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| 1 | Pharmacological challenges in chronic pancreatitis显示文摘Drug absorption in patients with chronic pancreatitis might be affected by the pathophysiology of the disease.The exocrine pancreatic insufficiency is associated with changes in gastrointestinal intraluminal pH,motility disorder,bacterial overgrowth and changed pancreatic gland secretion.Together these factors can result in malabsorption and may also affect the efficacy of pharmacological intervention.The lifestyle of chronic pancreatitis patients may also contribute to gastrointestinal changes.Many patients limit their food intake because of the pain caused by eating and in some cases food intake is more or less substituted with alcohol,tobacco and coffee.Alcohol and drug interaction are known to influence the pharmacokinetics by altering either drug absorption or by affecting liver metabolism.Since patients suffering from chronic pancreatitis experience severe pain,opioids are often prescribed as pain treatment.Opioids have intrinsic effects on gastrointestinal motility and hence can modify the absorption of other drugs taken at the same time.Furthermore,the increased fluid absorption caused by opioids will decrease water available for drug dissolution and may hereby affect absorption of the drug.As stated above many factors can influence drug absorption and metabolism in patients with chronic pancreatitis.The factors may not have clinical relevance,but may explain inter-individual variations in responses to a given drug,in patients with chronic pancreatitis. | Anne Estrup Olesen Anne Brokjaer Iben WD Fisher Isabelle M Larsen | 2013 | World Journal of Gastroenterology2013，19，42： | 3 |
| 2 | Translational pain research: Evaluating analgesic effect in experimental visceral pain models显示文摘Deep visceral pain is frequent and presents major challenges in pain management, since its pathophysiology is still poorly understood. One way to optimize treatment of visceral pain is to improve knowledge of the mechanisms behind the pain and the mode of action of analgesic substances. This can be achieved through stand-ardized experimental human pain models. Experimental pain models in healthy volunteers are advantageous for evaluation of analgesic action, as this is often diff icult to assess in the clinic because of confounding factors such as sedation, nausea and general malaise. These pain models facilitate minimizing the gap between knowledge gained in animal and human clinical studies. Combining experimental pain studies and pharmacokinetic stud- ies can improve understanding of the pharmacokinetic-pharmacodynamic relationship of analgesics and, thus, provide valuable insight into optimal clinical treatment of visceral pain. To improve treatment of visceral pain, it is important to study the underlying mechanisms of pain and the action of analgesics used for its treatment. An experimental pain model activates different modalities and can be used to investigate the mechanism of action of different analgesics in detail. In combination with pharmacokinetic studies and objective assessment such as electroencephalography, new information re-garding a given drug substance and its effects can be obtained. Results from experimental human visceral pain research can bridge the gap in knowledge between animal studies and clinical condition in patients suffering from visceral pain, and thus constitute the missing link in translational pain research. | Anne Estrup Olesen Trine Andresen Lona Louring Christrup Richard N Upton | 2009 | World Journal of Gastroenterology2009，15，2： | 3 |
| 3 | Opioid-Induced Bowel Dysfunction显示文摘 | Christina Brock S?ren Schou Olesen Anne Estrup Olesen Jens Br?ndum Fr?kjaer Trine Andresen Asbj?rn Mohr Drewes | 2012 | Drugs2012，，14： | 1 |
| 4 | Structural models of the reconstructed W{001} surface显示文摘 | BARKER R A ESTRUP P J JONA F | 1978 | Solid State Commun1978，25，： | 1 |
| 5 | 铁对仔猪健康和生长的重要作用显示文摘虽然大多数猪场饲养员会给出生后一周内的仔猪补铁,但在猪群饲养中,铁作为保证健康和促生长的重要角色并没有引起更广泛的关注。“这种情况非常奇怪。”哥本哈根大学彼得·尼尔森教授表示。他认为增加对铁的关注会有多方面的优势。 | 黎先伟 Adam Estrup | 2014 | 兽医导刊2014，，4： | 1 |
| 6 | Opioid-Induced Bowel Dysfunction显示文摘 | Christina Brock S?ren Schou Olesen Anne Estrup Olesen Jens Br?ndum Fr?kjaer Trine Andresen Asbj?rn Mohr Drewes | 2012 | Drugs2012，，14： | 1 |
| 7 | Opioid-Induced Bowel Dysfunction显示文摘 | Christina Brock S?ren Schou Olesen Anne Estrup Olesen Jens Br?ndum Fr?kjaer Trine Andresen Asbj?rn Mohr Drewes | 2012 | Drugs2012，，14： | 1 |
| 8 | Different effects of morphine and oxycodone in experimentally evoked hyperalge- sia:a human translational study 显示文摘 | Anne Estrup Olesen Camilla Staahl Lars Arendt-Nielsen | 2010 | British Journal of Clinical Pharma- cology2010，13，2： | 1 |
| 9 | Low cost PC based scanning Kelvin probe显示文摘 | Baike I D Estrup P J | 1998 | Rev Sci Instrum1998，69，11： | 1 |
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