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| 1 | Prognostic significance of hepatic encephalopathy in patients with cirrhosis treated with current standards of care显示文摘BACKGROUND Hepatic encephalopathy(HE)is a reversible neuropsychiatric complication of liver cirrhosis and occurs in up to 50%of cirrhotic patients.Studies examining the prognostic significance of HE are limited despite the high prevalence in cirrhosis.AIM To define the clinical outcomes of patients after an episode of HE treated with current standards-of-care.METHODS All patients hospitalised with HE requiring Rifaximin to 3 tertiary centres over46-mo(2012–2016)were identified via pharmacy dispensing records.Patients with hepatocellular carcinoma and those prescribed Rifaximin prior to admission were excluded.Medical records were reviewed to determine baseline characteristics and survival.The Kaplan-Meier method was used to calculate survival probability.Univariate survival analysis was performed with variables reaching statistical significance included in a multivariate analysis.The primary outcome was 12-mo mortality following commencement of Rifaximin.RESULTS188 patients were included.Median age was 57 years(IQR 50-65),71%were male and median model for end stage liver disease and Child Pugh scores were 25(IQR 18-31)and 11(IQR 9-12)respectively.The most common causes of cirrhosis were alcohol(62%),hepatitis C(31%)and non-alcoholic fatty liver disease(20%).A precipitating cause for HE was found in 92%patients with infection(43%),GI bleeding(16%),medication non-compliance(15%)and electrolyte imbalance(14%)the most common.During a mean follow up period of 12±13 mo 107(57%)patients died and 32(17%)received orthotopic liver transplantation.Themost common causes of death were decompensated chronic liver disease(57%)and sepsis(19%).The probability of survival was 44%and 35%at 12-and 24-mo respectively.At multivariate analysis a model for end stage liver disease>15 and international normalised ratio reached statistical significance in predicting mortality.CONCLUSION Despite advances made in the management of HE patients continue to have poor survival.Thus,in all patients presenting with HE the appropriateness of orthotopic liver transplantation should be considered. | Anuj Bohra Thomas Worland Samuel Hui Ryma Terbah Ann Farrell Marcus Robertson | 2020 | World Journal of Gastroenterology2020，26，18： | 4 |
| 2 | Mutant TP53 in Duodenal Samples of Pancreatic Juice From Patients With Pancreatic Cancer or High-Grade Dysplasia显示文摘 | Mitsuro Kanda Yoshihiko Sadakari Michael Borges Mark Topazian James Farrell Sapna Syngal Jeffrey Lee Ihab Kamel Anne Marie Lennon Spencer Knight Sho Fujiwara Ralph H. Hruban Marcia Irene Canto Michael Goggins | 2013 | Clinical Gastroenterology and Hepatology2013，，6： | 2 |
| 3 | SU11248 inhibits tumor growth and CSF-1R-dependent osteolysis in an experimental breast cancer bone metastasis model显示文摘 | Lesley J. Murray Tinya J. Abrams Kelly R. Long Theresa J. Ngai Lisa M. Olson Weiru Hong Paul K. Keast Jacqueline A. Brassard Anne Marie O’Farrell Julie M. Cherrington Nancy K. Pryer | 2003 | Clinical and Experimental Metastasis2003，，8： | 1 |
| 4 | National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. Diagnosis and Staging Working Group Report显示文摘 | Alexandra H. Filipovich Daniel Weisdorf Steven Pavletic Gerard Socie John R. Wingard Stephanie J. Lee Paul Martin Jason Chien Donna Przepiorka Daniel Couriel Edward W. Cowen Patricia Dinndorf Ann Farrell Robert Hartzman Jean Henslee-Downey David Jacobsohn | 2005 | Biology of Blood and Marrow Transplantation2005，，12： | 1 |
| 5 | Guided versus blind liver biopsy for chronic hepatitis C: clinical benefits and costs显示文摘 | Richard J Farrell Pauline F Smiddy Ruth M Pilkington Anne A Tobin Eoghan E Mooney Ian J Temperley George S McDonald Heather A Bowmer Graham F Wilson Dermot Kelleher | 1999 | Journal of Hepatology1999，，4： | 1 |
| 6 | National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. Diagnosis and Staging Working Group Report显示文摘 | Alexandra H. Filipovich Daniel Weisdorf Steven Pavletic Gerard Socie John R. Wingard Stephanie J. Lee Paul Martin Jason Chien Donna Przepiorka Daniel Couriel Edward W. Cowen Patricia Dinndorf Ann Farrell Robert Hartzman Jean Henslee-Downey David Jacobsohn | 2005 | Biology of Blood and Marrow Transplantation2005，，： | 1 |
| 7 | National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. Diagnosis and Staging Working Group Report显示文摘 | Alexandra H. Filipovich Daniel Weisdorf Steven Pavletic Gerard Socie John R. Wingard Stephanie J. Lee Paul Martin Jason Chien Donna Przepiorka Daniel Couriel Edward W. Cowen Patricia Dinndorf Ann Farrell Robert Hartzman Jean Henslee-Downey David Jacobsohn | 2005 | Biology of Blood and Marrow Transplantation2005，，12： | 1 |
| 8 | Influence of montmorillonite layered silicate on plasticized poly( l -lactide) blown films显示文摘 | Christopher Thellen Caitlin Orroth Danielle Froio David Ziegler Jeanne Lucciarini Richard Farrell Nandika Ann D’Souza Jo Ann Ratto | 2005 | Polymer2005，，25： | 1 |
| 9 | Influence of psychiatric diagnosis on treatment uptake and interferon side effects in patients with hepatitis C显示文摘 | Jing Yuan J Wu Bruce Shadbolt Narci Teoh Anne Blunn Caroline To Ilys Rodriguez‐Morales Shivakumar Chitturi Graham Kaye Kalyana Rodrigo Geoff Farrell | 2014 | J Gastroenterol Hepatol2014，，6： | 1 |
| 10 | Alcoholic liver disease and mast cells:What's your gut got to do with it?显示文摘Alcoholic liver disease(ALD)remains one of the leading causes of liver injury and death when left un-treated.The gut microbiota has been recognized as a key regulator of a number of pathologies,including ALD.The role of mast cells(MCs)during liver disease progression has been demonstrated in a number of animal models and in human liver diseases.The interaction between the gut microbiota and MCs has been investigated,and links between the gut and these immune cells are being uncovered.The interplay between the gut microbiota and MCs during ALD has been evaluated and studies suggest that there could be an important link between MCs,their mediators and gut inflammation during the progression of ALD. | Julie Ann Tolefree Abigail Joy Garcia Jenee Farrell Vik Meadows Lindsey Kennedy Laura Hargrove Jennifer Demieville Nicole Francis Julia Mirabel Heather Francis | 2019 | Liver Research2019，3，1： | 1 |
| 11 | Building social capital in early childhood education and care: an Australian study显示文摘 | Ann Farrell Collette Tayler Lee Tennent | 2004 | British Educational Research Journal2004，，5： | 1 |
| 12 | Mutant TP53 in Duodenal Samples of Pancreatic Juice From Patients With Pancreatic Cancer or High-Grade Dysplasia显示文摘 | Mitsuro Kanda Yoshihiko Sadakari Michael Borges Mark Topazian James Farrell Sapna Syngal Jeffrey Lee Ihab Kamel Anne Marie Lennon Spencer Knight Sho Fujiwara Ralph H. Hruban Marcia Irene Canto Michael Goggins | 2013 | Clinical Gastroenterology and Hepatology2013，，6： | 1 |
| 13 | 利用流行电视节目“美国忍者”(ANW)进行体育课程设计显示文摘当今流行文化占据了美国学生大量的时间。因此,教育工作者理应承认并拥抱当前流行的电视节目、电子游戏和文化现象,并利用这些'热点',将关键的教学内容与学生的兴趣衔接起来。以美国流行的电视节目'美国忍者'(ANW)的运动单元为借鉴,根据学龄儿童青少年的特点和学校体育场馆器械的现实对流行电视节目的运动单元和理念进行整合,形成'忍者勇士'(PE-NW)体育课程;详细介绍课程的安排、计划和实施,课程包含的以障碍挑战的形式进行体育练习的方式方法、针对的学生身体素质内容以及安全原则、训练原则等内容。我国学龄儿童青少年同样处于与美国同龄人类似的环境和情况,了解国外优秀体育课程开发和设计的思路,可以为开发出适应中国国情或地域特定情况的、更有效果的体育课提供借鉴。 | Laura E.Bruno(美) Anne Farrell(美) 杨圣韬(译校) | 2020 | 体育科研2020，41，1： | 0 |
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