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    题名 作者 年代 出处 被引量
1Acute fatty liver of pregnancy:Over six months follow-up study of twenty-five patients显示文摘AIM:To evaluate the prognosis of patients with acute fatty liver of pregnancy(AFLP)6 mo or longer after discharge.METHODS:The records of pregnant patients diagnosed with AFLP at Beijing Ditan Hospital over a 16-year period were reviewed in November 2012.Patients weremonitored using abdominal ultrasound,liver and kidney functions,and routine blood examination.RESULTS:A total of 42 patients were diagnosed with AFLP during the study period,and 25 were followed.The mean follow-up duration was 54.5 mo(range:6.5-181 mo).All patients were in good physical condition,but one patient had gestational diabetes.The renal and liver functions normalized in all patients after recovery,including in those with pre-existing liver or kidney failure.The ultrasound findings were normal in12 patients,an increasingly coarsened echo-pattern and increased echogenicity of the liver in 10 patients,and mild to moderate fatty liver infiltration in 3 patients.Cirrhosis or liver nodules were not observed in any patient.CONCLUSION:Acute liver failure and acute renal failure in AFLP patients is reversible.Patients do not require any specific long-term follow-up after recovery from AFLP if their liver function tests have normalized and they remain well.Hao-Feng Xiong Jing-Yuan Liu Li-Min Guo Xing-Wang Li 2015World Journal of Gastroenterology2015,21,6:25
2妊娠期急性脂肪肝患者门诊筛查时机和筛查方案的探讨显示文摘目的:探讨妊娠期急性脂肪肝(acute fatty liver of pregnancy,AFLP)患者的门诊筛查时机、指标和方案。方法:回顾性分析2006年1月至2013年12月间中南大学湘雅医院和湘雅二医院收治的、符合国内临床诊断和英国Swansea诊断标准的AFLP患者的病例资料(n=78);并与国内外其他大型医疗中心或三级综合性医院报道的AFLP临床资料进行对比分析。结果:国内临床诊断和英国Swansea诊断标准对本组AFLP患者的诊断效率差异有统计学意义(P<0.05)。孕产妇病死率为14.10%(11/78),围产儿病死率为17.95%(14/78)。平均终止妊娠的孕龄为35.6周。85%以上的患者入院时有转氨酶、胆红素、白细胞总数和凝血功能的异常;50%~85%的患者有消化道症状、黄疸、肾功能受损和超声示肝脏声像改变或腹水;50%以下的患者出现低血糖、高血氨和肝性脑病等表现。结论:妊娠34周后可开始AFLP患者门诊筛查,血常规、肝功能联合凝血功能的检测可作为AFLP门诊筛查的一线指标和方案,消化道症状、肾功能、腹部超声可作为门诊筛查的二线指标和方案。朱特选 李琪 张卫社 黄健 彭巧珍 刘月兰 王为男 吴新华 张丽娟 2015中南大学学报(医学版)2015,40,7:15
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