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| 1 | Cancer epigenetics: a perspective on the role of DNA methylation in acquired endocrine resistance显示文摘Epigenetic mechanisms, including DNA methylation, are responsible for determining and maintaining cell fate, stably differentiating the various tissues in our bodies. Increasing evidence shows that DNA methylation plays a significant role in cancer, from the silencing of tumor suppressors to the activation of oncogenes and the promotion of metastasis. Recent studies also suggest a role for DNA methylation in drug resistance. This perspective article discusses how DNA methylation may contribute to the development of acquired endocrine resistance, with a focus on breast cancer. In addition, we discuss DNA methylome profiling and how recent developments in this field are shedding new light on the role of epigenetics in endocrine resistance. Hormone ablation is the therapy of choice for hormone-sensitive breast tumors, yet as many as 40% of patients inevitably relapse, and these hormone refractory tumors often have a poor prognosis. Epigenetic studies could provide DNA methylation biomarkers to predict and diagnose acquired resistance in response to treatment. Elucidation of epigenetic mechanisms may also lead to the development of new treatments that specifically target epigenetic abnormalities or vulnerabilities in cancer cells. Expectations must be tempered by the fact that epigenetic mechanisms of endocrine resistance remain poorly understood, and further study is required to better understand how altering epigenetic pathways with therapeutics can promote or inhibit endocrine resistance in different contexts. Going forward, DNA methylome profiling will become increasingly central to epigenetic research, heralding a network-based approach to epigenetics that promises to advance our understanding of the etiology of cancer in ways not previously possible. | Michael P. Trimarchi Mary Mouangsavanh Tim Hui-Ming | 2011 | Chinese Journal of Cancer2011，30，11： | 6 |
| 2 | Acute small bowel obstruction caused by endometriosis:A case report and review of the literature显示文摘Gastrointestinal involvement of endometriosis has been found in 3%-37% of menstruating women and exclusive localization on the ileum is very rare(1%-7%).Endometriosis of the distal ileum is an infrequent cause of intestinal obstruction,ranging from 7% to 23% of all cases with intestinal involvement.We report a case in which endometrial infiltration of the small bowel caused acute obstruction requiring emergency surgery,in a woman whose symptoms were not related to menses.Histology of the resected specimen showed that endometriosis was mainly prevalent in the muscularis propria and submucosa and that the mucosa was not ulcerated but had inflammation and glandular alteration.Endometrial lymph node involvement,with a cystic glandular pattern was also detected. | Antonella De Ceglie Claudio Bilardi Sabrina Blanchi Massimo Picasso Massimo Conio Marcello Di Muzio Alberto Trimarchi | 2008 | World Journal of Gastroenterology2008，14，21： | 5 |
| 3 | 难治性疼痛和高血压在急性B型主动脉夹层中的重要性:国际急性主动脉夹层登记的意见显示文摘急性B型主动脉夹层患者,可表现出对药物治疗无效的反复、难治性疼痛和(或)难治性高血压,当出现这些症状时有时可作为介入治疗的指征。研究者利用国际急性主动脉夹层登记(international registry of a-cute aortic dissection,IRAD)的资料调查难治性疼痛和(或)难治性高血压对急性B型主动脉夹层患者临床转归的影响。 | 张玲玉 叶鹏 Trimarchi S Eagle KA Nienaber CA Pyeritz RE Jonker FH Suzuki T O'Gara PT Hutchinson SJ Rampoldi V Grassi V Bossone E Muhs BE Evangelista A Tsai TT Froehlich JB Cooper JV Montgomery D Mein-hardt G Myrmel T Upchurch GR Sundt TM Issel-bacher EM | 2010 | 中华高血压杂志2010，18，12： | 4 |
| 4 | Acute Aortic Dissection: Perspectives from the International Registry of Acute Aortic Dissection (IRAD)显示文摘 | T.T. Tsai S. Trimarchi C.A. Nienaber | 2008 | European Journal of Vascular & Endovascular Surgery2008，，2： | 2 |
| 5 | A pathobiologic link between risk factors profile and morphological markers of carotid instability显示文摘 | Alessandro Mauriello Giuseppe M. Sangiorgi Renu Virmani Santi Trimarchi David R. Holmes Frank D. Kolodgie David G. Piepgras Giulia Piperno Doriana Liotti Jagat Narula Paolo Righini Arnaldo Ippoliti Luigi G. Spagnoli | 2009 | Atherosclerosis2009，，2： | 2 |
| 6 | Dissection: insights from the International registry of acute aortic dissection long- term survival in patients presenting with type B acute aortic显示文摘 | Tsai TT Fattori R Trimarchi S | 2006 | Circulation2006，114，21： | 1 |
| 7 | Acute aortic dissection:perspectives from the International registry of acute aorticdissection(IRAD)显示文摘 | Tsai T T Trimarchi S Nienaber C A | 2009 | Eur J Vasc Endovasc Surg2009，37，2： | 1 |
| 8 | Acute aortic dissection:perspectives from the International Registry of Acute Aortic Dissection(IRAD)显示文摘 | Tsai T T Trimarchi S Nienaber C A | 2009 | Eur J Vasc Endovasc Surg2009，37，2： | 1 |
| 9 | E2F3 is critical for normal cellular proliferation显示文摘 | HUMBERT P O VERONA R TRIMARCHI J M | 2000 | Genes Dev2000，14，6： | 1 |
| 10 | Use of Chimney graft after accidental coverage of the left common carotid artery in TEVAR procedure显示文摘 | Derbel B Tolenaar JL Trimarchi S | 2014 | Latunisie Med2014，92，12： | 1 |
| 11 | Increased birefringence in the meiotic spindle provides a new marker for the onset of activation in living oocytes显示文摘 | Liu L Trimarchi JR Oldenbourg R | 2000 | Biol Reprod2000，63，1： | 1 |
| 12 | Retroperitoneal hematoma after pereutaneous coronary intervention : prevalence, risk factors, manage- ment,outcomes,and predictors of mortality:a report from the BMC2 (Blue Cross Blue Shield of Michigan Cardiovascular Consortium ) registry 显示文摘 | Trimarchi S Smith DE Share D | 2010 | JACC Cardiovase Interv2010，3，8： | 1 |
| 13 | Pregnancy outcome in in vitro fertilization decrea- ses to a plateau with repeated cycles 显示文摘 | Silberstein T Trimarchi JR Gonzalez L | 2005 | Fertil Steril2005，84，4： | 1 |
| 14 | Prcocalci- tonin and inflammation in chronic hemodialysis显示文摘 | Trimarchi H Dicugno M Muryan A | 2013 | Medicina(B Aires)2013，73，5： | 1 |
| 15 | Contemporary results of surgery in acute type A aortic dissection: The International Registry of Acute Aortic Dissection experience 显示文摘 | Trimarchi S Nienaber CA Rampoldi V | 2005 | J Thorac Cardiovasc Surg2005，129，1： | 1 |
| 16 | Pregnancy outcome in in vitro fertilization decreases to a plateau with repeated cycles 显示文摘 | Silberstein T Trimarchi JR Gonzalez L | 2005 | Fertil Steril2005，84，4： | 1 |
| 17 | Long-term survival in patientspresenting with type B acute aortic dissection : insights from theInternational Registry of Acute Aortic Dissection显示文摘 | Tsai T Fattori R Trimarchi S | 2006 | Circulation2006，114，21： | 1 |
| 18 | Long-term survival in patients presenting with type B acute aortic dissection:insights from the International Reg-istry of Actcte Aortic Dissection显示文摘 | TSAI T T FATTORI R TRIMARCHI S | 2006 | Circulation2006，114，： | 1 |
| 19 | E2f3 is critical for nor- real cellular proliferation显示文摘 | Humbert PO Verona R Trimarchi JM | 2000 | Genes Dev2000，14，6： | 1 |
| 20 | Expression of Hepatocyte Growth Factor in Hashimoto's Thyroiditis with Nodular Lesions显示文摘 | Ruggeri RM Sciacchitano S Trimarchi F | 2007 | Eur J Histochem2007，51，3： | 1 |
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