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| 1 | Hepatocyte nuclear factor 4-alpha involvement in liver and intestinal inflammatory networks显示文摘Hepatocyte nuclear factor 4-alpha(HNF4-α)is a nuclear receptor regulating metabolism,cell junctions,differentiation and proliferation in liver and intestinal epithelial cells.Mutations within the HNF4A gene are associated with human diseases such as maturityonset diabetes of the young.Recently,HNF4A has also been described as a susceptibility gene for ulcerative colitis in genome-wide association studies.In addition,specific HNF4A genetic variants have been identified in pediatric cohorts of Crohn’s disease.Results obtained from knockout mice supported that HNF4-αcan protect the intestinal mucosae against inflammation.However,the exact molecular links behind HNF4-αand inflammatory bowel diseases remains elusive.In this review,we will summarize the current knowledge about the role of HNF4-αand its isoforms in inflammation.Specific nature of HNF4-αP1 and P2 classes of isoforms will be summarized.HNF4-αrole as a hepatocyte mediator for cytokines relays during liver inflammation will be integrated based on documented examples of the literature.Conclusions that can be made from these earlier liver studies will serve as a basis to extrapolate correlations and divergences applicable to intestinal inflammation.Finally,potential functional roles for HNF4-αisoforms in protecting the intestinal mucosae from chronic and pathological inflammation will be presented. | Jean-Philippe Babeu Franois Boudreau | 2014 | World Journal of Gastroenterology2014，20，1： | 12 |
| 2 | G eant 4—a simulation toolkit显示文摘 | S. Agostinelli J. Allison K. Amako J. Apostolakis H. Araujo P. Arce M. Asai D. Axen S. Banerjee G. Barrand F. Behner L. Bellagamba J. Boudreau L. Broglia A. Brunengo H. Burkhardt S. Chauvie J. Chuma R. Chytracek G. Cooperman G. Cosmo P. Degtyarenko A. Del | 2003 | and Methods in Physics Research, A2003，，3： | 3 |
| 3 | Organized living: from cell surfaces to basement membranes显示文摘 | Boudreau N J | 2003 | Sci STKE2003，196，： | 2 |
| 4 | Elevated Aortic Pulse Wave Velocity, a Marker of Arterial Stiffness, Predicts Cardiovascular Events in Well-Functioning Older Adults显示文摘 | Kim Sutton-Tyrrell Samer S. Najjar Robert M. Boudreau Lakshmi Venkitachalam Varant Kupelian Eleanor M. Simonsick Richard Havlik Edward G Lakatta Harold Spurgeon Stephen Kritchevsky Marco Pahor Douglas Bauer Anne Newman | 2005 | Circulation2005，，25： | 2 |
| 5 | Extracellular matrix and integrin signalling:the shape of things to come显示文摘 | Boudreau N J Jones P L | 1999 | Biochem J1999，339，3： | 2 |
| 6 | Description of six new capsular types (29-34) of Streptococcus suis显示文摘 | Higgins R Gottschalk M Boudreau M | 1995 | J Vet Diagn Invest1995，7，3： | 1 |
| 7 | Accounting for the contradictory consequences of information technology:Theoretical directions and methodological implications显示文摘 | Robey D Boudreau M | 1999 | Information Systems Research1999，10，2： | 1 |
| 8 | Linear and quadratic time-frequency signal representations 显示文摘 | Hlawatsch F Boudreaus B F | 1992 | IEEE Signal Process Mag1992，，9： | 1 |
| 9 | A highly oriented thin film of zeolite A 显示文摘 | Boudreau L C Tsapatsis M | 1997 | Chem Mater1997，9，8： | 1 |
| 10 | The importance of physician listening from the patients’ perspective: Enhancing diagnosis, healing, and the doctor–patient relationship显示文摘 | Justin Jagosh Joseph Donald Boudreau Yvonne Steinert Mary Ellen MacDonald Lois Ingram | 2011 | Patient Education and Counseling2011，，3： | 1 |
| 11 | Association of the S-100- related calpactin I light chain with the NH2-terminal tail of the 36- kDa heavy chain显示文摘 | Glenney JR Boudreau M Galyean R | 1986 | J Biol Chem1986，261，10： | 1 |
| 12 | Forming behaviour of tailor (laser) welded blanks of automotive steel sheet显示文摘 | Boudreau G Andreychuk P | 2006 | Canadian Metallurgical Quarterly2006，45，2： | 1 |
| 13 | A Highly Oriented Thin Film of Zeolite A显示文摘 | Boudreau L C Tsapatsis M | 1997 | Chem Mater1997，9，8： | 1 |
| 14 | The synthesis of planar parallel manipulators with a genetic algorithm 显示文摘 | Boudreau R Gosselin C M | 1999 | ASME : Journal of Mechanical Design1999，121，4： | 1 |
| 15 | Synthesis of planar parallel mechanisms while considering workspace,dexterity stiffness and singularity avoidance显示文摘 | ARSENAULT M BOUDREAU R | 2006 | ASME Journal of Mechanical Design2006，128，： | 1 |
| 16 | CDKN2A promoter methylation in gastric adenocarcinomas:clinical variables显示文摘 | Vo Q N Geradts J Boudreau D A | 2002 | Hum Pathol2002，33，12： | 1 |
| 17 | Job-search behavior ofemployed managers显示文摘 | Bretz R D Boudreau J W Judge | | 0，，47： | 1 |
| 18 | Hepatoeyte-nuclear-factor-lalpha(HNF-lalpha), GATA-4 and caudal-related homeodomain protein Cdx2 functionally interact to modulate intestinal gene transcription:Implication for the developmental regulation of the sucrase-isomaltase gene 显示文摘 | Boudreau F Rings E H Wering H M V | 2002 | Journal of Biological Chemistry2002，，31： | 1 |
| 19 | Accounting for the Contradictory Organizational Consequences of Information Technology:Theoretical Directions and Methodological Implications显示文摘 | ROBEY D M C BOUDREAU | 1999 | Information Systems Research1999，10，2： | 1 |
| 20 | Modeling the sulfide-oxygen reaction and associated pH gradients in porewaters显示文摘 | BOUDREAU B P | 1991 | Geochim Cosmochim Acta1991，55，1： | 1 |
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