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| 1 | Characterization of the caprine stearoyl-CoA desaturase gene and its mRNA showing an unusually long 3′-UTR sequence arising from a single exon显示文摘 | Laurence Bernard Christine Leroux Hélène Hayes Mathieu Gautier Yves Chilliard Patrice Martin | 2001 | Gene2001，，1： | 2 |
| 2 | Reproducibility of blood tests of liver fibrosis in clinical practice显示文摘 | Paul Calès Pascal Veillon Anselme Konaté Elisabeth Mathieu Catherine Ternisien Alain Chevailler Alban Godon Yves Gallois Fran?oise Joubaud Isabelle Hubert-Fouchard Frédéric Oberti Stéphane Réaud Gilles Hunault Fran?oise Mauriat Fran?oise Lunel-Fabiani | 2007 | Clinical Biochemistry2007，，1： | 1 |
| 3 | Study of silicon–germanium interdiffusion from pure germanium deposited layers显示文摘 | Mathieu Gavelle El Mehdi Bazizi Emmanuel Scheid Claude Armand Pier Francesco Fazzini Olivier Marcelot Yves Campidelli Aomar Halimaoui Fuccio Cristiano | 2008 | Materials Science & Engineering B2008，，： | 1 |
| 4 | A new pear scab resistance gene Rvp1 from the European pear cultivar ‘ Navara’ maps in a genomic region syntenic to an apple scab resistance gene cluster on linkage group 2显示文摘 | Lydie Bouvier Marie Bourcy Mathieu Boulay Marie Tellier Philippe Guérif Caroline Denancé Charles-Eric Durel Yves Lespinasse | 2012 | Tree Genetics & Genomes2012，8，1： | 1 |
| 5 | Efficient Data Access Management for FPGA-based Image Processing SoCs 显示文摘 | Zahir Larabi Yves Mathieu | 2009 | IEEE/IFIP International Symposium on Rapid System Prototyping(S1074-6005)2009，20，1： | 1 |
| 6 | HIV Integrase Inhibitors显示文摘 | Mathieu Métifiot Christophe Marchand Yves Pommier | 2013 | Advances in Pharmacology2013，，： | 1 |
| 7 | Fetal Vesicoallantoic Cyst and Intraabdominal Defects: An Unusual Case and Review of the Literature显示文摘We present an unusual and,until now,unreported case of vesicoallantoic cyst associated with multiple malformations in a fetus.A differential diagnosis is discussed,including the hypothesis of a genetic disorder. | Mathieu Delvaux Yves Sznajer Etienne Marbaix Jean Marc Biard Corinne Hubinont | 2022 | Maternal-Fetal Medicine2022，4，2： | 0 |
| 8 | Experimental evidence of Wolbachia introgressive acquisition between terrestrial isopod subspecies显示文摘Wolbachia are the most widespread endosymbiotic bacteria in animals.In many arthropod host species,they manipulate reproduction via several mechanisms that favor their maternal transmission to offspring.Among them,cytoplasmic incompatibility(Cl)promotes the spread of the symbiont by specifically decreasing the fertility of crosses involving infected males and uninfected females,via embryo mortality.These differences in reproductive efficiency may select for the avoidance of incompatible mating,a process called reinforcement,and thus contribute to population divergence.In the terrestrial isopod Porcellio dilatatus,the Wolbachia wPet strain infecting the subspecies P.d.petiti induces unidirectional Cl with uninfected individuals of the subspecies P.d.dilatatus.To study the consequences of Cl on P.d.dilatatus and P.d.petiti hybridization,mitochondrial haplotypes and Wolbachia infection dynamics,we used population cages seeded with different proportions of the 2 subspecies in which we monitored these genetic parameters 5 and 7 years after the initial setup.Analysis of microsatellite markers allowed evaluating the degree of hybridization between individuals of the 2 subspecies.These markers revealed an increase in P.d.dilatatus nuclear genetic signature in all mixed cages,reflecting an asymmetry in hybridization.Hybridization led to the introgressive acquisition of Wolbachia and mitochondrial haplotype from P.d.petiti into nuclear genomes dominated by alleles of P.d.dilatatus.We discuss these results with regards to Wolbachia effects on their host(Cl and putative fitness cost),and to a possible reinforcement that may have led to assortative mating,as possible factors contributing to the observed results. | Nicolas Bech Sophie Beltran-Bech Cassandre Chupeau Jean Peccoud Magali Thierry Roland Raimond Yves Caubet Mathieu Sicard Pierre Greve | 2021 | Current Zoology2021，67，4： | 0 |
| 9 | MP联合沙利度胺、MP和低强度自体干细胞移植治疗老年多发性骨髓瘤(IFM99—06):一项随机试验显示文摘背景对于老年人多发性骨髓瘤,马法兰与泼尼松联合化疗方案(MP)目前仍被认为是标准治疗方案。本试验旨在评价在MP方案的基础上联用沙利度胺或低强度的自体干细胞移植能否提高患者的存活率。
方法从2000年5月22日到2005年8月8日,共招募447例初治多发性骨髓瘤患者,年龄65~75岁,随机接受MP方案(n=196)、MP联合沙利度胺方案(MPT,n=125)或低强度(马法兰,100mg/m^2)的自体干细胞移植方案(MEL100,n=126)。主要终点为总体存活率。采用意向治疗分析。本试验已在ClinicalTrials.gov注册,注册号为NCT00367185。
结果中位随访51.5个月(IQR34.4~63.2),中位总体存活时间:MP组为33.2个月(13.8~54.8),MPT组为51.6个月(26.6~未到达),MELl00组为38.3个月(13.0~61.6)。在中位总体存活率方面,MPT方案优于MP方案(HR0.59,95%C10.46~0.81:P=0.0006)或MEL100方案(HR0.69,95%C10.49~0.96;P=0.027)。而MEL100方案和MP方案无差异(HR0.86,95%C10.65~1.15;P=0.32)。
结论试验结果提示,MPT方案目前应作为老年多发性骨髓瘤初治的推荐方案。 | Thierry Facon Jean Yves Mary Cyrille Hulin Lotfi Benboubker Michel Attal Brigitte Pegourie Marc Renaud Jean Luc Harou-sseau Gaelle Guillerm Carine Chaleteix Mamoun Dib Laurent Voillat Herve Maisonneuve Jacques Troncy Veronique Dorv-aux Mathieu Monconduit Claude Martin Philippe Casassus Jerome Jaubert Henry Jardel Chantal Doyen Brigitte Kolb Bruno Anglaret Bernard Grosbois Ibrahim Yakoub-Agha Claire Mathiot Herve Avet-Loiseau 王鸿鹄(译) | 2008 | 世界临床医学2008，2，1： | 0 |
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