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| 1 | Prognostic value of site-specific metastases in pancreatic adenocarcinoma: A Surveillance Epidemiology and End Results database analysis显示文摘AIM To evaluate the prognostic value of site-specific metastases among patients with metastatic pancreaticc arcinoma registered within the Surveillance, Epidemiology and End Results(SEER) database.METHODS SEER database(2010-2013) has been queried through SEER*Stat program to determine the presentation, treatment outcomes and prognostic outcomes of metastatic pancreatic adenocarcinoma according to the site of metastasis. In this study, metastatic pancreatic adenocarcinoma patients were classified according to the site of metastases(liver, lung, bone, brain and distant lymph nodes). We utilized chi-square test to compare the clinicopathological characteristics among different sites of metastases. We used Kaplan-Meier analysis and log-rank testing for survival comparisons. We employed Cox proportional model to perform multivariate analyses of the patient population; and accordingly hazard ratios with corresponding 95%CI were generated. Statistical significance was considered if a two-tailed P value < 0.05 was achieved. RESULTS A total of 13233 patients with stage Ⅳ pancreatic cancer and known sites of distant metastases were identified in the period from 2010-2013 and they were included into the current analysis. Patients with isolated distant nodal involvement or lung metastases have better overall and pancreatic cancer-specific survival compared to patients with isolated liver metastases(for overall survival: lung vs liver metastases: P < 0.0001; distant nodal vs liver metastases: P < 0.0001)(for pancreatic cancer-specific survival: lung vs liver metastases: P < 0.0001; distant nodal vs liver metastases: P < 0.0001). Multivariate analysis revealed that age < 65 years, white race, being married, female gender; surgery to the primary tumor and surgery to the metastatic disease were associated with better overall survival and pancreatic cancer-specific survival.CONCLUSION Pancreatic adenocarcinoma patients with isolated liver metastases have worse outcomes compared to patients with isolated lung or distant nodal metastases. Further research is needed to identify the highly selected subset of patients who may benefit from local treatment of the primary tumor and/or metastatic disease. | Hani Oweira Ulf Petrausch Daniel Helbling Jan Schmidt Meinrad Mannhart Arianeb Mehrabi Othmar Schob Anwar Giryes Michael Decker Omar Abdel-Rahman | 2017 | World Journal of Gastroenterology2017，23，10： | 13 |
| 2 | Incidence trends and survival prediction of hepatoblastoma in children:a population-based study显示文摘Background:Hepatoblastoma is a rare disease that nevertheless accounts for the majority of liver malignancies in children.Due to limited epidemiological data,therapy for hepatoblastoma tends to be individualized.This study aimed to evaluate incidence trends of hepatoblastoma and to develop a nomogram to predict the survival of children with newly diagnosed hepatoblastoma on a population-based level.Methods:Individuals up to 18 years of age with hepatoblastoma recorded in 18 registries of the Surveillance,Epi-demiology,and End Results(SEER)database between 2004 and 2015 were examined.Joinpoint regression analyses were applied to assess incidence trends in annual percentage change(APC).Multivariable Cox regression was used to identify factors associated with overall survival(OS).A nomogram was constructed to predict OS in individual cases based on independent predictors.Concordance index(C-index)and calibration curves were used to evaluate predic-tive performance.Results:Between 2004 and 2015,hepatoblastoma incidence increased significantly(APC,2.2%;95%confidence interval[CI]0.5%to 3.8%,P<0.05).In particular,this increase was observed among 2-to 4-year-old patients,males,and African-Americans.The 5-and 10-year OS rates were 81.5%and 81.0%,respectively.Age of 2 to 4 years,Afri-can-American ethnicity,and no surgery were independent predictors for short OS.Distant disease at presentation was found not to be an independent factor of survival.The nomogram had a C-index of 0.79(95%CI 0.74-0.84)with appropriate calibration curve fitting.Conclusions:We constructed a nomogram that integrates common factors associated with survival for hepatoblas-toma patients.It provides accurate prognostic prediction for children with hepatoblastoma. | Jincheng Feng Georgios Polychronidis Ulrike Heger Giovanni Frongia Arianeb Mehrabi Katrin Hoffmann | 2019 | Cancer Communications2019，39，1： | 10 |
| 3 | A systematic review and meta-analysis of laparoscopic versus open distal pancreatectomy for benign and malignant lesions of the pancreas: It’s time to randomize显示文摘 | Arianeb Mehrabi Mohammadreza Hafezi Jalal Arvin Majid Esmaeilzadeh Camelia Garoussi Golnaz Emami Julia K?ssler-Ebs Beat Peter Müller-Stich Markus W. Büchler Thilo Hackert Markus K. Diener | 2014 | Surgery2014，，： | 4 |
| 4 | Hepatocellular Carcinoma: Current Management and Perspectives for the Future显示文摘 | Nuh N. Rahbari Arianeb Mehrabi Nathan M. Mollberg Sascha A. Müller Moritz Koch Markus W. Büchler Jürgen Weitz | 2011 | Annals of Surgery2011，，3： | 3 |
| 5 | Mesohepatectomy as an Option for the Treatment of Central Liver Tumors显示文摘 | Arianeb Mehrabi Zhoobin Mood Navid Roshanaei Hamidreza Fonouni Sascha A. Müller Bruno M. Schmied Ulf Hinz Jürgen Weitz Markus W. Büchler Jan Schmidt | 2008 | Journal of the American College of Surgeons2008，，4： | 1 |
| 6 | Primary malignant hepatic epithelioidhemangioendothelioma:a comprehensive review of the literature withemphasis Oil the surgical therapy显示文摘 | Mehrabi Arianeb Kashfi | 2006 | Cancer2006，107，9： | 1 |
| 7 | Intestinal transplantation: review of operative techniques显示文摘 | Arash Nickkholgh Pietro Contin Kareem Abu‐Elmagd Mohammad Golriz Daniel Gotthardt Christian Morath Peter Schemmer Arianeb Mehrabi | 2013 | Clin Transplant2013，，： | 1 |
| 8 | Primary malignant hep-atic epithelioid hemangioendothelioma: a comprehensive review ofthe literature with emphasis oil the surgical therapy 显示文摘 | MehrabiA Arianeb A Kashfi H | 2006 | Cancer2006，107，9： | 1 |
| 9 | Transient elastography with the XL probe rapidly identifies patients with nonhepatic ascites显示文摘 | Sebastian Mueller Laurent Sandrin Cecile Bastard Gunda Millonig Esteban Durango Anna Kohlhaas Helmut Karl Seitz Buchler Arianeb Mehrabi Mohammad Golriz | 2012 | Hepatic Medicine: Evidence and Research . 2012 (defa)2012，，： | 1 |
| 10 | Development and internal validation of the Comprehensive ALPPS Preoperative Risk Assessment(CAPRA)score:is the patient suitable for Associating Liver Partition and Portal vein ligation for Staged hepatectomy(ALPPS)?显示文摘Background:Preoperative patient selection in Associating Liver Partition and Portal vein ligation for Staged hepatectomy(ALPPS)is not always reliable with currently available scores,particularly in patients with primary liver tumor.This study aims to(I)to determine whether comorbidities and patients characteristics are a risk factor in ALPPS and(II)to create a score predicting 90-day mortality preoperatively.Methods:Thirteen high-volume centers participated in this retrospective multicentric study.A risk analysis based on patient characteristics,underlying disease and procedure type was performed to identify risk factors and model the Comprehensive ALPPS Preoperative Risk Assessment(CAPRA)score.A nonparametric receiver operating characteristic analysis was performed to estimate the predictive ability of our score against the Charlson Comorbidity Index(CCI),the age-adjusted CCI(aCCI),the ALPPS risk score before Stage 1(ALPPS-RS1)and Stage 2(ALPPS-RS2).The model was internally validated applying bootstrapping.Results:A total of 451 patients were included.Mortality was 14.4%.The CAPRA score is calculated based on the following formula:(0.1×age)−(2×BSA)+1(in the presence of primary liver tumor)+1(in the presence of severe cardiovascular disease)+2(in the presence of moderate or severe diabetes)+2(in the presence of renal disease)+2(if classic ALPPS is planned).The predictive ability was 0.837 for the CAPRA score,0.443 for CCI,0.519 for aCCI,0.693 for ALPPS-RS1 and 0.807 for ALPPS-RS2.After 1,000 cycles of bootstrapping the C statistic was 0.793.The accuracy plot revealed a cut-off for optimal prediction of postoperative mortality of 4.70.Conclusions:Comorbidities play an important role in ALPPS and should be carefully considered when planning the procedure.By assessing the patient’s preoperative condition in relation to ALPPS,the CAPRA score has a very good ability to predict postoperative mortality. | Ivan Capobianco Karl J.Oldhafer Mohammed-Hossein Fard-Aghaie Ricardo Robles-Campos Roberto Brusadin Henrik Petrowsky Michael Linecker Arianeb Mehrabi Katrin Hoffmann Jun Li Asmus Heumann Roberto Hernandez-Alejandro Mauro Enrique Tun-Abraham Elio Jovine Matteo Serenari Bergthor Bjornsson Per Sandström Ruslan Alikhanov Mikhail Efanov Paolo Muiesan Andrea Schlegel Thomas M.van Gulik Pim B.Olthof Gregor Alexander Stavrou Lina Maria Serna-Higuita Alfred Königsrainer Silvio Nadalin | 2022 | Hepatobiliary Surgery and Nutrition2022，11，1： | 1 |
| 11 | Bleeding complications in pediatric ABO-incompatible kidney transplantation显示文摘 | Betti Schaefer Burkhard T?nshoff Jan Schmidt Mohammad Golriz Arianeb Mehrabi Petra Gombos Christian Morath Elke Wühl Franz Schaefer Claus Peter Schmitt | 2013 | Pediatric Nephrology2013，，2： | 1 |
| 12 | Exact CT-Based Liver Volume Calculation Including Nonmetabolic Liver Tissue in Three-Dimensional Liver Reconstruction显示文摘 | Sascha A. Müller Karin Bl?uer Michael Kremer Matthias Thorn Arianeb Mehrabi Hans-Peter Meinzer Ulf Hinz Jürg Metzger Markus W. Büchler Bruno M. Schmied | 2010 | Journal of Surgical Research2010，，2： | 1 |
| 13 | Surgical Treatment of Primary Hepatic Epithelioid Hemangioendothelioma显示文摘 | Arianeb Mehrabi Arash Kashfi Peter Schemmer Peter Sauer Jens Encke Hamidreza Fonouni Helmut Friess Jürgen Weitz Jan Schmidt Markus W. Büchler Thomas W. Kraus | 2005 | Transplantation (S Suppl)2005，，1： | 1 |
| 14 | Stapler Hepatectomy is a Safe Dissection Technique: Analysis of 300 Patients显示文摘 | Peter Schemmer Helmut Friess Ulf Hinz Arianeb Mehrabi Thomas W. Kraus Kaspar Z’graggen Jan Schmidt Waldemar Uhl Markus W. Büchler | 2006 | World Journal of Surgery2006，，3： | 1 |
| 15 | Successful combination of direct antiviral agents in livertransplanted patients with recurrent hepatitis C virus显示文摘AIM To analyze the safety and efficiency of direct-actingantiviral(DAA) regimens in liver-transplanted patients with hepatitis C virus(HCV) reinfection.METHODS Between January 2014 and December 2016, 39 patients with HCV reinfection after liver transplantation were treated at our tertiary referral center with sofosbuvir(SOF)-based regimens, including various combinations with interferon(IFN), daclatasvir(DAC), simeprivir(SIM) and/or ledipasvir(LDV). Thirteen patients were treated with SOF + IFN ± RBV. Ten patients were treated with SOF + DAC ± RBV. Fiveteen patients were treated with fixed-dose combination of SOF + LDV ± RBV. One patient was treated with SOF + SIM + RBV. Three patients with relapse were retreated with SOF + LDV + RBV. The treatment duration was 12-24 wk in all cases. The decision about the HCV treatment was made by specialists at our transplant center, according to current available or recommended medications.RESULTS The majority of patients were IFN-experienced(29/39, 74.4%) and had a history of hepatocellular carcinoma(26/39, 66.7%) before liver transplantation. Sustained virological response at 12 wk(SVR12) was achieved in 10/13(76.9%) of patients treated with SOF + IFN ± RBV. All patients with relapse were treated with fixed-dose combination of SOF + LDV + RBV. Patients treated with SOF + DAC + RBV or SOF + LDV + RBV achieved 100% SVR12. SVR rates after combination treatment with inhibitors of the HCV nonstructural protein(NS)5 A and NS5 B for 24 wk were significantly higher, as compared to all other therapy regimens(P = 0.007). Liver function was stable or even improved in the majority of patients during treatment. All antiviral therapies were safe and well-tolerated, without need of discontinuation of treatment or dose adjustment of immunosuppression. No serious adverse events or any harm to the liver graft became overt. No patient experienced acute cellular rejection during the study period. CONCLUSION Our cohort of liver-transplanted patients achieved high rates of SVR12 after a 24-wk course of treatment, especially with combination of NS5 A and NS5 B inhibitors. | Christian Rupp Theresa Hippchen Manuel Neuberger Peter Sauer Jan Pfeiffenberger Wolfgang Stremmel Daniel Nils Gotthardt Arianeb Mehrabi Karl-Heinz Weiss | 2018 | World Journal of Gastroenterology2018，24，12： | 1 |
| 16 | Review of various techniques of pancreas transplantation显示文摘 | Zhoobin A Arianeb Bruno | 2008 | Jounal of Surgical Research2008，145，2： | 1 |
| 17 | Vascular Resection in Pancreatic Cancer Surgery: Survival Determinants显示文摘 | Sascha A. Müller Mark Hartel Arianeb Mehrabi Thilo Welsch David J. Martin Ulf Hinz Bruno M. Schmied Markus W. Büchler | 2009 | Journal of Gastrointestinal Surgery2009，，4： | 1 |
| 18 | Mesohepatectomy as an Option for the Treatment of Central Liver Tumors显示文摘 | Arianeb Mehrabi Zhoobin Mood Navid Roshanaei Hamidreza Fonouni Sascha A. Müller Bruno M. Schmied Ulf Hinz Jürgen Weitz Markus W. Büchler Jan Schmidt | 2008 | Journal of the American College of Surgeons2008，，4： | 1 |
| 19 | Sorafenib treatment is save and may affect survival of recurrent hepatocellular carcinoma after liver transplantation显示文摘 | Jan Pfeiffenberger Ronald Koschny Katrin Hoffmann Arianeb Mehrabi Anne Schmitz Boris Radeleff Wolfgang Stremmel Peter Schemmer Tom M. Ganten | 2013 | Langenbeck’s Archives of Surgery2013，，8： | 1 |
| 20 | Hepatocellular Carcinoma: Current Management and Perspectives for the Future显示文摘 | Nuh N. Rahbari Arianeb Mehrabi Nathan M. Mollberg Sascha A. Müller Moritz Koch Markus W. Büchler Jürgen Weitz | 2011 | Annals of Surgery2011，，3： | 1 |
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