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| 1 | Impaired contractility and remodeling of the upper gastrointestinal tract in diabetes mellitus type-1显示文摘AIM: To investigate that both the neuronal function of the contractile system and structural apparatus of the gastrointestinal tract are affected in patients with longstanding diabetes and auto mic neuropathy. METHODS: The evoked esophageal and duodenal contractile activity to standardized bag distension was assessed using a specialized ultrasound-based probe. Twelve type-1 diabetic patients with autonomic neuropathy and severe gastrointestinal symptoms and 12 healthy controls were studied. The geometry and biomechanical parameters (strain, tension/stress, and stiffness) were assessed. RESULTS: The diabetic patients had increased frequency of distension-induced contractions (6.0 ± 0.6 vs 3.3 ± 0.5, P < 0.001). This increased reactivity was correlated with the duration of the disease (P = 0.009). Impaired coordination of the contractile activity in diabetic patients was demonstrated as imbalance between the time required to evoke the first contraction at the distension site and proximal to it (1.5 ± 0.6 vs 0.5 ± 0.1, P = 0.03). The esophageal wall and especially the mucosa-submucosa layer had increased thickness in the patients (P < 0.001), and the longitudinal and radial compressive stretch was less in diabetics (P <0.001). The esophageal and duodenal wall stiffness and circumferential deformation induced by the distensions were not affected in the patients (all P > 0.14). CONCLUSION: The impaired contractile activity with an imbalance in the distension-induced contractions likely reflects neuronal abnormalities due to autonomic neuropathy. However, structural changes and remodeling of the gastrointestinal tract are also evident and may add to the neuronal changes. This may contribute to the pathophysiology of diabetic gut dysfunction and impact on future management of diabetic patients with gastrointestinal symptoms. | Jens BrΦndum FrΦkjΦr SΦren Due Andersen Niels EjskjΦr Peter Funch-Jensen AsbjΦrn Mohr Drewes Hans Gregersen | 2007 | World Journal of Gastroenterology2007，13，36： | 8 |
| 2 | Safety and efficacy of Profermin~to induce remission in ulcerative colitis显示文摘AIM:To test the efficacy and safety of Profermin in inducing remission in patients with active ulcerative colitis(UC).METHODS:The study included 39 patients with mild to moderate UC defined as a Simple Clinical Colitis Activity Index(SCCAI)>4 and<12(median:7.5),who were treated open-label with Profermintwice daily for 24 wk.Daily SCCAI was reported observer blinded via the Internet.RESULTS:In an intention to treat(ITT)analysis,the mean reduction in SCCAI score was 56.5%.Of the 39 patients,24(62%)reached the primary endpoint,which was proportion of patients with≥50%reduction in SCCAI.Our secondary endpoint,the proportion of patients in remission defined as SCCAI≤2.5,was in ITT analysis reached in 18 of the 39 patients(46%).In a repeated-measure regression analysis,the estimated mean reduction in score was 5.0 points(95%CI:4.1-5.9,P<0.001)and the estimated mean time taken to obtain half the reduction in score was 28 d(95%CI:26-30).There were no serious adverse events(AEs)or withdrawals due to AEs.Profermin was generally well tolerated.CONCLUSION:Profermin is safe and may be effective in inducing remission of active UC. | Aleksander Krag Hans Israelsen Bjrn von Ryberg Klaus K Andersen Flemming Bendtsen | 2012 | World Journal of Gastroenterology2012，18，15： | 2 |
| 3 | Communica- tion among oral bacteria 显示文摘 | Kolenbrander PE Andersen RN Blehert DS | 2002 | Microbiol Mol Biol Rev2002，66，3： | 1 |
| 4 | Communication among oral bacteria显示文摘 | Kolenbrander PE Andersen RN Blehert DS | 2002 | Microbiol Mol Biol Rev2002，66，3： | 1 |
| 5 | β-endorphin and β-lipotropin plasma levels in himute women:correlation with body weight显示文摘 | Givens JR Wiedemann E Andersen RN | 1980 | J Clin Endocrinol Mete1980，50，： | 1 |
| 6 | Matrix Protein 2 of Influenza A Virus Blocks Autophagosome Fusion with Lysosomes显示文摘 | Monique Gannagé Dorothee Dormann Randy Albrecht J?rn Dengjel Tania Torossi Patrick C. R?mer Monica Lee Till Strowig Frida Arrey Gina Conenello Marc Pypaert Jens Andersen Adolfo García-Sastre Christian Münz | 2009 | Cell Host & Microbe2009，，4： | 1 |
| 7 | Matrix Protein 2 of Influenza A Virus Blocks Autophagosome Fusion with Lysosomes显示文摘 | Monique Gannagé Dorothee Dormann Randy Albrecht J?rn Dengjel Tania Torossi Patrick C. R?mer Monica Lee Till Strowig Frida Arrey Gina Conenello Marc Pypaert Jens Andersen Adolfo García-Sastre Christian Münz | 2009 | Cell Host & Microbe2009，，4： | 1 |
| 8 | Coaggregation of Fusobacterium nucleatum,Selenomonas flueggei,Selenomonas infelix,Selenomonas noxia,and Selenomonas sputigena with strains from 11 genera of oral bacteria显示文摘 | Kolenbrander PE Andersen RN Moore LV | 1989 | Infect Immun1989，57，10： | 1 |
| 9 | β- endorphin and β -lipotropin plasma levels in hirsute women:correlation with body weight显示文摘 | Givens JR Wiedemann E Andersen RN | 1980 | J Clin Endocrinol Metab1980，50，： | 1 |
| 10 | Improved sensitivity and specificity of a single measurement of serum progesterone over serial quantitative beta-human chorionic gonadotrophin in screening for ectopic pregnancy显示文摘 | Stovall TG Ling FW Andersen RN | | 0，，05： | 1 |
| 11 | Challenges in global ballast water management显示文摘 | ?yvind Endresen Hanna Lee Behrens Sigrid Brynestad Aage Bj?rn Andersen Rolf Skjong | 2004 | Marine Pollution Bulletin2004，，7： | 1 |
| 12 | Oral dehydroepiandrosterone in physiologic doses modulatesimmune function in postmenopausal women显示文摘 | Casson PR Andersen RN Herrod HG | | 0，，06： | 1 |
| 13 | GPX Pro198Leu and OGG1 Ser326Cys polymorphisms and risk of development of colorectal adenomas and colorectal cancer显示文摘 | Rikke Hansen Mona S?b? Camilla Furu Skjelbred Bj?rn Andersen Nex? Per Christian Hagen Günther Bock Inger Marie Bowitz Lothe Egil Johnson Steinar Aase Inger-Lise Hansteen Ulla Vogel Elin H. Kure | 2005 | Cancer Letters2005，，1： | 1 |
| 14 | Multi-modal induction and assessment of allodynia and hyperalgesia in the human oesophagus显示文摘 | Asbj?rn Mohr Drewes Klaus-Peter Schipper Georg Dimcevski Poul Petersen Ole K?seler Andersen Hans Gregersen Lars Arendt-Nielsen | 2003 | European Journal of Pain2003，，6： | 1 |
| 15 | Neuropeptide Y and nitrite levels in preeclampic and normotensive gravid women显示文摘 | Egerman RS Andersen RN manejwala FM | 1991 | Am J Obstet Gynecol1991，181，4： | 1 |
| 16 | Coaggregation of Fusobacterium nucleatum, Selenomonas flueggei, Selenomonas infelix, Selenomonas noxia, and Selenomohas sputigena with strains from 11 genera of oral bacteria显示文摘 | Kolenbrander PE Andersen RN Moore LV | 1989 | Infect Immun1989，57，10： | 1 |
| 17 | Communication among oral bacteria显示文摘 | Kolenbrander PE Andersen RN Blehert DS | 2002 | Microbiol Mol Biol Rev2002，66，3： | 1 |
| 18 | Vaccination with autologous dendritic cells pulsed with multiple tumor antigens for treatment of patients with malignant melanoma: results from a phase I/II trial显示文摘 | Redas Trepiakas Annika Berntsen Sine Reker Hadrup Jon Bj? rn Poul F. Geertsen Per Thor Straten Mads H. Andersen Anders E. Pedersen Amir Soleimani Torben Lorentzen Julia S. Johansen Inge Marie Svane | 2010 | Cytotherapy2010，，： | 1 |
| 19 | Different alliance relationships for project design and execution显示文摘 | Brian Hobbs and Bjψrn Andersen | 2001 | International Journal of Project Management2001，19，8： | 1 |
| 20 | Helicobacter Pylori Adherts Selectively to Fusobacterium Spp显示文摘 | Ganeshskumar N Kolenbrander PE | 1998 | Oral Microbiology Immunol1998，13，1： | 1 |
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