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| 1 | Histone tails regulate DNA methylation by allosterically activating de novo methyltransferase显示文摘genomic DNA 的 Cytosine methylation 控制基因表示并且维持染色体稳定性。一个特定的 DNA 序列怎么被 methyltransferase 为 methylation 指向,大部分是未知的。这里,我们证明 histone H3 跟踪缺乏离氨酸 4 (K4 ) methylation 功能作为为由到它的植物 homeodomain (哲学博士) 的绑定的 methyltransferase Dnmt3a 的 allosteric 使活跃之物。在 vitro, histone H3 肽相对地刺激了 Dnmt3a 的 methylation 活动直到 8 褶层,以一种方式与 K4 methylation 的水平相关。allosteric 规定的生物意义被在 PHD 和其变化由 H3 肽然而并非 H3 肽的绑定损害了 methylation 活动的刺激的 Dnmt3a 的催化领域的分子的建模和关键残余的鉴定表明。显著地,这些变异的 Dnmt3a 蛋白质在 DNA methylation 是几乎不活跃的当他们到 genomic 的招募指向时,什么时候在老鼠表示了胚胎的干细胞,是未改变的。我们因此为 de novo DNA methylation 建议二拍子的圆舞机制 - 染色质绑定或 DNA 有约束力的因素可能帮助的 methyltransferase 的第一招募,然后取决于在 Dnmt3a 和 histone 之间的相互作用的 allosteric 激活跟踪 - 后者可能为 methylation 活动用作一个检查点。 | Bin-Zhong Li Zheng Huang Qing-Yan Cui Xue-Hui Song Lin Du Albert Jeltsch Ping Chen Guohong Li En Li Guo-Liang Xu | 2011 | Cell Research2011，21，8： | 17 |
| 2 | SciFinder-guided rational design of fluorescent carbon dots for ratiometric monitoring intracellular pH fluctuations under heat shock显示文摘Intracellular pH plays a significant role in various biological processes, including cell proliferation,apoptosis, metabolism, enzyme activity and homeostasis. In this work, a novel design strategy for the preparation of pH responsive carbon dots(CDs-pH) for ratiometric intracellular imaging was reported. By using SciFinder database, fluorescent CDs-pH with the required p Kavalue of 6.84 were rationally designed, which is vital important for precise sensing of intracellular pH. As a result, the synthesized CDspH demonstrated robust ability to test pH fluctuations within the physiological range of 5.4-7.4. The CDspH was further utilized for fluorescent ratiometric imaging of pH in living HeLa cells, effectively avoided the influence of autofluorescence from native cellular species. Moreover, real-time monitoring of intracellular pH fluctuation under heat shock was successfully realized. This SciFinder-guided design strategy is simple and flexible, which has a great potential to be used for the development of other types of CDs for various applications. | Haifang Liu Yuanqiang Sun Zhaohui Li Ran Yang Jie Yang Aaron Albert Aryee Xiaoge Zhang Jia Ge Lingbo Qu Yuehe Lin | 2019 | Chinese Chemical Letters2019，30，9： | 3 |
| 3 | An electronic nose using a single graphene FET and machine learning for water, methanol, and ethanol显示文摘The poor gas selectivity problem has been a long-standing issue for miniaturized chemical-resistor gas sensors.The electronic nose(e-nose)was proposed in the 1980s to tackle the selectivity issue,but it required top-down chemical functionalization processes to deposit multiple functional materials.Here,we report a novel gas-sensing scheme using a single graphene field-effect transistor(GFET)and machine learning to realize gas selectivity under particular conditions by combining the unique properties of the GFET and e-nose concept.Instead of using multiple functional materials,the gas-sensing conductivity profiles of a GFET are recorded and decoupled into four distinctive physical properties and projected onto a feature space as 4D output vectors and classified to differentiated target gases by using machine-learning analyses.Our single-GFET approach coupled with trained pattern recognition algorithms was able to classify water,methanol,and ethanol vapors with high accuracy quantitatively when they were tested individually.Furthermore,the gas-sensing patterns of methanol were qualitatively distinguished from those of water vapor in a binary mixture condition,suggesting that the proposed scheme is capable of differentiating a gas from the realistic scenario of an ambient environment with background humidity.As such,this work offers a new class of gas-sensing schemes using a single GFET without multiple functional materials toward miniaturized e-noses. | Takeshi Hayasaka Albert Lin Vernalyn C.Copa Lorenzo P.Lopez Jr Regine A.Loberternos Laureen Ida M.Ballesteros Yoshihiro Kubota Yumeng Liu Arnel A.Salvador Liwei Lin | 2020 | Microsystems & Nanoengineering2020，6，1： | 2 |
| 4 | Correlation between sea surface temperature and wind speed in Greenland Sea and their relationships with NAO variability显示文摘The North Atlantic Oscillation (NAO) is one of the major causes of many recent changes in the Arctic Ocean. Generally, it is related to wind speed, sea surface temperature (SST), and sea ice cover. In this study, we analyzed the distributions of and correlations between SST, wind speed, NAO, and sea ice cover from 2003 to 2009 in the Greenland Sea at 10°W to 10°E, 65°N to 80°N. SST reached its peak in July, while wind speed reached its minimum in July. Seasonal variability of SST and wind speed was different for different regions. SST and wind speed mainly had negative correlations. Detailed correlation research was focused on the 75°N to 80°N band. Regression analysis shows that in this band, the variation of SST lagged three months behind that of wind speed. Ice cover and NAO had a positive correlation, and the correlation coefficient between ice cover and NAO in the year 2007 was 0.61. SST and NAO also had a positive correlation, and SST influenced NAO one month in advance. The correlation coefficients between SST and NAO reached 0.944 for the year 2005, 0.7 for the year 2008, and 0.74 for the year 2009 after shifting SST one month later. NAO also had a positive correlation with wind speed, and it also influenced wind speed one month in advance. The correlation coefficients between NAO and wind speed reached 0.783, 0.813, and 0.818 for the years 2004, 2005, and 2008, respectively, after shifting wind speed one month earlier. | Bo QU Albert J. GABRIC Jing-nan ZHU Dao-rong LIN Feng QIAN Min ZHAO | 2012 | Water Science and Engineering2012，5，3： | 2 |
| 5 | Low power 3.1–10.6 GHz IR-UWB transmitter for Gbps wireless communications显示文摘This paper reviews and discusses the design of a low-power single-full-band (3.1-10.6 GHz) non- carrier impulse-radio ultra wideband (UWB) transmitter featuring 5th-order Gaussian derivative pulse shaping, integrated BPSK modulation, and 2.5 kV whole-chip ESD (electrostatic discharge) protection. The UWB transmitter design has been implemented in a commercial 0.18 μm CMOS technology with a very small die size of 0.25 mm2. The fabricated chips have demonstrated full functionality, extremely low power consumption of 0.14 pJ/p-mV, and an ultra short pulse width of 394 ps. This ESD-protected UWB transmitter has the potential to support wireless streaming to gigabit per second (Gbps). | WANG Xin LIN Lin TANG He ZHAO Hui FANG Qiang LIU Jian FAN SiQiang WANG Albert ZHAO Bin YANG LiWu ZHANG Gary | 2011 | Science China(Information Sciences)2011，54，5： | 2 |
| 6 | 遗传性肥胖与心房颤动的关系显示文摘观察性研究已经确定了体质量指数(body mass index,BMI)与心房颤动之间的关联。然而,从观察性研究中推断因果关系会受到混杂因素、逆因果关系和偏倚的影响。该研究的主要目的是应用BMI的遗传学预测因子评估BMI与心房颤动之间的因果关系。方法:纳入1987-2002年期间在美国、冰岛和荷兰实施的7个前瞻性人群队列研究中基线无心房颤动的欧洲血统个体51 646人, | 刘莉 叶鹏 Chatterjee NA Giulianini F Geelhoed B Lunetta KL Misialek JR Niemeijer MN Rienstra M Rose LM Smith AV Arking DE Ellinor PT Heeringa J Lin H Lubitz SA Soliman EZ Verweij N Alonso A Benjamin EJ Gudnason V Stricker BH van der Harst P Chasman DI Albert CM | 2017 | 中华高血压杂志2017，25，2： | 2 |
| 7 | Dexmedetomidine Infusion for Analgesia and Prevention of Emergence Agitation in Children with Obstructive Sleep Apnea Syndrome Undergoing Tonsillectomy and Adenoidectomy显示文摘 | Anuradha Patel Melissa Davidson Minh C. J. Tran Huma Quraishi Catherine Schoenberg Manasee Sant Albert Lin Xiuru Sun | 2010 | Anesthesia & Analgesia2010，，4： | 2 |
| 8 | Optimization of random diffraction gratings in thin-film solar cells using genetic algorithms显示文摘 | Lin Albert Phillips Jamie | 2008 | Solar Energy Materia ls and Solar Cells2008，92，12： | 1 |
| 9 | Prognostic role of mieroRNA-34a expression in colorectal cancer 显示文摘 | Lin Albert Y Kouzminova Natalia B Pollack J | 2014 | ASCO Meeting Abstracts2014，32，3： | 1 |
| 10 | Relation of Increased Prebeta-1 High-Density Lipoprotein Levels to Risk of Coronary Heart Disease显示文摘 | Lin T. Guey Clive R. Pullinger Brian Y. Ishida Patricia M. O’Connor Christian Zellner Omar L. Francone Jason M. Laramie Josefina M. Naya-Vigne Ketevan A. Siradze Prakash Deedwania Rita F. Redberg Philip H. Frost Albert B. Seymour John P. Kane Mary J. Mall | 2011 | The American Journal of Cardiology2011，，3： | 1 |
| 11 | Relation of Increased Prebeta-1 High-Density Lipoprotein Levels to Risk of Coronary Heart Disease显示文摘 | Lin T. Guey Clive R. Pullinger Brian Y. Ishida Patricia M. O'Connor Christian Zellner Omar L. Francone Jason M. Laramie Josefina M. Naya-Vigne Ketevan A. Siradze Prakash Deedwania Rita F. Redberg Philip H. Frost Albert B. Seymour John P. Kane Mary J. Mall | 2011 | The American Journal of Cardiology2011，，3： | 1 |
| 12 | Off-Label Utilization of Antihypertensive Medications in Children显示文摘 | Esther Y. Yoon Kevin J. Dombkowski Albert Rocchini Jen-Jar Lin Matthew M. Davis | 2007 | Ambulatory Pediatrics2007，，4： | 1 |
| 13 | Dendritic cells in-tegrate signals from the tumor microenvironment to modulate immuni-ty and tumor growth显示文摘 | Albert Lin Anita Schildknecht Nguyen L T | 2010 | Immunology Letters2010，127，： | 1 |
| 14 | Randomized controlled trial of recombinant alpha-2a-interferon for chronic hepatitis C显示文摘 | David D. Douglas MD Dr. Jorge Rakela MD Hsiang Ju Lin DSc F. Blaine Hollinger MD Howard F. Taswell MD Albert J. Czaja MD John B. Gross MD Monte L. Anderson MD Kevin Parent MD C. Richard Fleming MD John R. Cangemi MD Peter C. O’Brien PhD Pauline E. Powis R | 1993 | Digestive Diseases and Sciences1993，，4： | 1 |
| 15 | Dexmedetomidine Infusion for Analgesia and Prevention of Emergence Agitation in Children with Obstructive Sleep Apnea Syndrome Undergoing Tonsillectomy and Adenoidectomy显示文摘 | Anuradha Patel Melissa Davidson Minh C. J. Tran Huma Quraishi Catherine Schoenberg Manasee Sant Albert Lin Xiuru Sun | 2010 | Anesthesia & Analgesia2010，，4： | 1 |
| 16 | Chicken HSP70 DNA vaccine inhibits tumor growth in a canine cancer model显示文摘 | Wen-Ying Yu Tien-Fu Chuang Cécile Guichard Hanane El-Garch Dominique Tierny Albert Taiching Laio Ching-Si Lin Kuo-Hao Chiou Cheng-Long Tsai Chen-Hsuan Liu Wen-Chiuan Li Laurent Fischer Rea-Min Chu | 2011 | Vaccine2011，，18： | 1 |
| 17 | The role of polyphenol oxidase and peroxidase in the browning of water caltrop pericarp during heat treatment显示文摘 | Jhih-Ying Ciou Hsin-Hung Lin Po-Yuan Chiang Chiun-C. Wang Albert Linton Charles | 2011 | Food Chemistry2011，，2： | 1 |
| 18 | The Mechanism on Cyclization, Debenzylation and Oxidation of 1-[1-(Benzyloxy)-3-methylnaphthalen-4-yloxy]propan-2-one显示文摘1-[1-(Benzyloxy)-3-methylnaphthalen-4-yloxy]propan-2-one (1a) took place a cycli- zation, debenzylation and oxidation to form 9-substitued benzo[de]chromene-7,8-dione (2a) and 5-benzyl-9-substitued benzo[de]chromene-7,8-dione (3a). The mechanisms for these reactions were discussed. | Shi Liang HUANG Yi LUO Zhi Shu HUANG Xian Zhang BU Pei Qing LIU Lin MA Yue Ming LI Albert S. C. CHAN Lian Quan GU | 2006 | Chinese Chemical Letters2006，17，6： | 1 |
| 19 | Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4显示文摘 | G. R. Pettit S. B. Singh E. Hamel C. M. Lin D. S. Alberts D. Garcia-Kendal | 1989 | Experientia1989，，2： | 1 |
| 20 | An Ana- lytical Finite Element Model for Predicting Three-dimen- sional Tool Forces and Chip Flow 显示文摘 | STRENKOWSKI John S SHIH Albert J LIN J C | 2002 | International Jour- nal of Mach-ine Tools and Manufacture2002，42，5： | 1 |
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