|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Alcoholic liver disease and hepatitis C:A frequently underestimated combination显示文摘Alcoholic liver disease(ALD) and hepatitis C virus(HCV) infection represent, either alone or in combination, more than two thirds of all patients with liver disease in the Western world.This review discusses the epidemiology and combined impact of ALD and HCV on the progres sion of liver disease.ALD and HCV affect the progres sion of liver disease to liver cirrhosis and hepatocellular carcinoma(HCC) in a synergistic manner.Thus, the risk for HCC increases f ive times with a daily alcohol con sumption of 80 g;in the presence of HCV it is increased 20fold, and a combination of both risk factors leads to a more than 100fold risk for HCC development.Alcohol consumption also decreases the response to interferon treatment which is probably due to a lack of compliance than a direct effect on HCV replication.Several molecu lar mechanisms are discussed that could explain the synergistic interaction of alcohol and HCV on disease progression.They include modulation of the immune response and apoptosis, increased oxidative stress via induction of CYP2E1 and the hepatic accumulation of iron.Thus, both HCV and alcohol independently cause hepatic iron accumulation in > 50% of patients probably due to suppression of the liversecreted systemic iron hormone hepcidin.A better understanding of hepcidin regulation could help in developing novel therapeutic approaches to treat the chronic disease in the future.For now, it can be generally concluded that HCVinfect ed patients should abstain from alcohol and alcoholicsshould be encouraged to participate in detoxification programs. | Sebastian Mueller Gunda Millonig Helmut K Seitz | 2009 | World Journal of Gastroenterology2009，15，28： | 18 |
| 2 | Increased liver stiffness in alcoholic liver disease:Differentiating fibrosis from steatohepatitis显示文摘AIM:To test if inflammation also interferes with liver stiffness (LS) assessment in alcoholic liver disease (ALD) and to provide a clinical algorithm for reliable fibrosis assessment in ALD by FibroScan (FS).METHODS:We first performed sequential LS analysis before and after normalization of serum transaminases in a learning cohort of 50 patients with ALD admitted for alcohol detoxification. LS decreased in almost all patients within a mean observation interval of 5.3 d. Six patients (12%) would have been misdiagnosed with F3and F4 fibrosis but LS decreased below critical cut-off values of 8 and 12.5 kPa after normalization of trans-aminases. RESULTS:Of the serum transaminases,the decrease in LS correlated best with the decrease in glutamic oxaloacetic transaminase (GOT). No significant chang-es in LS were observed below GOT levels of 100 U/L. After establishing the association between LS and GOT levels,we applied the rule of GOT < 100 U/L for reliable LS assessment in a second validation cohort of 101 patients with histologically confi rmed ALD. By ex-cluding those patients with GOT > 100 U/L at the time of LS assessment from this cohort,the area under the receiver operating characteristic (AUROC) for cirrhosis detection by FS improved from 0.921 to 0.945 while specificity increased from 80% to 90% at a sensitivity of 96%. A similar AUROC could be obtained for lower F3 fibrosis stage if LS measurements were restricted to patients with GOT < 50 U/L. Histological grading of inflammation did not further improve the diagnostic accuracy of LS.CONCLUSION:Coexisting steatohepatitis markedly increases LS in patients with ALD independent of fibrosis stage. Postponing cirrhosis assessment by FS during alcohol withdrawal until GOT decreases to < 100 U/mL signif icantly improves the diagnostic accuracy. | Sebastian Mueller Gunda Millonig Lucie Sarovska Stefanie Friedrich Frank M Reimann Maria Pritsch Silke Eisele Felix Stickel Thomas Longerich Peter Schirmacher Helmut Karl Seitz | 2010 | World Journal of Gastroenterology2010，16，8： | 10 |
| 3 | Developing Landmark- Based Pedestrian-Nabigation Systems 显示文摘 | Millonig A Sehechtner K | 2007 | IEEE Transactions on Intelligent Transportation Systems2007，8，1： | 1 |
| 4 | Institutional Capital:Com- petitive Advantage In Light Of The New Institutional- ism In Organization Theory 显示文摘 | Bresser R K F Millonig K | 2003 | Schmalenbach Busi- ness Review2003，，3： | 1 |
| 5 | Cross-reactive B-cell epitopes of microbial and human heat shock protein 60/65 in athero- sclerosis 显示文摘 | Perschinka H Mayr M Millonig G | 2003 | Arterioscler Thromb Vasc Biol2003，23，6： | 1 |
| 6 | Extrahepatic cholestasis increases liver stiffness (FibroScan) irrespective of fibrosis 显示文摘 | Millonig G Reimann FM Friedrich S | 2008 | Hepatology2008，48，5： | 1 |
| 7 | Extrahepatic cholestasis increases liver stiffness (FibroScan) irrespective of fibrosis 显示文摘 | MILLONIG G REIMANN FM FRIEDRICH S | 2008 | Hepatology2008，48，5： | 1 |
| 8 | Atherosclerosis as an-auto immune disease:an update显示文摘 | Wick G Perschinka H Millonig G | | 0，，12： | 1 |
| 9 | Network of vascularassociated dendritic cells in intima of healthy young individuals 显示文摘 | Millonig G Niederegger H Rabl W | 2001 | Arterioscler Thromb Vasc Biol2001，21，4： | 1 |
| 10 | Increased venous pressure increases liver stiffness ( Fibroscan ) independent of liver fibrosis 显示文摘 | Millonig G Friedrich S Adolf S | 2009 | Hepatology2009，50，： | 1 |
| 11 | Cannabinoid receptor type I modulates alcohol - induced liver fibrosis显示文摘 | Patsenker E Stoll M Millonig G | 2011 | Mol Med2011，17，1112： | 1 |
| 12 | Support for the Homeobox Transcription Factor Gene ENGRAILED 2 as an Autism Spectrum Disorder Susceptibility Locus显示文摘 | Rym Benayed Neda Gharani Ian Rossman Vincent Mancuso Gloria Lazar Silky Kamdar Shannon E. Bruse Samuel Tischfield Brett J. Smith Raymond A. Zimmerman Emanuel DiCicco-Bloom Linda M. Brzustowicz James H. Millonig | 2005 | The American Journal of Human Genetics2005，，5： | 1 |
| 13 | The vascular-associated lymphoid tissue: a new site of local immunity显示文摘 | Millonig G Schwenmer C Mueller P | 2011 | Curr Opin Lipidol2011，12，5： | 1 |
| 14 | Early inflammatory-immunological lesions inJuvenile atherosclerosis from the Pathobio logical Determinants of Atherosclerosis in Youth (PDAY)-study显示文摘 | Millonig G Malcom GT Wickg | 2002 | Atherosclerosis2002，160，2： | 1 |
| 15 | Cross-reactive B-Cell epitopes of microbial and human heat shock protein 60/65 in atherosclerosis显示文摘 | Perschinka H Mayr M Millonig G | | 0，，23： | 1 |
| 16 | En2 knockout mice display neurobehavioral and neurochemical alterations relevant to autism spectrum disorder显示文摘 | Cheh MA Millonig JH Roselli LM | 2006 | Brain Research2006，1116，： | 1 |
| 17 | Extrahepatic cholestasis increases liver stiffness(FibroScan)irrespective of fibrosis显示文摘 | Millonig G Reimann FM Friedrich S | | 0，，05： | 1 |
| 18 | Transient elastography with the XL probe rapidly identifies patients with nonhepatic ascites显示文摘 | Sebastian Mueller Laurent Sandrin Cecile Bastard Gunda Millonig Esteban Durango Anna Kohlhaas Helmut Karl Seitz Buchler Arianeb Mehrabi Mohammad Golriz | 2012 | Hepatic Medicine: Evidence and Research . 2012 (defa)2012，，： | 1 |
| 19 | Institutional capital : competitive advantage in light of the new institutionalism in organization theory 显示文摘 | Bresser R Millonig K | 2003 | Schmalenbach Business Review2003，7，55： | 1 |
| 20 | The Structural Basis for the Intrinsic Disorder of Actin Filament:The Lateral Slipping Model 显示文摘 | BREMER A MILLONIG R C SUTTERLIN R | 1991 | J Cell Biol1991，115，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员