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| 1 | Usefulness of noninvasive transient elastography for assessment of liver fibrosis stage in chronic hepatitis C显示文摘AIM:To evaluate the method of noninvasive transient elastography for assessment of histological stage of liver fibrosis in patients with chronic hepatitis C (CHC). METHODS: Two hundred and thirty-seven patients with CHC were included in this study. Liver biopsy was performed under ultrasonography on 217 of the patients, excluding twenty with clear clinical evidence of liver cirrhosis. Fifty subjects without liver disease were enrolled as a control group (stage 0). Twenty- five patients with sustained virological response (SVR) to interferon (IFN) therapy were also enrolled. These patients underwent liver biopsy before IFN therapy. Examination of liver stiffness (LS) was performed by elastography. RESULTS: Medians (50% levels) of LS were 4.1 (3.5-4.9), 6.3 (4.8-8.5), 8.8 (6.8-12.0), 14.6 (10.5-18.6), and 22.2 (15.4-28.0), respectively, in the fibrosis stages 0-4 (P < 0.001). LS was significantly correlated with four serum fibrosis markers. LS values in patients with SVR were 3.8 (3.5-5.6), 5.2 (4.4-6.8), 6.8 (6.1-7.6), and 6.1 (3.6-7.9), respectively, in the fibrosis stages 1-4. In all stages, LS for patients with SVR was significantly lower than that for patients who did not undergo IFN therapy. LS was significantly correlated with serum concentrations of hyaluronic acid, type Ⅳ collagen, type Ⅳ collagen 7S, and type Ⅲ procollagen N peptide. CONCLUSION: LS correlated well with the histologicalstage of fibrosis. Changes in liver fibrosis stage may thus be estimated noninvasively using transient elastography. | Tadashi Takeda Takahiro Yasuda Yuji Nakayama Mika Nakaya Megumi Kimura Mariko Yamashita Ayumi Sawada Koji Abo Setsuko Takeda Hiroki Sakaguchi Susumu Shiomi Hitoshi Asai Shuichi Seki | 2006 | World Journal of Gastroenterology2006，12，48： | 16 |
| 2 | Formaldehyde induces toxic effects and regulates the expression of damage response genes in BM-MSCs显示文摘在这研究,我们在老鼠骨头髓上估计了甲醛(FA ) 的有毒的效果间充质的干细胞(BM-MSCs ) 。Cytotoxicity 被使用 MTT 试金测量。DNA 海滨破裂被与朊酶 K (PK ) 修改的标准碱的彗星试金和彗星试金检测。DNAprotein 交叉连接(DPC ) 被 KCl-SDS 降水试金检测。我们发现在从 75 ~ 200 M 的集中的 FA 禁止了房间幸存并且在 125 M 上导致了 DPC。修改 PK 的彗星试金证明那导致 FA 的 DNA 海滨破裂从 75 ~ 200 M 以一种剂量依赖者方式被增加。在另一方面,标准碱的彗星试金证明那 DNA 海滨破裂在 125 M 上与 FA 集中被减少。我们由使用在 DPC 和幸存率之间有否定线性关联的皮尔森关联证实了(r = 0.987, P < 0.01 ) 并且在 DPC 和(i) 姐妹染色单体交换之间的积极线性关系并且(ii ) micronucleus (r = 0.995, P < 0.01;r = 0.968, P < 0.01 ) 。DNA 损坏 RT2 剖析程序聚合酶链反应数组被用来在损坏反应基因的表达式调查变化。相应再结合小径的核苷酸切除修理小径和 Brca2, Rad51,和 Xrcc2 的 Xpa 和 Xpc 都在 75 和 125 M FA 是起来调整的。然而,一样的基因与 175 M FA 是下面调整的。Chek1 和 Hus1 的表情,涉及房间周期规定,与 75, 125,和 175 M FA 以一样的方式被改变。这些结果显示 Xpa, Xpc, Brca2, Rad51, Xrcc2, Chek1,和 Hus1 是必要的让 BM-MSCs 抵抗 FA 的效果。 | Yali She Yi Li Yongqi Liu Guli Asai Shaobo Sun Jianxin He Zheng Pan Yan Cui | 2013 | Acta Biochimica et Biophysica Sinica2013，45，12： | 8 |
| 3 | Successful resection of metachronous para-aortic, Virchow lymph node and liver metastatic recurrence of rectal cancer显示文摘A 66-year-old female presented with the main complaint of defecation trouble and abdominal distention. With diagnosis of rectal cancer, c SS, c N0, c H0, c P0, c M0 c Stage Ⅱ, Hartmann's operation with D3 lymph node dissection was performed and a para-aortic lymph node and a disseminated node near the primary tumor were resected. Histological examination showed moderately differentiated adenocarcinoma, p SS, p N3, p H0, p P1, p M1(para-aortic lymph node, dissemination) f Stage Ⅳ. After the operation, the patient received chemotherapy with FOLFIRI regimen. After 12 cycles of FOLFIRI regimen, computed tomography(CT) detected an 11 mm of liver metastasis in the posteroinferior segment of right hepatic lobe. With diagnosis of liver metastatic recurrence, we performed partial hepatectomy. Histological examination revealed moderately differentiated adenocarcinoma as a metastatic rectal cancer with cut end microscopically positive. After the second operation, the patient received chemotherapy with TS1 alone for 2 years. Ten months after the break, CT detected a 20 mm of paraaortic lymph node metastasis and a 10 mm of lymph node metastasis at the hepato-duodenal ligament. With diagnosis of lymph node metastatic recurrences, we performed lymph node dissection. Histological examination revealed moderately differentiated adenocarcinoma as metastatic rectal cancer in paraaortic and hepato-duodenal ligament areas. After the third operation, we started chemotherapy with modified FOLFOX6 regimen. After 2 cycles of modified FOLFOX6 regimen, due to the onset of neutropenia and liver dysfunction, we switched to capecitabine aloneand continued it for 6 mo and then stopped. Eleven months after the break, CT detected two swelling 12 mm of lymph nodes at the left supraclavicular region. With diagnosis of Virchow lymph node metastatic recurrence, we started chemotherapy with capecitabine plus bevacizumab regimen. Due to the onset of neutropenia and hand foot syndrome(Grade 3), we managed to continue capecitabine administration with extension of interval period and dose reduction. After 2 years and 2 mo from starting capecitabine plus bevacizumab regimen, Virchow lymph nodes had slowly grown up to 17 mm. Because no recurrence had been detected besides Virchow lymph nodes for this follow up period, considering the side effects and quality of life, surgical resection was selected. We performed left supraclavicular lymph node dissection. Histological examination revealed moderately differentiated adenocarcinoma as a metastatic rectal cancer. After the fourth operation, the patient selected follow up without chemotherapy. Now we follow up her without recurrence and keep her quality of life high. | Nobuyoshi Takeshita Toru Fukunaga Masayuki Kimura Yuji Sugamoto Kentaro Tasaki Isamu Hoshino Takumi Ota Tetsuro Maruyama Tomohide Tamachi Takashi Hosokawa Yo Asai Hisahiro Matsubara | 2015 | World Journal of Gastroenterology2015，21，44： | 4 |
| 4 | Comparison of the effects of retrieval balloons and basket catheters for bile duct stone removal on the rate of post-ERCP pancreatitis显示文摘To the Editor:Endoscopic retrograde cholangiopancreatography(ERCP)is one of the most important techniques for diagnosis and treatment in pancreatobiliary medicine.Post-ERCP pancreatitis(PEP)is a common complication of ERCP with incidence about 3.8%–15.1%[1–4].The precutting technique,contrast injection into the pancreatic duct,prolonged cannulation and procedure times,sphincterotomy. | Kotaro Takeshita Satoshi Asai Naoki Fujimoto Takumi Ichinona Eisuke Akamine | 2021 | Hepatobiliary & Pancreatic Diseases International2021，20，2： | 3 |
| 5 | G eant 4—a simulation toolkit显示文摘 | S. Agostinelli J. Allison K. Amako J. Apostolakis H. Araujo P. Arce M. Asai D. Axen S. Banerjee G. Barrand F. Behner L. Bellagamba J. Boudreau L. Broglia A. Brunengo H. Burkhardt S. Chauvie J. Chuma R. Chytracek G. Cooperman G. Cosmo P. Degtyarenko A. Del | 2003 | and Methods in Physics Research, A2003，，3： | 3 |
| 6 | Crystal orientation of non-magnetic materials by imposition of a high magnetic field显示文摘 | Shigeo Asai Ken-suke Sassa Masahiro Tahashi | 2003 | Science and Technology of Advanced Materials2003，，5： | 3 |
| 7 | Effect of dietary docosahexaenoic acid in the rat middle cerebral artery thrombosis model显示文摘 | K. Umemura Y. Toshima F. Asai M. Nakashima | 1995 | Thrombosis Research1995，，5： | 2 |
| 8 | Water entry of decelerating spheres simulations using improved ISPH method显示文摘In this paper, we simulated the vertical impact of spheres on a water surface using three-dimensional incompressible smoothed particle hydrodynamics(3-D ISPH) method. The sphere motion is taken to be a rigid body motion and it is modeled by ISPH method. The governing equations are discretized and solved numerically using ISPH method. A stabilized incompressible SPH method by relaxing the density invariance condition is adopted. Here, we computed the motions of a rigid body by direct integration of the fluid pressure at the position of each particle on the body surface. The equations of translational and rotational motion were integrated in time domain to update the position of the rigid body at each time step. In this study, we improved the boundary treatment between fluid and fixed solid boundary by using virtual marker technique. In addition, an improved algorithm based on the virtual marker technique for the boundary particles is proposed to treat the moving boundary of the rigid body motion. The force exerted on the moving rigid boundary particles by the surrounding particles, is calculated by the SPH approximation at the virtual marker points. The applicability and efficiency of the current ISPH method are tested by comparison with reference experimental results. | Abdelraheem M.Aly Mitsuteru Asai | 2018 | Journal of Hydrodynamics2018，30，6： | 2 |
| 9 | Liver transplantation for acute intermittent porphyria:a viable treatment?显示文摘BACKGROUND:Acute intermittent porphyria (AIP) is the most common hepatic porphyria.Its clinical presentation includes severe disabling and life-threatening neurovisceral symptoms and acute psychiatric symptoms.These symptoms result from the overproduction and accumulation of porphyrin precursors,5-aminoleuvulinic acid (ALA) and porphobilinogen (PBG).The effect of medical treatment is transient and is not effective once irreversible neurological damage has occurred.Liver transplantation (LT) replaces hepatic enzymes and can restore normal excretion of ALA and PBG and prevent acute attacks.METHOD:Two cases of LT for AIP were identified retrospectively from a prospectively maintained LT database.RESULT:LT was successful with resolution of AIP in two patients who suffered from repeated acute attacks.CONCLUSION:LT can correct the underlying metabolic abnormality in AIP and improves quality of life significantly. | Faisal S Dar Koji Asai Ali Raza Haque Thomas Cherian Mohamed Rela Nigel Heaton | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，1： | 2 |
| 10 | Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness显示文摘 | Takayuki Kondo Masashi Asai Kayoko Tsukita Yumiko Kutoku Yutaka Ohsawa Yoshihide Sunada Keiko Imamura Naohiro Egawa Naoki Yahata Keisuke Okita Kazutoshi Takahashi Isao Asaka Takashi Aoi Akira Watanabe Kaori Watanabe Chie Kadoya Rie Nakano Dai Watanabe Kei | 2013 | Cell Stem Cell2013，，4： | 2 |
| 11 | Biochar amendment techniques for upland rice production in Northern Laos显示文摘 | Hidetoshi Asai Benjamin K. Samson Haefele M. Stephan Khamdok Songyikhangsuthor Koki Homma Yoshiyuki Kiyono Yoshio Inoue Tatsuhiko Shiraiwa Takeshi Horie | 2008 | Field Crops Research2008，，1： | 2 |
| 12 | Kinetixs model for batch bacterial dissolution of pyrite particles by Thiobacillus ferrooxidans 显示文摘 | Asai S | 1992 | Chem Eng Sci1992，，1： | 2 |
| 13 | Association of Methylenetetrahydrofolate Reductase Gene Polymorphism With Carotid Atherosclerosis Depending on Smoking Status in a Japanese General Population显示文摘 | Nozomu Inamoto Tomohiro Katsuya Yoshihiro Kokubo Toshifumi Mannami Takashi Asai Shunroku Baba Jun Ogata Hitonobu Tomoike Toshio Ogihara | 2003 | Stroke: Journal of the American Heart Association2003，，7： | 2 |
| 14 | Analysis of electronic structures of 3d transition metal-doped TiO 2 based on band calculations显示文摘 | Tsutomu Umebayashi Tetsuya Yamaki Hisayoshi Itoh Keisuke Asai | 2002 | Journal of Physics and Chemistry of Solids2002，，10： | 2 |
| 15 | The growth factor midkine regulates the renin-angiotensin system in mice显示文摘 | Hobo Akinori Yuzawa Yukio Kosugi Tomoki Kato Noritoshi Asai Naoto Sato Waichi Maruyama Shoichi Ito Yasuhiko Kobori Hiroyuki Ikematsu Shinya Nishiyama Akira Matsuo Seiichi Kadomatsu Kenji | 2009 | Journal of Clinical Investigation2009，，6： | 2 |
| 16 | Preparation and Characterization of Natural Lower Dimensional Layered Perovskite- type Compounds显示文摘 | Tabuchi Y Asai K Rikukawa M | 2000 | Journal of Physics and Chemistry of Solid2000，61，： | 2 |
| 17 | Recent development and prospect of electromagnetic processing of materials显示文摘 | S Asai | 2001 | Science and Technology of Advanced Materials2001，，4： | 2 |
| 18 | Development of an anisotropic conductive adhesive film(ACAF) from epoxy resins 显示文摘 | Asai Ueki Saruta | 1995 | J Appl Sci1995，56，： | 2 |
| 19 | Esophageal intramural pseudodiverticulosis of the residual esophagus after esophagectomy for esophageal cancer显示文摘A 91-year-old man was referred to our hospital with intermittent dysphagia. He had undergone esophagectomy for esophageal cancer(T3N2M0 Stage Ⅲ) 11 years earlier. Endoscopic examination revealed an anastomotic stricture; signs of inflammation,including redness,erosion,edema,bleeding,friability,and exudate with white plaques; and multiple depressions in the residual esophagus. Radiographical examination revealed numerous fine,gastrografinfilled projections and an anastomotic stricture. Biopsy specimens from the area of the anastomotic stricture revealed inflammatory changes without signs of malignancy. Candida glabrata was detected with a culture test of the biopsy specimens. The stricture was diagnosed as a benign stricture that was caused by esophageal intramural pseudodiverticulosis. Accordingly,endoscopic balloon dilatation was performed and antifungal therapy was started in the hospital. Seven weeks later,endoscopic examination revealed improvement in the mucosal inflammation; only the pseudodiverticulosis remained. Consequently,the patient was discharged. At the latest follow-up,the patient was symptomfree and the pseudodiverticulosis remained in the residual esophagus without any signs of stricture or inflammation. | Nobuyoshi Takeshita Naoki Kanda Toru Fukunaga Masayuki Kimura Yuji Sugamoto Kentaro Tasaki Masaya Uesato Tetsutaro Sazuka Tetsuro Maruyama Naohiro Aida Tomohide Tamachi Takashi Hosokawa Yo Asai Hisahiro Matsubara | 2015 | World Journal of Gastroenterology2015，21，30： | 2 |
| 20 | Antimicrobial resistance of Campylobacterjejuni and Campylobacter coli isolates in Japan 显示文摘 | Niwa H Asai Y Yamai S | 2004 | Vet Rec2004，25，： | 1 |
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