|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Consequences of dysthyroidism on the digestive tract and viscera显示文摘Thyroid hormones def ine basal metabolism throughout the body, particularly in the intestine and viscera. Gastrointestinal manifestations of dysthyroidism are numerous and involve all portions of the tract. Thyroid hormone action on motility has been widely studied, but more complex pathophysiologic mechanisms have been indicated by some studies although these are not fully understood. Both thyroid hormone excess and def iciency can have similar digestive manifestations, such as diarrhea, although the mechanism is different in each situation. The liver is the most affected organ in both hypo-and hyperthyroidism. Specifi c digestive diseases may be associated with autoimmune thyroid processes, such as Hashimoto's thyroiditis and Grave's disease. Among them, celiac sprue and primary biliary cirrhosis are the most frequent although a clear common mechanism has never been proven. Overall, thyroid-related digestive manifestations were described decades ago but studies are still needed in order to conf irm old concepts or elucidate undiscovered mechanisms. All practitioners must be aware of digestive symptoms due to dysthyroidism in order to avoid misdiagnosis of rare but potentially lethal situations. | Ronald Daher Thierry Yazbeck Joe Bou Jaoude Bassam Abboud | 2009 | World Journal of Gastroenterology2009，15，23： | 9 |
| 2 | Artificial Intelligence in Healthcare:Review and Prediction Case Studies显示文摘Artificial intelligence(AI)has been developing rapidly in recent years in terms of software algorithms,hardware implementation,and applications in a vast number of areas.In this review,we summarize the latest developments of applications of AI in biomedicine,including disease diagnostics,living assistance,biomedical information processing,and biomedical research.The aim of this review is to keep track of new scientific accomplishments,to understand the availability of technologies,to appreciate the tremendous potential of AI in biomedicine,and to provide researchers in related fields with inspiration.It can be asserted that,just like AI itself,the application of AI in biomedicine is still in its early stage.New progress and breakthroughs will continue to push the frontier and widen the scope of AI application,and fast developments are envisioned in the near future.Two case studies are provided to illustrate the prediction of epileptic seizure occurrences and the filling of a dysfunctional urinary bladder. | Guoguang Rong Arnaldo Mendez Elie Bou Assi Bo Zhao Mohamad Sawan | 2020 | Engineering2020，6，3： | 7 |
| 3 | Gastroesophageal reflux disease, obesity and laparoscopic sleeve gastrectomy: The burning questions显示文摘Obesity is a global health epidemic with considerable economic burden.Surgical solutions have become increasingly popular following technical advances leading to sustained efficacy and reduced risk.Sleeve gastrectomy accounts for almost half of all bariatric surgeries worldwide but concerns regarding its relationship with gastroesophageal reflux disease(GERD)has been a topic of debate.GERD,including erosive esophagitis,is highly prevalent in the obese population.The role of pre-operative endoscopy in bariatric surgery has been controversial.Two schools of thought exist on the matter,one that believes routine upper endoscopy before bariatric surgery is not warranted in the absence of symptoms and another that believes that symptoms are poor predictors of underlying esophageal pathology.This debate is particularly important considering the evidence for the association of laparoscopic sleeve gastrectomy(LSG)with de novo and/or worsening GERD compared to the less popular Roux-en-Y gastric bypass procedure.In this paper,we try to address 3 burning questions regarding the inter-relationship of obesity,GERD,and LSG:(1)What is the prevalence of GERD and erosive esophagitis in obese patients considered for bariatric surgery?(2)Is it necessary to perform an upper endoscopy in obese patients considered for bariatric surgery?And(3)What are the long-term effects of sleeve gastrectomy on GERD and should LSG be done in patients with pre-existing GERD? | Halim Bou Daher Ala I Sharara | 2019 | World Journal of Gastroenterology2019，25，33： | 6 |
| 4 | Myxedema ascites with high CA-125:Case and a review of literature显示文摘Ascites appearing in a previously healthy female patient is usually ascribed to a variety of causes,among which,is a cancerous process,especially if it comes with a raised CA-125 level.Although the CA-125 antigen is present on more than 80% of malignant epithelial ovarian tissue of non-mucinous type,it is also found on both healthy and malignant cells of mesothelial and non-mesothelial origin.Myxedema ascites which is caused by hypothyroidism is a rare entity,but on the other hand is easy to treat.It is one of the differential diagnoses when the ascites is refractory to treatment and no other obvious cause can be identified.If the diagnosis is delayed,patients will frequently receive unnecessary procedures,while treatment has very good response rates and ascites resolve with serum CA-125 normalization after adequate hormonal treatment. | Bou Khalil Roula El Rassi Patrick Chammas Nizar Obeid Jean Ghabach Maroun Sakr Charles Itani Tarek Farhat Said | 2013 | World Journal of Hepatology2013，5，2： | 4 |
| 5 | Prospect of creating trans-genic animals by using sper-matogonial transplantation显示文摘Transgenic animal technology is a powerful tool for researching bioscience, biomedicine, bioreactor, and ag- riculture. There are various ways to produce transgenic animals. The most common ways currently available are pronuclear microinjection and nuclear transfer techniques. However, these methods usually result in low efficiency, causing mosaic (in pronuclear microinjection), or develop- mental abnormalities (in nuclear transfer). In 1994, Brinster and his colleagues reported an original method to transfer spermatogonial stem cells from donor to recipient mice. The donor spermatogonia were able to form spermatozoa in re- cipient testes, and to produce progeny carrying the donor’s genetic characters. Since then, a series of novel methods were invented by using spermatogonia transplantation. These new methods facilitate the research and application of sper- matogonia. Some of these methods, when combining with genetic modification methods, will form a novel methodology for creating transgenic animals. The present paper reviews the achievements of research on spermatogonia transplanta- tion related to creating transgenic animal. Such as, trans- plantation techniques, cryopreservation of spermatogonia, preparation of recipients, long-term proliferation of sper- matogonia in culture, genetic modification of spermatogonia, and characterization of germ line transmission of the modi- fied gene, etc. Furthermore the methodologies for creating transgenic animals by using spermatogonia transplantation were described. Based on the difference between donors and recipients used, the methodology is categorized into two groups: allogeneic transplantation, and autologous trans- plantation. Although progress in this research area has been swift, potential difficulties remain to be overcome in each approach. The advantages and existing problems in the methodology are discussed. | BOU Shorgan | 2005 | Chinese Science Bulletin2005，50，22： | 3 |
| 6 | Linking multiple pathogenic pathways in Alzheimer's disease显示文摘Alzheimer's disease(AD) is a chronic neurodegenerative disorder presenting as progressive cognitive decline with dementia that does not, to this day, benefit from any disease-modifying drug. Multiple etiologic pathways have been explored and demonstrate promising solutions. For example, iron ion chelators, such as deferoxamine, are a potential therapeutic solution around which future studies are being directed. Another promising domain is related to thrombin inhibitors. In this minireview, a common pathophysiological pathway is suggested for the pathogenesis of AD to prove that all these mechanisms converge onto the same cascade of neuroinflammatory events. This common pathway is initiated by the presence of vascular risk factors that induce brain tissue hypoxia, which leads to endothelial cell activation. However, the ensuing hypoxia stimulates the production and release of reactive oxygen species and pro-inflammatory proteins. Furthermore, the endothelial activation may become excessive and dysfunctional in predisposed individuals, leading to thrombin activation and iron ion decompartmentalization. The oxidative stress that results from these modifications in the neurovascular unit will eventually lead to neuronal and glial cell death, ultimately leading to the development of AD. Hence, future research in this field should focus on conducting trials with combinations of potentially efficient treatments, such as the combination of intranasal deferoxamine and direct thrombin inhibitors. | Rami Bou Khalil Elie Khoury Salam Koussa | 2016 | World Journal of Psychiatry2016，6，2： | 3 |
| 7 | Production of transgenic cashmere goat embryos expressing red fluorescent protein and containing IGF1 hair-follicle-cell specific expression cassette by somatic cell nuclear transfer显示文摘In the present study, cashmere goat fetal fibroblasts were transfected with pCDsR-KI, a hair-follicle-cell specific expression vector for insulin-like growth factor 1 (IGF1) that contains two markers for selection (red fluorescent protein gene and neomycin resistant gene). The transgenic fibroblasts cell lines were obtained after G418 selection. Prior to the somatic cell nuclear transfer (SCNT), the maturation rate of caprine cumulus oocytes complexes (COCs) was optimized to an in vitro maturation time of 18 h. Parthenogenetic ooctyes were used as a model to investigate the effect of two activation methods, one with calcium ionophore IA23187 plus 6-DMAP and the other with ethanol plus 6-DMAP. The cleavage rates after 48 h were respectively 88.7% and 86.4%, with no significant difference (P>0.05). There was no significant difference between the cleavage rate and the blastocyst rate in two different media (SO- Faa and CR1aa; 86.3% vs 83.9%, P>0.05 and 23.1% vs 17.2%,P>0.05). The fusion rate of a 190 V/mm group (62.4%) was significantly higher than 130 V/mm (32.8%) and 200 V/mm (42.9%), groups (P<0.05). After transgenic somatic cell nuclear transfer (TSCNT) manipulation, 203 reconstructed embryos were obtained in which the cleavage rate after in vitro development (IVD) for 48 h was 79.3% (161/203). The blastocyst rate after IVD for 7 to 9 d was 15.3% (31/203). There were 17 embryos out of 31 strongly ex- pressing red fluorescence. Two of the red fluorescent blastocysts were randomly selected to identify transgene by polymerase chain reaction. Both were positive. These results showed that: (i) RFP and Neor genes were correctly expressed indicating that transgenic somatic cell lines and positive trans- genic embryos were obtained; (ii) one more selection at the blastocyst stage was necessary although the donor cells were transgenic positive, because only partially transgenic embryos expressing red fluorescence were obtained; and (iii) through TSCNT manipulation and optimization, transgenic cash- mere goat embryos expressing red fluorescence and containing an IGF1 expression cassette were obtained, which was sufficient for production of transgenic cashmere goats. | BOU ShorGan | 2009 | Science China(Life Sciences)2009，52，4： | 2 |
| 8 | Outer membrane vesicles as an acellular vaccine against Acinetobacter baumannii显示文摘 | Michael J. McConnell Carlos Rumbo Germán Bou Jerónimo Pachón | 2011 | Vaccine2011，，34： | 2 |
| 9 | Emerging role of caldesmon in cancer:A potential biomarker for colorectal cancer and other cancers显示文摘Colorectal cancer(CRC) is a devastating disease, mainly because of metastasis. As a result, there is a need to better understand the molecular basis of invasion and metastasis and to identify new biomarkers and therapeutic targets to aid in managing these tumors. The actin cytoskeleton and actin-binding proteins are known to play an important role in the process of cancer metastasis because they control and execute essential steps in cell motility and contractility as well as cell division. Caldesmon(CaD) is an actin-binding protein encoded by the CALD1 gene as multiple transcripts that mainly encode two protein isoforms: High-molecular-weight CaD, expressed in smooth muscle, and low-molecular weight CaD(l-CaD), expressed in nonsmooth muscle cells. According to our comprehensive review of the literature, CaD, particularly l-CaD, plays a key role in the development, metastasis, and resistance to chemoradiotherapy in colorectal, breast, and urinary bladder cancers and gliomas, among other malignancies. CaD is involved in many aspects of the carcinogenic hallmarks, including epithelial mesenchymal transition via transforming growth factor-beta signaling, angiogenesis, resistance to hormonal therapy, and immune evasion. Recent data show that CaD is expressed in tumor cells as well as in stromal cells, such as cancerassociated fibroblasts, where it modulates the tumor microenvironment to favor the tumor. Interestingly, CaD undergoes selective tumor-specific splicing, and the resulting isoforms are generally not expressed in normal tissues, making these transcripts ideal targets for drug design. In this review, we will analyze these features of CaD with a focus on CRC and show how the currently available data qualify CaD as a potential candidate for targeted therapy in addition to its role in the diagnosis and prognosis of cancer. | Alya R Alnuaimi Vidhya A Nair Lara J Bou Malhab Eman Abu-Gharbieh Anu Vinod Ranade Gianfranco Pintus Mohamad Hamad Hauke Busch Jutta Kirfel Rifat Hamoudi Wael M Abdel-Rahman | 2022 | World Journal of Gastrointestinal Oncology2022，14，9： | 2 |
| 10 | Two-point compression ultrasonography: Enough to rule out lower extremity deep venous thrombosis?显示文摘BACKGROUND: Deep venous thrombosis(DVT) is a major cause of morbidity and is a common presenting complaint to the emergency department(ED). Point-of-care two-point compression ultrasonography has evolved as a quick and effective way of diagnosing DVT. The purpose of this study is to validate the prevalence and distribution of venous thrombi isolated to proximal lower extremity veins, other than common femoral and popliteal veins in patients with DVT.METHODS: This is a single-center retrospective study that looked at patients presenting to the ED of a tertiary care hospital between January 2014 and August 2018. The clinical presentation and laboratory and imaging results were obtained using the hospital's electronic medical record.RESULTS: A total of 2,507 patients underwent a lower extremity duplex ultrasound during the study period. Among them, 379(15%) were included in the study. The percentages of isolated thrombi to the femoral vein and deep femoral vein were 7.92% and 0.53%, respectively. When the patients were stratified into the two groups of isolated DVT and two-point compression DVT, there were no statistically significant differences in the laboratory results between both groups. However, immobilized patients and patients with recent surgeries were more likely to have an isolated DVT.CONCLUSIONS: Thrombi isolated to proximal lower extremity veins other than the common femoral and popliteal veins make up 8.45% of DVTs. Given this significant number of missed DVTs, the authors recommend the addition of the femoral and deep femoral veins to the two-point compression exam. | Ralphe Bou Chebl Nader El Souki Mirabelle Geha Imad Majzoub Rima Kaddoura Hady Zgheib | 2021 | World Journal of Emergency Medicine2021，12，4： | 2 |
| 11 | Microstructural study of opaque glazes obtained from frits of the system: SiO 2 -Al 2 O 3 -B 2 O 3 -(P 2 O 5 )-CaO-K 2 O-TiO 2显示文摘 | Encarna Bou Arnaldo Moreno Agustín Escardino Ana Gozalbo | 2006 | Journal of the European Ceramic Society2006，，2： | 2 |
| 12 | Biosynthesis and ultrasonic degradation of bacterial poly ( gamma-glutamic acid ) 显示文摘 | Perez-Camero G Congregado F Bou J J | 1999 | Biotechnol Bioeng1999，63，1： | 1 |
| 13 | Biochemical and genetic characteristics of TEM-29B,a novel extended-spectrum beta-lactamase显示文摘 | Bou G Martlnez B J Cervero G | 1999 | FEMS Microbiol Lett1999，174，1： | 1 |
| 14 | Molecular characterization of FOX- 4, a new AmpC-type plasmid-mediated beta-lactamase from an Escherichia coli strain isolated in Spain 显示文摘 | Bou G Oliver A Ojeda M | 2000 | Antimicrob Agents Chemother2000，44，9： | 1 |
| 15 | Beta-lactamase inhibitors:the story so far显示文摘 | Pérez-Llarena FJ Bou G | | 0，，28： | 1 |
| 16 | OXA-24,a novel class D betalactamase with carbapenemase activity in an Acinetobacter baumannii clinical strain显示文摘 | Oliver A Martinez-Beltran J | 2000 | Antimicrob Agents Chemother2000，44，6： | 1 |
| 17 | l Comparison of nebu lized budeson ide and oral predn iso lone with p lacebo in th e treatment of acu te exacerbations of chron ic obstructive pulmon ary disease:a randomized controlled tria显示文摘 | Maltais F Os tinelli J Bou rbeau J et a | 2002 | l Am J Resp ir Crit CareM ed2002，165，： | 1 |
| 18 | Conformation of tri-and tetra-substituted 2-fluorocyclohexanones:proton non-equivalence F-H and F-C coupling constants,conformational dependence of ^3JFH and ^4JFH显示文摘 | Solladié-Cavallo A Jierry L Bouérat L | 2002 | Tetrahedron2002，58，： | 1 |
| 19 | Electron paramagnetic resonance studies of radical species of proanthocyanidins and gallate esters显示文摘 | BOUS W MICHEL C STETTMAIER K | 2000 | Archives of Biochemistry and Biophysics2000，374，2： | 1 |
| 20 | miR-449 inhibits cell proliferation and is down-regu- lated in gastric cancer显示文摘 | BOU KHEIR T FUTOMA-KAZMIERCZAK E JACOBSEN A | 2011 | Mol Cancer2011，18，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员