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| 1 | Dual-sugar tests of small intestinal permeability are poor predictors of bacterial infections and mortality in cirrhosis: a prospective study显示文摘AIM: To prospectively analyze the impact of increased intestinal permeability(IP) on mortality and the occurrence of infections in patients with cirrhosis.METHODS: IP was quantified using the lactulose/mannitol(L/M) test in 46 hospitalized patients with cirrhosis(25 Child-Pugh A/B, 21 Child-Pugh C) and in 16 healthy controls. Markers of inflammation [LPSbinding protein, Interleukin-6(IL-6)] and enterocyte death [intestinal fatty-acid binding protein(I-FABP)] were determined in serum using enzyme-linked immunosorbent assays. Patients were followed for one year and assessed for survival, liver transplantation, the necessity of hospitalization and the occurrence of bacterial infections. The primary endpoint of the study was defined as differences in survival between patients with pathological and without pathological lactulose/mannitol test.RESULTS: Thirty-nine(85%) patients with cirrhosis had a pathologically increased IP index(L/M ratio > 0.07) compared to 4(25%) healthy controls(P < 0.0001). The IP index correlated with the ChildPugh score(r = 0.484, P = 0.001) and with serum IL-6(r = 0.342, P = 0.02). Within one year, nineteen(41%) patients developed a total of 33 episodes of hospitalization with bacterial or fungal infections. Although patients who developed spontaneous bacterial peritonitis(SBP)(n = 7) had a higher IP index than patients who did not(0.27 vs 0.14, P = 0.018), the baseline IP index did not predict time to infection, infection-free survival or overall survival, neither when assessed as linear variable, as tertiles, nor dichotomized using an established cut-off. In contrast, model for end-stage liver disease score, Child-Pugh score, the presence of ascites, serum IL-6 and I-FABP were univariate predictors of infection-free survival.CONCLUSION: Although increased IP is a frequent phenomenon in advanced cirrhosis and may predispose to SBP, it failed to predict infection-free and overall survival in this prospective cohort study. | Anika Vogt Philipp A Reuken Sven Stengel Andreas Stallmach Tony Bruns | 2016 | World Journal of Gastroenterology2016，22，11： | 8 |
| 2 | The efficacy and effectiveness of machine learning for weaning in mechanically ventilated patients at the intensive care unit: a systematic review显示文摘Weani ng from mechanical ventilation in the in tensive care unit (ICU) is a complex clinical problem and relevant for future organ engineering. Prolonged mechanical ventilation (MV) leads to a range of medical complications that increases length of stay and costs as well as contributes to morbidity and even mortality and long-term quality of life. The need to reduce MV is both clinical and economical. Artificial intelligence or machine learning (ML) methods are promising opportunities to positively influence patient outcomes. ML methods have been proposed to enhance clinical decisions processes by using the large amount of digital information generated in the ICU setting. There is a particular interest in empirical methods (such as ML) to improve management of 'difficult-to-wean' patients, due to the associated costs and adverse events associated with this population. A systematic literature search was performed using the OVID, IEEEXplore, PubMed, and Web of Science databases. All publications that included (1) the application of ML to weaning from MV in the ICU and (2) a clinical outcome measurement were reviewed. A checklist to assess the study quality of medical ML publications was modified to suit the critical assessment of ML in MV weaning literature. The systematic search identified nine studies that used ML for weaning management from MV in critical care. The weaning management application areas included (1) prediction of successful spontaneous breathing trials (SBTs),(2) prediction of successful extubation,(3) prediction of arterial blood gases, and (4) ventilator setting and oxygenation-adjustment advisory systems. Seven of the nine studies scored seven out of eight on the quality index. The remaining two of the nine studies scored one out of eight on the quality index. This scoring may, in part, be explained by the publications' focus on technical novelty, and therefore focusing on issues most important to a technical audience, instead of issues most important for a systematic medical review. This review showed that only a limited number of studies have started to assess the efficacy and effectiveness of ML for MV in the ICU. However, ML has the potential to be applied to the prediction of SBT failure, extubation failure, and blood gases, and also the adjustment of ventilator and oxygenation settings. The available databases for the development of ML in this clinical area may still be inadequate. None of the reviewed studies reported on the procedure, treatment, or sedation strategy undergone by patients. Such information is unlikely to be required in a technical publication but is potentially vital to the development ML techniques that are sufficiently robust to meet the needs of the'difficult-to-wean'patient population. | Man Ting Kwong Glen Wright Colopy Anika M.Weber Ari Ercole Jeroen H.M.Bergmann | 2019 | Bio-Design and Manufacturing2019，2，1： | 3 |
| 3 | Towards a versatile point-of-care systemcombining femtosecond laser generatedmicrofluidic channels and direct laserwritten microneedle arrays显示文摘Microneedle-based microfluidic systems have a great potential to become well-accepted medical devices for simple,accurate,and painless drug delivery and lab-on-a-chip diagnostics.In this work,we report on a novel hybrid approach combining femtosecond direct laser written microneedles with femtosecond laser generated microfluidic channels providing an important step towards versatile medical point-of-care systems.Hollow microneedle arrays are fabricated by a laser system designed for two-photon polymerization applications.Compression tests of two different types of truncated cone-shaped microneedle arrays prepared from OrmoComp^(■)give information about the microneedle mechanical strength,and the results are compared to skin insertion forces.Three-dimensional microchannels are directly created inside PMMA bulk material by an ultrashort pulse laser system with vertical channels having adjustable cross-sectional areas,which allow attaching of microneedles to the microfluidic system.A comprehensive parameter study varying pulse duration and repetition rate is performed on two-photon polymerization to identify an optimal laser power range for fabricating microneedles using the same pulse duration and repetition rate as for microchannels.This addresses the advantage of a single laser system process that overcomes complex fabrication methods.A proof of concept flow test with a rhodamine B dye solution in distilled water demonstrates that the combination of microneedles and microchannels qualifies for microfluidic injection and extraction applications. | Anika Trautmann Gian-Luca Roth Benedikt Nujiqi Thomas Walther Ralf Hellmann | 2019 | Microsystems & Nanoengineering2019，5，1： | 3 |
| 4 | Chemometric analysis of femtosecond transient absorption spectroscopy data:Study of the photochromism of anils显示文摘Chemometric methods are applied for the purpose of extracting relevant information from transient absorption spectroscopy data probing the photochromism of molecules from the family of salicylidene aniline. The process consists of an ultrafast excited state intramolecular proton transfer occurring from an enol form which is then followed by a cis-trans isomerization to finally reach a trans-keto photo-product. This work focuses on the potential of combining multivariate curve resolution for modeling pure profiles and two dimensional correlation spectroscopy data analysis for providing information on the dynamics of spectral features. The results obtained for one derivative of salicylidene aniline provide information regarding the number of species created after the proton transfer and characterization of their absorption spectra and their kinetics in the picosecond time scale. The spectral resolution of two cis-keto* forms is proposed for the first time. It is also found that both cis-keto* species are involved in the formation of the trans-keto photo-product. The main precursor of the trans-keto photo-product is the cis-keto* form which has the shortest characteristic time. | Cyril RUCKEBUSCH Nicolas MOUTON Thomas GLADYTZ Anika RENDELMANN Guy BUNTINX Michel SLIWA | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，6： | 3 |
| 5 | Microplastic fiber and drought effects on plants and soil are only slightly modified by arbuscular mycorrhizal fungi显示文摘Microplastics are increasingly recognized as a factor of global change. By altering soil inherentproperties and processes, ripple-on effects on plants and their symbionts can be expected.Additionally, interactions with other factors of global change, such as drought, can influence theeffect of microplastics. We designed a greenhouse study to examine effects of polyester microfibers,arbuscular mycorrhizal (AM) fungi and drought on plant, microbial and soil responses. We found thatpolyester microfibers increased the aboveground biomass of Allium cepa under well-watered anddrought conditions, but under drought conditions the AM fungal-only treatment reached the highestbiomass. Colonization with AM fungi increased under microfiber contamination, however, plantbiomass did not increase when both AM fungi and fibers were present. The mean weight diameter ofsoil aggregates increased with AM fungal inoculation overall but decreased when the system wascontaminated with microfibers or drought stressed. Our study adds additional support to themounting evidence that microplastic fibers in soil can affect the plant–soil system by promoting plantgrowth, and favoring key root symbionts, AM fungi. Although soil aggregation is usually positivelyinfluenced by plant roots and AM fungi, and microplastic promotes both, our results show that plasticstill had a negative effect on soil aggregates. Even though there are concerns that microplastic mightinteract with other factors of global change, our study revealed no such effect for drought. | Anika Lehmann Eva FLeifheit Linshan Feng Joana Bergmann Anja Wulf Matthias C.Rillig | 2022 | Soil Ecology Letters2022，4，1： | 2 |
| 6 | Effects of synbiotic fermentation products on primary chemoprevention in human colon cells显示文摘 | Katrin Stein Anke Borowicki Daniel Scharlau Anika Schettler Kerstin Scheu Ursula Obst Michael Glei | 2012 | The Journal of Nutritional Biochemistry2012，，7： | 2 |
| 7 | Dentin matrix protein 1 and phosphate homeostasis are critical for postnatal pulp, dentin and enamel formation显示文摘Deletion or mutation of dentin matrix protein 1 (DMP1) leads to hypophosphatemic rickets and defects within the dentin. However, it is largely unknown if this pathological change is a direct role of DMP1 or an indirect role of phosphate (Pi) or both. It has also been previously shown that Klotho-deficient mice, which displayed a high Pi level due to a failure of Pi excretion, causes mild defects in the dentinal structure. This study was to address the distinct roles of DMP1 and Pi homeostasis in cell differentiation, apoptosis and mineralization of dentin and enamel. Our working hypothesis was that a stable Pi homeostasis is critical for postnatal tooth formation, and that DMP1 has an antiapoptotic role in both amelogenesis and dentinogenesis. To test this hypothesis, Dmp1-null (Dmp1 2/2 ), Klotho-deficient (kl/kl), Dmp1/Klotho-double-deficient (Dmp1 2/2 /kl/kl) and wild-type (WT) mice were killed at the age of 6 weeks. Combinations of X-ray, microcomputed tomography (mCT), scanning electron microscopy (SEM), histology, apoptosis and immunohistochemical methods were used for characterization of dentin, enamel and pulp structures in these mutant mice. Our results showed that Dmp1 2/2 (a low Pi level) or kl/kl (a high Pi level) mice displayed mild dentin defects such as thin dentin and a reduction of dentin tubules. Neither deficient mouse line exhibited any apparent changes in enamel or pulp structure. However, the double-deficient mice (a high Pi level) displayed severe defects in dentin and enamel structures, including loss of dentinal tubules and enamel prisms, as well as unexpected ectopic ossification within the pulp root canal. TUNEL assay showed a sharp increase in apoptotic cells in ameloblasts and odontoblasts. Based on the above findings, we conclude that DMP1 has a protective role for odontoblasts and ameloblasts in a pro-apoptotic environment (a high Pi level). | Afsaneh Rangiani Zheng-Guo Cao Ying Liu Anika Voisey Rodgers Yong Jiang Chun-Lin Qin Jian-Quan Feng | 2012 | International Journal of Oral Science2012，4，4： | 2 |
| 8 | Calculations of dietary exposure to aerylamide 显示文摘 | Polly E Boon Anika de Mul Hilko van der Voet | 2005 | Mutation Research2005，580，12： | 1 |
| 9 | Emission of ESBL/AmpC-producing Escherichia coli from pig fattening farms to surrounding areas显示文摘 | Christina von Salviati Henriette Laube Beatriz Guerra Uwe Roesler Anika Friese | 2014 | Veterinary Microbiology2014，，： | 1 |
| 10 | Lack of Association Between the MEF2A Gene and Myocardial Infarction显示文摘 | Wolfgang Lieb Bj?rn Mayer Inke R. K?nig Iris Borwitzky Anika G?tz Silke Kain Christian Hengstenberg Patrick Linsel-Nitschke Marcus Fischer Angela D?ring H -Erich Wichmann Thomas Meitinger Reinhold Kreutz Andreas Ziegler Heribert Schunkert Jeanette Erdmann | 2008 | Circulation2008，，2： | 1 |
| 11 | Primary preventive potential of major lifestyle risk factors for acute myocardial infarction in men: an analysis of the EPIC-Heidelberg cohort显示文摘 | Kuanrong Li Stefano Monni Anika Hüsing Andrea Wendt Jutta Kneisel Marie-Luise Gro? Rudolf Kaaks | | European Journal of Epidemiology0，，1： | 1 |
| 12 | Physical exercise prevents age-related decline in precursor cell activity in the mouse dentate gyrus 显示文摘 | Golo Kronenberg Anika Bick-Sander Eva Bunk | 2006 | Neurobiology of Aging2006，27，： | 1 |
| 13 | Endocrine cancer syndromes:an update显示文摘 | AnikA Abaci A | 2014 | Minerva Pediatr2014，66，6： | 1 |
| 14 | Ultrasonic welding of polyamide:influence of moisture on the process relevant material properties显示文摘 | CHRISTIAN H ANIKA A | 2014 | Ultrasonics2014，58，6： | 1 |
| 15 | Poor prognosis of constitutive γ-H2AX expressing triple-negative breast cancers is associated with telomere length显示文摘 | Anika Nagelkerke Simon JA van Kuijk John W Martens Fred CGJ Sweep Nicoline Hoogerbrugge Johan Bussink Paul N Span | 2015 | Biomark. Med2015，，4： | 1 |
| 16 | Satiety elicited by cholecystokinin in intact and vagotomized rats 显示文摘 | Anika S M Houpt T R Houpt K A | 1977 | Physiol Behav1977，19，6： | 1 |
| 17 | Quantitative PCR assays for mouse enteric flora reveal strain-dependent differences in composition that are influenced by the microenvironment显示文摘 | A. Deloris Alexander Roger P. Orcutt JaNell C. Henry Joseph Baker Anika C. Bissahoyo David W. Threadgill | 2006 | Mammalian Genome2006，，11： | 1 |
| 18 | Satiety elicited by cholecystokinin in intact and vagotomized rats显示文摘 | Anika S M Houpt T R Houpt K A | 1977 | Physiol Behav1977，19，6： | 1 |
| 19 | Amyloid-p contributes to blood-brain barrier leakagein transgenic human amyloid precursor protein mice and inhumans with cerebral amyloid angiopathy显示文摘 | Anika M S Hartz Bjorn Bauer Emma L B Soldner | 2012 | Stroke2012，43，2： | 1 |
| 20 | PAR1 Is a Matrix Metalloprotease-1 Receptor that Promotes Invasion and Tumorigenesis of Breast Cancer Cells显示文摘 | Adrienne Boire Lidija Covic Anika Agarwal Suzanne Jacques Sheida Sherifi Athan Kuliopulos | 2005 | Cell2005，，3： | 1 |
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