|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Copy number variations are progressively associated with the pathogenesis of colorectal cancer in ulcerative colitis显示文摘AIM: To evaluate the association of known copy number variations(CNVs) in ulcerative colitis(UC) progressing to colorectal cancer.METHODS: Microsatellite instability analysis using the National Cancer Institute's panel of markers, and CNV association studies using Agilent 2 × 105 k arrays were done in tissue samples from four patient groups with UC: those at low risk(LR) or high risk of developing colorectal cancer, those with premalignant dysplastic lesions, and those with colitis-associated colorectal cancer(CAC). DNA from tissue samples of these groups were independently hybridized on arrays and analyzed. The data obtained were further subjected to downstream bioinformatics enrichment analysis to examine the correlation with CAC progression.RESULTS: Microarray analysis highlighted a progressive increase in the total number of CNVs [LR(n = 178) vs CAC(n = 958), 5.3-fold], gains and losses [LR(n = 37 and 141) vs CAC(n = 495 and 463), 13.4- and 3.3-fold, respectively], size [LR(964.2 kb) vs CAC(10540 kb), 10.9-fold] and the number of genes in such regions [LR(n = 119) vs CAC(n = 455), 3.8-fold]. Chromosomewise analysis of CNVs also showed an increase in the number of CNVs across each chromosome. There were 38 genes common to all four groups in the study; 13 of these were common to cancer genes from the Genetic Disease Association dataset. The gene set enrichment analysis and ontology analysis highlighted many cancerassociated genes. All the samples in the different groupswere microsatellite stable.CONCLUSION: Increasing numbers of CNVs are associated with the progression of UC to CAC, and warrant further detailed exploration. | Bhadravathi Marigowda Shivakumar Harish Rotti Thanvanthri Gururajan Vasudevan Aswath Balakrishnan Sanjiban Chakrabarty Ganesh Bhat Lakshmi Rao Cannanore Ganesh Pai Kapaettu Satyamoorthy | 2015 | World Journal of Gastroenterology2015，21，2： | 10 |
| 2 | Earnings quality in UK private firms: comparative loss recognition timeliness显示文摘 | Ray Ball Lakshmanan Shivakumar | 2004 | Journal of Accounting and Economics2004，，1： | 7 |
| 3 | Perioperative challenges in management of diabetic patients undergoing non-cardiac surgery显示文摘Prediabetes and diabetes are important disease processes which have several perioperative implications.About one third of the United States population is considered to have prediabetes.The prevalence in surgical patients is even higher.This is due to the associated micro and macrovascular complications of diabetes that result in the need for subsequent surgical procedures.A careful preoperative evaluation of diabetic patients and patients at risk for prediabetes is essential to reduce perioperative mortality and morbidity.This preoperative evaluation involves an optimization of preoperative comorbidities.It also includes optimization of antidiabetic medication regimens,as the avoidance of unintentional hypoglycemic and hyperglycemic episodes during the perioperative period is crucial.The focus of the perioperative management is to ensure euglycemia and thus improve postoperative outcomes.Therefore,prolonged preoperative fasting should be avoided and close monitoring of blood glucose should be initiated and continued throughout surgery.This can be accomplished with either analysis in blood gas samples,venous phlebotomy or point-of-care testing.Although capillary and arterial whole blood glucose do not meet standard guidelines for glucose testing,they can still be used to guide insulin dosing in the operating room.Intraoperative glycemic control goals may vary slightly in different protocols but overall the guidelines suggest a glucose range in the operating room should be between 140 mg/dL to 180 mg/dL.When hyperglycemia is detected in the operating room,blood glucose management may be initiated with subcutaneous rapid-acting insulin,with intravenous infusion or boluses of regular insulin.Fluid and electrolyte management are other perioperative challenges.Notably diabetic ketoacidosis and hyperglycemic hyperosmolar nonketotic state are the two most serious acute metabolic complications of diabetes that must be recognized early and treated. | Ursula Galway Praveen Chahar Marc T Schmidt Jorge A Araujo-Duran Jeevan Shivakumar Alparslan Turan Kurt Ruetzler | 2021 | World Journal of Diabetes2021，12，8： | 5 |
| 4 | 钻头冠部形状对破岩效果的影响显示文摘用有限元方法模拟了不同形状钻头的破岩效果,研究了地层应力分布及裂缝延伸模式。按照国际钻井商协会(IADC)分类标准设计了14种钻头形状。设计了地层模型,给出了钻头尺寸、地层性质、网格划分方法和边界条件等。采用拟静态条件和质量缩放法以减少模拟时间、提高模拟精度。模拟结果表明,对于9种常用钻头形状,增加锥体高度高应力区面积会增大,而保径高度与产生的应力之间没有明显关系。减小保径高度,高应力区从鼻端和中心部位转移到保径区。对于非常用钻头形状,凸形钻头产生的应力场较大,双心钻头导眼体底部应力较集中。裂缝主要产生在保径区和鼻端,锥体高度和保径高度较大的钻头产生的垂直裂缝较长。使用平形和凸形钻头时没有产生较长的垂直裂缝。双心钻头可抑制保径区的垂直裂缝,却使地层更易出现水平裂缝,有中间段扩眼器的钻头造成的井壁损伤更小。 | HEYDARSHAHY Seyed Ali KAREKAL Shivakumar | 2017 | 石油勘探与开发2017，44，4： | 4 |
| 5 | Molecular alterations in colitis-associated colorectal neoplasia: Study from a low prevalence area using magnifying chromo colonoscopy显示文摘 | Bhadravathi Marigowda Shivakumar Balasubramanian Lakshman Kumar Ganesh Bhat Deepak Suvarna Lakshmi Rao C. Ganesh Pai Kapaettu Satyamoorthy | 2011 | Journal of Crohn’s and Colitis2011，，6： | 3 |
| 6 | Modified mixed-mode bending test apparatus for measuring delamination fracture toughness of laminated composites 显示文摘 | KUNIGAL N SHIVAKUMAR JOHN H CREWS J R Vishnu S Avva | 1998 | Journal of Composites1998，32，9： | 2 |
| 7 | Intravenous administration of ulinastatin (human urinary trypsin inhibitor) in severe sepsis: a multicenter randomized controlled study显示文摘 | Dilip R. Karnad Rakesh Bhadade Pradeep K. Verma Nivedita D. Moulick Mradul K. Daga Neelima D. Chafekar Shivakumar Iyer | 2014 | Intensive Care Medicine2014，，6： | 2 |
| 8 | Accuracy of contrast-enhanced harmonic EUS with a second-generation perflutren lipid microsphere contrast agent (with video)显示文摘 | Joseph Romagnuolo Brenda Hoffman Stacie Vela Robert Hawes Shivakumar Vignesh | 2011 | Gastrointestinal Endoscopy2011，，1： | 2 |
| 9 | Self-selection of auditors and audit pricing in private firms显示文摘 | Chaney P K Jeter D C Shivakumar L | 2004 | The Accounting Review2004，79，1： | 1 |
| 10 | The RASSF1A tumor suppressor blocks cell cycle progression and inhibits cyclin D1 accumulation显示文摘 | SHIVAKUMAR L MINNA J SAKAMAKI T | 2002 | Mol Cell Biol2002，22，12： | 1 |
| 11 | The RASSF1A tumor suppressor blocks cell cycle progression and inhibits cyclin D1 accumulation显示文摘 | Shivakumar L Minna J Sakamaki T | 2002 | Mol Cell Biol2002，22，12： | 1 |
| 12 | Accruals, cash flows and the post- earnings-announcement drift 显示文摘 | Shivakumar L | 2006 | Journal of Business Finance & Accounting2006，33，： | 1 |
| 13 | Neonatal NK cells target the mouse duct epithelium via Nkg2d and drive tissue-specific injury in experimental biliary atresia显示文摘 | Shivakumar P Sabla GE Whitington P | | 0，，08： | 1 |
| 14 | Active Constrained Layer Damping of Geometrically Nonlinear Transient Vibrations of Composite Plates Using Piezoelectric Fiber-Reinforced Composite显示文摘 | RAY M SHIVAKUMAR J | | 0，，2： | 1 |
| 15 | Natural killer cells promote long -term hepatobiliary inflammation in a low - dose rotavirus model of experimental biliary atresia 显示文摘 | SQUIRES JE SHIVAKUMAR P MOURYA R | 2015 | PLoS One2015，10，5： | 1 |
| 16 | The rassfla tumor suppressor blocks cell cycle progression and inhibits cyclin D1 accumulation显示文摘 | Shivakumar L Minna J Sakamaki T | 2002 | Mol Cell Biol2002，22，12： | 1 |
| 17 | The RASSF1A tumor suppressor blocks cell cycle progression and inhibits cyclin D1 accumulation显示文摘 | Shivakumar L Minna J Sakamaki T | 2002 | Mol Cell Biol2002，22，12： | 1 |
| 18 | Mg deficiency enhances oxidative stress and collagen synthesis in vivo in the aorta of rat 显示文摘 | Shivakumar K Kumar B P | 1997 | Int J Biochem Cell Biol1997，29，： | 1 |
| 19 | Synthesis of benzofuran analogs of fenamates as non steroidal anti-inflammatory agents显示文摘 | Mane B Y Agasimundin Y S Shivakumar B | 2010 | Indian Journal of Chemistry2010，49，2： | 1 |
| 20 | Back-propagation and counterpropagation neural networks for phylogenetic classification of ribosomal RNA sequences 显示文摘 | Wu C Shivakumar S | 1994 | Nucleic Acids Research1994，22，20： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员