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| 1 | Open label trial of granulocyte apheresis suggests therapeutic efficacy in chronically active steroid refractory ulcerative colitis显示文摘AIM:To study the efficacy, safety, and feasibility of a granulocyte adsorptive type apheresis system for the treatment of patients with chronically active ulcerative colitis despite standard therapy.METHODS: An open label multicenter study was carried out in 39 patients with active ulcerative colitis (CAI6-8) despite continuous use of steroids (a minimum total dose of 400 mg prednisone within the last 4 wk).Patients received a total of five aphereses using a granulocyte adsorptive technique (Adacolumn(R), Otsuka Pharmaceutical Europe, UK). Assessments at wk 6 and during follow-up until 4 mo comprised clinical (CAI) and endoscopic (EI) activity index, histology, quality of life(IBDQ), and laboratory tests.RESULTS: Thirty-five out of thirty-nine patients were qualified for intent-to-treat analysis. After the apheresis treatment at wk 6, 13/35 (37.1%) patients achieved clinical remission and 10/35 (28.6%) patients had endoscopic remission (CAI<4, EI<4). Quality of life (IBDQ) increased significantly (24 points, P<0.01)at wk 6. Apheresis could be performed in all but one patient. Aphereses were well tolerated, only one patient experienced anemia.CONCLUSION: In patients with steroid refractory ulcerative colitis, five aphereses with a granulocyte/monocyte depleting filter show potential short-term efficacy. Tolerability and technical feasibility of the procedure are excellent. | Wolfgang Kruis Axel Dignass Elisabeth Steinhagen-Thiessen Julia Morgenstern Joachim M(o|¨)ssner Stephan Schreiber Maurizio Vecchi Alberto Malesci Max Reinshagen Robert L(o|¨)fberg | 2005 | World Journal of Gastroenterology2005，11，44： | 4 |
| 2 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 3 | Chemokine receptors intracellular traf? cking 显示文摘 | Elena M B Alberto M Massimo L | 2010 | Pharmacol Therap2010，127，： | 1 |
| 4 | Valsartan benefits left ventricular structure and function in heart failure: Val-HeFT echocardiographic study显示文摘 | Maylene Wong Lidia Staszewsky Roberto Latini Simona Barlera Alberto Volpi Yann-Tong Chiang Raymond L Benza Sidney O Gottlieb Thomas D Kleemann Franco Rosconi Pieter M Vandervoort Jay N Cohn | 2002 | Journal of the American College of Cardiology2002，，： | 1 |
| 5 | Database techniques for the World Wide Web显示文摘 | DANIELA F ALON L ALBERTO M | 2005 | Sigmod Record2005，32，3： | 1 |
| 6 | Risk of Liver Decompensation Among HIV/Hepatitis C Virus–Coinfected Individuals With Advanced Fibrosis: Implications for the Timing of Therapy显示文摘 | Juan Macías Manuel Márquez Francisco Téllez Dolores Merino Patricia Jiménez-Aguilar Luis F. López-Cortés Enrique Ortega Miguel A. von Wichmann Antonio Rivero María Mancebo Jesús Santos Montserrat Pérez-Pérez Ignacio Suárez-Lozano Alberto Romero-Palacios A | 2013 | Clinical Infectious Diseases2013，，10： | 1 |
| 7 | Light, temperature, and anthocyanin production 显示文摘 | ISAAC R ALBERTO L M | 1986 | Plant Physiology1986，81，： | 1 |
| 8 | Perceived Performance Effects of ICT in Manufacturing SMEs显示文摘 | Alberto B M Margarita B Fernando L L | 2013 | Industrial Management&Data Systems2013，113，1： | 1 |
| 9 | Uniform invariance principle:robustness with respect to parameter variation显示文摘 | Rodrigues H M Alberto L F C Bretas N G | 2001 | Journal of Differential Equations2001，169，1： | 1 |
| 10 | Keratins 8, 10, 13, and 17 are useful markers in the diagnosis of human cervix carcino- mas显示文摘 | Carrilho C Alberto M Buane L | 2004 | Hum Pathol2004，35，5： | 1 |
| 11 | Studies on the mode of action of the antifungal hexapeptide PAF26 显示文摘 | ALBERTO M BELEN L G JOSE F M | 2006 | Antimicrob Agents Chemother2006，50，9： | 1 |
| 12 | Erythropoietin in heart and vessels:focus on transcription and signalling pathways显示文摘 | Francesca M Alberto L Giulio C | 2008 | J Thromb Thrombolysis2008，，3： | 1 |
| 13 | Robust Stability Analysis for Current-Programmed Regulators显示文摘 | JORGE Alberto M MARGARITO M | 2002 | IEEE Trans on Industrial Electronics2002，49，5： | 1 |
| 14 | Keratins 8, 10, 13, and 17 are useful markers in the diagnosis of human cervix carcinomas 显示文摘 | Carrilho C Alberto M Buane L | 2004 | Hum Pathol2004，35，5： | 1 |
| 15 | Determi-nation of SO2 in wines using a flow injection analysis system withpotentiometric detection显示文摘 | ALBERTO N A CRISTINA M C M C JOSEL F C L | 1998 | J Agric Food Chem1998，46，1： | 1 |
| 16 | Effect of glu- cose oxidase, transglutaminase, and pentosanase on wheat proteins: Relationship with dough properties and bread - making quality 显示文摘 | Steffolani M E Ribotta P D Alberto E L | 2010 | Journal of Cereal Science2010，51，： | 1 |
| 17 | Catapano pharmacology of competitive inhibitors of HMG-CoA beductase 显示文摘 | Alberto C Franco M M Alberico L | 1995 | Pharmacological Research1995，31，1： | 1 |
| 18 | Database Techniques for the World Wide Web: A Suwey显示文摘 | Daniela F Alon L Alberto M | 1998 | SIGMOD Record1998，27，3： | 1 |
| 19 | Stem cell therapy for human neurodegenerative disorders-how tomake it work显示文摘 | OLLE L ZAAL K ALBERTO M S | 2004 | Neurodegeneration2004，7，9： | 1 |
| 20 | Keratins 81013 and 17 are useful markers in the diagnosis of human cervix carcinomas显示文摘 | Carrilho C Alberto M Buane L | 2004 | Human Pathology2004，35，5： | 1 |
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