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| 1 | FAIR Principles:Interpretations and Implementation Considerations显示文摘The FAIR principles have been widely cited,endorsed and adopted by a broad range of stakeholders since their publication in 2016.By intention,the 15 FAIR guiding principles do not dictate specific technological implementations,but provide guidance for improving Findability,Accessibility,Interoperability and Reusability of digital resources.This has likely contributed to the broad adoption of the FAIR principles,because individual stakeholder communities can implement their own FAIR solutions.However,it has also resulted in inconsistent interpretations that carry the risk of leading to incompatible implementations.Thus,while the FAIR principles are formulated on a high level and may be interpreted and implemented in different ways,for true interoperability we need to support convergence in implementation choices that are widely accessible and(re)-usable.We introduce the concept of FAIR implementation considerations to assist accelerated global participation and convergence towards accessible,robust,widespread and consistent FAIR implementations.Any self-identified stakeholder community may either choose to reuse solutions from existing implementations,or when they spot a gap,accept the challenge to create the needed solution,which,ideally,can be used again by other communities in the future.Here,we provide interpretations and implementation considerations(choices and challenges)for each FAIR principle. | Annika Jacobsen Ricardo de Miranda Azevedo Nick Juty Dominique Batista Simon Coles Ronald Cornet Melanie Courtot Merce Crosas Michel Dumontier Chris T.Evelo Carole Goble Giancarlo Guizzardi Karsten Kryger Hansen Ali Hasnain Kristina Hettne Jaap Heringa Rob W.W.Hooft Melanie Imming Keith G.Jeffery Rajaram Kaliyaperumal Martijn GKersloot Christine R.Kirkpatrick Tobias Kuhn Ignasi Labastida Barbara Magagna PeterMcQuilton Natalie Meyers Annalisa Montesanti Mirjam van Reisen Philippe Rocca-Serra Robert Pergl Susanna-Assunta Sansone Luiz Olavo Bonino da Silva Santos Juliane Schneider George Strawn Mark Thompson Andra Waagmeester Tobias Weigel Mark D.Wilkinson Egon L.Willighagen Peter Wittenburg Marco Roos Barend Mons Erik Schultes | 2020 | Data Intelligence2020，2，1： | 26 |
| 2 | Interleukins and interleukin receptors in rheumatoid arthritis: Research, diagnostics and clinical implications显示文摘Rheumatoid arthritis(RA) is an autoimmune disease, resulting in a chronic, systemic inflammatory disorder. It may affect many tissues and organs, but it primarily affects the flexible joints. In clinical practice patient care generates many questions about diagnosis, prognosis, and treatment. It is challenging for health care specialists to keep up to date with the medical literature. This review summarizes the pathogenesis, the polymorphisms of interleukin and interleukin genes and the standard available and possible future immunologictargets for RA treatment. The identification of diseaseassociated interleukin and interleukin receptor genes can provide precious insight into the genetic variations prior to disease onset in order to identify the pathways important for RA pathogenesis. The knowledge of the complex genetic background may prove useful for developing novel therapies and making personalized medicine based on the individual's genetics. | Lili Magyari Dalma Varszegi Erzsebet Kovesdi Patricia Sarlos Bernadett Farago Andras Javorhazy Katalin Sumegi Zsolt Banfai Bela Melegh | 2014 | World Journal of Orthopedics2014，5，4： | 17 |
| 3 | Genetic update on inflammatory factors in ulcerative colitis: Review of the current literature显示文摘Ulcerative colitis(UC) is one of the main types of inflammatory bowel disease, which is caused by dysregulated immune responses in genetically predisposed individuals. Several genetic factors, including interleukin and interleukin receptor gene polymorphisms and other inflammation-related genes play central role in mediating and modulating the inflammation in the human body, thereby these can be the main cause of development of the disease. It is clear these data are very important for understanding the base of the disease, especially in terms of clinical utility and validity, but summarized literature is exiguous for challenge health specialist that can used in the clinical practice nowadays. This review summarizes the current literature on inflammationrelated genetic polymorphisms which are associated with UC. We performed an electronic search of Pubmed Database among publications of the last 10 years, using the following medical subject heading terms: UC, ulcerative colitis, inflammation, genes, polymorphisms, and susceptibility. | Patricia Sarlos Erzsebet Kovesdi Lili Magyari Zsolt Banfai Andras Szabo Andras Javorhazy Bela Melegh | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，3： | 15 |
| 4 | Intermittent fasting promotes adipose thermogenesis and metabolic homeostasis via VEGF-mediated alternative activation of macrophage显示文摘 | Kyoung-Han Kim Yun Hye Kim Joe Eun Son Ju Hee Lee Sarah Kim Min Seon Choe Joon Ho Moon Jian Zhong Kiya Fu Florine Lenglin Jeong-Ah Yoo Philip J Bilan Amira Klip Andras Nagy Jae-Ryong Kim Jin Gyoon Park Samer MI Hussein Kyung-Oh Doh Chi-chung Hui Hoon-Ki Sung | 2017 | Cell Research2017，27，11： | 9 |
| 5 | Interleukin and interleukin receptor gene polymorphisms in inflammatory bowel diseases susceptibility显示文摘Inflammatory bowel disease(IBD),which includes Crohn’s disease(CD)and ulcerative colitis(UC),represents a group of chronic inflammatory disorders caused by dysregulated immune responses in genetically predisposed individuals.Genetic markers are associated with disease phenotype and long-term evolution,but their value in everyday clinical practice is limited at the moment.IBD has a clear immunological background and interleukins play key role in the process.Almost130 original papers were revised including meta-analysis.It is clear these data are very important for understanding the base of the disease,especially in terms of clinical utility and validity,but text often do not available for the doctors use these in the clinical practice nowadays.We conducted a systematic review of the current literature on interleukin and interleukin receptor gene polymorphisms associated with IBD,performing an electronic search of PubMed Database from publications of the last 10 years,and used the following medical subject heading terms and/or text words:IBD,CD,UC,interleukins and polymorphisms. | Lili Magyari Erzsebet Kovesdi Patricia Sarlos Andras Javorhazy Katalin Sumegi Bela Melegh | 2014 | World Journal of Gastroenterology2014，20，12： | 8 |
| 6 | Enhanced Photocatalytic Activity of TiO2 Nanofibers and Their Flexible Composite Films: Decomposition of Organic Dyes and Efficient H2 Generation from Ethanol-Water Mixtures显示文摘与磅和 Pd nanoparticles 装饰的 TiO2 nanofibers 在各种各样的 photocatalytic 过程被综合了并且学习。在水里的器官的染料的分解的优秀 photocatalytic 行为,灵活独立纤维素 / 催化剂的表面上的器官的污点的降级合成电影并且在从乙醇用的氢的产生推迟了并且使不能调动催化剂被表明。基于 nanofiber 的 TiO2 材料的表演是在某情况 outperformstheir 的竞争 withand 常规基于 nanoparticle 的对应物。在所有情况中,装饰 Pd 的 TiO2 nanoparticles 和 nanofibers 证明了比他们的基于磅的对应物更有效,它能在在 TiO2 和金属 nanoparticles 之间的接触根据缩放 nano 的 Schottky 接口的形成被解释。形成纤维素 / 催化剂 composites 的可行性提供在大区域的涂层和独立电影利用光催化剂材料的一个新奇方法。 | Ming-Chung Wu Andras Sapi Anna Avila Maria Szabo Jussi Hiltunen Mika Huuhtanen Geza Toth Akos Kukovecz Zoltan Konya Riitta Keiski Wei-Fang Su Heli Jantunen Krisztian Kordas | 2011 | Nano Research2011，4，4： | 7 |
| 7 | Five-year mortality and coronary heart disease development after normal coronary angiogram显示文摘 | Jason T McMullan Christopher J Lindsell Andra L Blomkalns | 2011 | World Journal of Emergency Medicine2011，2，1： | 6 |
| 8 | The diagnosis and management of adult intussusception显示文摘 | Dennis G. Begos Andras Sandor Irvin M. Modlin | 1997 | The American Journal of Surgery1997，，2： | 4 |
| 9 | Tonglian Decoction(通莲汤)Arrests the Cell Cycle in S-phase by Targeting the Nuclear Factor-Kappa B Signal Pathway in Esophageal Carcinoma Eca109 Cells显示文摘Objective:To investigate the anti-tumor activity and molecular mechanism of Tonglian Decoction(通莲汤,TLD) on esophageal carcinoma Eca109 cells.Methods:Eca109 cells were treated with TLD and its separated formulae,including the clearing-heat and detoxification formula(Q),activating-blood and promoting-qi formula(H) and nourishing-yin and blood formula(Z).Cell proliferation was measured using the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide assay,cell morphology was observed using a microscope,the cell cycle was measured using flow cytometry and the activity of the nuclear factor-kappa B(NF-κB) signal pathway was detected by Western blot.Results:The half maximal inhibitory concentrations of TLD,Q and H were 386,771 and 729 mg/L,respectively.TLD,Q and H significantly inhibited cell proliferation,with 69.43%,60.84%and 61.90%of treated cells in the G1 phase of the cell cycle.The percentage of cells in S phase increased significantly after treatment with TLD,Q,and H compared with the control group(P<0.05),and TLD showed the strongest effect.Z had no influence on the cell cycle compared with the control group(P>0.05).Western blot detection indicated slight differences in the inhibition of the NF- k B pathway by the different formulae.TLD formula strongly inhibited IKKβ,NF-κB,interleukin-6 and tumor necrosis factor-α expression compared with the control group.Conclusions:TLD inhibited Eca109 cell proliferation by arresting cells in S phase.The possible mechanism might be related to inhibiting the NF- κB transduction cascade.The combination of the herbs found in the three separate formulae,H,Q and Z,work synergistically in TLD to produce the inhibitory effects of TLD treatment on Eca109 proliferation. | 贾永森 胡雪琴 李继安 Andras Szasz Gabriella Hegyi 韩炳生 | 2016 | Chinese Journal of Integrative Medicine2016，22，5： | 3 |
| 10 | ECG stress test induced atrial ischemia in a patient with old inferior myocardial infarction due to a distal coronary artery lesion显示文摘 | Andras Vereckei Gabor Katona Zsuzsanna Szelenyi Edit Takacs Pal Maurovich-Horvat David Becker | 2017 | Journal of Geriatric Cardiology2017，14，1： | 3 |
| 11 | Using the BirdTree.org website to obtain robust phylogenies for avian comparative studies: A primer显示文摘 | Diego RUBOLINI Andras LIKER Laszlo Z. GARAMSZEGI Anders P. MOLLEIR Nicola SAINO | 2015 | Current Zoology2015，61，6： | 3 |
| 12 | Light Triggers the miRNA-Biogenetic Inconsistency for De-etiolated Seedling Survivability in Arabidopsis thaliana显示文摘The shift of dark-grown seedlings into light causes enormous transcriptome changes followed by a dramatic developmental transition.Here,we show that microRNA(miRNA)biogenesis also undergoes regulatory changes during de-etiolation.Etiolated seedlings maintain low levels of primary miRNAs(pri-miRNAs)and miRNA processing core proteins,such as Dicer-like 1,SERRATE,and HYPONASTIC LEAVES 1,whereas during de-etiolation both pri-miRNAs and the processing components accumulate to high levels.However,the levels of most miRNAs do not notably increase in response to light.To reconcile this inconsistency,we demonstrated that an unknown suppressor decreases miRNA-processing activity and light-induced SMALL RNA DEGRADING NUCLEASE 1 shortens the half-life of several miRNAs in de-etiolated seedlings.Taken together,these data suggest a novel mechanism,miRNA-biogenetic inconsistency,which accounts for the intricacy of miRNA biogenesis during de-etiolation.This mechanism is essential for the survival of de-etiolated seedlings after long-term skotomorphogenesis and their optimal adaptation to ever-changing light conditions. | Suk Won Choi Moon Young Ryu Andras Viczian Hyun Ju Jung Gu Min Kim Agustin LArce Natalia PAchkar Pablo Manavella Ulla Dolde Stephan Wenke Attila Molnar Ferenc Nagy Seok Keun Cho Seong Wook Yang | 2020 | Molecular Plant2020，13，3： | 3 |
| 13 | Functional Genomics Reveals a BMP-Driven Mesenchymal-to-Epithelial Transition in the Initiation of Somatic Cell Reprogramming显示文摘 | Payman Samavarchi-Tehrani Azadeh Golipour Laurent David Hoon-ki Sung Tobias A. Beyer Alessandro Datti Knut Woltjen Andras Nagy Jeffrey L. Wrana | 2010 | Cell Stem Cell2010，，1： | 3 |
| 14 | Acetytation of ACAP4 regutates CCL18-elicited breast cancer cell migration and invasion显示文摘Tumor metastasis represents the main causes of cancer-related death.Our recent study showed that chemokine CCL18 secreted from tumor-associated macrophages regulates breast tumor metastasis,but the underlying mechanisms remain less clear.Here, we show that ARF6 GTPase-activating protein ACAP4 regulates CCL18-elicited breast cancer cell migration via the acetyltransferase PCAF-mediated acetylation.CCL18 stimulation elicited breast cancer cell migration and invasion via PCAF-dependent acetylation.ACAP4 physically interacts with PCAF and is a cognate substrate of PCAF during CCL18 stimulation.The acetylation site of ACAP4 by PCAF was mapped to Lys311 by mass spectrometric analyses.Importantly,dynamic acetylation of ACAP4 is essential for CCL18-induced breast cancer cell migration and invasion,as overexpression of the persistent acetylation-mimicking or nonacetylatable ACAP4 mutant blocked CCL18-elicited cell migration and invasion.Mechanistically,the acetylation of ACAP4 at Lys311 reduced the lipid-binding activity of ACAP4 to ensure a robust and dynamic cycling of ARF6-ACAP4 complex with plasma membrane in response to CCL18 stimulation.Thus,these results present a previously undefined mechanism by which CCL18-elicited acetylation of the PH domain controls dynamic interaction between ACAP4 and plasma membrane during breast cancer cell migration and invasion. | Xiaoyu Song Wei Liu Xiao Yuan Jiying Jiang Wanjuan Wang McKay Mullen Xuannv Zhao Yin Zhang Fusheng Liu Shihao Du Adeel Rehman Ruijun Tian Jian Li Andra Frost Zhenwei Song Hadiyah-Nicole Green Calmour Henry Xing Liu Xia Ding Dongmei Wang Xuebiao Yao | 2018 | Journal of Molecular Cell Biology2018，10，6： | 3 |
| 15 | Minimally invasive image-guided therapy of primary and metastatic pancreatic cancer显示文摘Pancreatic cancer is a challenging malignancy with limited treatment options and poor life expectancy.The only curative option is surgical resection,but only 15%-20%of patients are resectable at presentation because more than 50%of patients has distant metastasis at diagnosis and the rest of them has locally advanced pancreatic cancer(LAPC).The standard of care first line treatment for LAPC patients is chemotherapy with or without radiation therapy.Recent developments in minimally invasive ablative techniques may add to the treatment armamentarium of LAPC.There are increasing number of studies evaluating these novel ablative techniques,including radiofrequency ablation,microwave ablation,cryoablation and irreversible electroporation.Most studies which included pancreatic tumor ablation,demonstrated improved overall survival in LAPC patients.However,the exact protocols are yet to set up to which stage of the treatment algorithm ablative techniques can be added and in what kind of treatment combinations.Patients with metastatic pancreatic cancer has dismal prognosis with 5-year survival is only 3%.The most common metastatic site is the liver as 90%of pancreatic cancer patients develop liver metastasis.Chemotherapy is the primary treatment option for patients with metastatic pancreatic cancer.However,when the tumor is not responding to chemotherapy or severe drug toxicity develops,locoregional liver-directed therapies can provide an opportunity to control intrahepatic disease progression and improve survival in selected patients.During the last decade new therapeutic options arose with the advancement of minimally invasive technologies to treat pancreatic cancer patients.These new therapies have been a topic of increasing interest due to the severe prognostic implications of locally advanced and metastatic pancreatic cancer and the low comorbid risk of these procedures.This review summarizes new ablative options for patients with LAPC and percutaneous liver-directed therapies for patients with liver-dominant metastatic disease. | Andras Bibok Dae Won Kim Mokenge Malafa Bela Kis | 2021 | World Journal of Gastroenterology2021，27，27： | 3 |
| 16 | Wafer-scale MOCVD growth of monolayer M0S2 on sapphire and SiO2显示文摘High-quality and large-scale growth of monolayer molybdenum disulfide(MoS2)has caught intensive attention because of its potential in many applications due to unique electronic properties.Here,we report the wafer-scale growth of high-quality mono layer MoS2 on singlecrystalline sapphire and also on SiO2 substrates by a facile metal-organic chemical vapor deposit!on(MOCVD)method.Prior to growth,an aqueous solution of sodium molybdate(Na2MoO4)is spun onto the substrates as the molybdenum precursor and diethyl sulfide((C2H5)2S)is used as the sulfur precursor duri ng the growth.The grown MoS2 films exhibit crystal I i nity,good electrical performa nee(electro n mobility of 22 cm2·V^-1·s^-1)and structural continuity maintained over the entire wafer.The sapphire substrates are reusable for subsequent growth.The same method is applied for the synthesis of tungsten disulfide(WS2).Our work provides a facile,reproducible and cost-efficient method for the scalable fabricati on of high-quality mono layer MoS2 for versatile applicati ons,such as electro nic and optoelectr onic devices as well as the membranes for desalination and power generation. | Huanyao Cun Michal Macha HoKwon Kim Ke Liu Yanfei Zhao Thomas LaGrange Andras Kis Aleksa ndra Radeno vic | 2019 | Nano Research2019，12，10： | 3 |
| 17 | Liver disease in pregnancy显示文摘 | Deepak Joshi Andra James Alberto Quaglia Rachel H Westbrook Michael A Heneghan | 2010 | The Lancet2010，，9714： | 2 |
| 18 | 开辟银行业务新格局:如何利用生态圈赢得小微企业市场显示文摘对银行而言,小微企业将是其重要的利润来源。但是,小微企业'经营难、融资难'仍是亟待解决的关键问题。生态圈的经营模式,不是科技公司的专利,它也为银行提供了独特且可规模化的解决方案。银行在生态圈战略上拥有海量数据和客户信任等独特优势,未来银行可以利用生态圈,赢得小微业务市场,突破传统业务,以实现收益最大化。能够针对所在市场找到正确方法的银行,将拥有巨大竞争优势,在金融服务和非金融服务方面进一步巩固其在小微企业客户中的地位。先人一步采取行动的银行能够获得先发优势,解锁生态圈的巨大潜力。 | 无 曲向军 周宁人 郭明杰 Chira Barua Balazs Gati Tara Lajumoke Zubin Taraporevala Andras Havas Miklos Radnai | 2019 | 新金融2019，0，11： | 2 |
| 19 | Combining extractive heterogeneous-azeotropic distillation and hydrophilic pervaporation for enhanced separation of non-ideal ternary mixtures显示文摘The separation of non-ideal mixtures using distillation can be an extremely complex process and there continues to be a need to further improve these techniques.A new method which combines extractive heterogeneous-azeotropic distillation(EHAD)and hydrophilic pervapora-tion(HPV)for the separation of non-ideal termary mixtures is demonstrated.This improved distillation method combines the benefits of heterogeneous-azeotropic and extractive distillations in one column but no added materials are needed as is usually the case with pervaporation.The separation of water-methanol-ethyl acetate and water-methanol-isopropyl acetate mixtures were investigated to demonstrate the accuracy of the combined EHAD/HPV technique.There is not currently an established treatment strategy for the separation of the second mixtures in the literature.These separation processes were rigorously modelled and optimized using a professional flowsheet.The objective functions were total cost and energy consumption and heat integration was also investigated.The verification of the process modelling was carried out using laboratory-scale measurements.Extractive heterogeneous-distillation combined with methanol dehydration was found to be more efficient than conventional distillation for the separation of these highly non-ideal mixtures. | Eniko Haaz Botond Szilagyi Daniel Fozer Andras Jozsef Toth | 2020 | Frontiers of Chemical Science and Engineering2020，14，5： | 2 |
| 20 | Remote Ischemic Preconditioning by Hindlimb Occlusion Prevents Liver Ischemic/Reperfusion Injury: The Role of High Mobility Group-Box 1显示文摘 | Feng Wang Simone E. Birch Ruijan He Patrick Tawadros Katalin Szaszi Andras Kapus Ori D. Rotstein | 2010 | Annals of Surgery2010，，2： | 2 |
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