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| 1 | 食管癌相关基因4的表达与食管癌预后的关系显示文摘目的分析了食管癌相关基因4在食管癌组织中的表达水平和修饰与食管癌预后的关系。方法收集食管癌手术后的食管癌肿瘤组织91例作为研究标本。采用免疫组化对肿瘤组织中的蛋白质表达水平进行分析。并分析ECRG4的表达水平与患者生存的关系。结果免疫组织化学鉴定ECRG低表达74例,高表达17例。ECRG4高表达患者术后5年累积复发率明显低于ECRG4低表达患者5年累积复发率(P<0.05)。而ECRG4高表达患者术后5年累积生存率明显高于ECRG4低表达患者5年累积生存率(P<0.05)。结论 ECRG4在食管癌肿瘤组织中呈低表达或不表达,与术后复发和生存有密切相关。 | 温一阳 胡晓舒 | 2016 | 医药论坛杂志2016，37，7： | 0 |
| 2 | Esophageal intramural pseudodiverticulosis显示文摘Esophageal intramural pseudodiverticulosis(EIPD)is a disease of unknown pathogenesis characterized by usually systemic,cystic dilatation of the excretory ducts of esophageal submucosal glands.In this article,I review the epidemiology,clinical manifestations,endoscopic findings,esophagographic findings,and histopathology of EIPD.I also discuss the etiology and possible pathogenesis of EIPD based on my experiences with this disease and a review of the literature.EIPD usually presents with dysphagia in middle-aged individuals.It is often complicated with secondary infections,most commonly candidiasis.On esophagography,EIPD is delineated as small,multiple,flask-shaped outward projections within the esophageal wall.In recent years,EIPD has been mainly diagnosed by endoscopic findings of multiple,localized,small mucosal depressions.The orifices of the“pseudodiverticula”periodically open and close,and excrete mucus onto the mucosal surface.On histopathological examination,the luminal surface of dilated ducts in EIPD is covered by multilayered,hyperplastic epithelial cells,but myoepithelial cells in the glandular acini are well preserved.Treatment of EIPD is usually symptomatic therapy,and prevention of the infectious complications is important.The etiology and pathogenesis of EIPD are largely unknown,but functional abnormalities of autonomic nerve fibers innervating the esophageal glands likely play an important role,since the structures of the glands are basically preserved in this disease. | Masako Shintaku | 2024 | World Journal of Gastroenterology2024，30，2： | 0 |
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