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| 1 | Upper gastrointestinal sensory-motor dysfunction in diabetes mellitus显示文摘胃肠(官方补给) 感觉马达的畸形在有糖尿病的病人是普通的并且可以包含官方补给的道的任何部分。畸形经常是无临床症状的,并且幸好,严重、威胁生活的问题仅仅很少发生。在糖尿病的反常上面的官方补给的感觉马达的功能的致病不完全地被理解并且是最可能的起源多因素。糖尿病的自治神经病以及糖尿病的尖锐非最优的控制被显示了损害官方补给的马达和感觉功能。词法并且官方补给的墙的机械改变在糖尿病的持续时间期间开发的简历,并且可以贡献马达和感觉机能障碍。在感觉的这评论和活动性,在糖尿病的上面的官方补给的道的混乱被讨论;并且与感觉马达的机能障碍有关的机械改变也是的词法变化和简历探讨了。 | Jingbo Zhao Jens Brφndum Frφkjaer Asbjφrn Mohr Drewes Niels Ejskjaer | 2006 | World Journal of Gastroenterology2006，12，18： | 15 |
| 2 | Long-term survival following radiofrequency ablation of colorectal liver metastases: A retrospective study显示文摘AIM: To retrospectively evaluate the long-term survivalof patients that received radiofrequency ablation(RFA) therapies of colorectal liver metastases. METHODS: In 2005 to 2008, RFA of 105 colorectal liver metastases(CRLM) were performed on 49 patients in our institution. The liver metastases were evaluated, both before and after ablation therapies, with contrast enhanced computerised tomography and contrast enhanced ultrasonography. Histological evidence of malignant liver metastases was obtained in the few instances where contrast enhanced ultrasonography gave equivocal results. Accesses to the CRLM were guided ultrasonically in all patients. The data obtained from records of these ablations were retrospectively analysed and survival data were compared with existing studies in the literature.RESULTS: 1-, 2-, 3-, 4- and 5-year survival rates, when no stringent selection criteria were applied, were 92%, 65%, 51%, 41% and 29% respectively. To explore the impact of the number and size of CRLM on patients' survival, an exclusion of 13 patients(26.5%) with number of CRLM ≥ 5 and tumour size ≥ 40 mm resulted in 1-, 2-, 3-, 4- and 5-year survival rates improving to 94%, 69%, 53%, 42% and 31% respectively. It is of note that 9 of 49 patients developed extra-hepatic metastases, not visible or seen on pretreatment scans, just after RFA treatment. These patients had poorer survival. The development of extra-hepatic metastases in nearly 20% of the patients included in our study can partly account for modestly lower survival rates as compared with earlier studies in the literature.CONCLUSION: Our study underscores the fact that optimum patients' selection before embarking on RFA treatment is vitally important to achieving a superior outcome. | Simeon Niyi Babawale Thomas MandФe Jensen Jens BrФndum FrФkjr | 2015 | World Journal of Gastrointestinal Surgery2015，7，3： | 11 |
| 3 | Impaired contractility and remodeling of the upper gastrointestinal tract in diabetes mellitus type-1显示文摘AIM: To investigate that both the neuronal function of the contractile system and structural apparatus of the gastrointestinal tract are affected in patients with longstanding diabetes and auto mic neuropathy. METHODS: The evoked esophageal and duodenal contractile activity to standardized bag distension was assessed using a specialized ultrasound-based probe. Twelve type-1 diabetic patients with autonomic neuropathy and severe gastrointestinal symptoms and 12 healthy controls were studied. The geometry and biomechanical parameters (strain, tension/stress, and stiffness) were assessed. RESULTS: The diabetic patients had increased frequency of distension-induced contractions (6.0 ± 0.6 vs 3.3 ± 0.5, P < 0.001). This increased reactivity was correlated with the duration of the disease (P = 0.009). Impaired coordination of the contractile activity in diabetic patients was demonstrated as imbalance between the time required to evoke the first contraction at the distension site and proximal to it (1.5 ± 0.6 vs 0.5 ± 0.1, P = 0.03). The esophageal wall and especially the mucosa-submucosa layer had increased thickness in the patients (P < 0.001), and the longitudinal and radial compressive stretch was less in diabetics (P <0.001). The esophageal and duodenal wall stiffness and circumferential deformation induced by the distensions were not affected in the patients (all P > 0.14). CONCLUSION: The impaired contractile activity with an imbalance in the distension-induced contractions likely reflects neuronal abnormalities due to autonomic neuropathy. However, structural changes and remodeling of the gastrointestinal tract are also evident and may add to the neuronal changes. This may contribute to the pathophysiology of diabetic gut dysfunction and impact on future management of diabetic patients with gastrointestinal symptoms. | Jens BrΦndum FrΦkjΦr SΦren Due Andersen Niels EjskjΦr Peter Funch-Jensen AsbjΦrn Mohr Drewes Hans Gregersen | 2007 | World Journal of Gastroenterology2007，13，36： | 8 |
| 4 | Morphological and functional evaluation of chronic pancreatitis with magnetic resonance imaging显示文摘Magnetic resonance imaging(MRI)techniques for assessment of morphology and function of the pancreas have been improved dramatically the recent years and MRI is very often used in diagnosing and follow-up of chronic pancreatitis(CP)patients.Standard MRI including fat-suppressed T1-weighted and T2-weighted imaging techniques reveal decreased signal and glandular atrophy of the pancreas in CP.In contrast-enhanced MRI of the pancreas in CP the pancreatic signal is usually reduced and delayed due to decreased perfusion as a result of chronic inflammation and fibrosis.Thus,morphological changes of the ductal system can be assessed by magnetic resonance cholangiopancreatography(MRCP).Furthermore,secretin-stimulated MRCP is a valuable technique to evaluate side branch pathology and the exocrine function of the pancreas and diffusion weighted imaging can be used to quantify both parenchymal fibrotic changes and the exocrine function of the pancreas.These standard and advanced MRI techniques are supplementary techniques to reveal morphological and functional changes of the pancreas in CP.Recently,spectroscopy has been used for assessment of metabolite concentrations in-vivo in different tissues and may have the potential to offer better tissue characterization of the pancreas.Hence,the purpose of the present review is to provide an update on standard and advanced MRI techniques of the pancreas in CP. | Tine Maria Hansen Matias Nilsson Mikkel Gram Jens Brφndum Frφkjr | 2013 | World Journal of Gastroenterology2013，19，42： | 7 |
| 5 | 糖尿病性上消化道感觉和运动功能异常显示文摘糖尿病患者胃肠感觉运动功能异常非常常见,其可涉及胃肠道各个部位。糖尿病性胃肠异常经常是亚临床的,庆幸的是罕有严重和危及生命的问题发生。人们尚未完全了解糖尿病性上消化道感觉运动功能异常的发病机制,但是其机制似乎是多源性的。研究表明,糖尿病性自主神经病变和急性血糖异常可损伤感觉运动功能。糖尿病发展过程中胃肠道结构和生物力学特性的重构也可能与感觉运动功能异常有关。本综述只讨论糖尿病性上消化道感觉运动功能异常,同时结合讨论胃肠道结构和生物力学特性的重构在糖尿病性上消化道感觉运动功能异常发展中的作用。 | 赵静波 Jens Brφndum Frφkjr Asbjφrn Mohr Drewes Niels Ejskjaer | 2008 | 医学综述2008，14，23： | 6 |
| 6 | Pain and chronic pancreatitis: A complex interplay of multiple mechanisms显示文摘Despite multiple theories on the pathogenesis of pain in chronic pancreatitis,no uniform and consistently successful treatment strategy exists and abdominal pain still remains the dominating symptom for most patients and a major challenge for clinicians.Traditional theories focussed on a mechanical cause of pain related to anatomical changes and evidence of increased ductal and interstitial pressures.These observations form the basis for surgical and endoscopic drainage procedures,but the outcome is variable and often unsatisfactory.This underscores the fact that other factors must contribute to pathogenesis of pain,and has shifted the focus towards a more complex neurobiological understanding of pain generation.Amongst other explanations for pain,experimental and human studies have provided evidence that pain perception at the peripheral level and central pain processing of the nociceptive information is altered in patients with chronic pancreatitis,and resembles that seen in neuropathic and chronic pain disorders.However,pain due to e.g.,complications to the disease and adverse effects to treatment must not be overlooked as an additional source of pain.This review outlines the current theories on pain generation in chronic pancreatitis which is crucial in order to understand the complexity and limitations of current therapeutic approaches.Furthermore,it may also serve as an inspiration for further research and development of methods that can evaluate the relative contribution and interplay of different pain mechanisms in the individual patients,before they are subjected to more or less empirical treatment. | Jakob Lykke Poulsen Sφren Schou Olesen Lasse Paludan Malver Jens Brφndum Frφkjr Asbjφrn Mohr Drewes | 2013 | World Journal of Gastroenterology2013，19，42： | 5 |
| 7 | Imaging of the gastrointestinal tract-novel technologies显示文摘Imaging of the gastrointestinal tract is very useful for research and clinical studies of patients with symptoms arising from the gastrointestinal tract and in visualising anatomy and pathology. Traditional radiological techniques played a leading role in such studies for a long time. However, advances in non-invasive modalities including ultrasound (US), computed tomography (CT), positron emission tomography (PET), magnetic resonance imaging (MRI), etc, have in the last decades revolutionised the way in which the gastrointestinal tract is studied. The resolution of imaging data is constantly being improved and 3D acquisition, tools for fi ltering, enhancement, segmentation and tissue classif ication are continually being developed. Additional co-registration techniques allow multimodal data acquisition with improved classif ication of tissue pathology. Furthermore, new functional imaging techniques have become available. Altogether, the future of gastrointestinal imaging looks very promising which will be of great benef it in clinical and research studies of gastrointestinal diseases. The purpose of this review is to highlight the capabilities of the newest techniques to explore the detailed morphology, biomechanical properties, function and pathology of the gastrointestinal tract. | Jens Brφndum Frφkjr Asbjφrn Mohr Drewes Hans Gregersen | 2009 | World Journal of Gastroenterology2009，15，2： | 2 |
| 8 | Self-Reported Food Intolerance in Chronic Inflammatory Bowel Disease显示文摘 | M. Ballegaard A. Bjergstr? m S. Br? ndum E. Hylander L. Jensen K. Ladefoged | 1997 | Scandinavian Journal of Gastroenterology1997，，6： | 1 |
| 9 | Opioid-Induced Bowel Dysfunction显示文摘 | Christina Brock S?ren Schou Olesen Anne Estrup Olesen Jens Br?ndum Fr?kjaer Trine Andresen Asbj?rn Mohr Drewes | 2012 | Drugs2012，，14： | 1 |
| 10 | Prediction of water holding capacity and composition of porcine meat by comparative spectroscopy显示文摘 | Br~ndum J Munck L Henckel P | 2000 | Meat Science2000，55，2： | 1 |
| 11 | Treatment-related frequency of venous thrombosis in lower esophageal, gastro-esophageal and gastric cancer – a clinical prospective study of outcome and prognostic factors显示文摘 | Anders Christian Larsen Jens Br?ndum Fr?kj?r Rune Vincents Fisker Victor Iyer Peter Br?ndum Mortensen Mette Karen Yilmaz Bjarne M?ller S?ren Risom Kristensen Ole Thorlacius-Ussing | 2015 | Thrombosis Research2015，，： | 1 |
| 12 | Nutritional status and long-term mortality in hospitalised patients with chronic obstructive pulmonary disease (COPD)显示文摘 | Runa Hallin Gunnar Gudmundsson Charlotte Suppli Ulrik Markku M. Nieminen Thorarinn Gislason Eva Lindberg Eva Br?ndum Tiina Aine Per Bakke Christer Janson | 2007 | Respiratory Medicine2007，，9： | 1 |
| 13 | Pro-rigor conditions in beef under varying temperature- and pH-falls studied with rigometer, NMR and NIR显示文摘 | TORNBERG E WAHLGREN M BR?NDUM J | 2000 | Food Chemistry2000，69，： | 1 |
| 14 | Fracture of the carpal scaphoid: frequency and distribution in a well-defined population 显示文摘 | Brθndum V Larsen CF Skov O | 1992 | Eur J Radiol1992，15，2： | 1 |
| 15 | Gastrointestinal sensitivity and gastroesophageal reflux disease显示文摘 | Annamaria Altomare Michele Pier Luca Guarino (Sara Emerenziani) Michele Cicala Asbj?rn Mohr Drewes Anne Lund Krarup Christina Brock Christian Lottrup Jens Br?ndum Fr?kj?r Rhonda F. Souza Gerardo Nardone Debora Compare | 2013 | Ann NY Acad Sci2013，，1： | 1 |
| 16 | Update of exocrine functional diagnostics in chronic pancreatitis显示文摘 | Camilla N?jgaard S?ren Schou Olesen Jens Br?ndum Fr?kj?r Asbj?rn Mohr Drewes | 2013 | Clin Physiol Funct Imaging2013，，3： | 1 |
| 17 | Pain severity reduces life quality in chronic pancreatitis: Implications for design of future outcome trials显示文摘 | S?ren Schou Olesen Jacob Juel Anders Klitgaard Nielsen Jens Br?ndum Fr?kj?r Oliver H.G. Wilder-Smith Asbj?rn Mohr Drewes | 2014 | Pancreatology2014，，6： | 1 |
| 18 | Opioid-Induced Bowel Dysfunction显示文摘 | Christina Brock S?ren Schou Olesen Anne Estrup Olesen Jens Br?ndum Fr?kjaer Trine Andresen Asbj?rn Mohr Drewes | 2012 | Drugs2012，，14： | 1 |
| 19 | Reduced Cortical Thickness of Brain Areas Involved in Pain Processing in Patients With Chronic Pancreatitis显示文摘 | Jens Br?ndum Fr?kj?r Stefan A.W. Bouwense S?ren Schou Olesen Flemming H. Lundager Simon F. Eskildsen Harry van Goor Oliver H.G. Wilder–Smith Asbj?rn Mohr Drewes | 2012 | Clinical Gastroenterology and Hepatology2012，，4： | 1 |
| 20 | Pre-rigor conditions in beef under valeting temperature- and pH-falls studied with rigometer,NMR and NIR显示文摘 | Tornberg E Wahlgren M Brφndum J | | 0，，04： | 1 |
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