|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Changing patterns and survival improvements of young breast cancer in China and SEER database, 1999-2017显示文摘Objective: Breast cancer in young females was usually considered more aggressive and requires aggressive therapy. We investigated whether early detection and improved treatments changed the patterns of characteristics,management and outcomes of young breast cancer patients over time.Methods: Females under 40 years of age diagnosed with breast cancer during the periods 1999-2017 and1999-2015 were identified in the Fudan University Shanghai Cancer Center(FUSCC) and the population-based Surveillance, Epidemiology, and End Results(SEER) registry, respectively. Clinicopathologic characteristics and treatment information were collected. Patients diagnosed before 2013 were followed up.Results: The proportions of young breast cancer patients were 15.0% and 5.3% in the FUSCC and SEER cohorts, respectively. In the FUSCC cohort, there was a significant increase in the proportion of ductal carcinoma in situ(DCIS)(from 8.8% to 16.9%;P<0.0001) and it remained stable in SEER cohort. The proportion of T1-stage tumors increased dramatically in the FUSCC cohort(from 35.3% to 41.9%;P=0.008), whereas it decreased in SEER cohort(from 42.4% to 33.0%;P<0.0001). The percentage of estrogen receptor(ER)-positive cancers was consistently increased in both the invasive ductal carcinoma(IDC) and DCIS patients in the two cohorts. Breastconserving surgery and immediate implant reconstruction after mastectomy both exhibited increased use over time in the FUSCC cohort. Both the FUSCC and SEER cohorts showed a significantly better prognosis in the recent time period.Conclusions: With the increased early-stage and ER-positive diseases in young patients as well as better systemic treatment strategies, improved survival has been observed in recent years. There has been a substantial deescalation in surgical therapies in young breast cancer patients. | Rong Guo Jing Si Jingyan Xue Yonghui Su Miao Mo Benlong Yang Qi Zhang Weiru Chi Yayun Chi Jiong Wu | 2019 | Chinese Journal of Cancer Research2019，31，4： | 24 |
| 2 | Influence of cosmic radiation on lymphocyte micronucleus,serum lipid peroxide and antioxidation capacity in aircrew members显示文摘This study looks into the influence of cosmic radiation at high altitudes on human bodies. Results reveal that the cytokinesis-block micronuclei (CBMN) and conventional cultured micronuclei in peripheral blood lymphocytes, serum levels of lipid peroxide, superoxide dismutase, and the total antioxidation capacity by chemical colorimetry all increased significantly in aircrew members. There exists a linear relationship between the CBMN and the average annual effective doses of radiation received or the average annual flying hours. With both of them, a trend shows that the serum lipid peroxide levels increase as well. Either the lipid peroxide or CBMN can sensitively reflect the recent changes in flight load. These findings indicate that cosmic radiation impairs the stability of chromosomes and genome, and induces lipid oxidative damage in aircrews; Lymphocyte CBMN and serum lipid peroxide can be used as monitoring indicators in the cosmic radiation protection for aircrew members. | CHEN Weiru FENG Yingjin LIU Jiangkuang ZHANG Haili GUO Ying ZHANG Yan DUAN Shiying PENG Xintao SUN Tianping JIA Baoshan ZHAO Junxian LI Hua | 2002 | Chinese Science Bulletin2002，47，8： | 3 |
| 3 | Arenobufagin is a novel isoform-specific probe for sensing human sulfotransferase 2A1显示文摘Human cytosolic sulfotransferase 2 A1(SULT2A1) is an important phase II metabolic enzyme. The detection of SULT2A1 is helpful for the functional characterization of SULT2A1 and diagnosis of its related diseases. However, due to the overlapping substrate specificity among members of the sulfotransferase family, it is difficult to develop a probe substrate for selective detection of SULT2A1. In the present study, through characterization of the sulfation of series of bufadienolides, arenobufagin(AB) was proved as a potential probe substrate for SULT2A1 with high sensitivity and specificity. Subsequently, the sulfation of AB was characterized by experimental and molecular docking studies. The sulfate-conjugated metabolite was identified as AB-3-sulfate.The sulfation of AB displayed a high selectivity for SULT2A1 which was confirmed by in vitro reaction phenotyping assays. The sulfation of AB by human liver cytosols and recombinant SULT2A1 both obeyed Michaelis-Menten kinetics, with similar kinetic parameters. Molecular docking was performed to understand the interaction between AB and SULT2A1, in which the lack of interaction with Met-137 and Tyr-238 of SULT2A1 made it possible to eliminate substrate inhibition of AB sulfation. Finally, the probe was successfully used to determine the activity of SULT2A1 and its isoenzymes in tissue preparations of human and laboratory animals. | Xiangge Tian Chao Wang Peipei Dong Yue An Xinyu Zhao Weiru Jiang Gang Wang Jie Hou Lei Feng Yan Wang Guangbo Ge Xiaokui Huo Jing Ning Xiaochi Ma | 2018 | Acta Pharmaceutica Sinica B2018，8，5： | 2 |
| 4 | Managing Software Requirements Changes Based on Negotiation-Style Revision显示文摘For any proposed software project,when the software requirements specification has been established,requirements changes may result in not only a modification of the requirements specification but also a series of modifications of all existing artifacts during the development.Then it is necessary to provide effective and flexible requirements changes management.In this paper,we present an approach to managing requirements changes based on Booth's negotiation-style framework for belief revision.Informally,we consider the current requirements specification as a belief set about the systemto-be.The request of requirements change is viewed as new information about the same system-to-be.Then the process of executing the requirements change is a process of revising beliefs about the system-to-be.We design a family of belief negotiation models appropriate for different processes of requirements revision,including the setting of the request of requirements change being fully accepted,the setting of the current requirements specification being fully preserved,and that of the current specification and the request of requirements change reaching a compromise.In particular,the prioritization of requirements plays an important role in reaching an agreement in each belief negotiation model designed in this paper. | 牟克典 Weiru Liu 金芝 Jun Hong David Bell | 2011 | Journal of Computer Science & Technology2011，26，5： | 2 |
| 5 | SU11248 inhibits tumor growth and CSF-1R-dependent osteolysis in an experimental breast cancer bone metastasis model显示文摘 | Lesley J. Murray Tinya J. Abrams Kelly R. Long Theresa J. Ngai Lisa M. Olson Weiru Hong Paul K. Keast Jacqueline A. Brassard Anne Marie O’Farrell Julie M. Cherrington Nancy K. Pryer | 2003 | Clinical and Experimental Metastasis2003，，8： | 1 |
| 6 | Inverse spectral problem for generalized row stochastic matrices显示文摘 | Lei Yingjie Xu Weiru | 2012 | Journal of An- hui University(Natural Sciences)2012，36，5： | 1 |
| 7 | Secular evolution of the lithosphere beneath the eastern North China Craton: Evidence from Mesozoie basalts and high-Mg andesites显示文摘 | Zhang Hongfu Sun Min Zhou Xinhua Zhou Meifu Fan Weiruing Zheng Jianping | 2003 | Geochim Cosmochim Acta2003，67，22： | 1 |
| 8 | A new random walk model for PCS networks显示文摘 | AKYILDIZ I F LIN Yibing LAI Weiru | 2000 | IEEE Journal on Selected Areas in Communications2000，18，7： | 1 |
| 9 | Is firm-specific innovationa associated with greater value appropriation? The roles of environmental dynamism and technological diversity 显示文摘 | Wanga Hell Chen Weiru | 2010 | Research Policy2010，39，1： | 1 |
| 10 | Learning Bayesian networks from data: An efficient approach based on information theory 显示文摘 | Cheng Jie Bell D Liu Weiru | 2002 | Artificial Intelligence2002，137，12： | 1 |
| 11 | Analyzing the degree of conflict among belie F funetions显示文摘 | Weiru L | 2006 | Artificial Intelligent2006，0，： | 1 |
| 12 | A new random walk model for PCS networks显示文摘 | AKYILDIZ I F LIN Yibing LAI Weiru | 2000 | IEEE Journal on Selected Areas in Communications2000，18，7： | 1 |
| 13 | Rough Operations on Boolean Algebras 显示文摘 | QI Guilin LIU Weiru | 2005 | Information Sciences2005，173，123： | 1 |
| 14 | A blame-based approach to generating proposals for handling inconsistency in software re- quirements显示文摘 | Kedian Mu Weiru Liu Jin | 2012 | International Journal of Knowledge and Sys- tems Science2012，3，1： | 1 |
| 15 | Modeling opportunity driven multiple access in UMTS 显示文摘 | LIN P LAI Weiru GAN C H | 2004 | IEEE Trans on Wireless Communications2004，3，5： | 1 |
| 16 | Learning Bayesian Networks from Data:An Efficient Approach Based on Information Theory显示文摘 | Cheng Jie Bell D Liu Weiru | 2002 | Artificial Intelligence2002，37，12： | 1 |
| 17 | A context-dependent algo- rithm for merging uncertain information in possibility theory 显示文摘 | HUNTER A LIU Weiru | 2008 | IEEE Transactions on Systems Man and Cybernetics: Part A Systems and Humans2008，38，6： | 1 |
| 18 | Fusion rules for merging uncertain information显示文摘 | HUNTER A WEIRU L | 2006 | Information Fusion2006，，7： | 1 |
| 19 | Genome-wide identification and analysis of late embryogenesis abundant (LEA) genes in Prunus mume显示文摘 | Dongliang Du Qixiang Zhang Tangren Cheng Huitang Pan Weiru Yang Lidan Sun | 2013 | Molecular Biology Reports2013，，2： | 1 |
| 20 | Rough operations on Boolean algebras显示文摘 | Guilin Qi Weiru Liu | 2005 | Information Sciences2005，173，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员