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| 1 | Long-term durable response to lenalidomide in a patient with hepatic epithelioid hemangioendothelioma显示文摘Epithelioid hemangioendothelioma(EH)is a rare tumor arising from the vascular endothelial cells of soft tissue or visceral organs.The most common visceral site is the liver,where it is often involved in a multifocal man-ner known as hepatic EH(HEH).Surgical resection with curative intent represents the gold standard therapy.When surgery is not feasible,or in cases of metastatic disease,no standard medical treatment is currently indicated.In small series,drugs with anti-angiogenic activity(such as bevacizumab,sorafenib,thalidomide,and lenalidomide)have been proposed with promising results.We describe a 73-year-old man with multifocal non-resectable HEH treated with lenalidomide.Disease status was evaluated by abdominal ultrasound and magnetic resonance every four months.The patient was treated for a total of 39 mo with prolonged disease stabilization and,at the time of writing,is still under treatment with a good tolerance profile.During a short period of treatment discontinuation,the disease showed slight progression that immediately resolved after the reintroduction of lenalidomide.Lenalidomide may represent a valid treatment option for HEH due to its anti-angiogenic and antineoplastic activities.This preliminary result merits further study in a large series. | Maria Caterina Pallotti Margherita Nannini Claudio Agostinelli Simona Leoni Valerio Di Scioscio Anna Mandrioli Cristian Lolli Maristella Saponara Stefano Pileri Luigi Bolondi Guido Biasco Maria Abbondanza Pantaleo | 2014 | World Journal of Gastroenterology2014，20，22： | 9 |
| 2 | G eant 4—a simulation toolkit显示文摘 | S. Agostinelli J. Allison K. Amako J. Apostolakis H. Araujo P. Arce M. Asai D. Axen S. Banerjee G. Barrand F. Behner L. Bellagamba J. Boudreau L. Broglia A. Brunengo H. Burkhardt S. Chauvie J. Chuma R. Chytracek G. Cooperman G. Cosmo P. Degtyarenko A. Del | 2003 | and Methods in Physics Research, A2003，，3： | 3 |
| 3 | Charge- density-based analysis of the current-voltage response of poly- thiophene/fullerene photovoltaic devices 显示文摘 | Campoy-Quiles M Ferenczi T Agostinelli T | 2008 | J Nat Mater2008，7，： | 1 |
| 4 | Mycloid sarcoma: extramedullary manifestation of myeloid disorders 显示文摘 | Campidelli C Agostinelli C Stitson R | 2009 | American journal of clinical pathology2009，132，3： | 1 |
| 5 | Geant4-a simulation toolkit显示文摘 | Agostinelli S Allison J Amako K | 2003 | Nuclear Instruments and Methods in Physics Research A2003，506，： | 1 |
| 6 | The metabolic syn-drome in overweight epileptic patients treated with valproic acid 显示文摘 | Verrotti A Manco R Agostinelli S | 2010 | Epilepsia2010，51，2： | 1 |
| 7 | Polyamines: fundamental characters in chemistry and biology显示文摘 | AGOSTINELLI E MARQUES M P CALHEIROS R | 2010 | Amino Acids2010，38，2： | 1 |
| 8 | Hyperthermia enhances cytotoxicity of amine oxidase and spermine on drugresistance LoVo colon adenocarcinoma cells显示文摘 | Agostinelli E Belli F Dalla Vedova L | | 0，，06： | 1 |
| 9 | A 12 - month longitudinal study of calcium metabolism and bone turnover during valproate monotherapy 显示文摘 | Verrotti A Agostinelli S Coppola G | 2010 | Eur J Neurol2010，17，2： | 1 |
| 10 | Peripheral T-cell lymphoma classification: the matter of cellular derivation显示文摘 | Piccaluga PP Agostinelli C Tripodo C | 2011 | Expert Rev Hematol2011，4，4： | 1 |
| 11 | Endoplasmic Reticulum stress induces hepatic stellate cell apoptosis and contributes to fibrosis resolution显示文摘 | De Minicis S Candelaresi C Agostinelli L | | 0，，： | 1 |
| 12 | Geant4-A simulation toolkit显示文摘 | AGOSTINELLI S | 2003 | Nuclear Instruments and Methods in Physics Research A2003，506，： | 1 |
| 13 | Geant4-A simulation toolkit显示文摘 | AGOSTINELLI S ALLISON J AMAKO K | | Nucl Instrum Methods A 200 3 506: 250-300，3，： | 1 |
| 14 | GEANT4 A simulation toolkit显示文摘 | AGOSTINELLI S ALLISON J AMAKO K | 2003 | Nucl Instrum Methods2003，506，3： | 1 |
| 15 | Geant4 A Simulation Toolkit 显示文摘 | Agostinelli S Allison J Amako K | 2003 | Nucl Instr Meth A2003，506，3： | 1 |
| 16 | Benign con- vulsions associated with mild gastroenteritis: a multicenter clinical study 显示文摘 | Verrotti A Nanni G Agostinelli S | 2011 | Epilepsy Res2011，93，2： | 1 |
| 17 | GEANT4-a simulation toolkit显示文摘 | Agostinelli S Allison J Amako K | 2003 | Nuclear Instruments and Methods in Physics Research A2003，506，3： | 1 |
| 18 | Synthesis of magnetic zeolite at low temperature using a waste material mixture:Fly ash and red mud显示文摘 | Belviso C Agostinelli E Belviso S | 2015 | Microporous and Mesoporous Materials2015，202，： | 1 |
| 19 | Molecular profiling of btastic plasmacytoid dendritic cell neoplasm reveals a unique pattern and suggests selective sensitivity to NF-KB pathway inhibition显示文摘 | Sapienza M R Fuligni F Agostinelli C | 2014 | Leukemia2014，28，8： | 1 |
| 20 | Polyamines: funda- mental characters in chemistry and biology显示文摘 | Agostinelli E Marques MP Calheiros R | 2010 | Amino Acids2010，38，2： | 1 |
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