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| 1 | Coarctation of the aorta:Management from infancy to adulthood显示文摘Coarctation of the aorta is a relatively common form of congenital heart disease, with an estimated incidence of approximately 3 cases per 10000 births. Coarctation is a heterogeneous lesion which may present across all age ranges, with varying clinical symptoms, in isolation, or in association with other cardiac defects. The first surgical repair of aortic coarctation was described in 1944, and since that time, several other surgical techniques have been developed and modified. Additionally, transcatheter balloon angioplasty and endovascular stent placement offer less invasive approaches for the treatment of coarctation of the aorta for some patients. While overall morbidity and mortality rates are low for patients undergoing intervention for coarctation, both surgical and transcatheter interventions are not free from adverse outcomes. Therefore, patients must be followed closely over their lifetime for complications such as recoarctation, aortic aneurysm, persistent hypertension, and changes in any associated cardiac defects. Considerable effort has been expended investigating the utility and outcomes of various treatment approaches for aortic coarctation, which are heavily influenced by a patient's anatomy, size, age, and clinical course. Here we review indications for intervention, describe and compare surgical and transcatheter techniques for management of coarctation, and explore the associated outcomes in both children and adults. | Rachel D Torok Michael J Campbell Gregory A Fleming Kevin D Hill | 2015 | World Journal of Cardiology2015，7，11： | 27 |
| 2 | Sperm DNA fragmentation, recurrent implantation failure and recurrent miscarriage显示文摘证据正在增加精子 DNA 的正直可能也与培植失败和周期性的流产(RM ) 有关。调查这,在有在 vitro 授精,与 RM 诊断的 16 个女人和七位最近的父亲(控制) 列在后面的周期性的培植失败(RIF ) 的 35 个女人的搭挡的精子 DNA 破碎被检验。精子由测试和终端 deoxynucleotidyl transferase dUTP 刻痕结束标记的精子染色质分散(SCD )(TUNEL ) 是检验密度前和密度以后的 centrifugation 试金。在在三之间的搭挡或精子集中,活动性或形态学组织的任何一个的年龄没有重要差别。而且,在 DNA 破碎由也测量了的精子没有明显的差别测试。不管多么虽然平均在所有的精子 DNA 破碎组织当由 SCD 测试测量了时,在准备精子是统计上更低的,这没从 TUNEL 试金与结果被看见。这些结果不支持精子 DNA 破碎是 RIF 或 RM 的一个重要原因的假设,否则测试的那精子 DNA 正直在如此的病人有价值。它也在从精子 DNA 破碎测试解释数据加亮测试方法论和精子准备方法之间的重要差别。 | Carol Coughlan Helen Clarke Rachel Cutting Jane Saxton Sarah Waite William Ledger Tinchiu Li Allan A Pacey | 2015 | Asian Journal of Andrology2015，17，4： | 17 |
| 3 | 【特刊综述】利用雄激素受体敲除(ARKO)小鼠模型认识人类雄激素缺乏显示文摘雄激素的作用机理很复杂。最近,使用转基因修饰小鼠模型进行的雄激素受体研究使我们对雄激素作用机理有了更进一步的理解。Cre-loxP系统能够完成组织和/或细胞特异性的敲除。通过使用Cre—loxP系统已经获得了大量整体性或组织特异性雄激素受体(ARK0)敲除模型。这些ARKO模型的多个雄激素作用位点,包括心血管系统、免疫和造血系统、骨骼、肌肉、脂肪组织、前列腺和脑,均已被检测。本篇综述着重阐述了通过针对这些雄激素作用位点的ARKO小鼠模型而取得的人类雄激素缺乏的研究成果,并且指出充分理解Cre-loxPdx鼠模型的优缺点才能正确认识其表型。 | Kesha Rana Rachel A Davey Jeffrey D Zajac | 2014 | Asian Journal of Andrology2014，16，2： | 13 |
| 4 | China Patient-centered Evaluative Assessment of Cardiac Events Prospective Study of Acute Myocardial Infarction: Study Design显示文摘 | Rachel P Dreyer Xi Li Xue Du Nicholas S Downing Li Li Hai-Bo Zhang Fang Feng Wen-Chi Guan Xiao Xu Shu-Xia Li Zhen-Qiu Lin Frederick A Masoudi John A Spertus Harlan M Krumholz Li-Xin Jiang | 2016 | Chinese Medical Journal2016，，1： | 13 |
| 5 | 发达国家纵向整合临床实习模式的发展及其对我国医学教育的启示显示文摘临床实习是医学生将理论知识转化为临床能力和深入临床环境学习的重要途径。纵向整合临床实习模式目前是一种创新性的临床教学方法和理念,它将连续性作为教学原则,很好地解决了原有临床实习中缺乏医疗连续性、课程连续性和教学指导连续性的问题,越来越多的医学院应用此种模式进行临床教学改革。本文对该实习模式的核心内涵、意义和哈佛剑桥模式及其发展与衍变进行阐述,并结合中国医学教育的实际需求进行分析,认为纵向整合临床实习模式可以提高我国临床医生培养质量,促进基层医疗人才队伍建设,增强住院医师规范化培训效果,有助于我国医学教育改革发展。 | 李鸿鹤 David A Hirsh Tara A Singh Yamini Saravanan Rachel Hathaway Bianca Shagrin Elizabeth Gaufberg Arundhati Ghosh 刘君 李扬龄 闻德亮 | 2020 | 中华医学教育杂志2020，40，9： | 10 |
| 6 | Protective role of PI3-kinase/Akt/eNOS signaling in mechanical stress through inhibition of p38 mitogenactivated protein kinase in mouse lung显示文摘 | Xin-qi PENG Mahendra DAMARLA Jarrett SKIRBALL Stephanie NONAS Xiao-ying WANG Eugenia J HAN Emile J HASAN Xuan CAO Adel BOUEIZ Rachel DAMICO Rubin M TUDER Alfred M SClUTO Dana R ANDERSON Joe GNGARCIA David A KASS Paul M HASSOUN Jun-tian ZHANG | 2010 | Acta Pharmacologica Sinica2010，31，2： | 6 |
| 7 | 血管紧张素受体阻断剂预防男性人群痴呆发生风险研究:前瞻性队列分析(摘要)显示文摘目的探讨血管紧张素受体拮抗剂能否预防阿尔茨海默病和老年痴呆症,或同时减少两种疾病的进展。
设计前瞻性队列分析。
资料来源2002—2006年美国退伍军人数据库。 | Nien-Chen Li Austin Lee Rachel A Whitmer Miia Kivipelto Elizabeth Lawler Lewis E Kazis Benjamin Wolozin 夏曙(译) 于世英(校) | 2010 | 英国医学杂志中文版2010，13，2： | 5 |
| 8 | Liver disease in pregnancy显示文摘 | Deepak Joshi Andra James Alberto Quaglia Rachel H Westbrook Michael A Heneghan | 2010 | The Lancet2010，，9714： | 2 |
| 9 | Statin use and cognitive function in middle-aged adults with type 1 diabetes显示文摘AIM To test associations between statin use and cognitive impairment in adults with childhood-onset type 1 diabetes(T1D).METHODS In 2010-13, n = 108 middle-aged participants from ongoing observational Pittsburgh Epidemiology of Diabetes Complications Study underwent neurocognitive assessment(mean age and T1 D duration of 49 and 41 years, respectively). All were diagnosed with childhoodonset(i.e., prior to age 18) T1 D between 1950 and 1980 and were seen within one year of diagnosis at Children's Hospital of Pittsburgh. Self-reported statin use(yes/no and if yes, name of statin) was collected biennially from parent study baseline(1986-1988) to time of neurocognitive testing. Logistic regression models tested associations between statin use groups and cognitive impairment(defined as having two or more cognitive test scores 1.5SD or worse than published norms) while linear regression models tested associations between statin use groups and cognitive domain z-scores(domains: Verbal IQ, memory, executive function, psychomotor speed, and visuo-construction). All models controlled for education and age. To address confounding by indication, models were repeated using a propensity score for statin use.RESULTS Of the 108 participants, 51 reported never using statins. Median duration of statin use among the 57 ever users was 6 years. These 57 ever statin users were split to create two groups(≤ or > median years of statin use): 1-6 years(n = 25), and 7-12 years(n = 32). Compared with never users, using statins 1-6 years tripled the odds of cognitive impairment(OR = 3.16; 95%CI: 0.93-10.72; P = 0.06) and using statins 7-12 years almost quintupled the odds of cognitive impairment(OR = 4.84; 95%CI: 1.63-14.44; P = 0.005). Compared with never users, using statins 1-6 or 7-12 years was related to worse performance in the memory domain(β =-0.52; P = 0.003, and-0.39; P = 0.014, respectively). Adjusting for coronary artery disease, low density lipoprotein cholesterol, and Apo E4 status did not substantially alter results, and none of these covariates were significantly related to cognitive outcomes(all P > 0.05). Propensity score analyses support that associations between poor cognitive outcomes and statin use were not due merely to confounding by indication. CONCLUSION Statin use was associated with cognitive impairment, particularly affecting memory, in these middle-aged adults with childhood-onset T1 D, whom at this age, should not yet manifest age-related memory deficits. | Karen A Nunley Trevor J Orchard Christopher M Ryan Rachel Miller Tina Costacou Caterina Rosano | 2017 | World Journal of Diabetes2017，8，6： | 2 |
| 10 | The CELLULOSE-SYNTHASE LIKE C (CSLC) Family of Barley Includes Members that Are Integral Membrane Proteins Targeted to the Plasma Membrane显示文摘纤维素象 SYNTHASE 一样 C (CSLC ) 家庭是在被认为在苔藓和脉管的植物的分叉前产生了的 CELLULOSE SYNTHASE/CELLULOSE 象 SYNTHASE 一样(CESA/CSL ) 多糖 synthase 总科以内的一个古老的系。作为在 flowering 植物的研究, Arabidopsis 建议了合成( 1,4 )-- xyloglucan ( XyG )的 glucan 脊梁,,拴住邻近的纤维素 microfibrils 到对方的墙多糖为 CSLC 的可能的功能, CSLC 功能在大麦( Hordeum vulgare L.)被调查,有在它的墙中的 XyG 的低数量的种。四大麦 CSLC 基因被识别(指明的 HvCSLC14 ) 。种系发生的分析在 flowering 植物揭示 CSLC 的三很好支持的 clades,与有在二这些 clades 的代表的大麦。四大麦 CSLC 在各种各样的纸巾被表示,与,包括有主要、第二等的房间墙的房间在在所有房间检测抄本的 situ PCR coleoptile 和根打字。合作表示分析证明 HvCSLC3 并列地与通常认为的 XyG xylosyltransferase 基因被表示。两免疫 -- 他们和膜分别证明 HvCSLC2 位于大麦的血浆膜暂停有教养的房间并且不在象 endoplasmic 那样的内部膜蜂窝胃或 Golgi 仪器。基于我们多糖合成的亚 cellular 地点的当前的知识,我们断定 CSLC 家庭可能包含多糖 synthase 的超过一种类型。 | Fenny M. Dwivany Dina Yulia Rachel A, Burton Neil J. Shirley Sarah M. Wilson Geoffrey B, Fincher Antony Bacic Ed Newbigin Monika S. Doblin | 2009 | Molecular Plant2009，2，5： | 2 |
| 11 | Para-aortic lymph node involvement should not be a contraindication to resection of pancreatic ductal adenocarcinoma显示文摘BACKGROUND Para-aortic lymph nodes(PALN)are found in the aortocaval groove and they are staged as metastatic disease if involved by pancreatic ductal adenocarcinoma(PDAC).The data in the literature is conflicting with some studies having associated PALN involvement with poor prognosis,while others not sharing the same results.PALN resection is not included in the standard lymphadenectomy during pancreatic resections as per the International Study Group for Pancreatic Surgery and there is no consensus on the management of these cases.AIM To investigate the prognostic significance of PALN metastases on the oncological outcomes after resection for PDAC.METHODS This is a retrospective cohort study of data retrieved from a prospectively maintained database on consecutive patients undergoing pancreatectomies for PDAC where PALN was sampled between 2011 and 2020.Statistical comparison of the data between PALN+and PALN-subgroups,survival analysis with the Kaplan-Meier method and risk analysis with univariable and multivariable time to event Cox regression analysis were performed,specifically assessing oncological outcomes such as median overall survival(OS)and disease-free survival(DFS).RESULTS 81 cases had PALN sampling and 17(21%)were positive.Pathological N stage was significantly different between PALN+and PALN-patients(P=0.005),while no difference was observed in any of the other characteristics.Preoperative imaging diagnosed PALN positivity in one case.OS and DFS were comparable between PALN+and PALN-patients with lymph node positive disease(OS:13.2 mo vs 18.8 mo,P=0.161;DFS:13 mo vs 16.4 mo,P=0.179).No difference in OS or DFS was identified between PALN positive and negative patients when they received chemotherapy either in the neoadjuvant or in the adjuvant setting(OS:23.4 mo vs 20.6 mo,P=0.192;DFS:23.9 mo vs 20.5 mo,P=0.718).On the contrary,when patients did not receive chemotherapy,PALN disease had substantially shorter OS(5.5 mo vs 14.2 mo;P=0.015)and DFS(4.4 mo vs 9.8 mo;P<0.001).PALN involvement was not identified as an independent predictor for OS after multivariable analysis,while it was for DFS doubling the risk of recurrence.CONCLUSION PALN involvement does not affect OS when patients complete the indicated treatment pathway for PDAC,surgery and chemotherapy,and should not be considered as a contraindication to resection. | Rupaly Pande Shafiq Chughtai Manish Ahuja Rachel Brown David C Bartlett Bobby V Dasari Ravi Marudanayagam Darius Mirza Keith Roberts John Isaac Robert P Sutcliffe Nikolaos A Chatzizacharias | 2022 | World Journal of Gastrointestinal Surgery2022，14，5： | 2 |
| 12 | IL 28 B genotype is not useful for predicting treatment outcome in A sian chronic hepatitis B patients treated with pegylated interferon‐α显示文摘 | Jacinta A Holmes Tin Nguyen Dilip Ratnam Neel M Heerasing Jane V Tehan Sara Bonanzinga Anouk Dev Sally Bell Stephen Pianko Robert Chen Kumar Visvanathan Rachel Hammond David Iser Ferry Rusli William Sievert Paul V Desmond D Scott Bowden Alexander J Thomps | 2013 | J Gastroenterol Hepatol2013，，5： | 2 |
| 13 | HDAC inhibitors overcome immunotherapy resistance in B-cell lymphoma显示文摘Immunotherapy has been applied successully to treat B-cell lymphomas in preclinical models or clinical settings.However,immunotherapy resistance is a major challenge for B-cell lymphoma treatment.To overcome this issue,combinatorlal therapeutic strategies have been pursued to achieve a better efficacy for treating B-cell lymphomas.One of such strategies is to combine immunotherapy with histone deacetylase(HDAC)inhi-bitors.HDAC inhibitors can potentially increase tumor immunogenicity,promote antitumor immune respon-ses,or reverse immunosuppressive tumor environments.Thus,the combination of HDAC inhibitors and immunotherapy has drawn much attention in current cancer treatment.However,not all HDAC inhibitors are created equal and their net effects are highly dependent on the specific inhibitors used and the HDACs they target.Hence,we suggest that optimal treatment effh-cacy requires personalized design and rational combination based on prognostic biomarkers and unique profiles of HDAC inhibitors.Here,we discuss the possible mechanisms by which B-cell lymphomas acquire immunotherapy resistance and the effects of HDAC inhibitors on tumor cells and immune cells that could help overcome immunotherapy resistance. | Xiaoguang Wang Brittany C.Waschke Rachel A Woolaver Samantha M.Y.Chen Zhangguo Chen Jing H.Wang | 2020 | Protein & Cell2020，11，7： | 2 |
| 14 | 急性附睾睾丸炎显示文摘急性附睾睾丸炎是原发于附睾的感染,有时继发累及睾丸。在35岁以下的病人中,通常由性传播的细菌引起,如沙眼衣原体或淋病奈瑟菌。尽管不是常见病原菌,生殖器支原体和解脲脲原体也曾被提及。 | Rachel A Lee Janet D Wilson 许可见(译) 刘跃华(校) | 2006 | 国际内科双语杂志(中英文)2006，6，4： | 2 |
| 15 | BRCA mutated pancreatic cancer:A change is coming显示文摘Pancreatic cancer remains a leading cause of cancer-related death with few available therapies for advanced disease.Recently,patients with germline BRCA mutations have received increased attention due to advances in the management of BRCA mutated ovarian and breast tumors.Germline BRCA mutations significantly increase risk of developing pancreatic cancer and can be found in up to 8%of patients with sporadic pancreatic cancer.In patients with germline BRCA mutations,platinum-based chemotherapies and poly(ADP-ribose)polymerase inhibitors are effective treatment options which may offer survival benefits.This review will focus on the molecular biology,epidemiology,and management of BRCA-mutated pancreatic cancer.Further-more,we will discuss future directions for this area of research and promising active areas of research. | Michael N Rosen Rachel A Goodwin Michael M Vickers | 2021 | World Journal of Gastroenterology2021，27，17： | 2 |
| 16 | Bidding llavior and Experience in Intemet Auctions 显示文摘 | Rachel A J Pownalh Leonard Wolk | 2013 | European Economic Review2013，，6： | 1 |
| 17 | Repression of Runx2 function by TGF-13 through recruitment of class Ⅱ histone deacetylases by Smad3 显示文摘 | Jong SK Tamara A Rachel D | 2005 | EMBO J2005，14，： | 1 |
| 18 | Enzyme production by obligate intestinal anaerobic bacteria isolated from oscars (Astronotus ocellatus),angelfish (Pterophyllum scalare) and southern flounder (Paralichthys lethostigma)显示文摘 | RACHEL F R BEVERLY A D | 2003 | Aquaculture2003，227，： | 1 |
| 19 | Blood lead levels and risk factors for lead poisoning among children in Jakarta显示文摘 | Rachel A Gary N Sharunda B | 2003 | Environmental Reseanch2003，，301： | 1 |
| 20 | Breast cancer incidence before and after diagnosis of type 2 diabetes naellitus in women: increased risk in the prediabetes phase显示文摘 | Adedayo A Onitilo Rachel V Stankowski Richard L Berg | 2014 | European journal of cancer prevention : the official journal of the European Cancer Prevention Or- ganisation (ECP)2014，23，2： | 1 |
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