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| 1 | Factors associated with incomplete small bowel capsule endoscopy studies显示文摘AIM:To identify patient risk factors associated with incomplete small bowel capsule endoscopy(CE) studies.METHODS:Data from all CE procedures performed at St.Paul's Hospital in Vancouver,British Columbia,Canada,between December 2001 and June 2008 were collected and analyzed on a retrospective basis.Data collection for complete and incomplete CE study groups included patient demographics as well as a number of potential risk factors for incomplete CE including indication for the procedure,hospitalization,diabetes mellitus with or without end organ damage,limitations in mobility,renal insufficiency,past history of bowel obstruction,abdominal surgery,abdominal radiation therapy and opiate use.Risk factors were analyzed using a univariable and multivariable logistic regression model.RESULTS:From a total of 535 CE procedures performed,158 were incomplete(29.5%).The univariable analysis showed that CE procedures performed for overt gastrointestinal bleeding(P = 0.002),and for patients with a prior history of abdominal surgery(P = 0.023) or bowel obstruction(P = 0.023) were significantly associated with incomplete CE studies.Patients on opiate medications(P = 0.094) as well as hospitalized patients(P = 0.054) were not statistically significant,but did show a trend towards incomplete CE.The multivariable analysis showed that independent risk factors for an incomplete CE procedure include prior history of bowel obstruction [odds ratios(OR) 2.77,P = 0.02,95% confidence intervals(CI):1.17-6.56] and procedures performed for gastrointestinal bleeding(Occult OR 2.04,P = 0.037,95% CI:1.04-4.02 and Overt OR 2.69,P = 0.002,95% CI:1.44-5.05).Patients with a prior history of abdominal surgery(OR 1.46,P = 0.068,95% CI:0.97-2.19),those taking opiate medications(OR 1.54,P = 0.15,95% CI:0.86-2.76) and hospitalized patients(OR 1.82,P = 0.124,95% CI:0.85-3.93) showed a trend towards statistical significance.CONCLUSION:We have identified a number of risk factors for incomplete CE procedures that can be used to risk-stratify patients and guide interventions to improve completion rates. | Mitchell M Lee Andrew Jacques Eric Lam Ricky Kwok Pardis Lakzadeh Ajit Sandhar Brandon Segal Sigrid Svarta Joanna Law Robert Enns | 2010 | World Journal of Gastroenterology2010，16，42： | 10 |
| 2 | 国际糖尿病足工作组:糖尿病足溃疡周围动脉病变诊断、预后与管理指南——《国际糖尿病足工作组:糖尿病足防治国际指南(2019)》的一部分显示文摘1999年以来,国际糖尿病足工作组(IWGDF)已经多次发表循证医学基础上的糖尿病足预防与管理指南。该指南是有关糖尿病足溃疡合并周围动脉病变(PAD)患者的诊断、预后和管理指南,更新了以前IWGDF指南的内容。高达50%的糖尿病足溃疡患者同时患有PAD,这种病变使得患者截肢和心血管病变的风险明显增加。这类患者的诊断、预后和治疗明显地不同于那些没有PAD的糖尿病患者,但仅有很少的关于这类患者的高质量的研究强调了这点。我们遵循GRADE方法来提出临床问题并以至少包括患者-干预-比较-结局(PICO)形式说明重要结局,进行了系统的医学科学文献评价,写出推荐意见及其合理性。这类推荐是建立在系统文献评价的循证医学基础上的,没有证据时则在权衡利弊和患者选择、便宜性和干预的费用等因素后,采用专家的观点。这里我们发布更新的2019年糖尿病足溃疡合并PAD患者的有关PAD诊断、预后和管理的指南,以及一些需要未来特别关注的研究课题。 | Robert J.Hinchliffe Rachael O.Forsythe Jan Apelqvist Ed J.Boyko Robert Fitridge Joon Pio Hong Konstantinos Katsanos Joseph L.Mills Sigrid Nikol Jim Reekers Maarit Venermo R.Eugene Zierler Nicolaas C.Schaper 无 许樟荣(译) 冉兴无(审校) | 2019 | 感染.炎症.修复2019，20，4： | 10 |
| 3 | Therapeutic potential of curcumin in gastrointestinal diseases显示文摘Curcumin,also known as diferuloylmethane,is derived from the plant Curcuma longa and is the active ingredient of the spice turmeric.The therapeutic activities of curcumin for a wide variety of diseases such as diabetes,allergies,arthritis and other chronic and inflammatory diseases have been known for a long time.More recently,curcumin's therapeutic potential for preventing and treating various cancers is being recognized.As curcumin's therapeutic promise is being explored more systematically in various diseases,it has become clear that,due to its increased bioavailability in the gastrointestinal tract,curcumin may be particularly suited to be developed to treat gastrointestinal diseases.This review summarizes some of the current literature of curcumin's anti-inflammatory,anti-oxidant and anti-cancer potential in inflammatory bowel diseases,hepaticfibrosis and gastrointestinal cancers. | Sigrid A Rajasekaran | 2011 | World Journal of Gastrointestinal Pathophysiology2011，2，1： | 8 |
| 4 | Ultrasound enhanced friction stir welding of aluminum and steel: Process and properties of EN AW 6061/DC04-Joints显示文摘In this work, the joining of aluminum to steel was conducted by ultrasound enhanced friction stir welding(USE-FSW). The power ultrasound was introduced into one of the metal sheets by an ultrasonic roll seam module synchronously to the FSW-process. The effect of the ultrasound on the resulting welds, their microstructure and their corrosion properties was investigated by light and scanning electron microscopy and corrosion investigations. The USE-FSW-joints showed less and smaller steel particles in the nugget zone as well as a thinner continuous intermetallic phase of FeAl_3 at the interface. The nondestructive testing method of computed laminography proved the observations made by optic microscopy due to non-porous joints for both techniques. Corrosion investigations showed only low corrosion current densities and no enhanced galvanic corrosion for the EN AW-6061/DC04-hybrid joints in sodium chloride solution. | Marco Thoma Guntram Wagner Benjamin Straβ Bernd Wolter Sigrid Benferc Wolfram Furbeth | 2018 | Journal of Materials Science & Technology2018，34，1： | 6 |
| 5 | Abdominal pain in Irritable Bowel Syndrome: A review of putative psychological, neural and neuro-immune mechanisms显示文摘 | Sigrid Elsenbruch | 2010 | Brain Behavior and Immunity2010，，3： | 5 |
| 6 | Comprehensive Level One Trauma Center Could Lower In-hospital Mortality of Severe Trauma in China显示文摘Trauma is a major health and social problem in the US and China.It constitutes the main cause of death in people aged 45 or under in both countries[1-2].There is clear evidence from clinical studies that a large percentage of these deaths are needless and preventable if better treatment and prevention programs are available[2-3]. | CAI Bin Burruss SIGRID Britt REDICK JIANG Hua SUN Ming Wei YANG Hao Charles Damien LU Mitchell Jay COHEN Henry CRYER ZENG Jun | 2014 | Biomedical and Environmental Sciences2014，27，7： | 5 |
| 7 | Strictures, diaphragms, erosions or ulcerations of ischemic type in the colon should always prompt consideration of nonsteroidal anti-inflammatory drug-induced lesions显示文摘AIM: To investigate whether NSAIDs/ASA lesions in the colon can histologically be diagnosed on the basis of ischemic necrosis similar to biopsy-based diagnosis of NSAIDs/ASA-induced erosions and ulcers of the stomach.METHODS: In the period between 1997 and 2002, we investigated biopsy materials obtained from 611 patients (415 women, 196 men, average age 60.5 years) with endoscopic focal erosions, ulcerations, strictures or diaphragms in the colon. In the biopsies obtained from these lesions, we always established the suspected diagnosis of NSAID-induced lesions whenever necroses of the ischemic type were found. Together with the histological report, we endosed a questionnaire to investigate the use of medication.The data provided by the questionnaire were then correlated with the endoscopic findings, the location, number and nature of the lesions, and the histological findings.RESULTS: At the time of their colonoscopy, 86.1% of the patients had indeed been taking NSAID/ASA medication for years (43.9%) or months (29.5%). The most common indication for the use of these drugs was pain (64.3%),and the most common indication for colonoscopy was bleeding (55.5%). Endoscopic inspection revealed multiple erosions and/or ulcers in 60.6%, strictures in 15.8%, and diaphragms in 3.0% of the patients. The lesions were located mainly in the right colon including the transverse colon (79.9%). A separate analysis of age and sex distribution,endoscopic and histological findings for NSAIDs alone,ASA alone, combined NSAID/ASA, and for patients denying the use of such drugs, revealed no significant differences among the groups.CONCLUSION: This uncontrolled retrospective study based on the histological finding of an ischemic necrosis shows that the histologically suspected diagnosis of NSAID-induced lesions in the colon is often correct. The true diagnostic validity of this finding and the differentiation from ischemic colitis should, however, be investigated in a prospective controlled study. | Manfred Stolte Diana Karimi Michael Vieth Hildegard Volkholz Klaus Dirschmid Sigrid Rappel Birgit Bethke | 2005 | World Journal of Gastroenterology2005，11，37： | 3 |
| 8 | Environmental monitoring study of selected veterinary antibiotics in animal manure and soils in Austria显示文摘 | Elena Martínez-Carballo Carmen González-Barreiro Sigrid Scharf Oliver Gans | 2006 | Environmental Pollution2006，，2： | 3 |
| 9 | 电池部分放电后析气量低的新型锌粉显示文摘用于碱性锌锰电池的锌粉在投产前都必须测定析气量,通常将使用的锌粉制成LR14 电池,采用2Ω恒电阻连续放电4 .5h 后在70 ℃下贮存7d ,如果锌粉释放出的气体量不高于负极集流体端部密封圈防爆孔开启压力的10 % ~20 % ,则该锌粉就可以使用。然而,有些合金锌粉在电池部分放电( 如放电40min) 后析气量剧增,为了研究锌粉的析气行为,我们测试了不同规格电池和锌粉在电池部分放电后的析气量,结果显示,Grillo 公司研制的一种新型锌粉在电池部分放电后析气量非常低,文章讨论了该锌粉的析气量和放电行为。 | Wolfgang Glaeser Sigrid Kunzel-Keune Petra Merkel Grillo-Werke AG,Werk Goslar (D-38644 Goslar, Germany) | 1999 | 电池工业1999，4，4： | 3 |
| 10 | Transition from a maternal to external nitrogen source in maize seedlings显示文摘Maximizing NO_3^- uptake during seedling development is important as it has a major influence on plant growth and yield.However,little is known about the processes leading to,and involved in,the initiation of root NO_3^- uptake capacity in developing seedlings.This study examines the physiological processes involved in root NO_3^- uptake and metabolism,to gain an understanding of how the NO_3^- uptake system responds to meet demand as maize seedlings transition from seed N use to external N capture.The concentrations of seedderived free amino acids within root and shoot tissues are initially high,but decrease rapidly until stabilizing eight days after imbibition(DAI).Similarly,shoot N% decreases,but does not stabilize until 12–13 DAI.Following the decrease in free amino acid concentrations,root NO_3^- uptake capacity increases until shoot N%stabilizes.The increase in root NO_3^- uptake capacity corresponds with a rapid rise in transcript levels of putative NO_3^- transporters,Zm NRT2.1 and Zm NRT2.2.The processes underlying the increase in root NO_3^- uptake capacity to meet N demand provide an insight into the processes controlling N uptake. | Kasra Sabermanesh Luke R. Holtham Jessey George Ute Roessner Berin A. Boughton Sigrid Heuer Mark Tester Darren C. Plett Trevor P. Garnett | 2017 | Journal of Integrative Plant Biology2017，59，4： | 2 |
| 11 | Vitreous Levels of Bevacizumab and Vascular Endothelial Growth Factor-A in Patients with Choroidal Neovascularization显示文摘 | Qi Zhu Focke Ziemssen Sigrid Henke-Fahle Olcay Tatar Peter Szurman Sabine Aisenbrey Nicole Schneiderhan-Marra Xun Xu Salvatore Grisanti | 2008 | Ophthalmology2008，，10： | 2 |
| 12 | Genetic diversity for mycorrhizal symbiosis and phosphate transporters in rice显示文摘Phosphorus(P) is a major plant nutrient and developing crops with higher P-use efficiency is an important breeding goal.In this context we have conducted a comparative study of irrigated and rainfed rice varieties to assess genotypic differences in colonization with arbuscular mycorrhizal(AM) fungi and expression of different P transporter genes.Plants were grown in three different soil samples from a rice farm in the Philippines.The data show that AM symbiosis in all varieties was established after 4 weeks of growth under aerobic conditions and that,in soil derived from a rice paddy,natural AM populations recovered within6 weeks.The analysis of AM marker genes(AM1,AM3,AM14) and P transporter genes for the direct Pi uptake(PT2,PT6) and AM-mediated pathway(PT11,PT13) were largely in agreement with the observed root AM colonization providing a useful tool for diversity studies.Interestingly,delayed AM colonization was observed in the aus-type rice varieties which might be due to their different root structure and might confer an advantage for weed competition in the field.The data further showed that P-starvation induced root growth and expression of the high-affinity P transporter PT6 was highest in the irrigated variety IR66 which also maintained grain yield under P-deficient field conditions. | Kwanho Jeong Nicolas Mattes Sheryl Catausan Joong Hyoun Chin Uta Paszkowski Sigrid Heuer | 2015 | Journal of Integrative Plant Biology2015，57，11： | 2 |
| 13 | Waixenicin A,a marine-derived TRPM7 inhibitor:a promising CNS drug lead显示文摘Ion channels are the third largest class of targets for therapeutic drugs.The pharmacology of ion channels is an important research area for identifying new treatment options for human diseases.The past decade or so has seen increasing interest in an ion channel protein belonging to the transient receptor potential(TRP)family,namely the melastatin subfamily member 7(TRPM7),as an emerging drug target.TRPM7 is a bifunctional protein with a magnesium and calcium-conducting divalent ion channel fused with an active kinase domain.TRPM7 is ubiquitously expressed in human tissues,including the brain,and regulates various cell biology processes such as magnesium and calcium homeostasis,cell growth and proliferation,and embryonic development.TRPM7 provides a link between cellular metabolic status and intracellular calcium homeostasis in neurons due to TRPM7’s unique sensitivity to fluctuating intracellular Mg·ATP levels.Thus,the protein plays a key role in ischemic and hypoxic neuronal cell death and brain injury,and is one of the key nonglutamate mechanisms in cerebral ischemia and stroke.Currently,the most potent and specific TRPM7 inhibitor is waixenicin A,a xenicane diterpenoid from the Hawaiian soft coral Sarcothelia edmondsoni.Using waixenicin A as a pharmacological tool,we demonstrated that TRPM7 is involved in promoting neurite outgrowth in vitro.Most recently,we found that waixenicin A reduced hypoxic-ischemic brain injury and preserved long-term behavioral outcomes in mouse neonates.We here suggest that TRPM7 is an emerging drug target for CNS diseases and disorders,and waixenicin A is a viable drug lead for these disorders. | Hong-Shuo Sun F.David Horgen Daniel Romo Kenneth G.Hull Sigrid A.Kiledal Andrea Fleig Zhong-Ping Feng | 2020 | Acta Pharmacologica Sinica2020，41，12： | 2 |
| 14 | Prediction of axial length on the basis of vitreous body length and lens thickness显示文摘 | Sigrid Roters Martin Hellmich Peter Szurman | 2002 | Journal of Cataract & Refractive Surgery2002，，5： | 2 |
| 15 | 骨髓动员对骨髓造血干细胞在心肌梗死后心脏中定植及分化的影响显示文摘目的观察小鼠心肌梗死后骨髓造血干细胞在心脏内的分化及细胞因子的影响。方法C57/BL6小鼠60只分为骨髓动员组和对照组,先后行脾切除、骨髓移植(骨髓供体为增强绿色荧光蛋白转基因小鼠)、骨髓动员及建立心肌梗死模型。心肌梗死后3周将小鼠心脏取出并切片行组织学及激光共聚焦显微镜免疫荧光检查。结果骨髓动员可以增加EGFP阳性细胞在心脏中梗死区和边缘区的定植,但绝大多数EGFP阳性细胞都同时表达CD45。仅发现有极少数骨髓来源的心肌细胞、成纤维细胞及血管内皮细胞,且与骨髓动员无相关性。结论骨髓动员能够明显促进骨髓来源细胞定植入小鼠心脏的梗死区;极少数骨髓造血干细胞可以分化为心肌细胞,其数量远不足以修复梗死心肌及改善心功能;骨髓造血干细胞不参与梗死区疤痕形成的病理过程。 | 田文 曾定尹 Michael Kuhl mann Sigrid Nikol | 2009 | 中国组织化学与细胞化学杂志2009，18，3： | 2 |
| 16 | Environmental monitoring study of selected veterinary antibiotics in animal manure and soils in Austria显示文摘 | Elena Martínez-Carballo Carmen González-Barreiro Sigrid Scharf Oliver Gans | 2006 | Environmental Pollution2006，，2： | 2 |
| 17 | Increased P53 mutation frequency during tumor progression-results from a breast cancer cohort显示文摘 | Torbjorn N Sigrid K Gunilla K | 2001 | Cancer Res2001，5，61： | 1 |
| 18 | Scheduling chains with identical jobs and constant delays on a single machine显示文摘 | Brucker Peter Knust Sigrid | 2006 | Mathematical Methods of Operations Research2006，63，1： | 1 |
| 19 | Ultrasound biomicroscopy in chronic ocular hypotony:its impact on diagnosis and management显示文摘 | Sigrid R Peter S Bert E Karl BS Gunter K | 2002 | Retina2002，22，5： | 1 |
| 20 | The impact of metal cleanliness on mechanical properties of die cast magnesium AM50 显示文摘 | Per Bakke Ketil Pettersen Sigrid Guldberg | 2000 | Magnesium Alloys and Their Applications2000，，： | 1 |
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