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| 1 | Management of pancreaticobiliary disease using a new intra-ductal endoscope:The Texas experience显示文摘AIM:To evaluate a new single-operator mini-endoscope, Spyglass,for its performance,feasibility and safety in the management of pancreaticobiliary disease. METHODS:In a multicenter retrospective analysis of patients undergoing intraductal endoscopy,we evaluated 128 patients(71 men,mean age 57.6 years).Indications were therapeutic(TX)in 72(56%) and diagnostic(DX)in 56(44%). RESULTS:Peroral endoscopy was performed in 121 and percutaneous in seven.TX indications included CBD stones in 41,PD stones in six,and biliary strictures in 25.DX indications included abnormal LFT’s in 15, abnormal imaging in 38 and cholangiocarcinoma staging in three.Visualization of the stone(s)was considered good in 31,fair in six,and poor in four. Advancement of the electrohydraulic lithotripsy probe was not possible in three patients and proper targeting of the lesion was partial in four patients.A holmium laser was used successfully in three patients.Ductal clearance was achieved in 37 patients after one procedure and in four patients after two procedures.Diagnosis of biliary strictures was modified in 20/29 and confirmed to be malignant in 10/23.Of the modified patients,no diagnosis was available in 17.Spyglass demonstrated malignancy in 8/17 and non-malignancy in nine.Suspected pathology by imaging studies and abnormal LFT’s was modified in 43/63(66%).Staging of cholangiocarcinoma demonstrated multicentric cholangiocarcinoma in 2/3.There was no morbidity associated with the use of Spyglass. CONCLUSION:Spyglass Spyscopeis a first generation, single operator miniature endoscope that can evaluate and treat various biliary and pancreatic tract diseases. | Douglas S Fishman Paul R Tarnasky Sandeep N Patel Isaac Raijman | 2009 | World Journal of Gastroenterology2009，15，11： | 22 |
| 2 | Sessile serrated adenomas:Demographic,endoscopic and pathological characteristics显示文摘AIM:To study the demographic and endoscopic characteristics of patients with sessile serrated adenoma(SSA) in a single center.METHODS:Patients with SSA were identified by review of the pathology database of Mayo Clinic Arizona from 2005 to 2007.A retrospective chart review was performed to extract data on demographics,polyp characteristics,presence of synchronous adenomatous polyps or cancer,polypectomy methods,and related complications.RESULTS:One hundred and seventy-one(2.9%) of all patients undergoing colonoscopy had a total of 226 SSAs.The mean(SE) size of the SSAs was 8.1(0.4) mm;42% of SSAs were ≤ 5 mm,and 69% were ≤ 9 mm.Fifty-one per cent of SSAs were located in the cecum or ascending colon.Approximately half of the patients had synchronous polyps of other histological types,including hyperplastic and adenomatous polyps.Synchronous adenocarcinoma was present in seven(4%) cases.Ninety-seven percent of polyps were removed by colonoscopy.CONCLUSION:Among patients with colon polyps,2.9% were found to have SSAs.Most of the SSAs were located in the right side and were safely managed by colonoscopy. | Suryakanth R Gurudu Russell I Heigh Giovanni De Petris Evelyn G Heigh Jonathan A Leighton Shabana F Pasha Isaac B Malagon Ananya Das | 2010 | World Journal of Gastroenterology2010，16，27： | 7 |
| 3 | Mitochondrial reactive oxygen species generation triggers inflammatory response and tissue injury associated with hepatic ischemia–reperfusion: Therapeutic potential of mitochondrially targeted antioxidants显示文摘 | Partha Mukhopadhyay B?la Horváth Zsuzsanna Zsengell?r Sándor Bátkai Zongxian Cao Malek Kechrid Eileen Holovac Katalin Erd?lyi Galin Tanchian Lucas Liaudet Isaac E. Stillman Joy Joseph Balaraman Kalyanaraman Pál Pacher | 2012 | Free Radical Biology and Medicine2012，，5： | 2 |
| 4 | Sepsis, SIRS and CARS显示文摘 | Bone R C Sir Isaac Newton | 1996 | Crit Care Med1996，24，7： | 2 |
| 5 | Construction and analysis of a microsatellite-based database of European wheat varieties显示文摘 | M. R?der K. Wendehake V. Korzun G. Bredemeijer D. Laborie L. Bertrand P. Isaac S. Rendell J. Jackson R. Cooke B. Vosman M. Ganal | 2002 | Theoretical and Applied Genetics2002，，1： | 2 |
| 6 | Prediction and measurement of an autoregulatory genetic modle 显示文摘 | Isaacs F J Hasty J Cantor C R | 2003 | PNAS2003，100，： | 1 |
| 7 | An Experi-mental Investigation of the Hahn - Noll Revenue NeutralAuction for Emissions Licenses 显示文摘 | FRANCIOSI R ISAAC R PINGRY D | 1993 | Journal of Environmen-tal Economics and Management1993，24，： | 1 |
| 8 | Development of prostate cancer treatment : the good news显示文摘 | Denmeade S R Isaacs J T | 2004 | Prostate2004，58，： | 1 |
| 9 | Silent synapses during development of thalamocortical input 显示文摘 | CRAIR M C NICOLL R A | 1997 | Neuron1997，18，： | 1 |
| 10 | Improving purchasing productivity at IBM with a normative decision support system显示文摘 | Bender P S Brown R W Isaac H | 1985 | Interfaces1985，15，： | 1 |
| 11 | The urban picturesque: an aes- thetic experience of urban pedestrian places 显示文摘 | ISAACS R | 2000 | Journal of Urban Design2000，5，2： | 1 |
| 12 | Stimulation of protein kinase C activity in ceils expressing human parathyroid hormone receptors by C-and N-terminally truncated fragments of parathyroid hormone 1-34 显示文摘 | Whitfield JF Isaacs R J Chakravarthy B | 2001 | J Bone Miner Res2001，16，3： | 1 |
| 13 | Assessment and validation of a microinjection method for kinetic analysis of Ca2+i in individual cells undergoing apoptosis显示文摘 | TOMBAL B DENMEADE S R ISAACS J T | 1999 | Cell Calcium1999，25，： | 1 |
| 14 | The eggshell lech- nique for prevention of cement leakage during kyphoplasty 显示文摘 | Greene D L Isaac R Neuwirth M | 2007 | Spinal Disord Tech2007，20，3： | 1 |
| 15 | Absolute and Relative Rewards for Individuals in Team Production 显示文摘 | Dickinson David L Isaac Mark R | 1998 | Manageri- al and Decision Economics1998，19，45： | 1 |
| 16 | Temperature distribution in a demonstration-scale filter vessel with and without ash bridging显示文摘 | ALl R GOODARZ Ahmadi ISAAC K | 2008 | Advanced Powder Technology2008，19，2： | 1 |
| 17 | The neprilysin (NEP) family of zinc metallo endopeptidases: genomics and function显示文摘 | Turner A J Isaac R E Coates D | 2001 | Bioessays2001，23，6： | 1 |
| 18 | Microplate fluorescence assay for the quantification of double stranded DNA using SYBR Green I dye显示文摘 | Leggate J Allain R Isaac L | 2006 | Biotechnol Lett2006，28，： | 1 |
| 19 | Crystal structure of an integral membrane light-harvesting complex from photosynthtic bacteria显示文摘 | McDermott G Prince S M Freer A A Hawthorthwaite-Lawless A M Papiz M Z Cogdell R J Isaacs N W | 1995 | Nature1995，374，6： | 1 |
| 20 | In search of predatory pricing 显示文摘 | Isaac R Mark and Vernon L Smith | 1985 | Journal of Political Economy1985，93，： | 1 |
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