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| 1 | Role of cholecystokinin and central serotonergic receptors in functional dyspepsia显示文摘机能性消化不良的症状被上面的腹的不快或疼痛描绘,早饱足,饭后的充分,膨胀,恶心并且呕吐。它非常是长期的混乱,与症状 3 瞬间每器质性病的年,和没有证据。不正常的活动性,改变的内脏的感觉,和精神分析聚会因素都作为主要 pathophysiological 机制被识别了。这些 pathophysiological 机制交往生产观察症状,这被相信。消化不良基于主导的症状被分成了三亚群。象 Dysmotility 一样消化不良描述其综合征通常与一个胃的感觉运动的机能障碍有关的病人的亚群。大脑勇气肽缩胆囊素(CCK ) 和血清素(5-HT ) 分享某些生理的效果。被显示了胃的倒空减少并且影响饱足。而且, CCK 导致了取决于的厌食可能经由中央小径行动的 serotonergic 功能。我们相信和一只亢奋的应答的海角工作到 CCK 或他们的相互作用的中央 serotonergic 受体的畸形可能为在机能性消化不良(FD ) 的症状的开始负责。 | Andrew Seng Boon Chua PWN Keeling TG Dinan | 2006 | World Journal of Gastroenterology2006，12，9： | 16 |
| 2 | Central serotonergic and noradrenergic receptors in functional dyspepsia显示文摘机能性消化不良是上面的腹的不快或疼痛,早饱足,马达畸形,当器质性病不在时的腹的膨胀和恶心描述的综合征。中枢神经系统在进行并且处理内脏的信号起一个重要作用。在大脑处理疼痛,感觉和感情方面的回答的改变可以是在机能性消化不良的致病的关键因素。中央 serotonergic 和也不肾上腺素能的受体系统涉及处理马达,感觉并且胃肠道的分泌活动。内脏的超敏性当前在机能性消化不良被认为是为马达改变和腹的疼痛负责的机制。一些研究建议在中央 serotonergic 和可以部分解释一些机能性消化不良的症状的也不肾上腺素能的系统有改变。在自主神经系统的改变可以在在内脏的敏感的马达畸形和这些病人的增加被含有。去甲肾上腺素是在交感神经系统的主要 neurotransmitter,再,在这个系统工作的改变可以在运动机能导致变化。机能性消化不良在病人和社会上引起可观的负担。机能性消化不良的病理生理学充分没被理解,但是在由 serotonergic 和也不肾上腺素能的系统的中央处理的改变可以为症状的至少一些提供貌似合理的解释并且为未来提供可能的治疗目标。 | S O'Mahony TG Dinan PW Keeling ASB Chua | 2006 | World Journal of Gastroenterology2006，12，17： | 13 |
| 3 | 术前肌电图和脑干听觉诱发电位与面肌痉挛微血管减压术后迟发性面瘫发生的关系(英文)显示文摘Background Delayed facial palsy ( DFP) after microvascular decompression ( MVD) in patients with hemifacial spasm ( HFS) is not uncommon,but the cause remains unknown. Objectives To assess whether intraoperative electromyography ( EMG) and brainstem auditory evoked potential ( BAEP) can predict DFP after MVD. Methods Between September 2009 and February 2011 we examined 86 patients,9 of whom ( 10. 4% ) developed DFP after MVD on the same side. All patients underwent MVD and were followed - up for a median period of 13 months ( range 6-22) . We retrospectively examined intraoperative facial EMG and BAEP findings using our MVD patients' registry. We excluded secondary HFS and immediate postoperative facial palsy after MVD in this study. We assessed the prevalence and clinical characteristics of DFP and compared EMG and BAEP findings between DFP and non-DFP groups. Results: All pa- tients recovered completely,with a mean time to recovery of 37. 8 days ( range 22-57) . There were no significant differences between DFP and non - DFP patients in terms of the amplitude and latency of intraoperative EMG and BAEP. Conclusion The usefulness of intraoperative facial EMG and BAEP is limited and cannot predict DFP after MVD for HFS. We speculate that DFP after MVD is not associated with permanent nerve damage according to the EMG findings. | Kim HJ Park YS Ryu JS Huh R Han I Shin DA Kim TG Cho KG Chung SS | 2012 | 中华神经外科疾病研究杂志2012，11，4： | 13 |
| 4 | 外科手术核对清单可全球范围内降低手术并发症发生率和手术死亡率(续前)显示文摘背景外科手术已经成为全球卫生保健构成整体所必需的一部分,估计每年实施的手术有2亿3千4百万次之多,手术并发症常见,并常常是可以预防的。我们设想,通过实施一份19项外科手术安全核对清单,以改善手术团队交流和治疗一致性,将会降低手术并发症发生率和手术死亡率。方法于2007年10月至2008年9月间,从8座城市(加拿大的多伦多、印度的新德里、约旦的安曼、新西兰的奥克兰、菲律宾的马尼拉、坦桑尼亚的伊法卡拉、英国的伦敦、华盛顿州的西雅图市)各选取1所医院共计8所医院参加世界卫生组织的'安全手术拯救生命项目',前瞻性地在临床治疗过程中和治疗结束时收集资料,共有3733例年龄16岁或16岁以上的进行非心脏手术的患者入选,随后在引入'外科手术安全核对清单'后收集了连续入选的3955名患者,主要终点事件为手术后30d内的并发症(包括死亡)发生率。结果在引入核对清单前死亡率为1.5%,手术并发症发生率为11.0%,而引入后死亡率和手术并发症发生率分别下降到0.8%(P=0.003)和7.0%(P<0.001)。结论实施外科手术核对清单可以降低不同医院16岁及16岁以上非心脏手术患者的死亡率和并发症发生率。结果在基线资料收集阶段我们入选了3733名患者,实施核对清单后入选3955名患者。表4罗列了这些患者的情况和医院分布,这两个阶段的患者情况没有明显差别。 | Haynes AB Weiser TG Berry WR 丁一妹 孙永华 高建川 | 2009 | 中华损伤与修复杂志(电子版)2009，4，3： | 9 |
| 5 | 高动态动脉僵硬度指数是普通中年人群年龄相关的肾小球滤过率快速下降的一个独立危险因素显示文摘Eriksen BO, Stefansson VT, Jenssen TG, Mathisen UD, Schei J, Solbu MD, Wilsgaard T, Melsom T. High ambulatory arte- rial stiffness index is an independent risk factor for rapid age-related glomerular filtration rate decline in the general middle- aged population. Hypertension, 2017,69 (4) : 651-659.动脉僵硬度是心血管病及慢性肾脏病的危险因素。流行病学研究难以足够精确测定肾小球滤过率(glomerular filtration rate, GFR),普通人群中,动脉僵硬度做为年龄相关GFR下降的预测因素,作用仍不明确。动态动脉僵硬度指数( ambulatory arterialstiffness index, AASI) 是一个易于从动态血压中计算得到的动脉僵硬度推荐指标。该研究在普通人群中评估AASI是否可预测碘海醇清除率评估的GFR下降。 | Eriksen BO Stefansson VT Jenssen TG Mathisen UD Schei J Solbu MD Wilsgaard T Melsom T 赵狄 练桂丽 | 2017 | 中华高血压杂志2017，25，3： | 8 |
| 6 | PNPLA3、TM6SF2和HSD17B13变异体对普通人群肝硬化和肝癌患病风险的综合影响显示文摘【据Hepatology 2020年3月报道】PNPLA3、TM6SF2和HSD17B13变异体对普通人群肝硬化和肝癌患病风险的综合影响(作者Gellert-Kristensen H等)作者假设脂肪肝的遗传风险评分(GRS)可影响肝硬化和肝细胞癌(HCC)的患病风险。来自丹麦的Gellert-Kristensen等将3种遗传变异[含patatin样磷脂酶结构域蛋白3(PNPLA3)p.I148M;跨膜6,超家族成员2(TM6SF2)p.E167K;以及羟基类固醇17-β脱氢酶13(HSD17B13)rs72613567]组成危险因素评分(等位基因为0到6个). | 朱倩 牛俊奇 GELLERT-KRISTENSEN H RICHARDSON TG DAVEY SMITH G | 2020 | 临床肝胆病杂志2020，36，10： | 6 |
| 7 | Metabolic and hepatic effects of liraglutide,obeticholic acid and elafibranor in diet-induced obese mouse models of biopsy-confirmed nonalcoholic steatohepatitis显示文摘AIM To evaluate the pharmacodynamics of compounds in clinical development for nonalcoholic steatohepatitis(NASH) in obese mouse models of biopsy-confirmedNASH.METHODS Male wild-type C57 BL/6 J mice(DIO-NASH) and Lep^(ob/ob)(ob/ob-NASH) mice were fed a diet high in trans-fat(40%), fructose(20%) and cholesterol(2%) for 30 and 21 wk, respectively. Prior to treatment, all mice underwent liver biopsy for confirmation and stratification of liver steatosis and fibrosis, using the nonalcoholic fatty liver disease activity score(NAS) and fibrosis staging system. The mice were kept on the diet and received vehicle, liraglutide(0.2 mg/kg, SC, BID), obeticholic acid(OCA, 30 mg/kg PO, QD), or elafibranor(30 mg/kg PO, QD) for eight weeks. Within-subject comparisons were performed on changes in steatosis, inflammation, ballooning degeneration, and fibrosis scores. In addition, compound effects were evaluated by quantitative liver histology, including percent fractional area of liver fat, galectin-3, and collagen 1 a1.RESULTS Liraglutide and elafibranor, but not OCA, reduced body weight in both models. Liraglutide improved steatosis scores in DIO-NASH mice only. Elafibranor and OCA reduced histopathological scores of hepatic steatosis and inflammation in both models, but only elafibranor reduced fibrosis severity. Liraglutide and OCA reduced total liver fat, collagen 1 a1, and galectin-3 content, driven by significant reductions in liver weight. The individual drug effects on NASH histological endpoints were supported by global gene expression(RNA sequencing) and liver lipid biochemistry.CONCLUSION DIO-NASH and ob/ob-NASH mouse models show distinct treatment effects of liraglutide, OCA, and elafibranor, being in general agreement with corresponding findings in clinical trials for NASH. The present data therefore further supports the clinical translatability and utility of DIO-NASH and ob/ob-NASH mouse models of NASH for probing the therapeutic efficacy of compounds in preclinical drug development for NASH. | Kirstine S Tolbol Maria NB Kristiansen Henrik H Hansen Sanne S Veidal Kristoffer TG Rigbolt Matthew P Gillum Jacob Jelsing Niels Vrang Michael Feigh | 2018 | World Journal of Gastroenterology2018，24，2： | 5 |
| 8 | Antimicrobial activity and essential oils of Curcuma aeruginosa,Curcuma mangga,and Zingiber cassumunar from Malaysia显示文摘Objective:To analyze the chemical composition of the essential oils of Curcuma aeruginosa (C.aeruginosa),Curcuma mangga(C.mangga),and Zingiber cassumunar(Z.cassumunar). and study their antimicrobial activity.Methods:Essential oils obtained by steam distillation were analyzed by gas chromatography-mass speclrometry(GC-MS).The antimicrobial activity of the essential oils was evaluated against four bacteria:Bacillus cereus(H.cereus).Staphylococcus aureus(S.aureus).Escherichia coli(E.coli).and Pseudomonas aeruginosa(P.aeruginosa);and two fungi:Candida albicans(C.albicans) and Cyptococcus neoformans(C.neoformans),using disc-diffusion and broth microdilution methods.Results:Cycloisolongifolene,8.9-dehydro-9- formyl(35.29%) and dihydrocoslunolide(22.51%) were the major compounds in C.aeruginosa oil; whereas caryophyllene oxide(18.71%) and caryophyllene(12.69%) were the major compounds in C.mangga oil:and 2,6.9,9-tetramethyl-2.6.10-cycloundecatrien-1-one(60.77%) andα-caryophyllene(23.92%) were abundant in Z.cassumunar oil.The essential oils displayed varying degrees of antimicrobial activity against all lested microorganisms.C.mangga oil had the highest and most broad-spectrum activity by inhibiting all microorganisms tested,with C.neoformans being the most sensitive microorganism by having the lowest minimum inhibitory concentration(MIC) and minimum fungicidal concentration(MFC) values of 0.1μL/mL. C.aeruginosa oil showed mild antimicrobial activity,whereas Z.cassumunar had very low or weak activity against the tested microorganisms.Conclusions:The preliminary results suggest promising antimicrobial properties of C.mangga and C.aeruginosa,which may be useful for food preservation,pharmaceutical treatment and natural therapies. | Tg Siti Amirah Tg Kamazeri Othman Abd Samah Muhammad Taher Deny Susanti Haitham Qaralleh | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，3： | 5 |
| 9 | Quantitative biochemical and ultrastructural comparison of mitochondrial permeability transition in isolated brain and liver mitochondria: evidence for reduced sensitivity of brain mitochondria 显示文摘 | Sarah BB Watkins SC Hastings TG | 2000 | Exp Neurol2000，16，： | 3 |
| 10 | Magnetic resonance imaging of hepatocellular carcinoma induced by diethylnitrosamine in Sprague-Dawley rats显示文摘Diethylnitrosamine (DENA) is able to induce various benign and malignant liver lesions in rats with a high success rate and a low mortality rate. It provides a more appropriate model that better simulates the various lesions occurring in humans than the usual model of tumor implantations. The aim of the present study was to evaluate MRI liver examination in Sprague-Dawley(SD) rats as a routine method to detect hepatocellular carcinoma (HCC) nodules induced by DENA and to follow up their growth. METHODS:Hepatic carcinogenesis was induced in 80 male SD rats using oral DENA solution. All animals were imaged for liver tumor detection with a 1.5 Tesla magnet (Siemens Sonata,Erlangen, Germany) using correspondence scan parameters and a radio-frequency knee coil. Macroscopic examinations were performed along the axial MRI sections to evaluate magnetic resonance imaging (MRI) findings, and histopathological assessment was also performed. RESULTS:No false negative results were obtained on MR images. Hepatic tumors in 72 rats were confirmed macro-scopically and 68 rats were detected by MRI till the 20th week. The smallest and the largest nodules detected by MRI were 2 mm and 37 mm in diameter respectively. The agreement rate of MRI with macroscopic observation was 39. 1% and 97. 4% respectively for 2 mm to 5 mm and more than 5 mm nodules. CONCLUSIONS:The hepatic tumor induced by DENA provides a more representative range of tumors for imaging diagnosis and interventional treatment. MRI is the best approach for scrutinizing pathological changes of rat livers in the period of observation. | Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China (Li X, Zhou XP and Guan YS) Department of Radiology, Ruijin Hospieal. Shanghai Second Medical University, Shanghai 200025 , China. Current address:Astra Zeneca R & D Alderley, Macclesfield SK 10 4 TG U. K. (Wang YX) | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 3 |
| 11 | Lipid bilayer partitioning and stability of camptothecin drugs显示文摘 | Burke TG Mishra AK Wani MC | 1993 | Biochemistry1993，32，： | 2 |
| 12 | Stability of TPT in low pH liposomes composed of distearoylphosphatidylcholine显示文摘 | Burke TG Gao X | 1994 | J Pharm Sci1994，83，： | 2 |
| 13 | 提高人类精液中圆形细胞数量测定的精确度显示文摘本研究的目的是提高用过氧化物酶试验检测精液中的白细胞时所得的圆形细胞数量的精确度。精液样本的圆形细胞浓度在(0.6~6)×10^6/mL之间,降低精液的稀释度,增加被测悬浮液的体积。1+5(1:6)的稀释度适合于测量过氧化物酶活性,并能为细胞检测提供足够清晰的背景。在该稀释度下,测定Neubauer-改良精子计数板两边所有18个网格中的细胞数量,额定细胞浓度为(1.9~3.3)×10^6/mL的10个样本中只有3个样本的圆形细胞数/〉400个。由于更低浓度的精子稀释液不适合测定圆形细胞或其过氧化物酶反应产物,所以无法精确测量(抽样误差5%)参考下限值(1×10^6/mL)。结果表明,正是由于测定精液中的10个样本中圆形细胞很难精确到1×10^6/mL,所以白细胞精液症临界值的确定一直存在诸多分歧。因此需要建立一些统计学上合理的参考限。 | Cooper TG Hellenkemper B 马蓉蓉 郑芹珠 季灵艳 周作民 | 2010 | 国际生殖健康/计划生育杂志2010，29，3： | 2 |
| 14 | Biopsy-directed immunosuppression following hepatic transplantation in man 显示文摘 | Willams JW Peters TG Vera SR | 1985 | Transplantation1985，39，6： | 2 |
| 15 | A novel coronavirus associated with severe acute respitatory syndrome显示文摘 | Ksiazek TG Erdman D Goldsmith CS | 2003 | N Engl J Med2003，348，： | 2 |
| 16 | Biodegradable polymeric microcellular foams by modified thermally induced phase separation method显示文摘 | Nam YS Park TG | | 0，，： | 2 |
| 17 | Triarylimidazole inhibitors of IL- 1 biosynthesis 显示文摘 | Gallageher TG Fier-Thompson SM Garigipati etal | 1995 | Bioorg Med Chem Lett1995，5，8： | 2 |
| 18 | A novel fabrication method of macroporous biodegradable polymer scaffolds using gas foaming salt as a porogen additive显示文摘 | Nam YS Yoon JJ Park TG | 2000 | J Biomater Res2000，53，1： | 2 |
| 19 | 作为药物作用靶的蠕虫神经系统显示文摘本文就蠕虫神经肌肉的生物学、生理学及作为药物作用靶的蠕虫神经肌肉系统作了较详尽的综述,为发展作用于蠕虫神经肌肉系统的新药提供了信息。 | Geary TG 任岚 | 1993 | 国外医学(寄生虫病分册)1993，20，1： | 2 |
| 20 | Vaginal childbirth and bladder neck mobility显示文摘 | Dietz HP Clarke B Vancaillie TG | 2002 | Aust N Z J Obstet Gynaecol2002，42，5： | 1 |
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