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| 1 | Indian hedgehog mutations causing brachydactyly type A1 impair Hedgehog signal transduction at multiple levels显示文摘Brachydactyly 打 A1 (BDA1 ) ,第一在人记录了孟德尔的正染色体的主导的混乱,被弄短或中间的指骨的缺席描绘。在印度刺猬(IHH ) 基因的异质接合的错误感觉变化作为 BDA1 的一个原因被识别了;然而,这些变化的生物化学的后果是不清楚的。在这份报纸,我们在印度刺猬(IhhN ) 的 N 终端碎片分析了三个 BDA1 变化(E95K, D100E,和 E131K ) 。结构的分析证明 E95K 变化在一条钙绑定沟把一个否定地控告的区域改变到一个断然控告的区域,并且 D100E 变化改变本地第三级的结构。而且,我们证明 E95K 和 D100E 变化导致了一温度敏感并且 IhhN 的钙依赖者不稳定性,它可能经由 lysosome 贡献变异的蛋白质的提高的细胞内部的降级。尤其是,所有三个变化影响了对受体 Patched1 (PTC1 ) 有约束力的 Hh,减少它的能力导致细胞的区别。我们建议这些是引起 BDA1 的变化的普通特征,影响 Hh 第三级的结构,细胞内部的命运,到受体 / 搭挡的绑定,和到细胞外的部件的绑定。这些特征的联合改变发信号的能力和范围,但是影响是可能的是变量和变化依赖者。在发信号的范围的潜在的变化被和 heparan 硫酸盐的一个提高的相互作用与 E95K 变化,然而并非 E131K 变化为 IHH 描绘。一起拿,我们的结果建议这些 IHH 变化影响在多重层次,引起的反常骨头发展和反常的位形成发信号的 Hh。 | Gang Ma Jiang Yu Yue Xiao Danny Chan Bo Gao Jianxin Hu Yongxing He Shengzhen Guo Jian Zhou Lingling Zhang Linghan Gao Wenjuan Zhang Yan Kang Kathryn SE Cheah Guoyin Feng Xizhi Guo Yujiong Wang Cong-zhao Zhou Lin He | 2011 | Cell Research2011，21，9： | 6 |
| 2 | Deoxynivalenol accumulation and detoxification in cereals and its potential role in wheat-Fusarium graminearum interactions显示文摘Deoxynivalenol(DON)is a prominent mycotoxin showing significant accumulation in cereal plants during infection by the phytopathogen Fusarium graminearum.It is a virulence factor that is important in the spread of F.graminearum within cereal heads,and it causes serious yield losses and significant contamination of cereal grains.In recent decades,genetic and genomic studies have facilitated the characterization of the molecular pathways of DON biosynthesis in F.graminearum and the environmental factors that influence DON accumulation.In addition,diverse scab resistance traits related to the repression of DON accumulation in plants have been identified,and experimental studies of wheat–pathogen interactions have contributed to understanding detoxification mechanisms in host plants.The present review illustrates and summarizes the molecular networks of DON mycotoxin production in F.graminearum and the methods of DON detoxification in plants based on the current literature,which provides molecular targets for crop improvement programs.This review also comprehensively discusses recent advances and challenges related to genetic engineering-mediated cultivar improvements to strengthen scab resistance.Furthermore,ongoing advancements in genetic engineering will enable the application of these molecular targets to develop more scab-resistant wheat cultivars with DON detoxification traits. | Kun Luo Jiao Guo Dejia He Guangwei Li Thérèse Ouellet | 2023 | aBIOTECH2023，4，2： | 2 |
| 3 | Excision biopsy findings of patients with breast needle core biopsies reported as suspicious of malignancy(B4) or lesion of uncertain malignant potential ( B3 ) 显示文摘 | Lee AH Denley HE Pinder SE | 2003 | Histopathology2003，42，4： | 1 |
| 4 | Graft failure after penetrating keratoplasty显示文摘 | Wilson SE Kaufman HE | 1990 | Surv Ophthalmol1990，34，5： | 1 |
| 5 | The role of the reticulo-epithelial cell network in the immuno-neuroendocrine regulation of intrathymic lymphopiesis 显示文摘 | Bodey B Siegel SE Kaiser HE | 2000 | Anticancer Res2000，20，3： | 1 |
| 6 | Mapping precursor movement through the postnatal thymus reveals specific microenvironments supporting defined stages of early lymphoid development 显示文摘 | Lind EF Pmckop SE and Porritt HE | 2001 | J Exp Med2001，194，： | 1 |
| 7 | 查看详情显示文摘 | Wilson SE He YG Loyds SA | | 0，，： | 1 |
| 8 | Fibroblast growth factor-1 receptor messenger RNA expression in corneal cells显示文摘 | Wilson SE Lloyd SA He YG | | 0，，3： | 1 |
| 9 | Excision of rectal lesions by the Kraske approach显示文摘 | Wilson SE Gordon HE | 1969 | Am J Surg1969，118，2： | 1 |
| 10 | Epithelial injury induces keratocyte apoptosis:hypothesized role for the interleukin-lsysten in the modulation of corneal tissue organization and wound healing显示文摘 | Wilson SE He YG Weng J | 1996 | Exp Eye Re1996，62，： | 1 |
| 11 | Epitelial injury induces keratocyte apoptosis:hypothesized role for the interleukin 1 system in the modulation of corneal tissue organization and wound healing显示文摘 | Wilson SE He YG Weng J | 1996 | Exp Eye Res1996，62，： | 1 |
| 12 | A prospective study of ge-netic polymorphism in MPO,antioxidant status,and breast cancerrisk显示文摘 | He C Tamimi RM Hankinson SE | 2009 | Breast Cancer Res Treat2009，113，3： | 1 |
| 13 | Temperature and soil organic matter decomposition rates-synthesis of current knowledge and a way forward显示文摘 | Conant RT Ryan MG Agren GI Birge HE Davidson EA Eliasson PE Evans SE Frey SD Giardina CP Hopkins FM Hyvǒnen R Kirschbaum MUF Lavallee JM Leifeld J Parton WJ Megan Steinweg J Wallenstein MD Martin Wetterstedt JA Bradford MA | | 0，，： | 1 |
| 14 | Gene-environment interaction in the determination of levels of plasma fibrinogen显示文摘 | Luong LA Montgomery HE | 1999 | Thromb Haemost1999，82，： | 1 |
| 15 | Fibroblast growth factor-1 receptor messenger RNA expression in corneal cells 显示文摘 | Wilson SE Liod SA He YG | 1993 | Cornea1993，12，： | 1 |
| 16 | Reemergence of pertussis in the highly vaccinated population of the Netherlands: observa- tions on surveillance data显示文摘 | Melker HE Schellekens JF Neppelenbroek SE | 2000 | Emerg Infect Dis2000，6，： | 1 |
| 17 | Review of thymic hormones in cancer diagnosis and treatment显示文摘 | Bodey B Siegal SE Kaiser HE | 2000 | Int J Immunopharmacol2000，22，： | 1 |
| 18 | Epithelial injury induces keratocytes apoptosis:hypothesized role for the interleukin-1 system in the modulation of corneal tissue organization and wound healing显示文摘 | Wilson SE He YG Weng J | 1996 | Exp Eye Res1996，62，4： | 1 |
| 19 | Gene-environment interaction in the determination of levels of haemostatic variables involved in thrombosis and fibrinolysis显示文摘 | Humphries SE Panahloo A Montgomery HE | 1997 | Thromb Haemost1997，78，1： | 1 |
| 20 | The role of the reticulo-epithelial cell network in the immuno-neuron-docrine regulation of intrathymic lymphopoiesis显示文摘 | Bodey B Siegel SE Kaiser HE | 2000 | Anticancer Res2000，20，3： | 1 |
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