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| 1 | Hepcidin modulation in human diseases: From research to clinic显示文摘By modulating hepcidin production, an organism controls intestinal iron absorption, iron uptake and mobilization from stores to meet body iron need. In recent years there has been important advancement in our knowledge of hepcidin regulation that also has implications for understanding the physiopathology of some human disorders. Since the discovery of hepcidin and the demonstration of its pivotal role in iron homeostasis, there has been a substantial interest in developing a reliable assay of the hormone in biological fluids. Measurement of hepcidin in biological fuuids can improve our understanding of iron diseases and be a useful tool for diagnosis and clinical management of these disorders. We reviewed the literature and our own research on hepcidin to give an updated status of the situation in this rapidly evolving fi eld. | Alberto Piperno Raffaella Mariani Paola Trombini Domenico Girelli | 2009 | World Journal of Gastroenterology2009，15，5： | 6 |
| 2 | Patatin-like phospholipase domain containing-3 gene I148M polymorphism, steatosis, and liver damage in hereditary hemochromatosis显示文摘AIM: To investigate whether the patatin-like phospholipase domain containing-3 gene (PNPLA3 ) I148M polymorphism is associated with steatosis, fibrosis stage, and cirrhosis in hereditary hemochromatosis (HH). METHODS: We studied 174 consecutive unrelated homozygous for the C282Y HFE mutation of HH (C282Y+/+ HH) patients from Northern Italy, for whom the presence of cirrhosis could be determined based on histological or clinical criteria, without excessive alcohol intake (< 30/20 g/d in males or females) or hepatitis B virus and hepatitis C virus viral hepatitis. Steatosis was evaluated in 123 patients by histology (n = 100) or ultrasound (n = 23). The PNPLA3 rs738409 single nucleotide polymorphism, encoding for the p.148M protein variant, was genotyped by a Taqman assay (assay on demand, Applied Biosystems). The association of the PNPLA3 I148M protein variant (p.I148M) with steatosis, fibrosis stage, and cirrhosis was evaluated by logistic regression analysis. RESULTS: PNPLA3 genotype was not associated with metabolic parameters, including body mass index (BMI), the presence of diabetes, and lipid levels, but the presence of the p.148M variant at risk was independently associated with steatosis [odds ratio (OR) 1.84 per p.148M allele, 95% confidence interval (CI): 1.05-3.31; P = 0.037], independently of BMI and alanine amino-transaminase (ALT) levels. The p.148M variant was also associated with higher aspartate aminotransferase (P = 0.0014) and ALT levels (P = 0.017) at diagnosis, independently of BMI and the severity of iron overload. In patients with liver biopsy, the 148M variant was independently associated with the severity (stage) of fibrosis (estimated coefficient 0.56 ± 0.27, P = 0.041). In the overall series of patients, the p.148M variant was associated with cirrhosis in lean (P = 0.049), but not in overweight patients (P = not significant). At logistic regression analysis, cirrhosis was associated with BMI ≥ 25 (OR 1.82, 95% CI: 1.02-3.55), ferritin > 1000 ng/mL at diagnosis (OR 19.3, 95% CI: 5.3-125), and with the G allele in patients with BMI < 25 (OR 3.26, 95% CI: 1.3-10.3). CONCLUSION: The PNPLA3 I148M polymorphism may represent a permissive factor for fibrosis progression in patients with C282Y+/+ HH. | Luca Valenti Paolo Maggioni Alberto Piperno Raffaela Rametta Sara Pelucchi Raffaella Mariani Paola Dongiovanni Anna Ludovica Fracanzani Silvia Fargion | 2012 | World Journal of Gastroenterology2012，18，22： | 4 |
| 3 | A pathobiologic link between risk factors profile and morphological markers of carotid instability显示文摘 | Alessandro Mauriello Giuseppe M. Sangiorgi Renu Virmani Santi Trimarchi David R. Holmes Frank D. Kolodgie David G. Piepgras Giulia Piperno Doriana Liotti Jagat Narula Paolo Righini Arnaldo Ippoliti Luigi G. Spagnoli | 2009 | Atherosclerosis2009，，2： | 2 |
| 4 | Chromogenic in situ hybridization to detect HER-2/neu gene amplification in histological and ThinPrepprocessed breast cancer fine-needle aspirates:a sensitive and practical method in the trastuzumab era显示文摘 | Vocaturo A Novelll F Benevolo M Piperno G | 2006 | Oncologist2006，11，： | 1 |
| 5 | Partitioned procedures for the transient solution of coupled aero elastic problemsPart Ⅱ:Energy transfer analysis and three-dimensional applications显示文摘 | PIPERNO S FARHAT C | | 0，，： | 1 |
| 6 | The iron-hypoxia link: Hepcidin has a central role in the response to acute and chronic exposure to hypobaric hypoxia 显示文摘 | Piperno A Peluechi S Mariani R | 2010 | Journal of Hyper- tension2010，，： | 1 |
| 7 | Phytolith evidence for early holocene eueurbita domestication in southwest Ecuador显示文摘 | Piperno D R Stothert K E | 2003 | Science2003，299，： | 1 |
| 8 | Glucosamine sulfate modulates dysregulated activities of human osteoarthritic chondrocytes in vitro 显示文摘 | Piperno M Reboul P Hellio Le Graverand M P | 2000 | Osteoarthritis and Cartilage2000，，8： | 1 |
| 9 | Increased plasma levels of atrial natriuretic factor, renin activity, and leukotriene CA in chronic obstructive pulmonary disease显示文摘 | Piperno D Pacheco Y Hosni R | 1993 | Chest1993，104，2： | 1 |
| 10 | Autologous chondrocyte implantation for traumatic full- thickness cartilage defects of the knee in 14 patients: 6-year functional outcomes显示文摘 | Viste A Piperno M Desmarchelier R | 2012 | Orthop Traumatol Surg Res2012，98，7： | 1 |
| 11 | Posttranslational mod- ifications of alpha tubulin: detyrosination and acetylation dif- ferentiate populations of interphase microtubules in cultured cells显示文摘 | Bulinski J C Riehards J E Piperno G | 1988 | JCellBiol1988，106，4： | 1 |
| 12 | Phylogenetic relationships among domesticated and wild species of Cucurbita (Cucurbitaceae) inferred from a mitochondrial gene:Implications for cro Pplant evolution and areas of origin 显示文摘 | Sanjur O I Piperno D R Andres T C | 2002 | PNAS2002，99，1： | 1 |
| 13 | Liver iron concentration inchronic viral hepatitis:a study of 98 patients显示文摘 | Piperno A D′Alba R Fargion S | 1995 | Eur J GastroenterolHepatol1995，7，： | 1 |
| 14 | Increased serum fer-ritin is common in men with essential hypertension 显示文摘 | Piperno A Trombini P’Gelosa M | 2002 | JHypertens2002，20，8： | 1 |
| 15 | Role of P53 and Bcl-2 in advanced rectal carcinomas treated with adjuvant therapy显示文摘 | Cosimelli M Perrone DR | 2004 | J Chemother2004，16，5： | 1 |
| 16 | Hemochromatosis in Italy in the last 30 years: Role of genetic and acquired factors显示文摘 | Anna Ludovica Fracanzani Alberto Piperno Luca Valenti Mirella Fraquelli Sabina Coletti Alessandra Maraschi Dario Consonni Enzo Coviello Dario Conte Silvia Fargion | 2010 | Hepatology2010，，2： | 1 |
| 17 | Phytoliths in the reproductive structures of maize and teosinte: implications for the study of maize evolution 显示文摘 | PIPERNO D R PEARSALL D M | 1993 | JArchaeol Sci1993，20，： | 1 |
| 18 | Distinguishing rice (Oryza sativa,Poaceae) from wild Oryza species through phytolith analysis: results of preliminary research 显示文摘 | PEARSALL D M PIPERNO D R DINAN E H | 1995 | Economic Bot1995，49，： | 1 |
| 19 | Ferritin, metabolic syndrome and NAFLD: e- lective attractions and dangerous liaisons 显示文摘 | Trombini P Piperno A | | J Hepatol0，46，4： | 1 |
| 20 | Explicit/Implicit Fluid/Structure Staggered Procedures with a Structural Predictor and Fluid Subcycling for 2D Inviscid Aeroelastic Simulations显示文摘 | PIPERNO S | 1997 | International Journal for Numerical Methods in Fluids1997，25，10： | 1 |
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