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| 1 | Radiomics and machine learning applications in rectal cancer:Current update and future perspectives显示文摘The high incidence of rectal cancer in both sexes makes it one of the most common tumors,with significant morbidity and mortality rates.To define the best treatment option and optimize patient outcome,several rectal cancer biological variables must be evaluated.Currently,medical imaging plays a crucial role in the characterization of this disease,and it often requires a multimodal approach.Magnetic resonance imaging is the first-choice imaging modality for local staging and restaging and can be used to detect high-risk prognostic factors.Computed tomography is widely adopted for the detection of distant metastases.However,conventional imaging has recognized limitations,and many rectal cancer characteristics remain assessable only after surgery and histopathology evaluation.There is a growing interest in artificial intelligence applications in medicine,and imaging is by no means an exception.The introduction of radiomics,which allows the extraction of quantitative features that reflect tumor heterogeneity,allows the mining of data in medical images and paved the way for the identification of potential new imaging biomarkers.To manage such a huge amount of data,the use of machine learning algorithms has been proposed.Indeed,without prior explicit programming,they can be employed to build prediction models to support clinical decision making.In this review,current applications and future perspectives of artificial intelligence in medical imaging of rectal cancer are presented,with an imaging modality-based approach and a keen eye on unsolved issues.The results are promising,but the road ahead for translation in clinical practice is rather long. | Arnaldo Stanzione Francesco Verde Valeria Romeo Francesca Boccadifuoco Pier Paolo Mainenti Simone Maurea | 2021 | World Journal of Gastroenterology2021，27，32： | 10 |
| 2 | Reliability in endoscopic diagnosis of portal hypertensive gastropathy显示文摘AIM: To analyze reliability among endoscopists in diagnosing portal hypertensive gastropathy (PHG) and to determine which criteria from the most utilized classifications are the most suitable. METHODS: From January to July 2009, in an academic quaternary referral center at Santa Casa of S o Paulo Endoscopy Service, Brazil, we performed this singlecenter prospective study. In this period, we included 100 patients, including 50 sequential patients who had portal hypertension of various etiologies; who were previously diagnosed based on clinical, laboratory and imaging exams; and who presented with esophageal varices. In addition, our study included 50 sequentialpatients who had dyspeptic symptoms and were referred for upper digestive endoscopy without portal hypertension. All subjects underwent upper digestive endoscopy, and the images of the exam were digitally recorded. Five endoscopists with more than 15 years of experience answered an electronic questionnaire, which included endoscopic criteria from the 3 most commonly used Portal Hypertensive Gastropathy classifications (McCormack, NIEC and Baveno) and the presence of elevated or flat antral erosive gastritis. All five endosco- pists were blinded to the patients' clinical information, and all images of varices were deliberately excluded for the analysis. RESULTS: The three most common etiologies of portal hypertension were schistosomiasis (36%), alcoholic cirrhosis (20%) and viral cirrhosis (14%). Of the 50 patients with portal hypertension, 84% were Child A, 12% were Child B, 4% were Child C, 64% exhibited previous variceal bleeding and 66% were previously endoscopic treated. The endoscopic parameters, presence or absence of mosaic-like pattern, red point lesions and cherry-red spots were associated with high inter-observer reliability and high specificity for diagnosing Portal Hypertensive Gastropathy. Sensitivity, specificity and reliability for the diagnosis of PHG (%) were as follows: mosaic-like pattern (100; 92.21; High); fine pink speckling (56; 76.62; Unsatisfactory); superficial reddening (69.57; 66.23; Unsatisfactory); red-point lesions (47.83; 90.91; High); cherry-red spots (39.13; 96.10; High); isolated red marks (43.48; 88.31; High); and confluent red marks (21.74; 100; Unsatisfactory). Antral elevated erosive gastritis exhibited high reliability and high specificity with respect to the presence of portal hypertension (92%) and the diagnosis of portal hypertensive gastropathy (88.31%). CONCLUSION: The most suitable endoscopic criteria for the diagnosis of PHG were mosaic-like pattern, redpoint lesions and cherry-red spots with no subdivisions,which were associated with a high rate of inter-observer reliability. | George Fred Soares de Macedo Fabio Gon alves Ferreira Maurício Alves Ribeiro Luiz Arnaldo Szutan Mauricio Saab Assef Lucio Giovanni Battista Rossini | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，7： | 9 |
| 3 | Artificial Intelligence in Healthcare:Review and Prediction Case Studies显示文摘Artificial intelligence(AI)has been developing rapidly in recent years in terms of software algorithms,hardware implementation,and applications in a vast number of areas.In this review,we summarize the latest developments of applications of AI in biomedicine,including disease diagnostics,living assistance,biomedical information processing,and biomedical research.The aim of this review is to keep track of new scientific accomplishments,to understand the availability of technologies,to appreciate the tremendous potential of AI in biomedicine,and to provide researchers in related fields with inspiration.It can be asserted that,just like AI itself,the application of AI in biomedicine is still in its early stage.New progress and breakthroughs will continue to push the frontier and widen the scope of AI application,and fast developments are envisioned in the near future.Two case studies are provided to illustrate the prediction of epileptic seizure occurrences and the filling of a dysfunctional urinary bladder. | Guoguang Rong Arnaldo Mendez Elie Bou Assi Bo Zhao Mohamad Sawan | 2020 | Engineering2020，6，3： | 7 |
| 4 | Endoscopic ultrasonography findings in autoimmune pancreatitis显示文摘Endoscopic ultrasonography is an established diagnostic tool for pancreatic masses and chronic pancreatitis.In recent years there has been a growing interest in the worldwide medical community in autoimmune pancreatitis (AIP),a form of chronic pancreatitis caused by an autoimmune process.This paper reviews the current available literature about the endoscopic ultrasonographic findings of AIP and the role of this imaging technique in the management of this protean disease. | Elisabetta Buscarini Stefania De Lisi Paolo Giorgio Arcidiacono Maria Chiara Petrone Arnaldo Fuini Rita Conigliaro Guido Manfredi Raffaele Manta Dario Reggio Claudio De Angelis | 2011 | World Journal of Gastroenterology2011，17，16： | 6 |
| 5 | Hepatitis C virus-related B cell subtypes in non Hodgkin's lymphoma显示文摘AIM:To evaluate if indolent B cell-non Hodgkin's lymphoma(B-NHL) and diffuse large B-cell lymphoma(DLBCL) in hepatitis C virus(HCV) positive patients could have different biological and clinical characteristics requiring different management strategies.METHODS:A group of 24 HCV related B-NHL patients(11 indolent,13 DLBCL) in whom the biological and clinical characteristics were described and confronted.Patients with DLBCL were managed with the standard of care of treatment.Patients with indolent HCV-related B-NHL were managed with antiviral treatment pegylated interferon plus ribavirin and their course observed.The outcomes of the different approaches were compared.RESULTS:Patients with DLBCL had a shorter duration of HCV infection and a higher prevalence of HCV genotype 1 compared to patients with indolent B-NHL in which HCV genotype 2 was the more frequent genotype.Five of the 9 patients with indolent HCV-relatedB-NHL treated with only antiviral therapy,achieved a complete response of their onco-haematological disease(55%).Seven of the 13 DLBCL patients treated with immunochemotheraphy obtained a complete response(54%).CONCLUSION:HCV genotypes and duration of HCV infection differed between B-NHL subtypes.Indolent lymphomas can be managed with antiviral treatment,while DLBCL is not affected by the HCV infection. | Adriano M Pellicelli Massimo Marignani Valerio Zoli Mario Romano Aldo Morrone Lorenzo Nosotti Giuseppe Barbaro Antonio Picardi Umberto Vespasiani Gentilucci Daniele Remotti Cecilia D'Ambrosio Caterina Furlan Fabrizio Mecenate Ettore Mazzoni Ignazio Majolino Roberto Villani Arnaldo Andreoli Giorgio Barbarini | 2011 | World Journal of Hepatology2011，3，11： | 4 |
| 6 | Effect of sewage sludge and sugarcane bagasse biochar on soil properties and sugar beet production显示文摘Recently, biochar has shown to be an alternative to waste disposal and a source of nutrients, acting as a soil amendment. The effects of two types of biochar on soil properties and sugar beet production as well as potential for carbon(C) sequestration were evaluated: biochar produced from sewage sludge(SB) and biochar produced from a 1:1 mixture of sewage sludge and sugarcane bagasse(MB). A greenhouse pot experiment was conducted using a sandy loam soil from the Brazilian savanna under treatments of MB applications at 2.5%, 5.0%, 7.5%, and 10.0%, SB application at 5.0%, and a conventional fertilization(CF) using lime and mineral fertilizers, with no fertilization as a control. After incubation for 45 d, seedlings were transplanted into each pot and cultivated for 55 d. Biochar characterization showed that pyrolysis reduced the biomass volume drastically, but concentrated the trace elements per unit of biochar weight. The MB treatments increased soil total C(by 27.8%) and pH(by 0.6), reduced the concentrations of nutrients, except for potassium(K), and chromium(Cr), and did not significantly alter lead(Pb) and cadmium(Cd) concentrations. Results of stable isotopes showed that all biochar treatments increased the total soil C stock and stability, suggesting a potential for application in C sequestration, and improved overall soil fertility. However, the biochar treatments also increased the concentrations of trace elements in the soil and plants. The sugar beet yields at 10.0% MB and 5.0% SB corresponded to 55%and 29% of the yield obtained in the CF treatment, respectively. These results may be due to biochar nutrients not being bioavailable when required by plants or to biochar nutrient adsorption. | Barbara Samartini Queiroz ALVES Katherin Prissila Sevilla ZELAYA Fernando COLEN Ledivan Almeida FRAZÃO Alfredo NAPOLI Sanjai J.PARIKH Luiz Arnaldo FERNANDES | 2021 | Pedosphere2021，31，4： | 4 |
| 7 | 创业决策的科学方法及其在中国的推广显示文摘创业决策的科学方法包括清晰地提出问题、开发关于行为影响的理论,以及使用现有数据或从定义明确的实验设计中获取的数据来检验理论。其运作机制能够有效地形成、检验和更新创业者对创业想法价值的信念,对创业想法终止、转向(pivoting)和创业绩效具有重要影响。本文综合理论、经验和实践导向的新兴文献,概括了科学决策方法的发展情况。最后,本文讨论了将科学方法推广到中国创业环境的益处和挑战。 | Arnaldo Camuffo Yanhong Ding(校订) Alfonso Gambardella 罗银燕(翻译) 林道谧(校订) | 2022 | 管理学季刊2022，7，4： | 3 |
| 8 | Endoscopic submucosal dissection in the treatment of gastric submucosal tumors: results from a retrospective cohort study显示文摘 | Filippo Catalano Luca Rodella Francesco Lombardo Marco Silano Anna Tomezzoli Arnaldo Fuini Maria Antonietta Cosmo Giovanni Manzoni Antonello Trecca | 2013 | Gastric Cancer2013，，4： | 3 |
| 9 | Association of nonalcoholic fatty liver disease and liver cancer显示文摘AIM:To investigate the association between nonalcoholic fatty liver disease(NAFLD) and liver cancer,and NAFLD prevalence in different liver tumors.METHODS:This is a retrospective study of the clinical,laboratory and histological data of 120 patients diagnosed with primary or secondary hepatic neoplasms and treated at a tertiary center where they underwent hepatic resection and/or liver transplantation,with subsequent evaluation of the explant or liver biopsy.The following criteria were used to exclude patients from the study:a history of alcohol abuse,hepatitis B or C infection,no tumor detected in the liver tissue examined by histological analysis,and the presence of chronic autoimmune hepatitis,hemochromatosis,Wilson's disease,or hepatoblastoma.The occurrence of NAFLD and the association with its known risk factors were studied.The risk factors considered were diabetes mellitus,impaired glucose tolerance,impaired fasting glucose,body mass index,dyslipidemia,and arterial hypertension.Presence of reticulin fibers in the hepatic neoplasms was assessed by histological analysis using slide-mounted specimens stained with either hematoxylin and eosin or Masson's trichrome and silver impregnation.Analysis of tumor-free liver parenchyma was carried out to determine the association between NAFLD and its histological grade.RESULTS:No difference was found in the association of NAFLD with the general population(34.2% and 30.0% respectively,95%CI:25.8-43.4).Evaluation by cancer type showed that NAFLD was more prevalent in patients with liver metastasis of colorectal cancer than in patients with hepatocellular carcinoma and intrahepatic cholangiocarcinoma(OR = 3.99,95%CI:1.78-8.94,P < 0.001 vs OR = 0.60,95%CI:0.18-2.01,P = 0.406 and OR = 0.70,95%CI:0.18-2.80,P = 0.613,respectively).There was a higher prevalence of liver fibrosis in patients with hepatocellular carcinoma(OR = 3.50,95%CI:1.06-11.57,P = 0.032).Evaluation of the relationship between the presence of NAFLD,nonalcoholic steatohepatitis,and liver fibrosis,and their risk factors,showed no significant statistical association for any of the tumors studied.CONCLUSION:NAFLD is more common in patients with liver metastases caused by colorectal cancer. | Perla Oliveira Schulz Fabio Goncalves Ferreira Maria de Fátima Araújo Nascimento Andrea Vieira Mauricio Alves Ribeiro André Ibrahim David Luiz Arnaldo Szutan | 2015 | World Journal of Gastroenterology2015，21，3： | 2 |
| 10 | Sofosbuvir plus daclatasvir for post-transplant recurrent hepatitis C: potent antiviral activity but no clinical benefit if treatment is given late显示文摘 | Adriano M. Pellicelli Marzia Montalbano Raffaella Lionetti Christine Durand Peter Ferenci Gianpiero D’Offizi Viola Knop Andrea Telese Ilaria Lenci Arnaldo Andreoli Stefan Zeuzem Mario Angelico | 2014 | Digestive and Liver Disease2014，，： | 2 |
| 11 | A pathobiologic link between risk factors profile and morphological markers of carotid instability显示文摘 | Alessandro Mauriello Giuseppe M. Sangiorgi Renu Virmani Santi Trimarchi David R. Holmes Frank D. Kolodgie David G. Piepgras Giulia Piperno Doriana Liotti Jagat Narula Paolo Righini Arnaldo Ippoliti Luigi G. Spagnoli | 2009 | Atherosclerosis2009，，2： | 2 |
| 12 | Water-aided colonoscopy: a systematic review显示文摘 | Felix W. Leung Arnaldo Amato Christian Ell Shai Friedland Judith O. Harker Yu-Hsi Hsieh Joseph W. Leung Surinder K. Mann Silvia Paggi Jürgen Pohl Franco Radaelli Francisco C. Ramirez Rodelei Siao-Salera Vittorio Terruzzi | 2012 | Gastrointestinal Endoscopy2012，，3： | 2 |
| 13 | Microstructural study of opaque glazes obtained from frits of the system: SiO 2 -Al 2 O 3 -B 2 O 3 -(P 2 O 5 )-CaO-K 2 O-TiO 2显示文摘 | Encarna Bou Arnaldo Moreno Agustín Escardino Ana Gozalbo | 2006 | Journal of the European Ceramic Society2006，，2： | 2 |
| 14 | Multifunctional flexible optical waveguide sensor: on the bioinspiration for ultrasensitive sensors development显示文摘This paper presents the development of a bioinspired multifunctional flexible optical sensor(BioMFOS)as an ultrasensitive tool for force(intensity and location)and orientation sensing.The sensor structure is bioinspired in orb webs,which are multifunctional devices for prey capturing and vibration transmission.The multifunctional feature of the structure is achieved by using transparent resins that present both mechanical and optical properties for structural integrity and strain/deflection transmission as well as the optical signal transmission properties with core/cladding configuration of a waveguide.In this case,photocurable and polydimethylsiloxane(PDMS)resins are used for the core and cladding,respectively.The optical transmission,tensile tests,and dynamic mechanical analysis are performed in the resins and show the possibility of light transmission at the visible wavelength range in conjunction with high flexibility and a dynamic range up to 150 Hz,suitable for wearable applications.The BioMFOS has small dimensions(around 2 cm)and lightweight(0.8 g),making it suitable for wearable application and clothing integration.Characterization tests are performed in the structure by means of applying forces at different locations of the structure.The results show an ultra-high sensitivity and resolution,where forces in theμN range can be detected and the location of the applied force can also be detected with a sub-millimeter spatial resolution.Then,the BioMFOS is tested on the orientation detection in 3D plane,where a correlation coefficient higher than 0.9 is obtained when compared with a gold-standard inertial measurement unit(IMU).Furthermore,the device also shows its capabilities on the movement analysis and classification in two protocols:finger position detection(with the BioMFOS positioned on the top of the hand)and trunk orientation assessment(with the sensor integrated on the clothing).In both cases,the sensor is able of classifying the movement,especially when analyzed in conjunction with preprocessing and clustering techniques.As another wearable application,the respiratory rate is successfully estimated with the BioMFOS integrated into the clothing.Thus,the proposed multifunctional device opens new avenues for novel bioinspired photonic devices and can be used in many applications of biomedical,biomechanics,and micro/nanotechnology. | Arnaldo Leal-Junior Leticia Avellar Vitorino Biazi M.Simone Soares Anselmo Frizera Carlos Marques | 2022 | Opto-Electronic Advances2022，5，10： | 2 |
| 15 | Effluent dissolved organic nitrogen and dissolved phosphorus removal by enhanced coagulation and micro- filtration显示文摘 | Arnaldos M Pagilla K | 2010 | Water Research2010，44，18： | 1 |
| 16 | Comparison of three different methods of evaluation of metabolic acid-base disorders显示文摘 | Arnaldo D Maria MM Fabio DM | 2007 | Crit Care Med2007，35，5： | 1 |
| 17 | Thin-layer boilover in diesel-oil fires:determining the increase of thermal hazards and safety distances 显示文摘 | Ferrero F Munoz M Arnaldos J | 2007 | Journal of Hazardous Materials2007，140，： | 1 |
| 18 | Application of molecular techniques to evaluate the methanogenic archaea and anaerobic bacteria in the presence of oxygen with different COD:Sulfate ratios in a UASB reactor显示文摘 | Julia Sumiko Hirasawa Arnaldo Sarti Nora Katia Saavedra Del Aguila Maria Bernadete A. Varesche | 2008 | Anaerobe2008，，4： | 1 |
| 19 | Procum Patricium 显示文摘 | Arnaldo Momigliano | 1966 | Journal of Roman Studies1966，，： | 1 |
| 20 | Expansion of gas-solid fluidized beds at pressure and high temperature显示文摘 | FLLOP M CASAL J ARNALDOS | 2000 | Powder Technol2000，107，3： | 1 |
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