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| 1 | Loss of disabled-2 expression is an early event in esophageal squamous tumorigenesis显示文摘AIM: Disabled-2 (DAB2) is a candidate tumor-suppressor gene identified in ovarian cancer that negatively influences mitogenic signal transduction of growth factors and blocks ras activity. In a recent study, we observed down-regulation of DAB2 transcripts in ESCCs using cDNA microarrays. In the present study, we aimed to determine the clinical significance of loss of DAB2 protein in esophageal tumorigenesis, hypothesizing that DAB2 promoter hypermethylation-mediated gene silencing may account for loss of the protein. METHODS: DAB2 expression was analyzed by immunohistochemistry in 50 primary esophageal squamous cell carcinomas (ESCCs), 30 distinct hyperplasia, 15 dysplasia and 10 non-malignant esophageal tissues. To determine whether promoter hypermethylation contributes to loss of DAB2 expression in ESCCs, methylation status of DAB2 promoter was analyzed in DAB2 immuno-negative tumors using methylation-specifi c PCR. RESULTS: Loss of DAB2 protein was observed in 5/30 (17%) hyperplasia, 10/15 (67%) dysplasia and 34/50 (68%) ESCCs. Significant loss of DAB2 protein was observed from esophageal normal mucosa to hyperplasia, dysplasia and invasive cancer (Ptrend < 0.001). Promoter hypermethylation of DAB2 was observed in 2 of 10 (20%) DAB2 immuno-negative ESCCs. CONCLUSION: Loss of DAB2 protein expression occurs in early pre-neoplastic stages of development of esophageal cancer and is sustained down the tumorigenic pathway. Infrequent DAB2 promoter methylation in ESCCs suggests that epigenetic genesilencing is only one of the mechanisms causing loss of DAB2 expression in ESCCs. | Kumar Anupam Chatopadhyay Tusharkant Siddhartha Datta Gupta Ralhan Ranju | 2006 | World Journal of Gastroenterology2006，12，37： | 11 |
| 2 | Gastric remnant twist in the immediate post-operative period following laparoscopic sleeve gastrectomy显示文摘Twist of stomach remnant post sleeve gastrectomy is a rare entity and difficult to diagnose pre-operatively. We are reporting a case of gastric volvulus post laparoscopic sleeve gastrectomy, which was managed conservatively. A 38-year-old lady with a body mass index of 54 underwent laparoscopic sleeve gastrectomy. Sleeve gastrectomy was performed over a 32 French bougie using Endo-GIA tri-stapler. On post-operative day 1, patient had nausea and non-bilious vomiting. An upper gastrointestinal gastrografin study on postoperative days 1 and 2 revealed collection of contrast in the fundic area of stomach with poor flow distally, and she vomited gastrograffin immediately post procedure. With the suspicion of a stricture in the mid stomach as the cause, the patient was taken back for a exploratory laparoscopy and intra-operative endoscopy. We found a twist in the gastric tube which was too tight for the endoscope to pass through. This was managed conservatively with a long stent to keep the gastric tube straight and patent. The stent was discontinued in 7 d and the patient did well. In laparoscopic sleeve gastrectomy the stomach is converted into a tube and is devoid of its supports. If the staples fired are not aligned appropriately, it can predispose this stomach tube to undergo torsion along its long axis. Such a twist can be avoided by properly aligning the staples and by placing tacking sutures to the omentum and new stomach tube. This twist is a functional obstruction rather than a stricture; thus, it can be managed by endoscopy and stent placement. | Gokulakkrishna Subhas Anupam Gupta Mubashir Sabir Vijay K Mittal | 2015 | World Journal of Gastrointestinal Surgery2015，7，11： | 6 |
| 3 | Post‐transplant biliary complications: An analysis from a predominantly living donor liver transplant center显示文摘 | Manav Wadhawan Ajay Kumar Subash Gupta Neerav Goyal Rajeev Shandil Sunil Taneja Anupam Sibal | 2013 | J Gastroenterol Hepatol2013，，6： | 1 |
| 4 | Dissipation of imidacloprid in Orthodox tea and its transfer from made tea to infusion显示文摘 | Monika Gupta Anupam Sharma Adarsh Shanker | 2008 | Food Chemistry2008，106，1： | 1 |
| 5 | Loss of disabled-2 expression is an early event in esophageal squamous tumorigenesis显示文摘 | Anupam K Tusharkant C Gupta SD | | 0，，37： | 1 |
| 6 | Dissipation of imidacloprid in Orthodox tea and its transfer from made tea to infusion显示文摘 | Monika Gupta Anupam Sharma Adarsh Shanker | 2007 | Food Chemistry2007，，1： | 1 |
| 7 | Loss of disable- 2 expression is an early event in esophageal squamous tumorigenesis 显示文摘 | Anupam K Tusharkant C Gupta SD | 2006 | World J Gastroenterol2006，12，37： | 1 |
| 8 | Relationship Between Corneal Biomechanical Properties, Central Corneal Thickness, and Intraocular Pressure Across the Spectrum of Glaucoma显示文摘 | Sushmita Kaushik Surinder Singh Pandav Anupam Banger Kanika Aggarwal Amod Gupta | 2012 | American Journal of Ophthalmology2012，，5： | 1 |
| 9 | Dissipation of imidacloprid in Orthodox tea and its transfer from made tea to infusion 显示文摘 | Monika Gupta Anupam Sharma Adarsh Shanker | 2008 | Food Chemistry2008，106，： | 1 |
| 10 | Dissipationof imidacloprid in Orthodox tea and its transfer from made teato infusion显示文摘 | Monika Gupta Anupam Sharma Adarsh Shanker | 2008 | Food Chemistry2008，106，： | 1 |
| 11 | Thermal-diffusivity measurement of 3D-stitched C–SiC composites显示文摘 | Suresh Kumar Anil Kumar Anupam Shukla G. Rohini Devi A.K. Gupta | 2008 | Journal of the European Ceramic Society2008，，3： | 1 |
| 12 | Investigation of thermal expansion of 3D-stitched C–SiC composites显示文摘 | Suresh Kumar Anil Kumar Anupam Shukla G. Rohini Devi A.K. Gupta | 2009 | Journal of the European Ceramic Society2009，，13： | 1 |
| 13 | Drainage of pancreatic fluid collections in acute pancreatitis:A comprehensive overview显示文摘Moderately severe and severe acute pancreatitis is characterized by local and systemic complications.Systemic complications predominate the early phase of acute pancreatitis while local complications are important in the late phase of the disease.Necrotic fluid collections represent the most important local complication.Drainage of these collections is indicated in the setting of infection,persistent or new onset organ failure,compressive or pressure symptoms,and intraabdominal hypertension.Percutaneous,endoscopic,and minimally invasive surgical drainage represents the various methods of drainage with each having its own advantages and disadvantages.These methods are often complementary.In this minireview,we discuss the indications,timing,and techniques of drainage of pancreatic fluid collections with focus on percutaneous catheter drainage.We also discuss the novel methods and techniques to improve the outcomes of percutaneous catheter drainage. | Akash Bansal Pankaj Gupta Anupam K Singh Jimil Shah Jayanta Samanta Harshal S Mandavdhare Vishal Sharma Saroj Kant Sinha Usha Dutta Manavjit Singh Sandhu Rakesh Kochhar | 2022 | World Journal of Clinical Cases2022，10，20： | 0 |
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