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| 1 | 溃结灵对溃疡性结肠炎患者DNA酶Ⅰ、Fascin蛋白表达的影响显示文摘目的观察溃结灵方治疗溃疡性结肠炎(UC)患者的临床效果及作用机制。方法将80例UC患者随机分为治疗组和对照组各40例,治疗组给予溃结灵方每日1剂和柳氮磺吡啶片每次1.0g,每日2次,对照组仅给予柳氮磺吡啶片,两组均8周为1个疗程。观察两组患者的临床疗效,治疗前后检测DNA酶Ⅰ、Fascin蛋白的表达。结果治疗组临床有效率(92.5%)高于对照组(72.5%),差异有统计学意义(P<0.05);治疗组患者治疗前后DNA酶Ⅰ分别为(109.73±28.46)、(135.13±36.10)μg/L,对照组治疗前后分别为(106.50±27.54)、(120.03±27.72)μg/L,两组治疗后均较治疗前明显提高(P<0.05或P<0.01),治疗后组间比较差异亦有统计学意义(P<0.05);治疗组Fascin蛋白转阴性率为86.49%,对照组为66.67%,治疗组显著高于对照组(P<0.05)。结论溃结灵治疗UC疗效确切,并能明显提高UC患者DNA酶Ⅰ活性,使Fascin蛋白表达转阴。 | 徐进康 陆喜荣 徐宏伟 吴坚芳 许邹华 陶鸣浩 | 2013 | 中医杂志2013，54，1： | 2 |
| 2 | A comprehensive review on clinical outcome of probiotic and synbiotic therapy for inflammatory bowel diseases显示文摘The composition of gut microflora and its metabolic activity are closely correlated with the host immune system, and the changes in the biometric of the microbiome lead to inflammatory diseases like inflammatory bowel disease. The supplementation of probiotics and synbiotic could indeed manipulate the microflora, which can be an alternative therapy for ulcerative colitis, and Crohn's disease. Several in vitro, in vivo and clinical studies for the initiation and maintenance of remission in patients with inflammatory bowel disease have been completed.Those studies evaluated the efficacy of many probiotic formulations, especially about VSL#3.Even though the clinical studies proved that almost all the probiotic interventions are safe and bring improvement to patients, some studies are deficient in sample size, proper controls, and follow-ups. This paper summarizes the possible mechanism of inflammatory bowel disease development, probiotics, the clinical outcome of probiotic and synbiotic interventions for ulcerative colitis and Crohn's disease, as well as the adverse effect of probiotic treatments. | Bhagavathi Sundaram Sivamaruthi | 2018 | Asian Pacific Journal of Tropical Biomedicine2018，8，3： | 1 |
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