|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 2 | Resequencing of 145 Landmark Cultivars Reveals Asymmetric Sub-genome Selection and Strong Founder Genotype Effects on Wheat Breeding in China显示文摘Controlled pedigrees and the multi-decade timescale of national crop plant breeding programs offer a unique experimental context for examining how selection affects plant genomes.More than 3000 wheat cultivars have been registered,released,and documented since 1949 in China.In this study,a set of 145 elite cultivars selected from historical points of wheat breeding in China were re-sequenced.A total of 43.75 Tb of sequence data were generated with an average read depth of 17.94x for each cultivar,and more than 60.92 million SNPs and 2.54 million InDels were captured,based on the Chinese Spring RefSeq genome v1.0.Seventy years of breeder-driven selection led to dramatic changes in grain yield and related phenotypes,with distinct genomic regions and phenotypes tar-geted by different breeders across the decades.There are very clear instances illustrating how introduced Italian and otherforeign germplasm was integrated into Chinese wheat programs and reshaped the genomic landscape of local modern cultivars.Importantly,the resequencing data also highlighted significant asymmetric breeding selec-tion among the three sub-genomes:this was evident in both the collinear blocks for homeologous chromosomes and among sets of three homeologous genes.Accumulation of more newly assembled genes in newer cultivars implied the potential value of these genes in breeding.Conserved and extended sharing of linkage disequilibrium(LD)blocks was highlighted among pedigree-related cultivars,in which fewer haplotype differences were detected.Fixation or replacement of haplotypes from founder genotypes after generations of breeding was related to their breeding value.Based on the haplotype frequency changes in LD blocks of pedigree-related cultivars,we propose a strategy for evaluating the breeding value of any given line on the basis of the accumulation(pyramiding)of bene-ficial haplotypes.Collectively,our study demonstrates the influence of 'founder genotypes' on the output of breeding efforts over many decades and also suggests that founder genotype perspectives are in fact more dy-namic when applied in the context of modern genomics-informed breeding. | Chenyang Hao Chengzhi Jiao Jian Hou Tian Li Hongxia Liu Yuquan Wang Jun Zheng Hong Liu Zhihong Bi Fengfeng Xu Jing Zhao Lin Ma Yamei Wang Uzma Majeed Xu Liu Rudi Appels Marco Maccaferri Roberto Tuberosa Hongfeng Lu Xueyong Zhang | 2020 | Molecular Plant2020，13，12： | 9 |
| 3 | MicroRNA-195 and microRNA-378 mediate tumor growth suppression by epigenetical regulation in gastric cancer显示文摘 | Hongxia Deng Yanan Guo Haojun Song Bingxiu Xiao Weiliang Sun Zhong Liu Xiuchong Yu Tian Xia Long Cui Junming Guo | 2013 | Gene2013，，： | 5 |
| 4 | Breast cancer-specific serum peptide profiles显示文摘Early detection of breast cancer is paramount to successful clinical therapy. Yet, early-stage breast cancer lacks specific symptoms or biomarkers. With the emerging of the mass spectrometric (MS) -based signatures as biomarkers, we investigated breast cancer-related serum profile pattern through class prediction and independent validation, and used Fourier transfer MS to identify breast cancer signature. We now show a distinctive serum peptide pattern that discriminates breast cancer from healthy controls with 93.2% sensitivity and 95.4% specificity. m/z 5901.70 and 4465.74 of ion fragment of FPA and alpha1-antichymotrypsin are found in the signatures that predominantly discriminate breast cancer from healthy individuals. These novel findings identify an MS-based serum peptide pattern of breast cancer that may have direct clinical utility in future. | WANG Na WEN XinYu WANG Jie LI AiLing LI WeiHua LI Tao Li Yan ZHANG XueMin WANG HongXia YANG SongCheng ZHOU Tao GONG WeiLi TIAN YaPing HE Kun | 2009 | Chinese Science Bulletin2009，54，3： | 4 |
| 5 | 中国第9次北极考察概述显示文摘中国第9次北极考察航次于2018年7月20日至9月26日执行,在白令海、楚科奇海、楚科奇海台、门捷列夫海岭和加拿大海盆开展了物理海洋、海洋气象、海冰、海洋化学、海洋生物、海洋生态、地质和地球物理等多学科综合考察。本文对中国第9次北极考察取得的主要成果进行了概述。 | WEI Zexun CHEN Hongxia LEI Ruibo YU Xiaoguo ZHANG Tao LIN Lina TIAN Zhongxiang ZHUANG Yanpei LI Tao YUAN Zhuoli | 2020 | Atmospheric and Oceanic Science Letters2020，13，1： | 4 |
| 6 | Fast integration and accumulation of beneficial breeding alleles through an AB–NAMIC strategy in wheat显示文摘Wheat(Triticum aestivum)is among the most important staple crops for safeguarding the food security of the growing world population.To bridge the gap between genebank diversity and breeding programs,we developed an advanced backcross-nested association mapping plus inter-crossed population(AB-NAMIC)by crossing three popular wheat cultivars as recurrent founders to 20 germplasm lines from a mini core collection.Selective backcrossing combined with selection against undesirable traits and extensive crossing within and between sub-populations created new opportunities to detect unknown genes and increase the frequency of beneficial alleles in the AB-NAMIC population.We performed phenotyping of 590 AB-NAMIC lines and a natural panel of 476 cultivars for six consecutive growing seasons and genotyped these 1066 lines with a 660K SNP array.Genome-wide association studies of both panels for plant development and yield traits demonstrated improved power to detect rare alleles and loci with medium genetic effects in AB-NAMIC.Notably,genome-wide association studies in AB-NAMIC detected the candidate gene TaSWEET6-7B(TraesCS7B03G1216700),which has high homology to the rice SWEET6b gene and exerts strong effects on adaptation and yield traits.The commercial release of two derived AB-NAMIC lines attests to its direct applicability in wheat improvement.Valuable information on genome-wide association studymapping,candidate genes,and their haplotypes for breeding traits are available through WheatGAB.Our research provides an excellent framework for fast-tracking exploration and accumulation of beneficial alleles stored in genebanks. | Chengzhi Jiao Chenyang Hao Tian Li Abhishek Bohra Lanfen Wang Jian Hou Hongxia Liu Hong Liu Jing Zhao Yamei Wang Yunchuan Liu Zhiwei Wang Xin Jing Xiue Wang Rajeev K.Varshney Junjie Fu Xueyong Zhang | 2023 | Plant Communications2023，4，3： | 3 |
| 7 | Diversity and sub-functionalization of TaGW8 homoeologs hold potential for genetic yield improvement in wheat显示文摘Grain Weight 8(GW8) in rice is a SQUAMOSA Promoter-Binding Protein-Like(SPL) family transcription factor with multiple biological functions. In this study, three GW8 homoeologs were cloned from homoeologous group 7 chromosomes of wheat. Subcellular localization and trans-activation activity assays suggested that Ta GW8 is a transcriptional activator.Ta GW8 genes were preferentially expressed in young spikes and developing grains. Ectopic expressions of Ta GW8 in Arabidopsis and rice resulted in enhanced vegetative growth,earlier flowering and larger seeds. Ta GW8-7 A was the most highly variable of the three homoeologs with four haplotypes(Hap-1/2/3/4). Ta GW8-7 B had two haplotypes(Hap-L/H).Ta GW8-7 A-Hap-2 was associated with high thousand-grain weight(TGW) and large kernel length and showed higher transcriptional levels and binding activity than the other haplotypes. The high frequency of Ta GW8-7 A-Hap-2 in Chinese wheat populations suggested that it had been extensively selected in breeding. This haplotype showed a high potential for exploitation in global wheat breeding because its frequency was low in exotic germplasm. Ta GW8-7 B-Hap-H produced abundant transcripts and was associated with early heading and maturity, less tiller number and high TGW. This haplotype might be suitable for multiple cropping systems due to short wheat season. In this study we identified sub-functionalization among Ta GW8 homoeologs and obtained functional molecular markers that can be used in breeding for high grain yield. | Lin Ma Chenyang Hao Hongxia Liu Jian Hou Tian Li Xueyong Zhang | 2019 | The Crop Journal2019，7，6： | 3 |
| 8 | Genomic footprints of wheat evolution in China reflected by a Wheat660K SNP array显示文摘Common wheat(Triticum aestiuum L.)is one of the most important crops because it provides about 20%of the total calories for humans.T.aestiuum is an excellent modern species for studying concerted evolution of sub-genomes in polyploid species,because of its large chromosome size and three well-known genome donors.Establishment of common wheat genome reference sequence and development of high-density SNP chips provide an excellent foundation to answer questions of wheat evolution and breeding at the genomic level.By genotyping more than 600 accessions of common wheat and their diploid and tetraploid ancestors using a Wheat660 K SNP array,we found dramatic genome changes due to tetraploidization and hexaploidization,in contrast to weaker influences of domestication and breeding on them.Further,since common wheat was introduced in China in 1500 BCE,Chinese landraces formed two subgroups(T.aestiuum-L1 and T.aestiuum-L2)with considerably diverse geographic distributions and agronomic traits.T.aestiuum-L2,mainly distributed in central and east China is found to have more but smaller oval grains with early maturity characteristics.We found that variation and selection in intergenic regions of the A and B sub-genomes dominated this differentiation,in which chromosomes 7 A and 3 B took the leading roles due to the existence of putative genes related to defense responses and environmental adaption in the highly differentiated regions.Large haplotype blocks were detected on 3 B(232.6-398.3 Mb)and 7 A(211.7-272.9 Mb)in the landraces,forming two distinct haplotypes,respectively.We discovered that artificial crosses in breeding promoted recombination in the whole genome,however,this recombination and differentiation was highly asymmetric among the three sub-genomes in homoeologous regions.In addition,we found that the wide use of European and northern American cultivars in breeding at early era,led dramatic changes in Chinese wheat genome,whereas,the recent breeding functioned to optimize it.This study will provide the insight for reconsideration of wheat evolution and breeding,and a new strategy for parent selection in breeding. | Zhiwei Wang Chenyang Hao Jing Zhao Chang Li Chengzhi Jiao Wei Xi Jian Hou Tian Li Hongxia Liu Xueyong Zhang | 2021 | The Crop Journal2021，9，1： | 2 |
| 9 | An improved least mean square/fourth direct adaptive equalizer for under-water acoustic communications in the Arctic显示文摘An improved least mean square/fourth direct adaptive equalizer(LMS/F-DAE)is proposed in this paper for underwater acoustic communication in the Arctic.It is able to process complex-valued baseband signals and has better equalization performance than LMS.Considering the sparsity feature of equalizer tap coefficients,an adaptive norm(AN)is incorporated into the cost function which is utilized as a sparse regularization.The norm constraint changes adaptively according to the amplitude of each coefficient.For small-scale coefficients,the sparse constraint exists to accelerate the convergence speed.For large-scale coefficients,it disappears to ensure smaller equalization error.The performance of the proposed AN-LMS/F-DAE is verified by the experimental data from the 9th Chinese National Arctic Research Expedition.The results show that compared with the standard LMS/F-DAE,AN-LMS/F-DAE can promote the sparse level of the equalizer and achieve better performance. | Yanan Tian Xiao Han Jingwei Yin Hongxia Chen Qingyu Liu | 2020 | Acta Oceanologica Sinica2020，39，9： | 1 |
| 10 | Study on the job stress of miners显示文摘 | LI Hongxia FAN Yongbin TIAN Shuicheng | 2014 | Procedia Engineering2014，84，： | 1 |
| 11 | Genetic variants of miRNA sequences and non-small cell lung cancer survival显示文摘 | Hu Zhibin Chen Jiaping Tian Tian Zhou Xiaoyi Gu Haiyong Xu Lin Zeng Yi Miao Ruifen Jin Guangfu Ma Hongxia Chen Yijiang Shen Hongbing | 2008 | Journal of Clinical Investigation2008，，7： | 1 |
| 12 | Minimum-costoptimization in muhicommodity logistic chain network显示文摘 | Li Hongxia Tian Shuicheng Pan Yuan | 2005 | Lecture Notes in Computer Science2005，3519，： | 1 |
| 13 | GPER in CAFs regulates hypoxia-driven breast cancer invasion in a CTGF-dependentmanner显示文摘 | Juan Ren Hui Guo Huili Wu Tao Tian Danfeng Dong Yuelang Zhang Yanxia Sui Yong Zhang Dongli Zhao Shufeng Wang Zongfang Li Xiaozhi Zhang Rui Liu Jianshneg Qian Hongxia Wei Wenjun Jiang Ya Liu Yi Li | 2015 | Oncology Reports2015，，： | 1 |
| 14 | Effect of temperature on chilling injury, decay and quality of Hami melon during storage显示文摘 | Bi Yang Tian Shiping Liu Hongxia | 2003 | Posthavest Biol Techno2003，29，： | 1 |
| 15 | Effect of temperature on chilling injury, decay and quality of Hami melon during storage显示文摘 | BI Yang TIAN Shiping L1U Hongxia | 2003 | Postharvest Biology and Technology2003，29，2： | 1 |
| 16 | Increased dissolution and oral absorption of itraconazole/Soluplus extrudate compared with itraconazole nanosuspension显示文摘 | Keru Zhang Hongxia Yu Qing Luo Shenshen Yang Xia Lin Yu Zhang Bin Tian Xing Tang | 2013 | European Journal of Pharmaceutics and Biopharmaceutics2013，，： | 1 |
| 17 | Effect of temperature on chilling injury, decay and quality of Hami melon during storage显示文摘 | Bi Yang Tian Shiping Lui Hongxia Zhao Jie Cao Jiankang Li Yongcai Zhang Weiyi | 2003 | Postharvest Biology and Technology2003，，： | 1 |
| 18 | Study on the efficacy of the safety incentive mechanisms显示文摘 | Tian Shuicheng Li Hongxia Feng Changgen | 2001 | Journal of Coal Science and Engineering2001，，1： | 1 |
| 19 | Effect of temperature on chilling injury, decay and quality of Hami melon during storage显示文摘 | Bi Yang Tian Shiping Liu Hongxia | 2003 | Postharvest Biology and Technology2003，29，： | 1 |
| 20 | Effect of temperature onchilling injury,decay and quality of Hami melon during storage显示文摘 | BI Yang TIAN Shiping LIU Hongxia | 2003 | Postharvest Biology and Technology2003，29，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员