 | 传秀云 INAGAKI Michio | 2005 | 矿物岩石地球化学通报2005，24，2： | 9 |
| 10 | 用于空气中水蒸气吸-脱附的微孔泡沫炭制备研究(英文)显示文摘以蜜胺泡沫体为模板,采用氟化聚酰亚胺制备了微孔泡沫炭。测定了其对环境中水气的吸附/脱附行为,发现:泡沫炭在空气中400℃活化1h,可以提高其对水气的吸附能力。与活化前相比,对水气的吸附量几乎高达3倍,尽管其微孔容积仅增大了1.5倍。对环境水气中的可逆吸附率与微孔容积成线性关系,微孔容积为0.75mL/g的泡沫炭,其水气吸附率约为质量分数40%。 | Naoto Ohta Yoko Nishi Takahiro Morishita Yumiko Ieko Akifumi Ito Michio Inagaki | 2008 | 新型炭材料2008，23，3： | 7 |
| 11 | Utility of tricalcium phosphate and osteogenic matrix cell sheet constructs for bone defect reconstruction显示文摘AIM: To determine the effects of transplanting osteogenic matrix cell sheets and beta-tricalcium phosphate(TCP) constructs on bone formation in bone defects.METHODS: Osteogenic matrix cell sheets were prepared from bone marrow stromal cells(BMSCs), and a porous TCP ceramic was used as a scaffold. Three experimental groups were prepared, comprised of TCP scaffolds(1) seeded with BMSCs;(2) wrapped with osteogenic matrix cell sheets; or(3) both. Constructs were implanted into a femoral defect model in rats and bone growth was evaluated by radiography, histology, biochemistry, and mechanical testing after 8 wk. RESULTS: In bone defects, constructs implanted with cell sheets showed callus formation with segmentalor continuous bone formation at 8 wk, in contrast to TCP seeded with BMSCs, which resulted in bone nonunion. Wrapping TCP constructs with osteogenic matrix cell sheets increased their osteogenic potential and resulting bone formation, compared with conventional bone tissue engineering TCP scaffolds seeded with BMSCs. The compressive stiffness(mean ± SD) values were 225.0 ± 95.7, 30.0 ± 11.5, and 26.3 ± 10.6 MPa for BMSC/TCP/Sheet constructs with continuous bone formation, BMSC/TCP/Sheet constructs with segmental bone formation, and BMSC/TCP constructs, respectively. The compressive stiffness of BMSC/TCP/Sheet constructs with continuous bone formation was significantly higher than those with segmental bone formation and BMSC/TCP constructs.CONCLUSION: This technique is an improvement over current methods, such as TCP substitution, and is useful for hard tissue reconstruction and inducing earlier bone union in defects. | Tomoyuki Ueha Manabu Akahane Takamasa Shimizu Yoshinobu Uchihara Yusuke Morita Naoya Nitta Akira Kido Yusuke Inagaki Kenji Kawate Yasuhito Tanaka | 2015 | World Journal of Stem Cells2015，7，5： | 7 |
| 12 | 压力下的炭化(英文)显示文摘述评了三类压力下的炭化途径:分解气体自升压状态下的炭化,水热反应和还原CO2成炭。尽管这些在加压状态下形成的不同形态和纳米织构的炭材料具有相当高的收率,然而在很多情况下它们是多种形态炭材料的混合物。述评着眼于温度-压力条件和所用的前驱体的化学组成,讨论了高纯度、分离态的炭球的形成条件。 | Michio INAGAKI Ki Chul PARK Morinobu ENDO | 2010 | 新型炭材料2010，25，6： | 5 |
| 13 | Clinicopathological utility of sialoglycoconjugates in diagnosing and treating colorectal cancer显示文摘Aberrant expression of glycoconjugates occurs during malignant transformation of cancer cells.Overexpression of sialoglycoconjugates in particular may play an important role in the progression,i.e.,invasion or metastasis,of cancer.Various types of sialoglycoconjugates have been investigated to clarify their biological significance and clinical utility in diagnosing and treating colorectal cancer.This review focuses specifically on expression of mucin(MUC)1 and it suggests that MUC1with the specific structure of a sialo-oligosaccharide has biological significance in determining the metastatic potential of colorectal cancer cells and clinicopathological utility in evaluating the effectiveness of treatments and the prognosis for patients with colorectal cancer.Further studies are expected to contribute to the expanded use of cancer-associated sialoglycoconjugates in cancer diagnosis and therapy. | Yoshinori Inagaki Jianjun Gao Peipei Song Norihiro Kokudo Munehiro Nakata Wei Tang | 2014 | World Journal of Gastroenterology2014，20，20： | 5 |
| 14 | Clinical significance of subcellular localization of KL-6 mucin in primary colorectal adenocarcinoma and metastatic tissues显示文摘瞄准:估计在颜色代替 KL-6 粘蛋白和它的 clinicopathological 意义的细胞的本地化表面的癌以及变形淋巴节点和肝纸巾。方法:Colorectal 癌纸巾和肝纸巾从经历了 colorectomy 或肝切除术的 82 个病人被收集。纸巾受到免疫组织化学的分析使用 KL-6 抗体。结果:82 颜色表面的癌病人, 6 没显示出染色, 29 显示出仅仅在顶端的膜的积极染色,并且 47 显示出在环绕的膜或细胞质的积极染色。积极染色没在非癌的颜色被观察包围肿瘤纸巾的表面的上皮细胞。五年的幸存率在显示出比显示出仅仅在顶端的膜(85.7%) 的积极染色的那些和不显示出染色的那些(100%) 的在环绕的膜或细胞质(63.0%) 的积极染色的情况中是显著地更低的。在 KL-6 粘蛋白的细胞的本地化在环绕的膜或细胞质看了那 KL-6 本地化的 clinicopathological 因素和代用品之间的统计分析显著地与静脉的侵略的存在被联系( P = 0.0003 ),淋巴的侵略( P<0.0001 ),淋巴节点转移( P<0.0001 ),肝转移( P = 0.058 ),并且先进组织学的舞台( P<0.0001 )。积极染色在测试的所有变形损害以及在三原色被观察表面的癌纸巾。结论:潜水艇在颜色的 KL-6 的细胞的染色模式表面的腺癌可以是为象淋巴节点和肝转移那样的相反的行为,以及为病人的预后的重要指示物。 | Qian Guo Wei Tang Yoshinori Inagaki Yutaka Midorikawa Norihiro Kokudo Yasuhiko Sugawara MunehiroNakata Toshiro Konishi Hirokazu Nagawa Masatoshi Makuuchi | 2006 | World Journal of Gastroenterology2006，12，1： | 5 |
| 15 | Assessment of GIAHS in Shizuoka: The Traditional Tea-grass Integrated System显示文摘1 Introduction In 2013,Chagusaba,which is traditional tea-grass integrated system in Shizuoka,were accepted as new world heritage site of agriculture.Shizuoka prefecture occupies a variety of elevations,from 0 to 3000m or more above sea level.Because of the diversity of land features and climates,this area produces 167 agricultural commodities.In addition,a lot of traditional agriculture and over200 local native varieties of crops have been conserved in | INAGAKI Hidehiro KUSUMOTO Yoshinobu | 2014 | Journal of Resources and Ecology2014，5，4： | 4 |
| 16 | 全球重要农业文化遗产静冈传统茶草综合系统:价值、保护与行动(英文)显示文摘日本静冈的传统茶草综合系统是当地政府申请的日本第一个全球重要农业遗产系统(GIAHS)。本文介绍了当初发现该系统的背景、为申报GIAHS所采取的措施以及被列入全球重要农业文化遗产名录后,静冈茶草系统当前的作用和面临的新情况。自2013年入选全球重要农业遗产系统,目前日本的半天然草原大幅减少,但在静冈的茶草系统里发现了独特的半天然草原,茶园里生物多样性非常丰富。这些茶草系统和采用的传统耕作方法被称为'Chagusaba'。然而,GIAHS的申请过程并不容易,因为许多当地农民不了解他们传统耕作方法和GIAHS品牌的价值。在Chagusaba入选GIAHS名单之后,我们的主要工作是相关的品牌推广,努力使传统农业生产出高品质的茶叶。随着日本农业节省劳动力技术的进步,劳动力成本降低,优质茶叶的价格也有所下降,因此,执行低效传统耕作方式的农民数量越来越少。有必要正确地重新认识传统农业方法种植的茶叶的价值,并在价格上得以体现。静冈县当地政府目前正致力于实施认证体系,包括利用GPS进行科学评估,以及引入生物多样性指标等等。 | Hidehiro INAGAKI Yoshinobu KUSUMOTO | 2019 | Journal of Resources and Ecology2019，10，5： | 4 |
| 17 | Characteristics of alpha-synucleinopathy in centenarians显示文摘 | Ding ZT Wang Y Jiang YP Hashizume Y Yoshida M Mimuro M Inagaki T Iwase T | 2006 | 中国生物学文摘2006，20，8： | 4 |
| 18 | Can magnifying endoscopy with narrow band imaging be useful for low grade adenomas in preoperative biopsy specimens?显示文摘 | Kazuhiro Miwa Hisashi Doyama Renma Ito Hiroyoshi Nakanishi Katsura Hirano Satoko Inagaki Kei Tominaga Naohiro Yoshida Kenichi Takemura Shinya Yamada Yoshibumi Kaneko Kazuyoshi Katayanagi Hiroshi Kurumaya Toshihide Okada Masakazu Yamagishi | 2012 | Gastric Cancer2012，，2： | 3 |
| 19 | 由柏木制备纳米孔结构炭材料Ⅰ. 制备与孔结构(英文)显示文摘柏木条经过热蒸气处理,成功地制备了纳米孔炭,无需另行活化,比表面积就可达1000m2/g以上。如果在800℃~870℃炭化,柏木炭外表面积可达400m2/g以上,与同样温度在氩气中炭化得到的柏木炭相比,后者微孔面积仅为30m2/g~40m2/g。在900℃以上炭化得到的柏木炭,微孔表面积高达800m2/g以上,外表面积约为150m2/g。柏木炭的孔结构可以通过调节过热蒸气的温度得到控制。 | Eiki Ito Ikuyoshi Kouchi Sylwia Mozia Masaharu Okuda Takashi Nakano Masahiro Toyoda Michio Inagaki | 2007 | 新型炭材料2007，22，3： | 3 |
| 20 | Systematic characterization by mass spectrometric analysis of phosphorylation sites in IRF-3 regulatory domain activated by IKK-i显示文摘 | Kiyonaga Fujii Shingo Nakamura Kiyohiro Takahashi Fuyuhiko Inagaki | 2010 | Journal of Proteomics2010，，6： | 2 |
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