|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Perspectives on new biomarkers in gastric cancer: Diagnostic and prognostic applications显示文摘Gastric cancer is considered one of the most deadly tumors worldwide. Even with the decline in its incidence, the mortality rate of this disease has remained high, mainly due to its late diagnosis and to the lack of precise prognostic markers. The main purpose of this review is to present genetic, epigenetic and proteomic molecular markers that may be used in a diagnostic and prognostic manner and to discuss the pros and cons of each type of marker for improving clinical practice. In this sense, we observed that the use of genetic markers, especially mutations and polymorphisms, should be carefully considered, as they are strongly affected by ethnicity. Proteomic-based markers show promise, but the higher costs of the associated techniques con-tinue to make this approach expensive for routine use. Alternatively, epigenetic markers appear to be very promising, as they can be detected in bodily fluids as well as tissues. However, such markers must be used carefully because epigenetic changes may occur due to environmental factors and aging. Despite the advances in technology and its access, to date, there are few defined biomarkers of prognostic and diagnostic use for gastric tumors. Therefore, the use of a panel of several approaches(genetic, epigenetic and proteomic) should be considered the best alternative for clinical practice. | Danilo do Rosário Pinheiro Wallax Augusto Silva Ferreira Mariceli Baia Leo Barros Mariana Diniz Araújo Symara Rodrigues-Antunes Bárbara do Nascimento Borges | 2014 | World Journal of Gastroenterology2014，20，33： | 4 |
| 2 | Melanoma of the gallbladder misdiagnosed as gallbladder cancer显示文摘To the Editor:Metastatic melanoma of the gallbladder is extremely rare,and despite appropriate therapy its prognosis is poor withfew patients surviving more than 2 years. We present acase of gallbladder involvement by malignant melanomain | Renata Potonyacz Colaneri Bárbara dos Santos Nunes Paulo Herman | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，1： | 3 |
| 3 | Worldwide trends in gastric cancer mortality (1980–2011), with predictions to 2015, and incidence by subtype显示文摘 | Ana Ferro Bárbara Peleteiro Matteo Malvezzi Cristina Bosetti Paola Bertuccio Fabio Levi Eva Negri Carlo La Vecchia Nuno Lunet | 2014 | European Journal of Cancer2014，，： | 3 |
| 4 | Short mucin 1 alleles are associated with low virulent H pylori strains infection显示文摘TO THE EDITOR We read with interest the article published by Nguyen et al[1] in the World Journal of Gastroenterology, | Bárbara Peleteiro Nuno Lunet Filipe Santos-Silva Leonor David Céu Figueiredo Henrique Barros | 2007 | World Journal of Gastroenterology2007，13，12： | 3 |
| 5 | Distribution of the P2X2 receptor and chemical coding in ileal enteric neurons of obese male mice(ob/ob)显示文摘AIM:To investigate the colocalization,density and profile of neuronal areas of enteric neurons in the ileum of male obese mice.METHODS:The small intestinal samples of male mice in an obese group(OG)(C57BL/6J ob/ob)and a control group(CG)(+/+)were used.The tissues were analyzed using a double immunostaining technique for immunoreactivity(ir)of the P2X2 receptor,nitric oxide synthase(NOS),choline acetyl transferase(ChAT)and calretinin(Calr).Also,we investigated the density and profile of neuronal areas of the NOS-,ChAT-and Calrir neurons in the myenteric plexus.Myenteric neurons were labeled using an NADH-diaphorase histochemical staining method.RESULTS:The analysis demonstrated that the P2X2receptor was expressed in the cytoplasm and in the nuclear and cytoplasmic membranes only in the CG.Neuronal density values(neuron/cm2)decreased 31%(CG:6579±837;OG:4556±407)and 16.5%(CG:7796±528;OG:6513±610)in the NOS-ir and calretininir neurons in the OG,respectively(P<0.05).Density of ChAT-ir(CG:6200±310;OG:8125±749)neurons significantly increased 31%in the OG(P<0.05).Neuron size studies demonstrated that NOS,ChAT,and Calr-ir neurons did not differ significantly between the CG and OG groups.The examination of NADH-diaphorase-positive myenteric neurons revealed an overall similarity between the OG and CG.CONCLUSION:Obesity may exert its effects by promoting a decrease in P2X2 receptor expression and modifications in the density of the NOS-ir,ChAT-ir and CalR-ir myenteric neurons. | Márcia Sanae Mizuno Amanda Rabello Crisma Primavera Borelli Bárbara Tavares Schfer Mariana Póvoa Silveira Patricia Castelucci | 2014 | World Journal of Gastroenterology2014，20，38： | 3 |
| 6 | Extramedullary plasmocytoma associated with a massive deposit of amyloid in the duodenum显示文摘We report a rare case of extramedullary plasmocytoma associated with a massive deposit of amyloid in the duodenum.A 72-year-old Japanese man was admitted to our hospital presenting with a 3-mo history of epigastric pain, vomiting and weight loss.On computed tomography(CT) a wall thickening of the fourth part of the duodenum was observed.Multiple biopsies obtained from the lesion showed inflltration of plasma cells and lymphocytes, but they were not conclusive.The patient underwent resection of the lesion and, on histopathological examination, the lesion consisted of a dense and diffuse inflltrate of plasma cells and a few admixed lymphocytes with reactive follicles extending to the muscular propria.An extensive deposition of amyloid was also observed.Immunohistochemical stains revealed that a few plasmacytoid cells showed λ light chain staining, though most were κ light chain positive.These cells also were positive for CD138 and CD56 but negative for CD20 and CD79.The flndings were consistent with extramedullary plasmocytomaassociated with a massive deposit of amyloid in duodenum.A subsequent workup for multiple myeloma was completely negative.The patient showed no signs of local recurrence or dissemination of the disease after 12 mo follow-up.Because of the association of plasmocytoma and amyloidosis, the patient must be followed up because of the possible systemic involvement of the neoplasm and amyloidosis in future. | Fabiana Pirani Carneiro Maria de Nazareth Machado Sobreira Lívia Bravo Maia Alesso Cervantes Sartorelli Luiz Eduardo de Almeida Prado Franceschi Mauro Brito Brando Bárbara Wosnjuk Calaca Fernando Silva Lustosa Joo Vieira Lopes | 2009 | World Journal of Gastroenterology2009，15，28： | 2 |
| 7 | Science Letters:Quantification of Helicobacter pylori levels in soil samples from public playgrounds in Spain显示文摘Helicobacter pylori are ubiquitous Gram-negative bacteria with a high estimated level of infection in the world populations, but a majority of the infected persons are asymptomatic. This pathogen has been classified by the World Health Organization as a class I carcinogen and recognized as the causal agent of most peptic ulcers and chronic gastritis that might lead to stomach cancer. Although not all the transmission pathways of these bacteria into humans have been properly identified, enough data have suggested that the oral-oral or fecal-oral ones are the main infection routes. Helicobacter pylori have been detected in non-treated water and in drinking water, which suggested that water might be an important infection source. As childhood is the critical period of infection, the aim of the present work was to examine the presence of Helicobacter pylori in soil samples from public playing areas of Spanish parks. | Leonardo Martín PéREZ Francesc CODONY Daniela LóPEZ LEYTON Mariana FITTIPALDI Bárbara ADRADOS Jordi MORATó | 2010 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2010，11，1： | 2 |
| 8 | Age at Onset Should Be a Major Criterion for Subclassification of Colorectal Cancer显示文摘 | José Perea Daniel Rueda Alicia Canal Yolanda Rodríguez Edurne álvaro Irene Osorio Cristina Alegre Bárbara Rivera Joaquín Martínez Javier Benítez Miguel Urioste | 2014 | The Journal of Molecular Diagnostics2014，，1： | 2 |
| 9 | What explains the low profitability of Chinese banks?显示文摘 | Alicia García-Herrero Sergio Gavilá Daniel Santabárbara | 2009 | Journal of Banking and Finance2009，，11： | 2 |
| 10 | Effects of High-Pressure Processing on the Quality of Sea Bass ( Dicentrarchus labrax ) Fillets During Refrigerated Storage显示文摘 | Bárbara Teixeira António Marques Rogério Mendes Amparo Gon?alves Liliana Fidalgo Marise Oliveira Jorge Alexandre Saraiva Maria Leonor Nunes | 2014 | Food and Bioprocess Technology2014，，5： | 1 |
| 11 | Mucinous colorectal adenocarcinoma: influence of mucin expression (Muc1, 2 and 5) on clinico-pathological features and prognosis显示文摘 | Rodrigo Oliva Perez Bárbara Helou Bresciani Cláudio Bresciani Igor Proscurshim Desiderio Kiss Joaquim Gama-Rodrigues Diego Daniel Pereira Viviane Rawet Ivan Cecconnello Angelita Habr-Gama | 2008 | International Journal of Colorectal Disease2008，，： | 1 |
| 12 | Advanced lung adenocarcinoma in an EGFR-positive patient treated with Erlotinib for 52 months显示文摘 | Ivone Gon?alves Inês Ladeira Ana Castro Ana Antunes Ana Barroso Bárbara Parente | 2013 | Respiratory Medicine Case Reports2013，，： | 1 |
| 13 | Nursing organizational climates in public and private hospitals显示文摘 | García IG Castillo RF Santa-Bárbara ES | 2013 | Nurs Ethics2013，21，4： | 1 |
| 14 | “What is a good digital library?” – A quality model for digital libraries显示文摘 | Marcos André Gon?alves Bárbara L. Moreira Edward A. Fox Layne T. Watson | 2006 | Information Processing and Management2006，，5： | 1 |
| 15 | Modeling teletraffic arrivals by a Poisson cluster process显示文摘 | Gilles Fa? Bárbara González-Arévalo Thomas Mikosch Gennady Samorodnitsky | 2006 | Queueing Systems2006，，2： | 1 |
| 16 | Do collagen meshes offer any benefits over preclude? ePTFE implants in contaminated surgical fields? A comparative in vitro and in vivo study显示文摘 | Rubén García‐Pumarino Gemma Pascual Marta Rodríguez Bárbara Pérez‐K?hler Juan Manuel Bellón | 2014 | J. Biomed. Mater. Res2014，，： | 1 |
| 17 | Liposomal superoxide dismutases and their use in the treatment of experimental arthritis显示文摘 | Cruz ME Manuela Gaspar M Bárbara M | 2005 | Methods Enzymol2005，391，： | 1 |
| 18 | Statistical evaluation of chronic toxicity data on aquatic organisms for the hazard identification: The chemicals toxicity distribution approach显示文摘 | Miguel González-Doncel José Ortiz Juan J. Izquierdo Bárbara Martín Paloma Sánchez José V. Tarazona | 2005 | Chemosphere2005，，5： | 1 |
| 19 | Importance and management of micronutrient deficiencies in patients with Alzheimer’s disease显示文摘 | Bárbara Cardoso Cozzolino Cominetti | 2013 | Clinical Interventions in Aging . 2013 (defa)2013，，： | 1 |
| 20 | Chromatographic analysis of natural and synthetic estrogens in milk and dairy products显示文摘 | Bárbara Socas-Rodríguez María Asensio-Ramos Javier Hernández-Borges Antonio V. Herrera-Herrera Miguel ángel Rodríguez-Delgado | 2013 | Trends in Analytical Chemistry2013，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员