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| 1 | 欧美国家胃癌手术并发症的诊断标准及风险评估显示文摘术后并发症是手术质量和安全控制的重要标准,然而由于国内外对并发症的认识、诊断缺乏共识,导致并发症的登记问题一直备受争议。为此,我们通过4个电话会议.了解西方国家单中心数据登记系统、国家数据登记系统以及国际多中心临床登记系统的实际操作情况。其中采访了澳大利亚皇家艾尔弗莱德王子医院消化道外科的Koh教授,了解其单中心的经验;同时还分别采访了STOMACH研究的vander Wielen医生和IMIGASTIC国际研究小组的Desiderio医生,以及荷兰上消化道癌国家级数据库的Wijnhoven教授.以了解其多中心研究情况。我们采访的问题主要包括以下几个方面:哪些并发症需要上报。上报并发症的定义.由谁完成并发症登记以及如何对并发症进行评估。在相关数据库中,DUCA和IMIGASTRIC给出了主要并发症的定义.其中DUCA的定义是在国际专家们经过4年商讨及共识会议后得出的LOW分类标准的基础上进一步完善的。然而,没有任何一个登记系统强制要求在参与中心以及外科医生实行统一诊断标准。相反,所有的登记系统均要求详细记录并发症的诊断策略并使用Clavien.Dindo评分系统完成并发症分类。大多数的数据登记是由外科医生或数据管理员在患者住院期间、或者出院后立即完成。登记系统中数据的质量控制由相关研究人员或第三方审查完成。从西方的经验我们可以看到,在不同的中心实现并发症诊断的标准化是一个艰巨的任务,需要花费大量的人力、物力和财力。目前,各中心在登记并发症的同时应记录诊断方法及相应的干预措施,以便后续各中心根据Clavien—Dindo分级标准对并发症进行分级。该分级系统现已被中西方大多数中心采纳.可作为未来胃癌术后并发症的标准评估体系。 | 吴舟桥 王琦 石晋瑶 Cherry Koh Desiderio Jacopo 李子禹 季加孚 | 2017 | 中华胃肠外科杂志2017，20，2： | 17 |
| 2 | Minimally invasive surgery for gastric cancer: A comparison between robotic, laparoscopic and open surgery显示文摘AIM To investigate the role of minimally invasive surgery for gastric cancer and determine surgical, clinical, and oncological outcomes.METHODS This is a propensity score-matched case-control study, comparing three treatment arms: robotic gastrectomy(RG), laparoscopic gastrectomy(LG), open gastrectomy(OG). Data collection started after sharing a specific study protocol. Data were recorded through a tailored and protected web-based system. Primary outcomes: harvested lymph nodes, estimated blood loss, hospital stay, complications rate. Among the secondary outcomes, there are: operative time, R0 resections, POD of mobilization, POD of starting liquid diet and soft solid diet. The analysis includes the evaluation of type and grade of postoperative complications. Detailed information of anastomotic leakages is also provided.RESULTS The present analysis was carried out of 1026 gastrectomies. To guarantee homogenous distribution of cases, patients in the RG, LG and OG groups were 1:1:2 matched using a propensity score analysis with a caliper = 0.2. The successful matching resulted in a total sample of 604 patients(RG = 151; LG = 151; OG = 302). The three groups showed no differences in all baseline patients characteristics, type of surgery(P = 0.42) and stage of the disease(P = 0.16). Intraoperative blood loss was significantly lower in the LG(95.93 ± 119.22) and RG(117.91 ± 68.11) groups compared to the OG(127.26 ± 79.50, P = 0.002). The mean number of retrieved lymph nodes was similar between the RG(27.78 ± 11.45), LG(24.58 ± 13.56) and OG(25.82 ± 12.07) approach. A benefit in favor of the minimally invasive approaches was found in the length of hospital stay(P < 0.0001). A similar complications rate was found(P = 0.13). The leakage rate was not different(P = 0.78) between groups.CONCLUSION Laparoscopic and robotic surgery can be safely performed and proposed as possible alternative to open surgery. The main highlighted benefit is a faster postoperative functional recovery. | Amilcare Parisi Daniel Reim Felice Borghi Ninh T Nguyen Feng Qi Andrea Coratti Fabio Cianchi Maurizio Cesari Francesca Bazzocchi Orhan Alimoglu Johan Gagnière Graziano Pernazza Simone D'Imporzano Yan-Bing Zhou Juan-Santiago Azagra Olivier Facy Steven T Brower Zhi-Wei Jiang Lu Zang Arda Isik Alessandro Gemini Stefano Trastulli Alexander Novotny Alessandra Marano Tong Liu Mario Annecchiarico Benedetta Badii Giacomo Arcuri Andrea Avanzolini Metin Leblebici Denis Pezet Shou-Gen Cao Martine Goergen Shu Zhang Giorgio Palazzini Vito D'Andrea Jacopo Desiderio | 2017 | World Journal of Gastroenterology2017，23，13： | 17 |
| 3 | Liver resection versus radiofrequency ablation in the treatment of cirrhotic patients with hepatocellular carcinoma显示文摘BACKGROUND: Hepatocellular carcinoma is the most common type of primary liver tumor and its incidence is increasing worldwide. The study aimed to compare patients subjected to liver resection or radiofrequency ablation. METHODS: One hundred and forty cirrhotic patients in stage A or B of Child-Pugh with single nodular or multinodular hepatocellular carcinoma were included in this retrospective study. Among them, 87 underwent surgical resection, and 53 underwent percutaneous radiofrequency ablation. Patient charac-teristics, survival, and recurrence-free survival were analyzed. RESULTS: Recurrence-free survival was longer in the resection group in comparison to the radiofrequency group with a median recurrence-free time of 36 versus 26 months, respectively (P=0.01, HR=1.52, 95% CI: 1.05-2.25). In the resection group, median survival was 46 months, with the 1-, 3- and 5-year survival rates of 89.7%, 72.4% and 40.2%. In the radiofrequency group, median survival was 32 months, with the 1-, 3- and 5-year survival rates of 83.0%, 43.4% and 22.6% (P<0.01). CONCLUSIONS: Surgical resection improves the overall survival and recurrence-free survival in comparison with radiofrequency ablation. New evidences are needed to define the real role of the percutaneous technique as an alternative to surgery. | Amilcare Parisi Jacopo Desiderio Stefano Trastulli Elisa Castellani Rosario Pasquale Roberto Cirocchi Carlo Boselli Giuseppe Noya | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，3： | 8 |
| 4 | Systematic review and meta‐analysis of randomized clinical trials comparing single‐incision versus conventional laparoscopic cholecystectomy显示文摘 | S. Trastulli R. Cirocchi J. Desiderio S. Guarino A. Santoro A. Parisi G. Noya C. Boselli | 2012 | Br J Surg2012，，2： | 5 |
| 5 | Safety and efficacy of endoscopic colonic stenting as a bridge to surgery in the management of intestinal obstruction due to left colon and rectal cancer: A systematic review and meta-analysis显示文摘 | Roberto Cirocchi Eriberto Farinella Stefano Trastulli Jacopo Desiderio Chiara Listorti Carlo Boselli Amilcare Parisi Giuseppe Noya Jayesh Sagar | 2012 | Surgical Oncology2012，，： | 4 |
| 6 | New totally intracorporeal reconstructive approach after robotic total gastrectomy: Technical details and short-term outcomes显示文摘AIM To show outcomes of our series of patients that underwent a total gastrectomy with a robotic approach and highlight the technical details of a proposed solution for the reconstruction phase.METHODS Data of gastrectomies performed from May 2014 to October 2016, were extracted and analyzed. Basic characteristics of patients, surgical and clinical outcomes were reported. The technique for reconstruction(Parisi Technique) consists on a loop of bowel shifted up antecolic to directly perform the esophago-enteric anastomosis followed by a second loop, measured up to 40 cm starting from the esojejunostomy, fixed to the biliary limb to create an enteroenteric anastomosis. The continuity between the two anastomoses is interrupted just firing a linear stapler, so obtaining the Roux-en-Y by avoiding to interrupt the mesentery.RESULTS Fifty-five patients were considered in the present analysis. Estimated blood loss was 126.55 ± 73 m L, no conversions to open surgery occurred, R0 resections were obtained in all cases. Hospital stay was 5(3-17) d, no anastomotic leakage occurred. Overall, a fast functional recovery was shown with a median of 3(3-6) d in starting a solid diet.CONCLUSION Robotic surgery and the adoption of a tailored reconstruction technique have increased the feasibility and safety of a minimally invasive approach for total gastrectomy. The present series of patients shows its implementation in a western center with satisfying short-term outcomes. | Amilcare Parisi Francesco Ricci Alessandro Gemini Stefano Trastulli Roberto Cirocchi Giorgio Palazzini Vito D'Andrea Jacopo Desiderio | 2017 | World Journal of Gastroenterology2017，23，23： | 4 |
| 7 | Fluorescence image-guided lymphadenectomy using indocyanine green and near infrared technology in robotic gastrectomy显示文摘In recent years, some researchers have tried to find a way to improve the surgical identification of the lymphatic drainage routes and lymph node stations during radical gastrectomy, thus starting a new research frontier in this field called 'navigation surgery'. Among the different reported solutions, the introduction of the indocyanine green(ICG) has drawn attention for its characteristics, a fluorescence dye that can be detected in the near infrared spectral band(NIR). A fluorescence imaging technology has been integrated in the latest version of the Da Vinci robotic system and surgeons have extensively reported their experiences in colorectal and hepato-biliary surgery for tumors, vascular and lymphatic structures visualization. However, up to date, the combined use of fluorescence imaging and robotic technology has not been adequately investigated during lymphadenectomy in gastric cancer. | Jacopo Desiderio Stefano Trastulli AlessANDro Gemini Domenico Di Nardo Giorgio Palazzini Amilcare Parisi Vito D'ANDrea | 2018 | Chinese Journal of Cancer Research2018，30，5： | 3 |
| 8 | Absence of Lymph Nodes in the Resected Specimen After Radical Surgery for Distal Rectal Cancer and Neoadjuvant Chemoradiation Therapy: What does it Mean?显示文摘 | Angelita Habr-Gama M.D. Ph.D. Rodrigo O. Perez M.D. Ph.D. Igor Proscurshim M.S. Viviane Rawet M.D. Ph.D. Diego D. Pereira M.S. Afonso H. S. Sousa M.D. Ph.D. Desiderio Kiss M.D. Ph.D. Ivan Cecconello M.D. Ph.D | 2008 | Diseases of the Colon & Rectum2008，，3： | 2 |
| 9 | Current status of robotic distal pancreatectomy: A systematic review显示文摘 | Roberto Cirocchi Stefano Partelli Andrea Coratti Jacopo Desiderio Amilcare Parisi Massimo Falconi | 2013 | Surgical Oncology2013，，： | 2 |
| 10 | High tie versus low tie of the inferior mesenteric artery in colorectal cancer: A RCT is needed显示文摘 | Roberto Cirocchi Stefano Trastulli Eriberto Farinella Jacopo Desiderio Nereo Vettoretto Amilcare Parisi Carlo Boselli Giuseppe Noya | 2012 | Surgical Oncology2012，，3： | 2 |
| 11 | Surgery in asymptomatic patients with colorectal cancer and unresectable liver metastases: the authors’ experience显示文摘 | Claudio Renzi Castellani Francesco Barberini Roberto Cirocchi Gemini Noya Boselli Parisi Corsi Desiderio Adriano Redler Trastulli Alberto Santoro | 2013 | 2013 (defa)2013，，： | 2 |
| 12 | Rapid determination of short chain carnitines in human plasma by electrospray ionisation-ion trap mass spectrometry using capillary electrophoresis instrument as sampler显示文摘 | Claudia Desiderio Angelo Mancinelli Antonella De Rossi Diana Valeria Rossetti Rosanna Inzitari Irene Messana Bruno Giardina Massimo Castagnola | 2006 | Journal of Chromatography A2006，，1： | 2 |
| 13 | Long-term survival of patients with stage Ⅱ and Ⅲgastric cancer who underwent gastrectomy with inadequate nodal assessment显示文摘BACKGROUND Gastric cancer is an aggressive disease with frequent lymph node(LN)involvement.The NCCN recommends a D2 lymphadenectomy and the harvesting of at least 16 LNs.This threshold has been the subject of great debate,not only for the extent of surgery but also for more appropriate staging.The reclassification of stage IIB through IIIC based on N3b nodal staging in the eighth edition of the American Joint Committee on Cancer(AJCC)staging system highlights the efforts to more accurately discriminate survival expectancy based on nodal number.Furthermore,studies have suggested that pathologic assessment of 30 or more LNs improve prognostic accuracy and is required for proper staging of gastriccancer.AIM To evaluate the long-term survival of advanced gastric cancer patients who deviated from expected survival curves because of inadequate nodal evaluation.METHODS Eligible patients were identified from the Surveillance,Epidemiology,and End Results database.Those with stage II-III gastric cancer were considered for inclusion.Three groups were compared based on the number of analyzed LNs.They were inadequate LN assessment(ILA,<16 LNs),adequate LN assessment(ALA,16-29 LNs),and optimal LN assessment(OLA,≥30 LNs).The main outcomes were overall survival(OS)and cancer-specific survival.Data were analyzed by the Kaplan-Meier product-limit method,log-rank test,hazard risk,and Cox proportional univariate and multivariate models.Propensity score matching(PSM)was used to compare the ALA and OLA groups.RESULTS The analysis included 11607 patients.Most had advanced T stages(T3=48%;T4=42%).The pathological AJCC stage distribution was IIA=22%,IIB=18%,IIIA=26%,IIIB=22%,and IIIC=12%.The overall sample divided by the study objective included ILA(50%),ALA(35%),and OLA(15%).Median OS was 24 mo for the ILA group,29 mo for the ALA group,and 34 mo for the OLA group(P<0.001).Univariate analysis showed that the ALA and OLA groups had better OS than the ILA group[ALA hazard ratio(HR)=0.84,95%confidence interval(CI):0.79-0.88,P<0.001 and OLA HR=0.73,95%CI:0.68-0.79,P<0.001].The OS outcome was confirmed by multivariate analysis(ALA HR=0.68,95%CI:0.64-0.71,P<0.001 and OLA:HR=0.48,95%CI:0.44-0.52,P<0.001).A 1:1 PSM analysis in 3428 patients found that the OLA group had better survival than the ALA group(OS:OLA median=34 mo vs ALA median=26 mo,P<0.001,which was confirmed by univariate analysis(HR=0.81,95%CI:0.75-0.89,P<0.001)and multivariate analysis:(HR=0.71,95%CI:0.65-0.78,P<0.001).CONCLUSION Proper nodal staging is a critical issue in gastric cancer.Assessment of an inadequate number of LNs places patients at high risk of adverse long-term survival outcomes. | Jacopo Desiderio Andrea Sagnotta Irene Terrenato Eleonora Garofoli Claudia Mosillo Stefano Trastulli Federica Arteritano Federico Tozzi Vito D'Andrea Yuman Fong Yanghee Woo Sergio Bracarda Amilcare Parisi | 2021 | World Journal of Gastrointestinal Surgery2021，13，11： | 2 |
| 14 | The identification of serum tuftsin by reverse-phase high-performance liquid chromatography and mass spectrometry 显示文摘 | Naim JO Desiderio DM Trimble J | 1987 | Anal Biochem1987，164，1： | 1 |
| 15 | Laparoscopic Peritoneal Lavage: A Definitive Treatment for Diverticular Peritonitis or a “Bridge” to Elective Laparoscopic Sigmoidectomy?: A Systematic Review显示文摘 | Roberto Cirocchi Stefano Trastulli Nereo Vettoretto Diego Milani Davide Cavaliere Claudio Renzi Olga Adamenko Jacopo Desiderio Maria Federica Burattini Amilcare Parisi Alberto Arezzo Abe Fingerhut | 2015 | Medicine2015，，： | 1 |
| 16 | Polygalacturonas - inhibiting proteins with different specificities are expressed in Phaseolus vulgaris显示文摘 | Desiderio A Aracri B Leckle F | 1997 | Mol Plant Microbe Interact1997，10，7： | 1 |
| 17 | Human primary bone sarco-mas contain CD133+cancer stem cells displaying high tumorigenic-ity in vivo显示文摘 | Tirino V Desiderio V Paino F | | 0，，06： | 1 |
| 18 | Hepatocyte growth factor in invasive growth of carcinomas 显示文摘 | Desiderio MA | 2007 | Cell Mol Life Sci2007，64，11： | 1 |
| 19 | Phospho- proteomic analysis of the human pituitary 显示文摘 | Beranova-Giorgianni S Zhao Y Desiderio DM | 2006 | Pituitary2006，9，2： | 1 |
| 20 | Mucinous colorectal adenocarcinoma: influence of mucin expression (Muc1, 2 and 5) on clinico-pathological features and prognosis显示文摘 | Rodrigo Oliva Perez Bárbara Helou Bresciani Cláudio Bresciani Igor Proscurshim Desiderio Kiss Joaquim Gama-Rodrigues Diego Daniel Pereira Viviane Rawet Ivan Cecconnello Angelita Habr-Gama | 2008 | International Journal of Colorectal Disease2008，，： | 1 |
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